Glyoxalase - Revision history

Michal Harel at 08:56, 16 July 2019

Michal Harel — Tue, 16 Jul 2019 08:56:45 GMT

←Older revision		Revision as of 08:56, 16 July 2019
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	</StructureSection>		</StructureSection>
-	==3D structures of glyoxalase==

-	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-	{{#tree:id=OrganizedByTopic\|openlevels=0\|
-
-	*Glyoxalase 1 or lactoylglutathione lyase
-
-	**[[1bh5]] – hGLO (mutant) – human<br />
-	**[[1fro]] – hGLO + benzyl glutathione<br />
-	**[[1qin]], [[1qip]] - hGLO + glutathione derivative<br />
-	**[[3w0u]], [[3w0t]], [[3vw9]] – hGLO + inhibitor<br />
-	**[[2za0]] – mGLO + methyl gerfelin – mouse<br />
-	**[[4x2a]] – mGLO + baicalein<br />
-	**[[4pv5]] – mGLO + glycyrrhetinic acid<br />
-	**[[4opn]] – mGLO + MAH<br />
-	**[[4kyk]], [[4kyh]] – mGLO + drug<br />
-	**[[5d7z]] – maGLO – maize<br />
-	**[[6bnn]], [[6bnx]], [[6bnz]] – maGLO (mutant)<br />
-	**[[1fa8]] – EcGLO – ''Escherichia coli''<br />
-	**[[1f9z]], [[1fa5]], [[1fa6]], [[1fa7]] – EcGLO + metal <br />
-	**[[2c21]] – GLO – ''Leishmania major''<br />
-	**[[3hdp]] – GLO + Ni – ''Clostridium acetobutylicum''<br />
-	**[[4z04]] - GLO + glutathione – ''Brucella abortus''<br />
-
-	*Glyoxalase 2
-
-	**[[1qh3]] – hGLO + actate + cacodylate<br />
-	**[[1qh5]] – hGLO + glutathione derivative<br />
-	**[[1xm8]] – GLO – ''Arabidopsis thaliana''<br />
-	**[[2p18]] - LiGLO – ''Leishmania infantum''<br />
-	**[[2p1e]] – LiGLO + lactate
-
-	*Glyoxalase 3
-
-	**[[4lru]] – GLO – ''Candida albicans''<br />
-
-	*Glyoxalase/bleomycin resistance protein/dioxygenase
-
-	**[[2rbb]] – GLXI (mutant) – ''Burkholderia phytofirmans''<br />
-	**[[4rt5]] – GLXI – ''Planctomyces limnophilus''<br />
-	**[[4qb5]] – GLXI – ''Albidiferax ferrireducens''<br />
-	**[[4n04]], [[4g6x]] – GLXI – ''Catenulispora acidiphia''<br />
-	**[[4mym]] – GLXI – ''Nocardioides''<br />
-	**[[4hc5]] – GLXI – ''Sphaerobacter thermophilus''<br />
-	**[[4gym]] – GLXI – ''Conexibacter woesei''<br />
-	**[[3vb0]] – GLXI – ''Sphingomonas wittichii''<br />
-	**[[3rri]] – GLXI – ''Alicyclobacillus acidocaldarius''<br />
-	**[[3kol]] – GLXI – ''Nostoc punctiforme''<br />
-	**[[3b59]] – GLXI – ''Novosphingobium aromaticivorans''<br />
-	**[[2rk9]] – GLXI (mutant) – ''Vibrio splendidus''<br />
-	**[[2rk0]] – GLXI – ''Frankia''<br />
-	**[[6cky]], [[5ump]], [[5umq]], [[5uhj]], [[5ujp]] – SuGLXI – ''Streptomyces uncialis''<br />
-	**[[6bbx]], [[5w27]], [[5umy]] – SuGLXI + antibiotic<br />
-	**[[5umw]], [[5umx]] – SuGLXI + riboflavin<br />
-	**[[5drh]], [[5d4f]], [[5cb9]], [[5c6x]], [[5c68]], [[5c4p]] – TcGLXI – ''Thermomonospora curvata''<br />
-	**[[5hcw]], [[5dfg]] – TcGLXI (mutant) <br />
-	**[[5v0f]] – TcGLXI (mutant) + roxarsone <br />
-	}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 08:55, 16 July 2019

Michal Harel — Tue, 16 Jul 2019 08:55:44 GMT

←Older revision		Revision as of 08:55, 16 July 2019
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	<scene name='50/508460/Cv/5'>Human GLO1 active site contains Zn+2 atom</scene><ref>PMID:10521255</ref>. Water molecules are shown as red spheres.		<scene name='50/508460/Cv/5'>Human GLO1 active site contains Zn+2 atom</scene><ref>PMID:10521255</ref>. Water molecules are shown as red spheres.
-	</StructureSection>	+
		+	==3D structures of glyoxalase==
		+	[[Glyoxalase 3D structures]]
		+
		+	</StructureSection>
	==3D structures of glyoxalase==		==3D structures of glyoxalase==

Michal Harel at 08:53, 16 July 2019

Michal Harel — Tue, 16 Jul 2019 08:53:56 GMT

←Older revision		Revision as of 08:53, 16 July 2019
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	**[[1bh5]] – hGLO (mutant) – human<br />		**[[1bh5]] – hGLO (mutant) – human<br />
-	**[[1fa8]] – EcGLO – ''Escherichia coli''<br />
-	**[[2c21]] – GLO – ''Leishmania major''<br />
	**[[1fro]] – hGLO + benzyl glutathione<br />		**[[1fro]] – hGLO + benzyl glutathione<br />
	**[[1qin]], [[1qip]] - hGLO + glutathione derivative<br />		**[[1qin]], [[1qip]] - hGLO + glutathione derivative<br />
	**[[3w0u]], [[3w0t]], [[3vw9]] – hGLO + inhibitor<br />		**[[3w0u]], [[3w0t]], [[3vw9]] – hGLO + inhibitor<br />
-	**[[1f9z]], [[1fa5]], [[1fa6]], [[1fa7]] – EcGLO + metal <br />
	**[[2za0]] – mGLO + methyl gerfelin – mouse<br />		**[[2za0]] – mGLO + methyl gerfelin – mouse<br />
	**[[4x2a]] – mGLO + baicalein<br />		**[[4x2a]] – mGLO + baicalein<br />
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	**[[4opn]] – mGLO + MAH<br />		**[[4opn]] – mGLO + MAH<br />
	**[[4kyk]], [[4kyh]] – mGLO + drug<br />		**[[4kyk]], [[4kyh]] – mGLO + drug<br />
		+	**[[5d7z]] – maGLO – maize<br />
		+	**[[6bnn]], [[6bnx]], [[6bnz]] – maGLO (mutant)<br />
		+	**[[1fa8]] – EcGLO – ''Escherichia coli''<br />
		+	**[[1f9z]], [[1fa5]], [[1fa6]], [[1fa7]] – EcGLO + metal <br />
		+	**[[2c21]] – GLO – ''Leishmania major''<br />
	**[[3hdp]] – GLO + Ni – ''Clostridium acetobutylicum''<br />		**[[3hdp]] – GLO + Ni – ''Clostridium acetobutylicum''<br />
-	**[[~~5d7z~~]] – GLO – ~~maize~~<br />	+	**[[4z04]] - GLO + glutathione – ''Brucella abortus''<br />

	*Glyoxalase 2		*Glyoxalase 2

-	**[[1xm8]] – GLO – ''Arabidopsis thaliana''<br />
-	**[[2p18]] - LiGLO – ''Leishmania infantum''<br />
	**[[1qh3]] – hGLO + actate + cacodylate<br />		**[[1qh3]] – hGLO + actate + cacodylate<br />
	**[[1qh5]] – hGLO + glutathione derivative<br />		**[[1qh5]] – hGLO + glutathione derivative<br />
		+	**[[1xm8]] – GLO – ''Arabidopsis thaliana''<br />
		+	**[[2p18]] - LiGLO – ''Leishmania infantum''<br />
	**[[2p1e]] – LiGLO + lactate		**[[2p1e]] – LiGLO + lactate

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	**[[4lru]] – GLO – ''Candida albicans''<br />		**[[4lru]] – GLO – ''Candida albicans''<br />
		+
		+	*Glyoxalase/bleomycin resistance protein/dioxygenase
		+
		+	**[[2rbb]] – GLXI (mutant) – ''Burkholderia phytofirmans''<br />
		+	**[[4rt5]] – GLXI – ''Planctomyces limnophilus''<br />
		+	**[[4qb5]] – GLXI – ''Albidiferax ferrireducens''<br />
		+	**[[4n04]], [[4g6x]] – GLXI – ''Catenulispora acidiphia''<br />
		+	**[[4mym]] – GLXI – ''Nocardioides''<br />
		+	**[[4hc5]] – GLXI – ''Sphaerobacter thermophilus''<br />
		+	**[[4gym]] – GLXI – ''Conexibacter woesei''<br />
		+	**[[3vb0]] – GLXI – ''Sphingomonas wittichii''<br />
		+	**[[3rri]] – GLXI – ''Alicyclobacillus acidocaldarius''<br />
		+	**[[3kol]] – GLXI – ''Nostoc punctiforme''<br />
		+	**[[3b59]] – GLXI – ''Novosphingobium aromaticivorans''<br />
		+	**[[2rk9]] – GLXI (mutant) – ''Vibrio splendidus''<br />
		+	**[[2rk0]] – GLXI – ''Frankia''<br />
		+	**[[6cky]], [[5ump]], [[5umq]], [[5uhj]], [[5ujp]] – SuGLXI – ''Streptomyces uncialis''<br />
		+	**[[6bbx]], [[5w27]], [[5umy]] – SuGLXI + antibiotic<br />
		+	**[[5umw]], [[5umx]] – SuGLXI + riboflavin<br />
		+	**[[5drh]], [[5d4f]], [[5cb9]], [[5c6x]], [[5c68]], [[5c4p]] – TcGLXI – ''Thermomonospora curvata''<br />
		+	**[[5hcw]], [[5dfg]] – TcGLXI (mutant) <br />
		+	**[[5v0f]] – TcGLXI (mutant) + roxarsone <br />
	}}		}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Alexander Berchansky at 11:47, 3 April 2019

Alexander Berchansky — Wed, 03 Apr 2019 11:47:08 GMT

←Older revision		Revision as of 11:47, 3 April 2019
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	== Structural highlights ==		== Structural highlights ==

-	<scene name='50/508460/Cv/4'>Human GLO1 active site contains Zn+2 atom</scene><ref>PMID:10521255</ref>. Water molecules are shown as red spheres.	+	<scene name='50/508460/Cv/5'>Human GLO1 active site contains Zn+2 atom</scene><ref>PMID:10521255</ref>. Water molecules are shown as red spheres.
	</StructureSection>		</StructureSection>
	==3D structures of glyoxalase==		==3D structures of glyoxalase==

Alexander Berchansky at 11:46, 3 April 2019

Alexander Berchansky — Wed, 03 Apr 2019 11:46:08 GMT

←Older revision		Revision as of 11:46, 3 April 2019
Line 11:		Line 11:
	== Structural highlights ==		== Structural highlights ==

-	<scene name='50/508460/Cv/4'>Human GLO1 active site contains Zn+2 atom</scene><ref>PMID:10521255</ref>. Water molecules shown as red spheres.	+	<scene name='50/508460/Cv/4'>Human GLO1 active site contains Zn+2 atom</scene><ref>PMID:10521255</ref>. Water molecules are shown as red spheres.
	</StructureSection>		</StructureSection>
	==3D structures of glyoxalase==		==3D structures of glyoxalase==

Michal Harel at 06:33, 5 June 2018

Michal Harel — Tue, 05 Jun 2018 06:33:16 GMT

←Older revision		Revision as of 06:33, 5 June 2018
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	== Function ==		== Function ==
-	'''Glyoxalase''' (GLO) is part of glyoxalase system which ~~detoxify~~ the highly toxic methylglyoxal and other aldehydes produced by metabolism<ref>PMID:10066594</ref>. <br />	+	'''Glyoxalase''' (GLO) is part of the glyoxalase system which detoxifies the highly toxic methylglyoxal and other aldehydes produced by metabolism<ref>PMID:10066594</ref>. <br />
-	* '''GLO1''' catalyzes the conversion of glutathione and methylglyoxal to lactoylglutathione.<br />	+	* '''GLO1''' or '''lactoylglutathione lyase''' catalyzes the conversion of glutathione and methylglyoxal to lactoylglutathione.<br />
	* '''GLO2''' is a metalloenzyme which catalyzes the hydrolysis of lactoylglutathione to glutathione and lactate. GLO2 exists as cytosolic and mitochondrial forms. For details on GLO2 see [[Leishmania infantum Glyoxalase II]].		* '''GLO2''' is a metalloenzyme which catalyzes the hydrolysis of lactoylglutathione to glutathione and lactate. GLO2 exists as cytosolic and mitochondrial forms. For details on GLO2 see [[Leishmania infantum Glyoxalase II]].

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	{{#tree:id=OrganizedByTopic\|openlevels=0\|		{{#tree:id=OrganizedByTopic\|openlevels=0\|

-	*Glyoxalase 1	+	*Glyoxalase 1 or lactoylglutathione lyase

	**[[1bh5]] – hGLO (mutant) – human<br />		**[[1bh5]] – hGLO (mutant) – human<br />
Line 25:		Line 25:
	**[[1fro]] – hGLO + benzyl glutathione<br />		**[[1fro]] – hGLO + benzyl glutathione<br />
	**[[1qin]], [[1qip]] - hGLO + glutathione derivative<br />		**[[1qin]], [[1qip]] - hGLO + glutathione derivative<br />
		+	**[[3w0u]], [[3w0t]], [[3vw9]] – hGLO + inhibitor<br />
	**[[1f9z]], [[1fa5]], [[1fa6]], [[1fa7]] – EcGLO + metal <br />		**[[1f9z]], [[1fa5]], [[1fa6]], [[1fa7]] – EcGLO + metal <br />
-	**[[2za0]] – ~~GLO~~ + methyl gerfelin – mouse<br />	+	**[[2za0]] – mGLO + methyl gerfelin – mouse<br />
-	**[[3hdp]] – GLO + Ni – ''Clostridium acetobutylicum''	+	**[[4x2a]] – mGLO + baicalein<br />
		+	**[[4pv5]] – mGLO + glycyrrhetinic acid<br />
		+	**[[4opn]] – mGLO + MAH<br />
		+	**[[4kyk]], [[4kyh]] – mGLO + drug<br />
		+	**[[3hdp]] – GLO + Ni – ''Clostridium acetobutylicum''<br />
		+	**[[5d7z]] – GLO – maize<br />

	*Glyoxalase 2		*Glyoxalase 2

Joel L. Sussman at 08:50, 20 October 2017

Joel L. Sussman — Fri, 20 Oct 2017 08:50:46 GMT

←Older revision		Revision as of 08:50, 20 October 2017
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-	<StructureSection load='~~1qin~~' size='350' side='right' scene='50/508460/Cv/1' caption='Human glyoxalase I dimer complex with glutathione derivative and Zn+2 ion (grey) [[1qin]]'>	+	<StructureSection load='' size='350' side='right' scene='50/508460/Cv/1' caption='Human glyoxalase I dimer complex with glutathione derivative and Zn+2 ion (grey) [[1qin]]'>

	== Function ==		== Function ==

Michal Harel at 21:13, 19 October 2017

Michal Harel — Thu, 19 Oct 2017 21:13:01 GMT

←Older revision		Revision as of 21:13, 19 October 2017
Line 1:		Line 1:
-	<StructureSection load='1qin' size='~~450~~' side='right' scene='50/508460/Cv/1' caption='Human glyoxalase I dimer complex with glutathione derivative and Zn+2 ion (grey) [[1qin]]'>	+	<StructureSection load='1qin' size='350' side='right' scene='50/508460/Cv/1' caption='Human glyoxalase I dimer complex with glutathione derivative and Zn+2 ion (grey) [[1qin]]'>

	== Function ==		== Function ==

Alexander Berchansky at 14:02, 16 March 2016

Alexander Berchansky — Wed, 16 Mar 2016 14:02:54 GMT

←Older revision		Revision as of 14:02, 16 March 2016
Line 1:		Line 1:
-	<StructureSection load='1qin' size='~~350~~' side='right' scene='50/508460/Cv/1' caption='Human glyoxalase I dimer complex with glutathione derivative and Zn+2 ion (grey) [[1qin]]'>	+	<StructureSection load='1qin' size='450' side='right' scene='50/508460/Cv/1' caption='Human glyoxalase I dimer complex with glutathione derivative and Zn+2 ion (grey) [[1qin]]'>

	== Function ==		== Function ==
Line 11:		Line 11:
	== Structural highlights ==		== Structural highlights ==

-	Human GLO1 active site contains Zn+2 atom<ref>PMID:10521255</ref>.	+	<scene name='50/508460/Cv/4'>Human GLO1 active site contains Zn+2 atom</scene><ref>PMID:10521255</ref>. Water molecules shown as red spheres.
	</StructureSection>		</StructureSection>
	==3D structures of glyoxalase==		==3D structures of glyoxalase==

Alexander Berchansky at 13:48, 16 March 2016

Alexander Berchansky — Wed, 16 Mar 2016 13:48:58 GMT

←Older revision		Revision as of 13:48, 16 March 2016
Line 1:		Line 1:
-	<StructureSection load='1qin' size='350' side='right' scene='' caption='Human glyoxalase I dimer complex with glutathione derivative and Zn+2 ion (grey) [[1qin]]'>	+	<StructureSection load='1qin' size='350' side='right' scene='50/508460/Cv/1' caption='Human glyoxalase I dimer complex with glutathione derivative and Zn+2 ion (grey) [[1qin]]'>

	== Function ==		== Function ==