Factor inhibiting HIF - Revision history

Michal Harel at 11:28, 26 February 2023

Michal Harel — Sun, 26 Feb 2023 11:28:13 GMT

←Older revision		Revision as of 11:28, 26 February 2023
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	**[[2cgn]] – hFIH1α + succinate<br />		**[[2cgn]] – hFIH1α + succinate<br />
	**[[2cgo]] – hFIH1α + fumarate<br />		**[[2cgo]] – hFIH1α + fumarate<br />
-	**[[1mzf]], [[2wa3]], [[2wa4]], [[2yc0]], [[2yde]], [[4z2w]], [[5jwk]] – hFIH1α + oxoglutarate derivative<br />	+	**[[1mzf]], [[2wa3]], [[2wa4]], [[2yc0]], [[2yde]], [[4z2w]], [[5jwk]], [[7a1j]], [[7a1k]], [[7a1l]], [[7a1m]] – hFIH1α + oxoglutarate derivative<br />
	**[[5jwk]], [[5jwl]] - hFIH1α (mutant) + ketoglutarate<br />		**[[5jwk]], [[5jwl]] - hFIH1α (mutant) + ketoglutarate<br />
	**[[5op6]], [[5op8]], [[5opc]] - hFIH1α + inhibitor<br />		**[[5op6]], [[5op8]], [[5opc]] - hFIH1α + inhibitor<br />
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	**[[1l8c]] - hFIH 1α C terminal + CREB-binding protein zinc finger<br />		**[[1l8c]] - hFIH 1α C terminal + CREB-binding protein zinc finger<br />
	**[[4h6j]] - hFIH 1α PAS B domain (mutant) + aryl hydrocarbon nuclear translocator<br />		**[[4h6j]] - hFIH 1α PAS B domain (mutant) + aryl hydrocarbon nuclear translocator<br />
-	**[[4b7e]], [[4b7k]], [[4jaa]], [[4nr1]] - hFIH1α + consensus ankyrin repeat peptide<br />	+	**[[4b7e]], [[4b7k]], [[4jaa]], [[4nr1]], [[7a1q]] - hFIH1α + consensus ankyrin repeat peptide<br />
		+	**[[7a1n]], [[7a1o]], [[7a1p]], [[7a1s]] - hFIH1α + consensus ankyrin repeat peptide + oxoglutarate derivative <br />
	**[[6h9j]], [[6ha6]] - hFIH1α + TRPV3 peptide + oxalylglycine<br />		**[[6h9j]], [[6ha6]] - hFIH1α + TRPV3 peptide + oxalylglycine<br />
	**[[6hc8]] - hFIH1α + TRPA1 peptide + oxalylglycine<br />		**[[6hc8]] - hFIH1α + TRPA1 peptide + oxalylglycine<br />

Michal Harel at 08:56, 26 July 2020

Michal Harel — Sun, 26 Jul 2020 08:56:19 GMT

←Older revision		Revision as of 08:56, 26 July 2020
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-	For details on '''Factor inhibiting HIF''' see [[Molecular Playground/FIH]]. HIF is hypoxia-inducible factor - transcription factors that respond to hypoxia, i.e., decrease in oxygen<ref>PMID:23606740</ref>. <scene name='48/480806/Cv/5'>Dimeric factor inhibiting HIF with oxogluterate derivative</scene>.	+	For details on '''Factor inhibiting HIF''' or '''Hypoxia-inducible factor 1-alpha inhibitor''' see [[Molecular Playground/FIH]]. HIF is hypoxia-inducible factor - transcription factors that respond to hypoxia, i.e., decrease in oxygen<ref>PMID:23606740</ref>. <scene name='48/480806/Cv/5'>Dimeric factor inhibiting HIF with oxogluterate derivative</scene>.

	<scene name='48/480806/Cv/6'>Fe/2-oxogluterate binding site</scene> (PDB code [[1mzf]]).<ref>PMID:12432100</ref>		<scene name='48/480806/Cv/6'>Fe/2-oxogluterate binding site</scene> (PDB code [[1mzf]]).<ref>PMID:12432100</ref>
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	**[[4h6j]] - hFIH 1α PAS B domain (mutant) + aryl hydrocarbon nuclear translocator<br />		**[[4h6j]] - hFIH 1α PAS B domain (mutant) + aryl hydrocarbon nuclear translocator<br />
	**[[4b7e]], [[4b7k]], [[4jaa]], [[4nr1]] - hFIH1α + consensus ankyrin repeat peptide<br />		**[[4b7e]], [[4b7k]], [[4jaa]], [[4nr1]] - hFIH1α + consensus ankyrin repeat peptide<br />
		+	**[[6h9j]], [[6ha6]] - hFIH1α + TRPV3 peptide + oxalylglycine<br />
		+	**[[6hc8]] - hFIH1α + TRPA1 peptide + oxalylglycine<br />
		+	**[[6hl6]] - hFIH1α + ASPP peptide + oxalylglycine<br />
		+	**[[6hl5]] - hFIH1α + ASPP1 peptide + oxalylglycine<br />
		+	**[[6hkp]] - hFIH1α + ASPP2 peptide + oxalylglycine<br />
		+	**[[6ruj]] - hFIH1α + ankyrin repeat + oxalylglycine<br />

	*FIH2α		*FIH2α

Alexander Berchansky at 11:23, 14 March 2019

Alexander Berchansky — Thu, 14 Mar 2019 11:23:32 GMT

←Older revision		Revision as of 11:23, 14 March 2019
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-	For details on '''Factor inhibiting HIF''' see [[Molecular Playground/FIH]]. HIF is hypoxia-inducible factor - transcription factors that respond to hypoxia, i.e., decrease in oxygen<ref>PMID:23606740</ref>. <scene name='48/480806/Cv/2'>Dimeric factor inhibiting HIF with oxogluterate derivative</scene>.	+	For details on '''Factor inhibiting HIF''' see [[Molecular Playground/FIH]]. HIF is hypoxia-inducible factor - transcription factors that respond to hypoxia, i.e., decrease in oxygen<ref>PMID:23606740</ref>. <scene name='48/480806/Cv/5'>Dimeric factor inhibiting HIF with oxogluterate derivative</scene>.

-	<scene name='48/480806/Cv/4'>Fe/2-oxogluterate binding site</scene> (PDB code [[1mzf]]).<ref>PMID:12432100</ref>	+	<scene name='48/480806/Cv/6'>Fe/2-oxogluterate binding site</scene> (PDB code [[1mzf]]).<ref>PMID:12432100</ref>
	</StructureSection>		</StructureSection>
	== 3D Structures of factor inhibiting HIF ==		== 3D Structures of factor inhibiting HIF ==

Michal Harel at 09:02, 22 May 2018

Michal Harel — Tue, 22 May 2018 09:02:41 GMT

←Older revision		Revision as of 09:02, 22 May 2018
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	**[[2cgn]] – hFIH1α + succinate<br />		**[[2cgn]] – hFIH1α + succinate<br />
	**[[2cgo]] – hFIH1α + fumarate<br />		**[[2cgo]] – hFIH1α + fumarate<br />
-	**[[1mzf]], [[2wa3]], [[2wa4]], [[2yc0]], [[2yde]], [[4z2w]] – hFIH1α + oxoglutarate derivative<br />	+	**[[1mzf]], [[2wa3]], [[2wa4]], [[2yc0]], [[2yde]], [[4z2w]], [[5jwk]] – hFIH1α + oxoglutarate derivative<br />
		+	**[[5jwk]], [[5jwl]] - hFIH1α (mutant) + ketoglutarate<br />
		+	**[[5op6]], [[5op8]], [[5opc]] - hFIH1α + inhibitor<br />
	**[[3kcx]], [[3kcy]], [[3od4]], [[4bio]] - hFIH1α + quinol derivative<br />		**[[3kcx]], [[3kcy]], [[3od4]], [[4bio]] - hFIH1α + quinol derivative<br />
	**[[4ai8]] - hFIH1α + daminozide<br />		**[[4ai8]] - hFIH1α + daminozide<br />

Michal Harel at 08:20, 11 May 2017

Michal Harel — Thu, 11 May 2017 08:20:13 GMT

←Older revision		Revision as of 08:20, 11 May 2017
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	**[[2cgn]] – hFIH1α + succinate<br />		**[[2cgn]] – hFIH1α + succinate<br />
	**[[2cgo]] – hFIH1α + fumarate<br />		**[[2cgo]] – hFIH1α + fumarate<br />
-	**[[1mzf]], [[2wa3]], [[2wa4]], [[2yc0]], [[2yde]] – hFIH1α + oxoglutarate derivative<br />	+	**[[1mzf]], [[2wa3]], [[2wa4]], [[2yc0]], [[2yde]], [[4z2w]] – hFIH1α + oxoglutarate derivative<br />
	**[[3kcx]], [[3kcy]], [[3od4]], [[4bio]] - hFIH1α + quinol derivative<br />		**[[3kcx]], [[3kcy]], [[3od4]], [[4bio]] - hFIH1α + quinol derivative<br />
	**[[4ai8]] - hFIH1α + daminozide<br />		**[[4ai8]] - hFIH1α + daminozide<br />
		+	**[[4z1v]] - hFIH1α + oxalylglycine + NO<br />

	*FIH1α complex with polypeptide		*FIH1α complex with polypeptide

	**[[1h2k]], [[1h2l]], [[1h2m]] – hFIH1α + HIF transactivation domain peptide<br />		**[[1h2k]], [[1h2l]], [[1h2m]] – hFIH1α + HIF transactivation domain peptide<br />
-	**[[2ilm]], [[3d8c]] - hFIH1α (mutant) + HIF peptide + α-ketoglutarate<br />	+	**[[2ilm]], [[3d8c]], [[5jwp]] - hFIH1α (mutant) + HIF peptide + α-ketoglutarate<br />
	**[[3p3n]], [[3p3p]] - hFIH1α + Notch 1 peptide<br />		**[[3p3n]], [[3p3p]] - hFIH1α + Notch 1 peptide<br />
	**[[2xum]] - hFIH1α (mutant) + Asp-substrate peptide + oxoglutarate derivative<br />		**[[2xum]] - hFIH1α (mutant) + Asp-substrate peptide + oxoglutarate derivative<br />

Alexander Berchansky at 12:31, 15 February 2016

Alexander Berchansky — Mon, 15 Feb 2016 12:31:33 GMT

←Older revision		Revision as of 12:31, 15 February 2016
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	For details on '''Factor inhibiting HIF''' see [[Molecular Playground/FIH]]. HIF is hypoxia-inducible factor - transcription factors that respond to hypoxia, i.e., decrease in oxygen<ref>PMID:23606740</ref>. <scene name='48/480806/Cv/2'>Dimeric factor inhibiting HIF with oxogluterate derivative</scene>.		For details on '''Factor inhibiting HIF''' see [[Molecular Playground/FIH]]. HIF is hypoxia-inducible factor - transcription factors that respond to hypoxia, i.e., decrease in oxygen<ref>PMID:23606740</ref>. <scene name='48/480806/Cv/2'>Dimeric factor inhibiting HIF with oxogluterate derivative</scene>.

-	<scene name='48/480806/Cv/4'>Fe/2-oxogluterate binding site</scene> PDB code [[1mzf]]).<ref>PMID:12432100</ref>	+	<scene name='48/480806/Cv/4'>Fe/2-oxogluterate binding site</scene> (PDB code [[1mzf]]).<ref>PMID:12432100</ref>
	</StructureSection>		</StructureSection>
	== 3D Structures of factor inhibiting HIF ==		== 3D Structures of factor inhibiting HIF ==

Alexander Berchansky at 12:31, 15 February 2016

Alexander Berchansky — Mon, 15 Feb 2016 12:31:13 GMT

←Older revision		Revision as of 12:31, 15 February 2016
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-	For details on '''Factor inhibiting HIF''' see [[Molecular Playground/FIH]]. HIF is hypoxia-inducible factor - transcription factors that respond to hypoxia, i.e., decrease in oxygen<ref>PMID:23606740</ref>. <scene name='48/480806/Cv/2'>Dimeric factor inhibiting HIF with oxogluterate derivative</scene>. <scene name='48/480806/Cv/4'>Fe/2-oxogluterate binding site</scene> PDB code [[1mzf]]).<ref>PMID:12432100</ref>	+	For details on '''Factor inhibiting HIF''' see [[Molecular Playground/FIH]]. HIF is hypoxia-inducible factor - transcription factors that respond to hypoxia, i.e., decrease in oxygen<ref>PMID:23606740</ref>. <scene name='48/480806/Cv/2'>Dimeric factor inhibiting HIF with oxogluterate derivative</scene>.
		+
		+	<scene name='48/480806/Cv/4'>Fe/2-oxogluterate binding site</scene> PDB code [[1mzf]]).<ref>PMID:12432100</ref>
	</StructureSection>		</StructureSection>
	== 3D Structures of factor inhibiting HIF ==		== 3D Structures of factor inhibiting HIF ==

Alexander Berchansky at 12:30, 15 February 2016

Alexander Berchansky — Mon, 15 Feb 2016 12:30:12 GMT

←Older revision		Revision as of 12:30, 15 February 2016
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-	For details on '''Factor inhibiting HIF''' see [[Molecular Playground/FIH]]. HIF is hypoxia-inducible factor - transcription factors that respond to hypoxia, i.e., decrease in oxygen<ref>PMID:23606740</ref>. <scene name='48/480806/Cv/2'>~~imeric~~ factor inhibiting HIF with oxogluterate derivative</scene>.	+	For details on '''Factor inhibiting HIF''' see [[Molecular Playground/FIH]]. HIF is hypoxia-inducible factor - transcription factors that respond to hypoxia, i.e., decrease in oxygen<ref>PMID:23606740</ref>. <scene name='48/480806/Cv/2'>Dimeric factor inhibiting HIF with oxogluterate derivative</scene>. <scene name='48/480806/Cv/4'>Fe/2-oxogluterate binding site</scene> PDB code [[1mzf]]).<ref>PMID:12432100</ref>
	</StructureSection>		</StructureSection>
	== 3D Structures of factor inhibiting HIF ==		== 3D Structures of factor inhibiting HIF ==

Alexander Berchansky at 12:14, 15 February 2016

Alexander Berchansky — Mon, 15 Feb 2016 12:14:47 GMT

←Older revision		Revision as of 12:14, 15 February 2016
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-	For details on '''Factor inhibiting HIF''' see [[Molecular Playground/FIH]]. HIF is hypoxia-inducible factor - transcription factors that respond to hypoxia, i.e., decrease in oxygen<ref>PMID:23606740</ref>.	+	For details on '''Factor inhibiting HIF''' see [[Molecular Playground/FIH]]. HIF is hypoxia-inducible factor - transcription factors that respond to hypoxia, i.e., decrease in oxygen<ref>PMID:23606740</ref>. <scene name='48/480806/Cv/2'>imeric factor inhibiting HIF with oxogluterate derivative</scene>.
	</StructureSection>		</StructureSection>
	== 3D Structures of factor inhibiting HIF ==		== 3D Structures of factor inhibiting HIF ==

Alexander Berchansky at 12:10, 15 February 2016

Alexander Berchansky — Mon, 15 Feb 2016 12:10:32 GMT

←Older revision		Revision as of 12:10, 15 February 2016
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-	<StructureSection load='1mzf' size='350' side='right' scene='' caption='~~Monomer of the dimeric~~ factor inhibiting HIF complex with oxogluterate derivative (PDB code [[1mzf]]) '>	+	<StructureSection load='1mzf' size='350' side='right' scene='48/480806/Cv/1' caption='Dimeric factor inhibiting HIF complex with oxogluterate derivative (PDB code [[1mzf]]) '>