Galactokinase - Revision history

Michal Harel at 10:50, 7 March 2023

Michal Harel — Tue, 07 Mar 2023 10:50:03 GMT

Michal Harel at 08:02, 2 August 2021

Michal Harel — Mon, 02 Aug 2021 08:02:54 GMT

←Older revision		Revision as of 08:02, 2 August 2021
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	[[6q91]] - hGALK + benzamide derivative + gal<br />		[[6q91]] - hGALK + benzamide derivative + gal<br />
	[[6q90]], [[6zgw]] - hGALK + pyridine derivative + gal<br />		[[6q90]], [[6zgw]] - hGALK + pyridine derivative + gal<br />
-	[[6q3x]] - hGALK + quinazoline derivative + gal<br />	+	[[6q3x]], [[6zfh]] - hGALK + quinazoline derivative + gal<br />
	[[6zgv]], [[6zgx]], [[6zgz]], [[6zgy]] - hGALK + pyrimidine derivative + gal<br />		[[6zgv]], [[6zgx]], [[6zgz]], [[6zgy]] - hGALK + pyrimidine derivative + gal<br />
	[[6qje]] - hGALK + imidazole derivative + gal<br />		[[6qje]] - hGALK + imidazole derivative + gal<br />

Alexander Berchansky at 13:58, 15 October 2020

Alexander Berchansky — Thu, 15 Oct 2020 13:58:04 GMT

←Older revision		Revision as of 13:58, 15 October 2020
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	*<scene name='86/864099/Cv/7'>Mg coordination site</scene>.		*<scene name='86/864099/Cv/7'>Mg coordination site</scene>.
	*<scene name='86/864099/Cv/9'>AMPPNP binding site</scene>.		*<scene name='86/864099/Cv/9'>AMPPNP binding site</scene>.
-	*<scene name='86/864099/Cv/10'>~~TextToBeDisplayed~~</scene>.	+	*<scene name='86/864099/Cv/10'>Whole binding site</scene>.

	==3D structures of galactokinase==		==3D structures of galactokinase==

Alexander Berchansky at 13:55, 15 October 2020

Alexander Berchansky — Thu, 15 Oct 2020 13:55:32 GMT

←Older revision		Revision as of 13:55, 15 October 2020
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-	<StructureSection load='1wuu' size='~~340~~' side='right' caption='Se-Met human GALK complex with galactopyranose, AMPPNP and Mg+2 ion (green) (PDB code [[1wuu]].' scene='86/864099/Cv/1'>	+	<StructureSection load='1wuu' size='400' side='right' caption='Se-Met human GALK complex with galactopyranose, AMPPNP and Mg+2 ion (green) (PDB code [[1wuu]].' scene='86/864099/Cv/1'>
	__TOC__		__TOC__
	== Function ==		== Function ==
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	The 3D structure of human GALK shows the sugar binding active site wedged between the N- and C-termini of the enzyme. The galactose forms <scene name='86/864099/Cv/5'>numerous interactions</scene> with GALK termini residues and in <scene name='86/864099/Cv/6'>particular forms hydrogen bonds with an Asp and Arg residues which are conserved in eukaryotic and prokaryotic GALK</scene><ref>PMID:15590630</ref>.		The 3D structure of human GALK shows the sugar binding active site wedged between the N- and C-termini of the enzyme. The galactose forms <scene name='86/864099/Cv/5'>numerous interactions</scene> with GALK termini residues and in <scene name='86/864099/Cv/6'>particular forms hydrogen bonds with an Asp and Arg residues which are conserved in eukaryotic and prokaryotic GALK</scene><ref>PMID:15590630</ref>.
	*<scene name='86/864099/Cv/7'>Mg coordination site</scene>.		*<scene name='86/864099/Cv/7'>Mg coordination site</scene>.
		+	*<scene name='86/864099/Cv/9'>AMPPNP binding site</scene>.
		+	*<scene name='86/864099/Cv/10'>TextToBeDisplayed</scene>.

	==3D structures of galactokinase==		==3D structures of galactokinase==

Alexander Berchansky at 13:35, 15 October 2020

Alexander Berchansky — Thu, 15 Oct 2020 13:35:16 GMT

←Older revision		Revision as of 13:35, 15 October 2020
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	The 3D structure of human GALK shows the sugar binding active site wedged between the N- and C-termini of the enzyme. The galactose forms <scene name='86/864099/Cv/5'>numerous interactions</scene> with GALK termini residues and in <scene name='86/864099/Cv/6'>particular forms hydrogen bonds with an Asp and Arg residues which are conserved in eukaryotic and prokaryotic GALK</scene><ref>PMID:15590630</ref>.		The 3D structure of human GALK shows the sugar binding active site wedged between the N- and C-termini of the enzyme. The galactose forms <scene name='86/864099/Cv/5'>numerous interactions</scene> with GALK termini residues and in <scene name='86/864099/Cv/6'>particular forms hydrogen bonds with an Asp and Arg residues which are conserved in eukaryotic and prokaryotic GALK</scene><ref>PMID:15590630</ref>.
		+	*<scene name='86/864099/Cv/7'>Mg coordination site</scene>.

	==3D structures of galactokinase==		==3D structures of galactokinase==

Alexander Berchansky at 15:15, 14 October 2020

Alexander Berchansky — Wed, 14 Oct 2020 15:15:35 GMT

←Older revision		Revision as of 15:15, 14 October 2020
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	== Structural highlights ==		== Structural highlights ==

-	The 3D structure of human GALK shows the sugar binding active site wedged between the N- and C-termini of the enzyme. The galactose forms <scene name='86/864099/Cv/5'>numerous interactions</scene> with GALK termini residues and in particular forms hydrogen bonds with an Asp and Arg residues which are conserved in eukaryotic and prokaryotic GALK<ref>PMID:15590630</ref>.	+	The 3D structure of human GALK shows the sugar binding active site wedged between the N- and C-termini of the enzyme. The galactose forms <scene name='86/864099/Cv/5'>numerous interactions</scene> with GALK termini residues and in <scene name='86/864099/Cv/6'>particular forms hydrogen bonds with an Asp and Arg residues which are conserved in eukaryotic and prokaryotic GALK</scene><ref>PMID:15590630</ref>.

	==3D structures of galactokinase==		==3D structures of galactokinase==

Alexander Berchansky at 15:11, 14 October 2020

Alexander Berchansky — Wed, 14 Oct 2020 15:11:46 GMT

←Older revision		Revision as of 15:11, 14 October 2020
Line 11:		Line 11:
	== Structural highlights ==		== Structural highlights ==

-	The 3D structure of human GALK shows the sugar binding active site wedged between the N- and C-termini of the enzyme. The galactose forms <scene name='86/864099/Cv/4'>numerous interactions</scene> with GALK termini residues and in particular forms hydrogen bonds with an Asp and Arg residues which are conserved in eukaryotic and prokaryotic GALK<ref>PMID:15590630</ref>.	+	The 3D structure of human GALK shows the sugar binding active site wedged between the N- and C-termini of the enzyme. The galactose forms <scene name='86/864099/Cv/5'>numerous interactions</scene> with GALK termini residues and in particular forms hydrogen bonds with an Asp and Arg residues which are conserved in eukaryotic and prokaryotic GALK<ref>PMID:15590630</ref>.

	==3D structures of galactokinase==		==3D structures of galactokinase==

Alexander Berchansky at 15:04, 14 October 2020

Alexander Berchansky — Wed, 14 Oct 2020 15:04:29 GMT

←Older revision		Revision as of 15:04, 14 October 2020
Line 11:		Line 11:
	== Structural highlights ==		== Structural highlights ==

-	The 3D structure of human GALK shows the sugar binding active site wedged between the N- and C-termini of the enzyme. The galactose forms <scene name='86/864099/Cv/3'>numerous interactions</scene> with GALK termini residues and in particular forms hydrogen bonds with an Asp and Arg residues which are conserved in eukaryotic and prokaryotic GALK<ref>PMID:15590630</ref>.	+	The 3D structure of human GALK shows the sugar binding active site wedged between the N- and C-termini of the enzyme. The galactose forms <scene name='86/864099/Cv/4'>numerous interactions</scene> with GALK termini residues and in particular forms hydrogen bonds with an Asp and Arg residues which are conserved in eukaryotic and prokaryotic GALK<ref>PMID:15590630</ref>.

	==3D structures of galactokinase==		==3D structures of galactokinase==

Alexander Berchansky at 15:02, 14 October 2020

Alexander Berchansky — Wed, 14 Oct 2020 15:02:10 GMT

←Older revision		Revision as of 15:02, 14 October 2020
Line 11:		Line 11:
	== Structural highlights ==		== Structural highlights ==

-	The 3D structure of human GALK shows the sugar binding active site wedged between the N- and C-termini of the enzyme. The galactose forms numerous interactions with GALK termini residues and in particular forms hydrogen bonds with an Asp and Arg residues which are conserved in eukaryotic and prokaryotic GALK<ref>PMID:15590630</ref>.	+	The 3D structure of human GALK shows the sugar binding active site wedged between the N- and C-termini of the enzyme. The galactose forms <scene name='86/864099/Cv/3'>numerous interactions</scene> with GALK termini residues and in particular forms hydrogen bonds with an Asp and Arg residues which are conserved in eukaryotic and prokaryotic GALK<ref>PMID:15590630</ref>.

	==3D structures of galactokinase==		==3D structures of galactokinase==

Alexander Berchansky at 14:47, 14 October 2020

Alexander Berchansky — Wed, 14 Oct 2020 14:47:39 GMT

←Older revision		Revision as of 14:47, 14 October 2020
Line 1:		Line 1:
-	<StructureSection load='1wuu' size='340' side='right' caption='Se-Met human GALK complex with galactopyranose, AMPPNP and Mg+2 ion (green) (PDB code [[1wuu]].' scene=''>	+	<StructureSection load='1wuu' size='340' side='right' caption='Se-Met human GALK complex with galactopyranose, AMPPNP and Mg+2 ion (green) (PDB code [[1wuu]].' scene='86/864099/Cv/1'>
	__TOC__		__TOC__
	== Function ==		== Function ==

←Older revision		Revision as of 10:50, 7 March 2023
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	[[6gr2]] - hGALK + ADP + gal - human<br />		[[6gr2]] - hGALK + ADP + gal - human<br />
		+	[[7rcl]], [[7rcm]] - hGALK (mutant) + ADP + gal <br />
	[[1wuu]] - hGALK + Mg + AMPPNP + gal<br />		[[1wuu]] - hGALK + Mg + AMPPNP + gal<br />
	[[6q3w]], [[6q8z]] - hGALK + pyrazine derivative + gal<br />		[[6q3w]], [[6q8z]] - hGALK + pyrazine derivative + gal<br />
	[[6q91]] - hGALK + benzamide derivative + gal<br />		[[6q91]] - hGALK + benzamide derivative + gal<br />
	[[6q90]], [[6zgw]] - hGALK + pyridine derivative + gal<br />		[[6q90]], [[6zgw]] - hGALK + pyridine derivative + gal<br />
-	[[6q3x]], [[6zfh]] - hGALK + quinazoline derivative + gal<br />	+	[[6q3x]], [[6zfh]], [[7s49]] - hGALK + quinazoline derivative + gal<br />
-	[[6zgv]], [[6zgx]], [[6zgz]], [[6zgy]] - hGALK + pyrimidine derivative + gal<br />	+	[[6zgv]], [[6zgx]], [[6zgz]], [[6zgy]], [[6zh0]] - hGALK + pyrimidine derivative + gal<br />
		+	[[7s4c]] - hGALK (mutant) + pyrimidine derivative + gal<br />
	[[6qje]] - hGALK + imidazole derivative + gal<br />		[[6qje]] - hGALK + imidazole derivative + gal<br />
		+	[[7ozx]] - hGALK + inhibitor + gal<br />
	[[2aj4]] - GALK + Mg + AMPPNP + gal - yeast<br />		[[2aj4]] - GALK + Mg + AMPPNP + gal - yeast<br />
	[[1s4e]] - GALK + Mg + ADP + gal - ''Pyrococcus furiosus''<br />		[[1s4e]] - GALK + Mg + ADP + gal - ''Pyrococcus furiosus''<br />