Follitropin - Revision history

Jaime Prilusky: Follistin moved to Follitropin: requested by Editor

Jaime Prilusky — Sun, 13 Jan 2019 16:32:58 GMT

Follistin moved to Follitropin: requested by Editor

←Older revision

Revision as of 16:32, 13 January 2019

Michal Harel at 11:35, 13 January 2019

Michal Harel — Sun, 13 Jan 2019 11:35:18 GMT

Michal Harel at 11:26, 13 January 2019

Michal Harel — Sun, 13 Jan 2019 11:26:46 GMT

←Older revision		Revision as of 11:26, 13 January 2019
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	Follitropin Beta is a form of follicular stimulating hormone (FSH), which acts through a transmembrane G-protein receptor on the surface of granulosa cells of the ovaries and sertoli cells of the testis. FSH first undergoes a conformational change that forms a new pocket on its surface. Its receptor, FSHR, then inserts a sulfotyrosine residue <scene name='75/758465/Tyr335/1'>(Sulfotyrosine Residue)</scene> that pocket to bind FSH, and with FSH bound the transmembrane receptor undergoes a conformational change. The conformational change by the receptor mechanically activates the G-protein, which detaches from the receptor and activates the second messenger adenylyl cyclase. Adenylyl cyclase leads to the increased production of cAMP that in turn activates a protein kinase cascade through protein kinase A. One protein kinase cascade that could be activated is the PI3K (phosphoinositide-3-kinase)/AKT pathway, which leads to the growth and maturation of germ cells.		Follitropin Beta is a form of follicular stimulating hormone (FSH), which acts through a transmembrane G-protein receptor on the surface of granulosa cells of the ovaries and sertoli cells of the testis. FSH first undergoes a conformational change that forms a new pocket on its surface. Its receptor, FSHR, then inserts a sulfotyrosine residue <scene name='75/758465/Tyr335/1'>(Sulfotyrosine Residue)</scene> that pocket to bind FSH, and with FSH bound the transmembrane receptor undergoes a conformational change. The conformational change by the receptor mechanically activates the G-protein, which detaches from the receptor and activates the second messenger adenylyl cyclase. Adenylyl cyclase leads to the increased production of cAMP that in turn activates a protein kinase cascade through protein kinase A. One protein kinase cascade that could be activated is the PI3K (phosphoinositide-3-kinase)/AKT pathway, which leads to the growth and maturation of germ cells.

		+	</StructureSection>

		+	==3D structures of follitropin==
		+	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
		+
		+	[[4ay9]], [[4mqw]], [[1xwd]] – hFTR b + FTR receptor + glycoprotein hormone – human<br />
	== References ==		== References ==
	<references/>		<references/>

Michal Harel at 11:17, 13 January 2019

Michal Harel — Sun, 13 Jan 2019 11:17:25 GMT

←Older revision		Revision as of 11:17, 13 January 2019
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	== Background <ref>pmhdev. (2017). Follitropin Beta (Subcutaneous route). PubMed Health. Retrieved from https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0045885</ref>==		== Background <ref>pmhdev. (2017). Follitropin Beta (Subcutaneous route). PubMed Health. Retrieved from https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0045885</ref>==
-	<Structure load='4mqw' size='400' frame='true' align='right' side='right' caption='Glycosylated human follitropin subunit β (red) complex with follitropin receptor (dark red) ~~and~~ glycoprotein hormone (gold) (PDB code [[4mqw]])'/>	+	<Structure load='4mqw' size='400' frame='true' align='right' side='right' caption='Glycosylated human follitropin subunit β (red) complex with follitropin receptor (dark red), glycoprotein hormone (gold), ethylene glycol and jeffamine (PDB code [[4mqw]])'/>

Michal Harel at 11:15, 13 January 2019

Michal Harel — Sun, 13 Jan 2019 11:15:40 GMT

←Older revision		Revision as of 11:15, 13 January 2019
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	== Background <ref>pmhdev. (2017). Follitropin Beta (Subcutaneous route). PubMed Health. Retrieved from https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0045885</ref>==		== Background <ref>pmhdev. (2017). Follitropin Beta (Subcutaneous route). PubMed Health. Retrieved from https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0045885</ref>==
-	<Structure load='4mqw' size='400' frame='true' align='right' side='right' caption='~~Human~~ follitropin subunit β (~~green~~) complex with follitropin receptor and glycoprotein hormone (~~grey~~) (PDB code [[4mqw]])'/>	+	<Structure load='4mqw' size='400' frame='true' align='right' side='right' caption='Glycosylated human follitropin subunit β (red) complex with follitropin receptor (dark red) and glycoprotein hormone (gold) (PDB code [[4mqw]])'/>

Michal Harel at 11:11, 13 January 2019

Michal Harel — Sun, 13 Jan 2019 11:11:50 GMT

←Older revision		Revision as of 11:11, 13 January 2019
Line 1:		Line 1:
	== Background <ref>pmhdev. (2017). Follitropin Beta (Subcutaneous route). PubMed Health. Retrieved from https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0045885</ref>==		== Background <ref>pmhdev. (2017). Follitropin Beta (Subcutaneous route). PubMed Health. Retrieved from https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0045885</ref>==
-	<Structure load='4mqw' size='400' frame='true' align='right' side='right' caption='~~hFSH~Receptor~~'/>	+	<Structure load='4mqw' size='400' frame='true' align='right' side='right' caption='Human follitropin subunit β (green) complex with follitropin receptor and glycoprotein hormone (grey) (PDB code [[4mqw]])'/>


-	Follitropin ~~beta~~ injection is used to treat infertility in both males and females. Brand names for follitropin beta include Follistim, Follistim AQ, and Gonal-F RFF. This hormone is man-made gonadotropin to replace a bodily hormone called Follicle Stimulating Hormone (FSH). In males, FSH controls the production of sperm and in females FSH controls the maturation of follicles and ultimately their ability to ovulate. FSH is produced by the pituitary gland after receiving a signal from the hypothalamus. Some fertility programs such as Assisted Reproductive Technology (ART) use follitropin beta, in conjunction with human chorionic gonadotropin (hCG), to help oocytes develop in women. Follitropin beta is also used in men, along with hCG to increase sperm count.	+	'''Follitropin β''' injection is used to treat infertility in both males and females. Brand names for follitropin beta include Follistim, Follistim AQ, and Gonal-F RFF. This hormone is man-made gonadotropin to replace a bodily hormone called Follicle Stimulating Hormone (FSH). In males, FSH controls the production of sperm and in females FSH controls the maturation of follicles and ultimately their ability to ovulate. FSH is produced by the pituitary gland after receiving a signal from the hypothalamus. Some fertility programs such as Assisted Reproductive Technology (ART) use follitropin beta, in conjunction with human chorionic gonadotropin (hCG), to help oocytes develop in women. Follitropin beta is also used in men, along with hCG to increase sperm count.

Brandon Chocklett at 00:37, 20 April 2017

Brandon Chocklett — Thu, 20 Apr 2017 00:37:47 GMT

←Older revision		Revision as of 00:37, 20 April 2017
Line 18:		Line 18:
	== References ==		== References ==
	<references/>		<references/>
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-	Follitropin Beta (By injection) - National Library of Medicine - PubMed Health. Retrieved March 28, 2017, from https://www.ncbi.nlm.nih.gov/pubmedhealth/PMHT0010381/?report=details
-	Follistim® AQ Cartridge [physician insert]. Food and Drug Administration. Retrieved March 26, 2017, from https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/021273lbl.pdf
-	DrugBank (Ed.). Follitropin beta. In DrugBank. Retrieved March 27, 2017, from https://www.drugbank.ca/drugs/DB00066
-	http://www.rcsb.org/pdb/explore/literature.do?structureId=1XWD - THE ONLY ONE THAT NEEDS TO BE DONE
-	https://www.drugbank.ca/drugs/DB00066
-	http://www.merck.com/product/usa/pi_circulars/f/follistim_aq_cartridge/follistim_cartridge_pi.pdf
-	https://www.drugs.com/sfx/follistim-aq-side-effects.html
-
-	Hillier, S. G. (1994). "Current concepts of the roles of follicle stimulating hormone and luteinizing hormone in folliculogenesis. Human Reproduction", 9(2), 188–191. [https://doi.org/10.1093/oxfordjournals.humrep.a138480]
-
-	DrugBank (Ed.). (2017, April 17). Follitropin beta. In DrugBank. Retrieved from https://www.drugbank.ca/drugs/DB00066
-
-	Drug Approval Package: Follistim AQ (Follitropin) NDA #021273. (n.d.). Retrieved April 18, 2017, from https://www.accessdata.fda.gov/drugsatfda_docs/nda/2005/021273s000TOC.cfm
-
-	Follistim AQ Side Effects in Detail. (n.d.). Retrieved April 18, 2017, from https://www.drugs.com/sfx/follistim-aq-side-effects.html
-
-	FOLLISTIM® AQ Cartridge. (n.d.). Retrieved April 18, 2017, from https://www.merckconnect.com/follistimaq/overview.html?hcpUser=yes
-
-	pmhdev. (2017). Follitropin Beta (Subcutaneous route). PubMed Health. Retrieved from https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0045885/ - by injection reference
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-	Telikicherla, D., Ambekar, A., Palapetta, S. M., Dwivedi, S. B., Raju, R., Sharma, J., … Pandey, A. (2011). A comprehensive curated resource for follicle stimulating hormone signaling. BMC Research Notes, 4, 408. https://doi.org/10.1186/1756-0500-4-408

Angelina Smeragulioulo at 00:37, 20 April 2017

Angelina Smeragulioulo — Thu, 20 Apr 2017 00:37:38 GMT

←Older revision		Revision as of 00:37, 20 April 2017
Line 13:		Line 13:
	The amino acid sequence and structure of follitropin beta are exactly the same as that of human urinary follicle-stimulating hormone (hFSH). Follitropin beta is a glycoprotein hormone that is created through recombinant DNA technology. The dimeric structure of follitropin beta contains 2 glycoprotein subunits – alpha, consisting of 92 amino acids, and beta, consisting of 111 amino acids. The alpha subunit is glycosylated at Asn 51 and Asn 78 <scene name='75/758465/Alpha_glycosylation/1'>(Glycosylated Alpha Subunit)</scene> the beta subunit is glycosylated at Asn 7 and Asn 24. <scene name='75/758465/Beta_subunit_glycosylation_sit/1'>(Glycosylated Beta Subunit)</scene>		The amino acid sequence and structure of follitropin beta are exactly the same as that of human urinary follicle-stimulating hormone (hFSH). Follitropin beta is a glycoprotein hormone that is created through recombinant DNA technology. The dimeric structure of follitropin beta contains 2 glycoprotein subunits – alpha, consisting of 92 amino acids, and beta, consisting of 111 amino acids. The alpha subunit is glycosylated at Asn 51 and Asn 78 <scene name='75/758465/Alpha_glycosylation/1'>(Glycosylated Alpha Subunit)</scene> the beta subunit is glycosylated at Asn 7 and Asn 24. <scene name='75/758465/Beta_subunit_glycosylation_sit/1'>(Glycosylated Beta Subunit)</scene>
	== Mechanism <ref>Telikicherla, D., Ambekar, A., Palapetta, S. M., Dwivedi, S. B., Raju, R., Sharma, J., … Pandey, A. (2011). A comprehensive curated resource for follicle stimulating hormone signaling. BMC Research Notes, 4, 408. https://doi.org/10.1186/1756-0500-4-408</ref>==		== Mechanism <ref>Telikicherla, D., Ambekar, A., Palapetta, S. M., Dwivedi, S. B., Raju, R., Sharma, J., … Pandey, A. (2011). A comprehensive curated resource for follicle stimulating hormone signaling. BMC Research Notes, 4, 408. https://doi.org/10.1186/1756-0500-4-408</ref>==
-	~~There are several pathways Follitropin Beta can take in order for signal transduction to occur.~~ Follitropin Beta is a form of follicular stimulating hormone (FSH), which acts through a transmembrane G-protein receptor on the surface of granulosa cells of the ovaries and sertoli cells of the testis. FSH first undergoes a conformational change that forms a new pocket on its surface. Its receptor, FSHR, then inserts a sulfotyrosine residue <scene name='75/758465/Tyr335/1'>(Sulfotyrosine Residue)</scene> that pocket to bind FSH, and with FSH bound the transmembrane receptor undergoes a conformational change. The conformational change by the receptor mechanically activates the G-protein, which detaches from the receptor and activates the second messenger adenylyl cyclase. Adenylyl cyclase leads to the increased production of cAMP that in turn activates a protein kinase cascade through protein kinase A. One protein kinase cascade that could be activated is the PI3K (phosphoinositide-3-kinase)/AKT pathway, which leads to the growth and maturation of germ cells.	+	Follitropin Beta is a form of follicular stimulating hormone (FSH), which acts through a transmembrane G-protein receptor on the surface of granulosa cells of the ovaries and sertoli cells of the testis. FSH first undergoes a conformational change that forms a new pocket on its surface. Its receptor, FSHR, then inserts a sulfotyrosine residue <scene name='75/758465/Tyr335/1'>(Sulfotyrosine Residue)</scene> that pocket to bind FSH, and with FSH bound the transmembrane receptor undergoes a conformational change. The conformational change by the receptor mechanically activates the G-protein, which detaches from the receptor and activates the second messenger adenylyl cyclase. Adenylyl cyclase leads to the increased production of cAMP that in turn activates a protein kinase cascade through protein kinase A. One protein kinase cascade that could be activated is the PI3K (phosphoinositide-3-kinase)/AKT pathway, which leads to the growth and maturation of germ cells.

Angelina Smeragulioulo at 00:36, 20 April 2017

Angelina Smeragulioulo — Thu, 20 Apr 2017 00:36:57 GMT

←Older revision		Revision as of 00:36, 20 April 2017
Line 13:		Line 13:
	The amino acid sequence and structure of follitropin beta are exactly the same as that of human urinary follicle-stimulating hormone (hFSH). Follitropin beta is a glycoprotein hormone that is created through recombinant DNA technology. The dimeric structure of follitropin beta contains 2 glycoprotein subunits – alpha, consisting of 92 amino acids, and beta, consisting of 111 amino acids. The alpha subunit is glycosylated at Asn 51 and Asn 78 <scene name='75/758465/Alpha_glycosylation/1'>(Glycosylated Alpha Subunit)</scene> the beta subunit is glycosylated at Asn 7 and Asn 24. <scene name='75/758465/Beta_subunit_glycosylation_sit/1'>(Glycosylated Beta Subunit)</scene>		The amino acid sequence and structure of follitropin beta are exactly the same as that of human urinary follicle-stimulating hormone (hFSH). Follitropin beta is a glycoprotein hormone that is created through recombinant DNA technology. The dimeric structure of follitropin beta contains 2 glycoprotein subunits – alpha, consisting of 92 amino acids, and beta, consisting of 111 amino acids. The alpha subunit is glycosylated at Asn 51 and Asn 78 <scene name='75/758465/Alpha_glycosylation/1'>(Glycosylated Alpha Subunit)</scene> the beta subunit is glycosylated at Asn 7 and Asn 24. <scene name='75/758465/Beta_subunit_glycosylation_sit/1'>(Glycosylated Beta Subunit)</scene>
	== Mechanism <ref>Telikicherla, D., Ambekar, A., Palapetta, S. M., Dwivedi, S. B., Raju, R., Sharma, J., … Pandey, A. (2011). A comprehensive curated resource for follicle stimulating hormone signaling. BMC Research Notes, 4, 408. https://doi.org/10.1186/1756-0500-4-408</ref>==		== Mechanism <ref>Telikicherla, D., Ambekar, A., Palapetta, S. M., Dwivedi, S. B., Raju, R., Sharma, J., … Pandey, A. (2011). A comprehensive curated resource for follicle stimulating hormone signaling. BMC Research Notes, 4, 408. https://doi.org/10.1186/1756-0500-4-408</ref>==
-	There are several pathways Follitropin Beta can take in order for signal transduction to occur. Follitropin Beta is a form of follicular stimulating hormone (FSH), which acts through a transmembrane G-protein receptor on the surface of granulosa cells of the ovaries and sertoli cells of the testis. FSH first undergoes a conformational change that forms a new pocket on its surface. Its receptor, FSHR, then inserts a sulfotyrosine residue <scene name='75/758465/~~Tyrosine~~/1'>(Sulfotyrosine Residue)</scene>~~into~~ that pocket to bind FSH, and with FSH bound the transmembrane receptor undergoes a conformational change. The conformational change by the receptor mechanically activates the G-protein, which detaches from the receptor and activates the second messenger adenylyl cyclase. Adenylyl cyclase leads to the increased production of cAMP that in turn activates a protein kinase cascade through protein kinase A. One protein kinase cascade that could be activated is the PI3K (phosphoinositide-3-kinase)/AKT pathway, which leads to the growth and maturation of germ cells.	+	There are several pathways Follitropin Beta can take in order for signal transduction to occur. Follitropin Beta is a form of follicular stimulating hormone (FSH), which acts through a transmembrane G-protein receptor on the surface of granulosa cells of the ovaries and sertoli cells of the testis. FSH first undergoes a conformational change that forms a new pocket on its surface. Its receptor, FSHR, then inserts a sulfotyrosine residue <scene name='75/758465/Tyr335/1'>(Sulfotyrosine Residue)</scene> that pocket to bind FSH, and with FSH bound the transmembrane receptor undergoes a conformational change. The conformational change by the receptor mechanically activates the G-protein, which detaches from the receptor and activates the second messenger adenylyl cyclase. Adenylyl cyclase leads to the increased production of cAMP that in turn activates a protein kinase cascade through protein kinase A. One protein kinase cascade that could be activated is the PI3K (phosphoinositide-3-kinase)/AKT pathway, which leads to the growth and maturation of germ cells.

Angelina Smeragulioulo at 00:32, 20 April 2017

Angelina Smeragulioulo — Thu, 20 Apr 2017 00:32:39 GMT

←Older revision		Revision as of 00:32, 20 April 2017
Line 13:		Line 13:
	The amino acid sequence and structure of follitropin beta are exactly the same as that of human urinary follicle-stimulating hormone (hFSH). Follitropin beta is a glycoprotein hormone that is created through recombinant DNA technology. The dimeric structure of follitropin beta contains 2 glycoprotein subunits – alpha, consisting of 92 amino acids, and beta, consisting of 111 amino acids. The alpha subunit is glycosylated at Asn 51 and Asn 78 <scene name='75/758465/Alpha_glycosylation/1'>(Glycosylated Alpha Subunit)</scene> the beta subunit is glycosylated at Asn 7 and Asn 24. <scene name='75/758465/Beta_subunit_glycosylation_sit/1'>(Glycosylated Beta Subunit)</scene>		The amino acid sequence and structure of follitropin beta are exactly the same as that of human urinary follicle-stimulating hormone (hFSH). Follitropin beta is a glycoprotein hormone that is created through recombinant DNA technology. The dimeric structure of follitropin beta contains 2 glycoprotein subunits – alpha, consisting of 92 amino acids, and beta, consisting of 111 amino acids. The alpha subunit is glycosylated at Asn 51 and Asn 78 <scene name='75/758465/Alpha_glycosylation/1'>(Glycosylated Alpha Subunit)</scene> the beta subunit is glycosylated at Asn 7 and Asn 24. <scene name='75/758465/Beta_subunit_glycosylation_sit/1'>(Glycosylated Beta Subunit)</scene>
	== Mechanism <ref>Telikicherla, D., Ambekar, A., Palapetta, S. M., Dwivedi, S. B., Raju, R., Sharma, J., … Pandey, A. (2011). A comprehensive curated resource for follicle stimulating hormone signaling. BMC Research Notes, 4, 408. https://doi.org/10.1186/1756-0500-4-408</ref>==		== Mechanism <ref>Telikicherla, D., Ambekar, A., Palapetta, S. M., Dwivedi, S. B., Raju, R., Sharma, J., … Pandey, A. (2011). A comprehensive curated resource for follicle stimulating hormone signaling. BMC Research Notes, 4, 408. https://doi.org/10.1186/1756-0500-4-408</ref>==
-	There are several pathways Follitropin Beta can take in order for signal transduction to occur. Follitropin Beta is a form of follicular stimulating hormone (FSH), which acts through a transmembrane G-protein receptor on the surface of granulosa cells of the ovaries and sertoli cells of the testis. FSH first undergoes a conformational change that forms a new pocket on its surface. Its receptor, FSHR, then inserts a sulfotyrosine residue <scene name='75/758465/Tyrosine/1'>~~TextToBeDisplayed~~</scene>into that pocket to bind FSH, and with FSH bound the transmembrane receptor undergoes a conformational change. The conformational change by the receptor mechanically activates the G-protein, which detaches from the receptor and activates the second messenger adenylyl cyclase. Adenylyl cyclase leads to the increased production of cAMP that in turn activates a protein kinase cascade through protein kinase A. One protein kinase cascade that could be activated is the PI3K (phosphoinositide-3-kinase)/AKT pathway, which leads to the growth and maturation of germ cells.	+	There are several pathways Follitropin Beta can take in order for signal transduction to occur. Follitropin Beta is a form of follicular stimulating hormone (FSH), which acts through a transmembrane G-protein receptor on the surface of granulosa cells of the ovaries and sertoli cells of the testis. FSH first undergoes a conformational change that forms a new pocket on its surface. Its receptor, FSHR, then inserts a sulfotyrosine residue <scene name='75/758465/Tyrosine/1'>(Sulfotyrosine Residue)</scene>into that pocket to bind FSH, and with FSH bound the transmembrane receptor undergoes a conformational change. The conformational change by the receptor mechanically activates the G-protein, which detaches from the receptor and activates the second messenger adenylyl cyclase. Adenylyl cyclase leads to the increased production of cAMP that in turn activates a protein kinase cascade through protein kinase A. One protein kinase cascade that could be activated is the PI3K (phosphoinositide-3-kinase)/AKT pathway, which leads to the growth and maturation of germ cells.

←Older revision		Revision as of 11:35, 13 January 2019
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-	'''Follitropin β''' injection is used to treat infertility in both males and females. Brand names for follitropin ~~beta~~ include Follistim, Follistim AQ, and Gonal-F RFF. This hormone is man-made gonadotropin to replace a bodily hormone called Follicle Stimulating Hormone (FSH). In males, FSH controls the production of sperm and in females FSH controls the maturation of follicles and ultimately their ability to ovulate. FSH is produced by the pituitary gland after receiving a signal from the hypothalamus. Some fertility programs such as Assisted Reproductive Technology (ART) use follitropin ~~beta~~, in conjunction with human chorionic gonadotropin (hCG), to help oocytes develop in women. Follitropin ~~beta~~ is also used in men, along with hCG to increase sperm count.	+	'''Follitropin β''' injection is used to treat infertility in both males and females. Brand names for follitropin β include Follistim, Follistim AQ, and Gonal-F RFF. This hormone is man-made gonadotropin to replace a bodily hormone called Follicle Stimulating Hormone (FSH). In males, FSH controls the production of sperm and in females FSH controls the maturation of follicles and ultimately their ability to ovulate. FSH is produced by the pituitary gland after receiving a signal from the hypothalamus. Some fertility programs such as Assisted Reproductive Technology (ART) use follitropin β, in conjunction with human chorionic gonadotropin (hCG), to help oocytes develop in women. Follitropin β is also used in men, along with hCG to increase sperm count.


	== Function and Clinical Use <ref>Drug Approval Package: Follistim AQ (Follitropin) NDA #021273. (n.d.). Retrieved April 18, 2017, from https://www.accessdata.fda.gov/drugsatfda_docs/nda/2005/021273s000TOC.cfm</ref>==		== Function and Clinical Use <ref>Drug Approval Package: Follistim AQ (Follitropin) NDA #021273. (n.d.). Retrieved April 18, 2017, from https://www.accessdata.fda.gov/drugsatfda_docs/nda/2005/021273s000TOC.cfm</ref>==
-	FSH stimulates the growth and healthy function of ovarian follicles. FSH in males is involved in maintaining normal levels of sperm production <ref name="Hillier">Hillier, S. G. (1994). "Current concepts of the roles of follicle stimulating hormone and luteinizing hormone in folliculogenesis. Human Reproduction", 9(2), 188–191. [https://doi.org/10.1093/oxfordjournals.humrep.a138480]</ref>. The first step of follicle formation is determined by the concentration of FSH. A woman who is not producing enough FSH will not be able to meet the concentration threshold necessary to begin pre-ovulatory development. If pre-ovulatory development does not occur a mature egg will not be formed to be fertilized. In females, FSH is critical for the onset of follicular development and the number of follicles reaching maturity. Follistim is used to treat these infertility issues. Human chorionic gonadotropin (hCG) must be given after follitropin ~~beta~~ injections in order for ovulation to take place after follicular growth. Follistim is intended for use in women who are participating in Assisted Reproductive Technology (ART) in order for multiple follicular development. It is also used in women who are unable to ovulate due to functional issues and not failure of the ovary itself.	+	FSH stimulates the growth and healthy function of ovarian follicles. FSH in males is involved in maintaining normal levels of sperm production <ref name="Hillier">Hillier, S. G. (1994). "Current concepts of the roles of follicle stimulating hormone and luteinizing hormone in folliculogenesis. Human Reproduction", 9(2), 188–191. [https://doi.org/10.1093/oxfordjournals.humrep.a138480]</ref>. The first step of follicle formation is determined by the concentration of FSH. A woman who is not producing enough FSH will not be able to meet the concentration threshold necessary to begin pre-ovulatory development. If pre-ovulatory development does not occur a mature egg will not be formed to be fertilized. In females, FSH is critical for the onset of follicular development and the number of follicles reaching maturity. Follistim is used to treat these infertility issues. Human chorionic gonadotropin (hCG) must be given after follitropin β injections in order for ovulation to take place after follicular growth. Follistim is intended for use in women who are participating in Assisted Reproductive Technology (ART) in order for multiple follicular development. It is also used in women who are unable to ovulate due to functional issues and not failure of the ovary itself.
	== Side Effects <ref>Follistim AQ Side Effects in Detail. (n.d.). Retrieved April 18, 2017, from https://www.drugs.com/sfx/follistim-aq-side-effects.html</ref>==		== Side Effects <ref>Follistim AQ Side Effects in Detail. (n.d.). Retrieved April 18, 2017, from https://www.drugs.com/sfx/follistim-aq-side-effects.html</ref>==
	Possible side effects from this drug include abnormal ovarian enlargement, Ovarian Hyperstimulation Syndrome (OHSS), spontaneous abortion, severe abdominal/stomach pain, bloating and rapid weight gain, nausea, and vomiting. Less common side effects include heavy non-menstrual vaginal bleeding, unusual tiredness and/or weakness, increased heart rate, and swelling of the breasts		Possible side effects from this drug include abnormal ovarian enlargement, Ovarian Hyperstimulation Syndrome (OHSS), spontaneous abortion, severe abdominal/stomach pain, bloating and rapid weight gain, nausea, and vomiting. Less common side effects include heavy non-menstrual vaginal bleeding, unusual tiredness and/or weakness, increased heart rate, and swelling of the breasts
-	== Structure <ref>DrugBank (Ed.). (2017, April 17). Follitropin ~~beta~~. In DrugBank. Retrieved from https://www.drugbank.ca/drugs/DB00066</ref>==	+	== Structure <ref>DrugBank (Ed.). (2017, April 17). Follitropin β. In DrugBank. Retrieved from https://www.drugbank.ca/drugs/DB00066</ref>==
-	The amino acid sequence and structure of follitropin ~~beta~~ are exactly the same as that of human urinary follicle-stimulating hormone (hFSH). Follitropin ~~beta~~ is a glycoprotein hormone that is created through recombinant DNA technology. The dimeric structure of follitropin ~~beta~~ contains 2 glycoprotein subunits – ~~alpha~~, consisting of 92 amino acids, and ~~beta~~, consisting of 111 amino acids. The ~~alpha~~ subunit is glycosylated at Asn 51 and Asn 78 <scene name='75/758465/Alpha_glycosylation/1'>(Glycosylated Alpha Subunit)</scene> the ~~beta~~ subunit is glycosylated at Asn 7 and Asn 24. <scene name='75/758465/Beta_subunit_glycosylation_sit/1'>(Glycosylated Beta Subunit)</scene>	+	The amino acid sequence and structure of follitropin β are exactly the same as that of human urinary follicle-stimulating hormone (hFSH). Follitropin β is a glycoprotein hormone that is created through recombinant DNA technology. The dimeric structure of follitropin β contains 2 glycoprotein subunits – α, consisting of 92 amino acids, and β, consisting of 111 amino acids. The α subunit is glycosylated at Asn 51 and Asn 78 <scene name='75/758465/Alpha_glycosylation/1'>(Glycosylated Alpha Subunit)</scene> the β subunit is glycosylated at Asn 7 and Asn 24. <scene name='75/758465/Beta_subunit_glycosylation_sit/1'>(Glycosylated Beta Subunit)</scene>
	== Mechanism <ref>Telikicherla, D., Ambekar, A., Palapetta, S. M., Dwivedi, S. B., Raju, R., Sharma, J., … Pandey, A. (2011). A comprehensive curated resource for follicle stimulating hormone signaling. BMC Research Notes, 4, 408. https://doi.org/10.1186/1756-0500-4-408</ref>==		== Mechanism <ref>Telikicherla, D., Ambekar, A., Palapetta, S. M., Dwivedi, S. B., Raju, R., Sharma, J., … Pandey, A. (2011). A comprehensive curated resource for follicle stimulating hormone signaling. BMC Research Notes, 4, 408. https://doi.org/10.1186/1756-0500-4-408</ref>==
-	Follitropin ~~Beta~~ is a form of follicular stimulating hormone (FSH), which acts through a transmembrane G-protein receptor on the surface of granulosa cells of the ovaries and sertoli cells of the testis. FSH first undergoes a conformational change that forms a new pocket on its surface. Its receptor, FSHR, then inserts a sulfotyrosine residue <scene name='75/758465/Tyr335/1'>(Sulfotyrosine Residue)</scene> that pocket to bind FSH, and with FSH bound the transmembrane receptor undergoes a conformational change. The conformational change by the receptor mechanically activates the G-protein, which detaches from the receptor and activates the second messenger adenylyl cyclase. Adenylyl cyclase leads to the increased production of cAMP that in turn activates a protein kinase cascade through protein kinase A. One protein kinase cascade that could be activated is the PI3K (phosphoinositide-3-kinase)/AKT pathway, which leads to the growth and maturation of germ cells.	+	Follitropin β is a form of follicular stimulating hormone (FSH), which acts through a transmembrane G-protein receptor on the surface of granulosa cells of the ovaries and sertoli cells of the testis. FSH first undergoes a conformational change that forms a new pocket on its surface. Its receptor, FSHR, then inserts a sulfotyrosine residue <scene name='75/758465/Tyr335/1'>(Sulfotyrosine Residue)</scene> that pocket to bind FSH, and with FSH bound the transmembrane receptor undergoes a conformational change. The conformational change by the receptor mechanically activates the G-protein, which detaches from the receptor and activates the second messenger adenylyl cyclase. Adenylyl cyclase leads to the increased production of cAMP that in turn activates a protein kinase cascade through protein kinase A. One protein kinase cascade that could be activated is the PI3K (phosphoinositide-3-kinase)/AKT pathway, which leads to the growth and maturation of germ cells.
-		+
-	~~</StructureSection>~~	+

	==3D structures of follitropin==		==3D structures of follitropin==
	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}		Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

-	[[4ay9]], [[4mqw]], [[1xwd]] – hFTR b + FTR receptor + glycoprotein hormone – human<br />	+	[[4ay9]], [[4mqw]], [[1xwd]] – hFTR β + FTR receptor + glycoprotein hormone – human<br />
	== References ==		== References ==
	<references/>		<references/>