Factor VIII - Revision history

Michal Harel at 08:56, 27 February 2023

Michal Harel — Mon, 27 Feb 2023 08:56:07 GMT

←Older revision		Revision as of 08:56, 27 February 2023
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	[[7kwo]] – hFVIII + VWF-XTEN<br />		[[7kwo]] – hFVIII + VWF-XTEN<br />
	[[4mo3]] - pFVIII light chain C2 domain – pig<br />		[[4mo3]] - pFVIII light chain C2 domain – pig<br />
		+	[[7s0p]] - pFVIII light chain C2 domain + phosphatidylserine<br />
	[[4ki5]] - mFVIII light chain C2 domain + monoclonal Fab – mouse<br />		[[4ki5]] - mFVIII light chain C2 domain + monoclonal Fab – mouse<br />
	== References ==		== References ==

Michal Harel at 07:29, 22 July 2021

Michal Harel — Thu, 22 Jul 2021 07:29:03 GMT

←Older revision		Revision as of 07:29, 22 July 2021
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	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}		Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

-	[[2r7e]], [[3cdz]], [[3j2q]], [[4bdv]], [[6mf2]] – hFVIII – human<br />	+	[[2r7e]], [[3cdz]], [[3j2q]], [[4bdv]], [[6mf2]] – hFVIII 19-760+1582-2351 – human<br />
-	[[3hnb]], [[3hny]], [[3hob]] – hFVIII light chain C2 domain<br />	+	[[6mf0]] – h/pFVIII<br />
		+	[[3hnb]], [[3hny]], [[3hob]], [[4pt6]] – hFVIII light chain C2 domain 2189-2347<br />
	[[1d7p]] - hFVIII light chain C2 domain (mutant)<br />		[[1d7p]] - hFVIII light chain C2 domain (mutant)<br />
	[[1cfg]], [[1fac]] - hFVIII light chain C2 domain membrane-binding peptide - NMR<br />		[[1cfg]], [[1fac]] - hFVIII light chain C2 domain membrane-binding peptide - NMR<br />
-	[[~~1iqd~~]] ~~- hFVIII light chain C2 domain (mutant)~~ + ~~monoclonal Fab~~<br />	+	[[7k66]], [[7kbt]] – h/pFVIII + antibody<br />
	[[4xzu]] - hFVIII light chain C2 domain + monoclonal Fab <br />		[[4xzu]] - hFVIII light chain C2 domain + monoclonal Fab <br />
-	[[~~4pt6~~]] - hFVIII ~~discoidin domain <br />~~	+	[[1iqd]] - hFVIII light chain C2 domain (mutant) + monoclonal Fab<br />
-	~~[[4ki5]] - mFVIII~~ light chain C2 domain + monoclonal Fab ~~– mouse~~<br />	+	[[3j2s]] - hFVIII light chain 1710-2356<br />
-	[[3j2s]] - hFVIII light chain<br />	+	[[5k8d]] - hFVIII heavy chain + light chain residues 104-329<br />
-	[[5k8d]] - hFVIII heavy chain + light chain ~~residus~~ 104-329<br />	+	[[7kwo]] – hFVIII + VWF-XTEN<br />
	[[4mo3]] - pFVIII light chain C2 domain – pig<br />		[[4mo3]] - pFVIII light chain C2 domain – pig<br />
-	[[~~6mf0~~]] – ~~p/hFVIII~~<br />	+	[[4ki5]] - mFVIII light chain C2 domain + monoclonal Fab – mouse<br />
	== References ==		== References ==
	<references/>		<references/>

Michal Harel at 09:06, 26 July 2020

Michal Harel — Sun, 26 Jul 2020 09:06:54 GMT

←Older revision		Revision as of 09:06, 26 July 2020
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	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}		Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

-	[[2r7e]], [[3cdz]], [[3j2q]], [[4bdv]] – hFVIII – human<br />	+	[[2r7e]], [[3cdz]], [[3j2q]], [[4bdv]], [[6mf2]] – hFVIII – human<br />
	[[3hnb]], [[3hny]], [[3hob]] – hFVIII light chain C2 domain<br />		[[3hnb]], [[3hny]], [[3hob]] – hFVIII light chain C2 domain<br />
	[[1d7p]] - hFVIII light chain C2 domain (mutant)<br />		[[1d7p]] - hFVIII light chain C2 domain (mutant)<br />
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	[[3j2s]] - hFVIII light chain<br />		[[3j2s]] - hFVIII light chain<br />
	[[5k8d]] - hFVIII heavy chain + light chain residus 104-329<br />		[[5k8d]] - hFVIII heavy chain + light chain residus 104-329<br />
-	[[4mo3]] - ~~FVIII~~ light chain C2 domain – pig<br />	+	[[4mo3]] - pFVIII light chain C2 domain – pig<br />
		+	[[6mf0]] – p/hFVIII<br />
	== References ==		== References ==
	<references/>		<references/>

Alexander Berchansky at 11:04, 2 January 2020

Alexander Berchansky — Thu, 02 Jan 2020 11:04:48 GMT

←Older revision		Revision as of 11:04, 2 January 2020
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	== Disease ==		== Disease ==

-	Defects in the protein result in hemophilia A.	+	Defects in the protein result in [[Hemophilia\|hemophilia]] A.

	== Relevance ==		== Relevance ==

Alexander Berchansky at 10:50, 17 March 2019

Alexander Berchansky — Sun, 17 Mar 2019 10:50:42 GMT

←Older revision		Revision as of 10:50, 17 March 2019
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	[[Factor VIII]] (FVIII) is a blood clotting factor. FVIII is a cofactor for [[Factor IX\|factor IXa]]<ref>PMID:2491949</ref> . See also [[Factor VIII (Hebrew)]].		[[Factor VIII]] (FVIII) is a blood clotting factor. FVIII is a cofactor for [[Factor IX\|factor IXa]]<ref>PMID:2491949</ref> . See also [[Factor VIII (Hebrew)]].

-	<scene name='45/451726/Cv/3'>First Ca coordination site</scene>.	+	<scene name='45/451726/Cv/7'>First Ca coordination site</scene>.

-	<scene name='45/451726/Cv/4'>Second Ca coordination site</scene>.	+	<scene name='45/451726/Cv/8'>Second Ca coordination site</scene>.

-	<scene name='45/451726/Cv/5'>First Cu coordination site</scene>.	+	<scene name='45/451726/Cv/9'>First Cu coordination site</scene>.

-	<scene name='45/451726/Cv/6'>Second Cu coordination site</scene> (PDB code [[2r7e]]).<ref>PMID:17965321</ref>	+	<scene name='45/451726/Cv/10'>Second Cu coordination site</scene> (PDB code [[2r7e]]).<ref>PMID:17965321</ref>
	== Disease ==		== Disease ==

Michal Harel at 09:12, 22 May 2018

Michal Harel — Tue, 22 May 2018 09:12:13 GMT

←Older revision		Revision as of 09:12, 22 May 2018
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	[[4ki5]] - mFVIII light chain C2 domain + monoclonal Fab – mouse<br />		[[4ki5]] - mFVIII light chain C2 domain + monoclonal Fab – mouse<br />
	[[3j2s]] - hFVIII light chain<br />		[[3j2s]] - hFVIII light chain<br />
		+	[[5k8d]] - hFVIII heavy chain + light chain residus 104-329<br />
	[[4mo3]] - FVIII light chain C2 domain – pig<br />		[[4mo3]] - FVIII light chain C2 domain – pig<br />
	== References ==		== References ==

Michal Harel at 08:43, 11 May 2017

Michal Harel — Thu, 11 May 2017 08:43:43 GMT

←Older revision		Revision as of 08:43, 11 May 2017
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	[[1cfg]], [[1fac]] - hFVIII light chain C2 domain membrane-binding peptide - NMR<br />		[[1cfg]], [[1fac]] - hFVIII light chain C2 domain membrane-binding peptide - NMR<br />
	[[1iqd]] - hFVIII light chain C2 domain (mutant) + monoclonal Fab<br />		[[1iqd]] - hFVIII light chain C2 domain (mutant) + monoclonal Fab<br />
		+	[[4xzu]] - hFVIII light chain C2 domain + monoclonal Fab <br />
		+	[[4pt6]] - hFVIII discoidin domain <br />
	[[4ki5]] - mFVIII light chain C2 domain + monoclonal Fab – mouse<br />		[[4ki5]] - mFVIII light chain C2 domain + monoclonal Fab – mouse<br />
	[[3j2s]] - hFVIII light chain<br />		[[3j2s]] - hFVIII light chain<br />

Alexander Berchansky at 13:12, 16 February 2016

Alexander Berchansky — Tue, 16 Feb 2016 13:12:42 GMT

←Older revision		Revision as of 13:12, 16 February 2016
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	<scene name='45/451726/Cv/4'>Second Ca coordination site</scene>.		<scene name='45/451726/Cv/4'>Second Ca coordination site</scene>.

-	<scene name='45/451726/Cv/5'>First Cu coordination site</scene>	+	<scene name='45/451726/Cv/5'>First Cu coordination site</scene>.
		+
		+	<scene name='45/451726/Cv/6'>Second Cu coordination site</scene> (PDB code [[2r7e]]).<ref>PMID:17965321</ref>
	== Disease ==		== Disease ==

Alexander Berchansky at 13:04, 16 February 2016

Alexander Berchansky — Tue, 16 Feb 2016 13:04:22 GMT

←Older revision		Revision as of 13:04, 16 February 2016
Line 5:		Line 5:

	<scene name='45/451726/Cv/3'>First Ca coordination site</scene>.		<scene name='45/451726/Cv/3'>First Ca coordination site</scene>.
		+
		+	<scene name='45/451726/Cv/4'>Second Ca coordination site</scene>.
		+
		+	<scene name='45/451726/Cv/5'>First Cu coordination site</scene>
	== Disease ==		== Disease ==

Alexander Berchansky at 12:53, 16 February 2016

Alexander Berchansky — Tue, 16 Feb 2016 12:53:14 GMT

←Older revision		Revision as of 12:53, 16 February 2016
Line 4:		Line 4:
	[[Factor VIII]] (FVIII) is a blood clotting factor. FVIII is a cofactor for [[Factor IX\|factor IXa]]<ref>PMID:2491949</ref> . See also [[Factor VIII (Hebrew)]].		[[Factor VIII]] (FVIII) is a blood clotting factor. FVIII is a cofactor for [[Factor IX\|factor IXa]]<ref>PMID:2491949</ref> . See also [[Factor VIII (Hebrew)]].

-	~~<!--~~	+	<scene name='45/451726/Cv/3'>First Ca coordination site</scene>.
-	~~===RECOMBINANT HUMAN CELLULAR COAGULATION FACTOR XIII===~~	+
-	~~The A subunit is composed of an activation peptide and 4 domains: the β-sandwich~~ <scene name='~~1f13~~/~~Chaina_domain1~~/~~1'>domain<~~/~~scene>, the central core domain, the barrel 1 domain, and the~~	+
-	~~<scene name='1f13/Fxiii_4domains_colored/1~~'>~~barrel 2 domain~~</scene>.~~-->~~	+
	== Disease ==		== Disease ==