Histone deacetylase 3D structures - Revision history

Michal Harel at 07:23, 22 May 2023

Michal Harel — Mon, 22 May 2023 07:23:30 GMT

←Older revision		Revision as of 07:23, 22 May 2023
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	**[[8bpa]], [[8bpb]], [[8c60]] – hHDAC2 + SIN3B + PF1 – Cryo EM<br />		**[[8bpa]], [[8bpb]], [[8c60]] – hHDAC2 + SIN3B + PF1 – Cryo EM<br />
	**[[8bpc]] – hHDAC2 + SIN3B + PF1 + SAHA – Cryo EM<br />		**[[8bpc]] – hHDAC2 + SIN3B + PF1 + SAHA – Cryo EM<br />
-	**[[4ly1]], [[5iwg]], [[5ix0]], [[6wbz]], [[6wbw]], [[6xdm]], [[6xeb]], [[6xec]], [[7js8]], [[7kbh]], [[7kbg]], [[7ltg]], [[7ltk]], [[7ltl]], [[7mot]], [[7mox]], [[7moy]] – hHDAC2 core domain + inhibitor<br />	+	**[[8bpa]], [[8bpb]], [[8c60]] – hHDAC2 + SIN3B + PF1 – Cryo EM<br />
		+	**[[8bpc]] – hHDAC2 + SIN3B + PF1 + SAHA – Cryo EM<br />
		+	**[[4ly1]], [[5iwg]], [[5ix0]], [[6wbz]], [[6wbw]], [[6xdm]], [[6xeb]], [[6xec]], [[7js8]], [[7kbh]], [[7kbg]], [[7ltg]], [[7ltk]], [[7ltl]], [[7mot]], [[7mox]], [[7moy]], [[7zzo]], [[7zzp]], [[7zzr]], [[7zzs]], [[7zzt]], [[7zzv]], [[7zzw]], [[8a0b]] – hHDAC2 core domain + inhibitor<br />
	**[[6whn]], [[6who]], [[6whq]], [[6whz]], [[6wi3]], [[7mos]], [[7moz]] – hHDAC2 core domain + peptide macrocycle<br />		**[[6whn]], [[6who]], [[6whq]], [[6whz]], [[6wi3]], [[7mos]], [[7moz]] – hHDAC2 core domain + peptide macrocycle<br />
		+	**[[7vrr]] – AtHDAC2a residues 1-95 – ''Arabidopsis thaliana''<br />
		+	**[[7vmf]], [[7vmh]] – AtHDAC2d residues 1-95 <br />
		+	**[[7vmi]] – AtHDAC2c residues 1-95 <br />

	*HDAC3		*HDAC3
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	**[[2v5x]] - hHDAC8 (mutant) + octanediamide derivative<br />		**[[2v5x]] - hHDAC8 (mutant) + octanediamide derivative<br />
	**[[4bz5]] – SmHDAC8 – ''Schistosoma mansoni''<br />		**[[4bz5]] – SmHDAC8 – ''Schistosoma mansoni''<br />
-	**[[4bz7]], [[4bz8]], [[4bz9]], [[4cqf]], [[6hsz]], [[6ht8]], [[6htg]], [[6hth]], [[6hti]], [[6htt]], [[6htz]], [[6hu0]], [[6hu1]], [[6hu2]], [[6hu3]], [[6hsh]], [[6hrq]], [[6hqy]], [[6tld]], [[7p3s]] – SmHDAC8 + inhibitor<br />	+	**[[4bz7]], [[4bz8]], [[4bz9]], [[4cqf]], [[6hsz]], [[6ht8]], [[6htg]], [[6hth]], [[6hti]], [[6htt]], [[6htz]], [[6hu0]], [[6hu1]], [[6hu2]], [[6hu3]], [[6hsh]], [[6hrq]], [[6hqy]], [[6tld]], [[7p2s]], [[7p2t]], [[7p2u]], [[7p2v]], [[7p3s]], [[7poz]] – SmHDAC8 + inhibitor<br />
	**[[6hsk]], [[6hsf]], [[6hsg]] – SmHDAC8 (mutant) + inhibitor<br />		**[[6hsk]], [[6hsf]], [[6hsg]] – SmHDAC8 (mutant) + inhibitor<br />
	**[[4bz6]], [[6gxw]], [[6gxu]], [[6gxa]], [[6gx3]], [[6fu1]] – SmHDAC8 + SAHA derivative<br />		**[[4bz6]], [[6gxw]], [[6gxu]], [[6gxa]], [[6gx3]], [[6fu1]] – SmHDAC8 + SAHA derivative<br />
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	*HDAC10 or polyamine deacetylase 10		*HDAC10 or polyamine deacetylase 10

-	**[[7kuv]] – zHDAC10 - zebrafish<br />	+	**[[5td7]], [[7kuv]] – zHDAC10 - zebrafish<br />
-	**[[6ufn]], [[6ufo]], [[6uhu]], [[6uhv]], [[6uii]], [[6uij]], [[6uil]], [[6uim]], [[6wbq]], [[6wdv]], [[6wdw]], [[6wdx]], [[6wdy]] – zHDAC10 + inhibitor<br />	+	**[[6ufn]], [[6ufo]], [[6uhu]], [[6uhv]], [[6uii]], [[6uij]], [[6uil]], [[6uim]], [[6wbq]], [[6wdv]], [[6wdw]], [[6wdx]], [[6wdy]], [[7sgg]], [[7sgi]], [[7sgj]], [[7sgk]], [[7u3m]], [[7u59]], [[7u69]], [[7u6a]], [[7u6b]] – zHDAC10 + inhibitor<br />
	**[[6vnq]], [[7kuq]], [[7kur]], [[7kus]], [[7kut]] – zHDAC10 (mutant) + inhibitor <br />		**[[6vnq]], [[7kuq]], [[7kur]], [[7kus]], [[7kut]] – zHDAC10 (mutant) + inhibitor <br />

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	**[[2ld7]] – hHDAC subunit SAP30 +SIN3A PAH 3 domain – NMR<br />		**[[2ld7]] – hHDAC subunit SAP30 +SIN3A PAH 3 domain – NMR<br />
	**[[5ikk]] – HDAC CLR3 – fission yeast<br />		**[[5ikk]] – HDAC CLR3 – fission yeast<br />
		+	**[[7q1b]], [[7q1c]] – HDAC DAC2 + inhibitor – ''Trypanosoma cruzi''<br />

	*'''HDAC class IIB'''		*'''HDAC class IIB'''

-	*HDAC6	+	*HDAC6; ; Domains – catalytic 2 288-646; CD1 – 40-440; CD2 440-798; zinc finger 1109-1213

	**[[3c5k]] – hHDAC6 zinc finger domain<br />		**[[3c5k]] – hHDAC6 zinc finger domain<br />
	**[[3gv4]] - hHDAC6 zinc finger domain + ubiquitin peptide<br />		**[[3gv4]] - hHDAC6 zinc finger domain + ubiquitin peptide<br />
	**[[3phd]] - hHDAC6 + polyubiquitin<br />		**[[3phd]] - hHDAC6 + polyubiquitin<br />
-	**[[5kh3]], [[5kh7]], [[5kh9]], [[5b8d]], [[6ce6]], [[6ce8]], [[6cea]], [[6cec]], [[6ced]], [[6cee]], [[6cef]], [[5wpb]], [[5wbn]] – hHDAC6 zinc finger + inhibitor<br />	+	**[[5kh3]], [[5kh7]], [[5kh9]], [[5b8d]], [[6ce6]], [[6ce8]], [[6cea]], [[6cec]], [[6ced]], [[6cee]], [[6cef]], [[5wpb]], [[5wbn]], [[8g43]], [[8g44]], [[8g45]] – hHDAC6 zinc finger + inhibitor<br />
		+	**[[7qno]] – zHDAC6 CD1+CD2 domain <br />
	**[[5eem]] – zHDAC6 catalytic domain<br />		**[[5eem]] – zHDAC6 catalytic domain<br />
-	**[[6cgp]], [[5wgm]], [[5wgl]], [[5wgi]], [[5wgk]], [[5g0j]], [[5g0i]], [[5g0h]], [[5g0g]], [[5g0f]], [[5efh]], [[5efg]], [[5efb]], [[5ef7]], [[5ef8]], [[5een]], [[5eek]], [[5eef]], [[6mr5]], [[6dvo]], [[6dvn]], [[6dvm]], [[6dvl]], [[6cw8]], [[6pye]], [[6pzo]], [[6pzr]], [[6pzs]], [[6pzu]], [[6q0z]], [[6r0k]], [[6tcy]], [[6thv]], [[6uo2]], [[6uo3]], [[6uo5]], [[6uo7]], [[6v79]], [[6v7a]], [[6vnr]], [[6zw1]], [[7jom]] – zHDAC6 catalytic domain + inhibitor <br />	+	**[[5edu]], [[6cgp]], [[5wgm]], [[5wgl]], [[5wgi]], [[5wgk]], [[5g0j]], [[5g0i]], [[5g0h]], [[5g0g]], [[5g0f]], [[5efh]], [[5efg]], [[5efb]], [[5ef7]], [[5ef8]], [[5een]], [[5eek]], [[5eef]], [[6mr5]], [[6dvo]], [[6dvn]], [[6dvm]], [[6dvl]], [[6cw8]], [[6pye]], [[6pzo]], [[6pzr]], [[6pzs]], [[6pzu]], [[6q0z]], [[6r0k]], [[6tcy]], [[6thv]], [[6uo2]], [[6uo3]], [[6uo5]], [[6uo7]], [[6v79]], [[6v7a]], [[6vnr]], [[6zw1]], [[7jom]], [[7o2p]], [[7o2r]], [[7u8z]], [[7uk2]], [[8d98]], [[8d99]], [[8d9a]], [[8d9b]], [[8d9c]] – zHDAC6 catalytic domain 2 + inhibitor <br />
	**[[6uo4]], [[6uo7]], [[6uob]], [[6uoc]], [[6wyo]] – zHDAC6 catalytic domain (mutant) + inhibitor <br />		**[[6uo4]], [[6uo7]], [[6uob]], [[6uoc]], [[6wyo]] – zHDAC6 catalytic domain (mutant) + inhibitor <br />
	**[[5eei]], [[6css]], [[6csr]], [[6csq]], [[6csp]], [[5w5k]] – zHDAC6 catalytic domain + SAHA derivative<br />		**[[5eei]], [[6css]], [[6csr]], [[6csq]], [[6csp]], [[5w5k]] – zHDAC6 catalytic domain + SAHA derivative<br />
	**[[6wyp]], [[6wyq]] – zHDAC6 catalytic domain (mutant) + SAHA derivative<br />		**[[6wyp]], [[6wyq]] – zHDAC6 catalytic domain (mutant) + SAHA derivative<br />
-	**[[6wsj]] – zHDAC6 catalytic domain + peptide <br />	+	**[[6wsj]], [[8eqi]] – zHDAC6 catalytic domain 2 + peptide <br />
		+	**[[5efj]] – zHDAC6 catalytic domain 2 + HC toxin <br />
	**[[5efn]], [[5efk]], [[53fj]] – zHDAC6 catalytic domain (mutant) + peptide <br />		**[[5efn]], [[5efk]], [[53fj]] – zHDAC6 catalytic domain (mutant) + peptide <br />
		+	**[[8a8z]] – zHDAC6 CD2 domain 440-798 + inhibitor <br />

	*HDAC15		*HDAC15

-	**[[6j6t]] – ~~HDAC15~~ HD domain ~~– ''Arabidopsis thaliana''~~<br />	+	**[[6j6t]] – AtHDAC15 HD domain <br />

	*'''HDAC class III'''		*'''HDAC class III'''
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	**[[5iqz]] – hSIRT7 N-terminal<br />		**[[5iqz]] – hSIRT7 N-terminal<br />
		+
		+	*HDAC-like
		+
		+	**[[1zz0]], [[5g1b]] – AbHDAH – ''Alcalifenaceae bacterium''<br />
		+	**[[1zz3]], [[2gh6]], [[2vcg]], [[5g1a]], [[5g1c]], [[5g3w]] – AbHDAH + inhibitor <br />
		+	**[[5g17]] – AbHDAH (mutant) + inhibitor <br />
		+	**[[1zz1]] – AbHDAH + SAHA <br />
		+	**[[5g0y]] – PaHDAH – ''Pseudomonas aeruginosa''<br />
		+	**[[5li3]] – PaHDAH + inhibitor <br />

	}}		}}

	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 09:40, 21 May 2023

Michal Harel — Sun, 21 May 2023 09:40:11 GMT

←Older revision		Revision as of 09:40, 21 May 2023
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	**[[3max]] – hHDAC2 + amide derivative <br />		**[[3max]] – hHDAC2 + amide derivative <br />
	**[[4lxz]], [[6g3o]] – hHDAC2 core domain + SAHA<br />		**[[4lxz]], [[6g3o]] – hHDAC2 core domain + SAHA<br />
		+	**[[8bpa]], [[8bpb]], [[8c60]] – hHDAC2 + SIN3B + PF1 – Cryo EM<br />
		+	**[[8bpc]] – hHDAC2 + SIN3B + PF1 + SAHA – Cryo EM<br />
	**[[4ly1]], [[5iwg]], [[5ix0]], [[6wbz]], [[6wbw]], [[6xdm]], [[6xeb]], [[6xec]], [[7js8]], [[7kbh]], [[7kbg]], [[7ltg]], [[7ltk]], [[7ltl]], [[7mot]], [[7mox]], [[7moy]] – hHDAC2 core domain + inhibitor<br />		**[[4ly1]], [[5iwg]], [[5ix0]], [[6wbz]], [[6wbw]], [[6xdm]], [[6xeb]], [[6xec]], [[7js8]], [[7kbh]], [[7kbg]], [[7ltg]], [[7ltk]], [[7ltl]], [[7mot]], [[7mox]], [[7moy]] – hHDAC2 core domain + inhibitor<br />
	**[[6whn]], [[6who]], [[6whq]], [[6whz]], [[6wi3]], [[7mos]], [[7moz]] – hHDAC2 core domain + peptide macrocycle<br />		**[[6whn]], [[6who]], [[6whq]], [[6whz]], [[6wi3]], [[7mos]], [[7moz]] – hHDAC2 core domain + peptide macrocycle<br />

Michal Harel at 09:46, 23 September 2021

Michal Harel — Thu, 23 Sep 2021 09:46:38 GMT

←Older revision		Revision as of 09:46, 23 September 2021
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	*'''HDAC class III'''		*'''HDAC class III'''
-	*SIRT1	+
		+	*SIRT1 or NAD-dependent protein deacetylase sirtuin-1

	**[[4ig9]] – hSIRT1 + Zn<br />		**[[4ig9]] – hSIRT1 + Zn<br />
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	**[[4y6q]] – hSIRT2+ ADP ribose derivative + Zn<br />		**[[4y6q]] – hSIRT2+ ADP ribose derivative + Zn<br />
	**[[4l3o]], [[4y6l]], [[4y6o]] – hSIRT2 + acetyl lysine peptide + Zn<br />		**[[4l3o]], [[4y6l]], [[4y6o]] – hSIRT2 + acetyl lysine peptide + Zn<br />
-	**[[4x3o]], [[4x3p]] – hSIRT2 + myristoyl peptide + Zn<br />	+	**[[4x3o]], [[4x3p]], [[6l65]], [[6l66]], [[6l71]], [[7bos]], [[7bot]] – hSIRT2 + myristoyl peptide + Zn<br />
	**[[4rmg]], [[5dy4]], [[5dy5]], [[5y5n]], [[5mat]], [[6nr0]] – hSIRT2 + inhibitor + Zn<br />		**[[4rmg]], [[5dy4]], [[5dy5]], [[5y5n]], [[5mat]], [[6nr0]] – hSIRT2 + inhibitor + Zn<br />
	**[[6qcn]] – hSIRT2 + ADP-ribose + quercetin derivative + Zn<br />		**[[6qcn]] – hSIRT2 + ADP-ribose + quercetin derivative + Zn<br />
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	**[[2b4y]], [[4bn4]] – hSIRT5 + ADP-ribose + Zn<br />		**[[2b4y]], [[4bn4]] – hSIRT5 + ADP-ribose + Zn<br />
	**[[2nyr]], [[5xhs]] – hSIRT5 + inhibitor + Zn<br />		**[[2nyr]], [[5xhs]] – hSIRT5 + inhibitor + Zn<br />
		+	**[[6ljk]], [[6ljm]], [[6ljn]] – hSIRT5 + peptide substrate + Zn<br />
	**[[3rig]], [[3riy]], [[4f4u]] – hSIRT5 + acetyl lysine peptide + Zn<br />		**[[3rig]], [[3riy]], [[4f4u]] – hSIRT5 + acetyl lysine peptide + Zn<br />
	**[[4gic]] – hSIRT5 + acetyl lysine peptide + carba-NAD + Zn<br/ >		**[[4gic]] – hSIRT5 + acetyl lysine peptide + carba-NAD + Zn<br/ >
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	*SIRT6		*SIRT6

-	**[[3k35]] – hSIRT6 + ADP-ribose + Zn<br />	+	**[[3k35]], [[6xuy]], [[6xv6]] – hSIRT6 + ADP-ribose + Zn<br />
	**[[5x16]] – hSIRT6 + oxolan derivative + Zn<br />		**[[5x16]] – hSIRT6 + oxolan derivative + Zn<br />
	**[[6hoy]] – hSIRT6 + ADP-ribose + trichostatin + Zn<br />		**[[6hoy]] – hSIRT6 + ADP-ribose + trichostatin + Zn<br />
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	**[[3pki]], [[3pkj]] – hSIRT6 (mutant) + ADP-ribose derivative + Zn<br />		**[[3pki]], [[3pkj]] – hSIRT6 (mutant) + ADP-ribose derivative + Zn<br />
	**[[3zg6]] – hSIRT6 + acetyl lysine peptide + ADP-ribose + Zn<br />		**[[3zg6]] – hSIRT6 + acetyl lysine peptide + ADP-ribose + Zn<br />
-	**[[5mgn]], [[5mfz]], [[5mfp]], [[5mf6]] – hSIRT6 + activator + Zn<br />	+	**[[5mgn]], [[5mfz]], [[5mfp]], [[5mf6]], [[6xv1]], [[6xvg]], [[6zu4]] – hSIRT6 + activator + Zn<br />
-	**[[5y2f]] – hSIRT6 + peptide activator + Zn<br />	+	**[[5y2f]], [[7cl0]], [[7cl1]] – hSIRT6 + peptide activator + Zn<br />

	*SIRT7		*SIRT7

Michal Harel at 09:11, 23 September 2021

Michal Harel — Thu, 23 Sep 2021 09:11:01 GMT

Michal Harel at 08:33, 19 August 2020

Michal Harel — Wed, 19 Aug 2020 08:33:43 GMT

Michal Harel at 08:08, 19 August 2020

Michal Harel — Wed, 19 Aug 2020 08:08:26 GMT

←Older revision		Revision as of 08:08, 19 August 2020
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	**[[3hgq]], [[3hgt]] – hHDAC1 subunit 3<br />		**[[3hgq]], [[3hgt]] – hHDAC1 subunit 3<br />
	**[[5icn]] – hHDAC1 + MTA1 + peptide<br />		**[[5icn]] – hHDAC1 + MTA1 + peptide<br />
		+	**[[6z2j]], [[6z2k]] – hHDAC1 + DNTTIP1 + Midac deacetylase – Cryo EM<br />
	**[[5j8j]] – yHDAC1 residues 457-698 – yeast<br />		**[[5j8j]] – yHDAC1 residues 457-698 – yeast<br />

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	**[[3max]] – hHDAC2 + amide derivative <br />		**[[3max]] – hHDAC2 + amide derivative <br />
-	**[[4lxz]] – hHDAC2 core domain + SAHA<br />	+	**[[4lxz]], [[6g3o]] – hHDAC2 core domain + SAHA<br />
-	**[[4ly1]], [[5iwg]], [[5ix0]] – hHDAC2 core domain + inhibitor<br />	+	**[[4ly1]], [[5iwg]], [[5ix0]], [[6wbz]], [[6wbw]], [[6xdm]], [[6xeb]], [[6xec]] – hHDAC2 core domain + inhibitor<br />

	*HDAC3		*HDAC3
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	**[[3ew8]], [[3ezp]], [[3ezt]], [[3f06]] – hHDAC8 (mutant)<br />		**[[3ew8]], [[3ezp]], [[3ezt]], [[3f06]] – hHDAC8 (mutant)<br />
	**[[3sff]], [[3sfh]] – hHDAC8 + inhibitor<br />		**[[3sff]], [[3sfh]] – hHDAC8 + inhibitor<br />
		+	**[[4qa1]], [[4qa2]], [[4qa3]], [[4qa4]] - hHDAC8 (mutant) + inhibitor<br />
	**[[1t64]], [[3f0r]], [[5ths]] – hHDAC8 + trichostatin A <br />		**[[1t64]], [[3f0r]], [[5ths]] – hHDAC8 + trichostatin A <br />
	**[[5tht]], [[5thu]], [[5thv]], [[5dc5]], [[5d1b]] - hHDAC8 (mutant) + amide derivative<br />		**[[5tht]], [[5thu]], [[5thv]], [[5dc5]], [[5d1b]] - hHDAC8 (mutant) + amide derivative<br />
-	**[[1t67]], [[1w22]], [[1vkg]], [[3f07]] - hHDAC8 + amide derivative<br />	+	**[[1t67]], [[1w22]], [[1vkg]], [[3f07]], [[6oda]], [[6odb]], [[6odc]] - hHDAC8 + amide derivative<br />
	**[[1t69]] - hHDAC8 + SAHA<br />		**[[1t69]] - hHDAC8 + SAHA<br />
	**[[4qa0]] - hHDAC8 (mutant) + SAHA<br />		**[[4qa0]] - hHDAC8 (mutant) + SAHA<br />
	**[[5fcw]], [[5fue]] - hHDAC8 + hydroxamate<br />		**[[5fcw]], [[5fue]] - hHDAC8 + hydroxamate<br />
	**[[5vi6]] - hHDAC8 + trapoxin A<br />		**[[5vi6]] - hHDAC8 + trapoxin A<br />
-	**[[4qa1]], [[4qa2]], [[4qa3]], [[4qa4]] - hHDAC8 (mutant) + inhibitor<br />
	**[[2v5w]] – hHDAC8 + tripeptide substrate<br />		**[[2v5w]] – hHDAC8 + tripeptide substrate<br />
	**[[4qa5]], [[4qa6]], [[4qa7]], [[3ewf]], [[5dc8]], [[5dc7]], [[5dc6]], [[5d1d]], [[5d1c]] - hHDAC8 (mutant) + tetrapeptide substrate<br />		**[[4qa5]], [[4qa6]], [[4qa7]], [[3ewf]], [[5dc8]], [[5dc7]], [[5dc6]], [[5d1d]], [[5d1c]] - hHDAC8 (mutant) + tetrapeptide substrate<br />
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	**[[2v5x]] - hHDAC8 (mutant) + octanediamide derivative<br />		**[[2v5x]] - hHDAC8 (mutant) + octanediamide derivative<br />
	**[[4bz5]] – SmHDAC8 – ''Schistosoma mansoni''<br />		**[[4bz5]] – SmHDAC8 – ''Schistosoma mansoni''<br />
-	**[[4bz7]], [[4bz8]], [[4bz9]], [[4cqf]], [[6hsz]], [[6ht8]], [[6htg]], [[6hth]], [[6hti]], [[6htt]], [[6htz]], [[6hu0]], [[6hu1]], [[6hu2]], [[6hu3]], [[6hsh]], [[6hrq]], [[6hqy]] – SmHDAC8 + inhibitor<br />	+	**[[4bz7]], [[4bz8]], [[4bz9]], [[4cqf]], [[6hsz]], [[6ht8]], [[6htg]], [[6hth]], [[6hti]], [[6htt]], [[6htz]], [[6hu0]], [[6hu1]], [[6hu2]], [[6hu3]], [[6hsh]], [[6hrq]], [[6hqy]], [[6tld]] – SmHDAC8 + inhibitor<br />
	**[[6hsk]], [[6hsf]], [[6hsg]] – SmHDAC8 (mutant) + inhibitor<br />		**[[6hsk]], [[6hsf]], [[6hsg]] – SmHDAC8 (mutant) + inhibitor<br />
	**[[4bz6]], [[6gxw]], [[6gxu]], [[6gxa]], [[6gx3]], [[6fu1]] – SmHDAC8 + SAHA derivative<br />		**[[4bz6]], [[6gxw]], [[6gxu]], [[6gxa]], [[6gx3]], [[6fu1]] – SmHDAC8 + SAHA derivative<br />
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	**[[1tqe]] – mHDAC9 + myocyte-specific enhancer factor + DNA – mouse		**[[1tqe]] – mHDAC9 + myocyte-specific enhancer factor + DNA – mouse
		+
		+	*HDAC10 or polyamine deacetylase 10
		+
		+	**[[6ufn]], [[6ufo]], [[6uhu]], [[6uhv]], [[6uii]], [[6uij]], [[6uil]], [[6uim]], [[6wbq]], [[6wdv]], [[6wdw]], [[6wdx]], [[6wdy]] – zHDAC10 + inhibitor - zebrafish<br />
		+	**[[6vnq]] – zHDAC10 (mutant) + inhibitor <br />

	*HDAC		*HDAC
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	**[[3phd]] - hHDAC6 + polyubiquitin<br />		**[[3phd]] - hHDAC6 + polyubiquitin<br />
	**[[5kh3]], [[5kh7]], [[5kh9]], [[5b8d]], [[6ce6]], [[6ce8]], [[6cea]], [[6cec]], [[6ced]], [[6cee]], [[6cef]], [[5wpb]], [[5wbn]] – hHDAC6 zinc finger + inhibitor<br />		**[[5kh3]], [[5kh7]], [[5kh9]], [[5b8d]], [[6ce6]], [[6ce8]], [[6cea]], [[6cec]], [[6ced]], [[6cee]], [[6cef]], [[5wpb]], [[5wbn]] – hHDAC6 zinc finger + inhibitor<br />
-	**[[5eem]] – zHDAC6 catalytic domain ~~- zebrafish~~<br />	+	**[[5eem]] – zHDAC6 catalytic domain<br />
-	**[[6cgp]], [[5wgm]], [[5wgl]], [[5wgi]], [[5wgk]], [[5g0j]], [[5g0i]], [[5g0h]], [[5g0g]], [[5g0f]], [[5efh]], [[5efg]], [[5efb]], [[5ef7]], [[5ef8]], [[5een]], [[5eek]], [[5eef]], [[6mr5]], [[6dvo]], [[6dvn]], [[6dvm]], [[6dvl]], [[6cw8]] – zHDAC6 catalytic domain + inhibitor <br />	+	**[[6cgp]], [[5wgm]], [[5wgl]], [[5wgi]], [[5wgk]], [[5g0j]], [[5g0i]], [[5g0h]], [[5g0g]], [[5g0f]], [[5efh]], [[5efg]], [[5efb]], [[5ef7]], [[5ef8]], [[5een]], [[5eek]], [[5eef]], [[6mr5]], [[6dvo]], [[6dvn]], [[6dvm]], [[6dvl]], [[6cw8]], [[6pye]], [[6pzo]], [[6pzr]], [[6pzs]], [[6pzu]], [[6q0z]], [[6r0k]], [[6thv]], [[6uo2]], [[6uo3]], [[6uo5]], [[6vnr]] – zHDAC6 catalytic domain + inhibitor <br />
		+	**[[6uo4]], [[6uo7]], [[6uob]], [[6uoc]] – zHDAC6 catalytic domain (mutant) + inhibitor <br />
	**[[5eei]], [[6css]], [[6csr]], [[6csq]], [[6csp]], [[5w5k]] – zHDAC6 catalytic domain + SAHA derivative<br />		**[[5eei]], [[6css]], [[6csr]], [[6csq]], [[6csp]], [[5w5k]] – zHDAC6 catalytic domain + SAHA derivative<br />
	**[[5efn]], [[5efk]], [[53fj]] – zHDAC6 catalytic domain (mutant) + peptide <br />		**[[5efn]], [[5efk]], [[53fj]] – zHDAC6 catalytic domain (mutant) + peptide <br />

		+	*HDAC15
		+
		+	**[[6j6t]] – HDAC15 HD domain – ''Arabidopsis thaliana''<br />

	*'''HDAC class III'''		*'''HDAC class III'''

Michal Harel: New page: == 3D Structures of histone deacetylase == Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| '''HDAC class I''' HD...

Michal Harel — Wed, 31 Jul 2019 09:10:20 GMT

New page: == 3D Structures of histone deacetylase == Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *'''HDAC class I''' *HD...

New page

== 3D Structures of histone deacetylase ==

Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|

*'''HDAC class I'''

*HDAC1

**[[4bkx]] – hHDAC1 + MTA1 – human 
**[[3hgq]], [[3hgt]] – hHDAC1 subunit 3 
**[[5icn]] – hHDAC1 + MTA1 + peptide 
**[[5j8j]] – yHDAC1 residues 457-698 – yeast 

*HDAC2

**[[3max]] – hHDAC2 + amide derivative 
**[[4lxz]] – hHDAC2 core domain + SAHA 
**[[4ly1]], [[5iwg]], [[5ix0]] – hHDAC2 core domain + inhibitor 

*HDAC3

**[[4a69]] – hHDAC3 + nuclear receptor corepressor 2 + inositol tetraphosphate

*HDAC8

**[[3ew8]], [[3ezp]], [[3ezt]], [[3f06]] – hHDAC8 (mutant) 
**[[3sff]], [[3sfh]] – hHDAC8 + inhibitor 
**[[1t64]], [[3f0r]], [[5ths]] – hHDAC8 + trichostatin A 
**[[5tht]], [[5thu]], [[5thv]], [[5dc5]], [[5d1b]] - hHDAC8 (mutant) + amide derivative 
**[[1t67]], [[1w22]], [[1vkg]], [[3f07]] - hHDAC8 + amide derivative 
**[[1t69]] - hHDAC8 + SAHA 
**[[4qa0]] - hHDAC8 (mutant) + SAHA 
**[[5fcw]], [[5fue]] - hHDAC8 + hydroxamate 
**[[5vi6]] - hHDAC8 + trapoxin A 
**[[4qa1]], [[4qa2]], [[4qa3]], [[4qa4]] - hHDAC8 (mutant) + inhibitor 
**[[2v5w]] – hHDAC8 + tripeptide substrate 
**[[4qa5]], [[4qa6]], [[4qa7]], [[3ewf]], [[5dc8]], [[5dc7]], [[5dc6]], [[5d1d]], [[5d1c]] - hHDAC8 (mutant) + tetrapeptide substrate 
**[[3rqd]] - hHDAC8 + largazole 
**[[4rn0]], [[4rn1]], [[4rn2]] - hHDAC8 (mutant) + largazole analog 
**[[5bwz]] - hHDAC8 (mutant) + droxinostat 
**[[3mz3]] - hHDAC8 (Co) + amide derivative 
**[[3mz7]] - hHDAC8 (Co) (mutant) + amide derivative 
**[[3mz4]] - hHDAC8 (Mn) (mutant) + amide derivative 
**[[3mz6]] - hHDAC8 (Fe) (mutant) + amide derivative 
**[[2v5x]] - hHDAC8 (mutant) + octanediamide derivative 
**[[4bz5]] – SmHDAC8 – ''Schistosoma mansoni'' 
**[[4bz7]], [[4bz8]], [[4bz9]], [[4cqf]], [[6hsz]], [[6ht8]], [[6htg]], [[6hth]], [[6hti]], [[6htt]], [[6htz]], [[6hu0]], [[6hu1]], [[6hu2]], [[6hu3]], [[6hsh]], [[6hrq]], [[6hqy]] – SmHDAC8 + inhibitor 
**[[6hsk]], [[6hsf]], [[6hsg]] – SmHDAC8 (mutant) + inhibitor 
**[[4bz6]], [[6gxw]], [[6gxu]], [[6gxa]], [[6gx3]], [[6fu1]] – SmHDAC8 + SAHA derivative 

*'''HDAC class IIA'''

*HDAC4

**[[2h8n]] – hHDAC4 N terminal 
**[[2o94]] - hHDAC4 N terminal (mutant) 
**[[2vqw]] - hHDAC4 catalytic domain (mutant) 
**[[2vqj]], [[2vqm]], [[4cbt]], [[5a2s]] – hHDAC4 catalytic domain + inhibitor 
**[[6fyz]] - hHDAC4 catalytic domain + SAHA derivative 
**[[2vqo]], [[2vqq]], [[2vqv]], [[4cby]] – hHDAC4 catalytic domain (mutant) + inhibitor 
**[[5zop]], [[5zoo]] - hHDAC4 catalytic domain (mutant) + SMRT corepressor 

*HDAC5

**[[5uwi]] – hHDAC5 + RAN + RANBP1 + exportin 

*HDAC7

**[[3c0y]] – hHDAC7 catalytic domain 
**[[3c0z]] - hHDAC7 catalytic domain + octanedioic acid hydroxyamide phenylamide 
**[[3c10]] - hHDAC7 catalytic domain + trichostatin A 
**[[3znr]], [[3zns]] - hHDAC7 catalytic domain + inhibitor 

*HDAC9

**[[1tqe]] – mHDAC9 + myocyte-specific enhancer factor + DNA – mouse

*HDAC

**[[4a6q]], [[4a90]] - hHDAC subunit SAP18 
**[[2hde]] – hHDAC subunit SAP18 (mutant) – NMR 
**[[4a8x]] - hHDAC subunit SAP18 + RNA-binding protein + hook-like 
**[[2kdp]] – hHDAC subunit SAP30 – NMR 
**[[2ld7]] – hHDAC subunit SAP30 +SIN3A PAH 3 domain – NMR 
**[[5ikk]] – HDAC CLR3 – fission yeast 

*'''HDAC class IIB'''

*HDAC6

**[[3c5k]] – hHDAC6 zinc finger domain 
**[[3gv4]] - hHDAC6 zinc finger domain + ubiquitin peptide 
**[[3phd]] - hHDAC6 + polyubiquitin 
**[[5kh3]], [[5kh7]], [[5kh9]], [[5b8d]], [[6ce6]], [[6ce8]], [[6cea]], [[6cec]], [[6ced]], [[6cee]], [[6cef]], [[5wpb]], [[5wbn]] – hHDAC6 zinc finger + inhibitor 
**[[5eem]] – zHDAC6 catalytic domain - zebrafish 
**[[6cgp]], [[5wgm]], [[5wgl]], [[5wgi]], [[5wgk]], [[5g0j]], [[5g0i]], [[5g0h]], [[5g0g]], [[5g0f]], [[5efh]], [[5efg]], [[5efb]], [[5ef7]], [[5ef8]], [[5een]], [[5eek]], [[5eef]], [[6mr5]], [[6dvo]], [[6dvn]], [[6dvm]], [[6dvl]], [[6cw8]] – zHDAC6 catalytic domain + inhibitor 
**[[5eei]], [[6css]], [[6csr]], [[6csq]], [[6csp]], [[5w5k]] – zHDAC6 catalytic domain + SAHA derivative 
**[[5efn]], [[5efk]], [[53fj]] – zHDAC6 catalytic domain (mutant) + peptide 

*'''HDAC class III'''
*SIRT1

**[[4ig9]] – hSIRT1 + Zn 
**[[4i5i]] – hSIRT1 + NAD + indole + Zn 
**[[4if6]], [[4kxq]] – hSIRT1 + ADP-ribose + Zn 
**[[5btr]] – hSIRT1 + acetyl lysine peptide + resveratol + Zn 
**[[4zzh]] – hSIRT1 + activator + Zn 
**[[4zzi]] – hSIRT1 + activator + inhibitor + Zn 
**[[4zzj]] – hSIRT1 + acetyl lysine peptide + activator + Zn 

*SIRT2

**[[2hjh]] – ySIRT2 + pseudosubstrate + nicotinamide + Zn 
**[[4iao]] – ySIRT2 + SIRT4 + ADP-ribose + Zn 
**[[1j8f]], [[3zgo]] – hSIRT2 + Zn 
**[[5yqo]], [[5yqn]], [[5yqm]], [[5yql]] – hSIRT2 + inhibitor + Zn 
**[[5y0z]] – hSIRT2 (mutant) + inhibitor + Zn 
**[[3zgv]], [[5d7o]] – hSIRT2+ ADP ribose + Zn 
**[[4y6q]] – hSIRT2+ ADP ribose derivative + Zn 
**[[4l3o]], [[4y6l]], [[4y6o]] – hSIRT2 + acetyl lysine peptide + Zn 
**[[4x3o]], [[4x3p]] – hSIRT2 + myristoyl peptide + Zn 
**[[4rmg]], [[5dy4]], [[5dy5]], [[5y5n]], [[5mat]] – hSIRT2 + inhibitor + Zn 
**[[5d7p]], [[5d7q]], [[5mar]] – hSIRT2 + inhibitor + ADP-ribose + Zn 
**[[4rmh]], [[4rmi]] – hSIRT2 + acetyl lysine peptide + inhibitor + Zn 
**[[4r8m]] – hSIRT2 + peptide + tridecanethial + Zn 
**[[4rmj]] – hSIRT2 + ADP-ribose + nicotinamide + Zn 
**[[5g4c]] – hSIRT2 + carba-NAD + Zn 
**[[5fyq]] – hSIRT2 + RAN AA peptide + Zn 
**[[5dy5]] – hSIRT2 + thiazole derivative + piperazine derivative + Zn 
**[[5dy4]] – hSIRT2 + thiazole derivative + NAD + Zn 
**[[5d7q]], [[5d7p]], [[5d7o]] – hSIRT2 + oxolan derivative + Zn 

*SIRT3

**[[5d7n]] – hSIRT3 + Zn 
**[[3gls]] – hSIRT3 (mutant) + Zn 
**[[3glu]], [[5ytk]], [[5y4h]] – hSIRT3 + peptide + Zn 
**[[5bwo]], [[5bwn]] – hSIRT3 + palmitoyl H3K9 peptide + Zn 
**[[5bwl]] – hSIRT3 + succinyl peptide + Zn 
**[[3glr]], [[3glt]], [[4fvt]], [[4bve]], [[6iso]] – hSIRT3 + acetyl lysine peptide + Zn 
**[[4hd8]] – hSIRT3 + acetyl lysine peptide + piceatannol + Zn 
**[[4fz3]] – hSIRT3 + acetyl lysine peptide + coumarine derivative + Zn 
**[[4c78]], [[4c7b]] – hSIRT3 + acetyl lysine peptide + resveratol derivative + Zn 
**[[5zgc]], [[5z94]], [[5z93]] – hSIRT3 + histone peptide + Zn 
**[[4jsr]], [[4jt8]], [[4jt9]], [[4o8z]] – hSIRT3 + inhibitor + Zn 
**[[4gbn5]] – hSIRT3 + inhibitor + carba-NAD + Zn 
**[[4bv3]] – hSIRT3 + inhibitor + NAD + ADP-ribose + Zn 
**[[4bvb]], [[4bvh]] – hSIRT3 + inhibitor + ADP-ribose + Zn 
**[[4bvf]], [[4bvg]] – hSIRT3 + acetyl lysine peptide + inhibitor + Zn 
**[[5h4d]] – hSIRT3 + agonist + NAD + Zn 

*SIRT4

**[[5ojn]] – hSIRT4 + ADP-ribose + Zn – ''Xenopus tropicalis'' 

*SIRT5

**[[2b4y]], [[4bn4]] – hSIRT5 + ADP-ribose + Zn 
**[[2nyr]], [[5xhs]] – hSIRT5 + inhibitor + Zn 
**[[3rig]], [[3riy]], [[4f4u]] – hSIRT5 + acetyl lysine peptide + Zn 
**[[4gic]] – hSIRT5 + acetyl lysine peptide + carba-NAD + Zn 
**[[4f56]] – hSIRT5 + peptide + intermediate + Zn 
**[[4hda]] – hSIRT5 + acetyl lysine peptide + resveratrol + Zn 
**[[6acp]], [[6aco]], [[6acl]], [[6ace]] – hSIRT5 + succinyl peptide + Zn 
**[[4utn]], [[4utr]], [[4utv]], [[4utx]], [[4utz]], [[4uu7]], [[4uu8]], [[4uua]], [[4uub]], [[6flg]], [[6fkz]], [[6fky]] – zSIRT5 + acetyl lysine peptide + inhibitor + Zn 
**[[6enx]], [[6eo0]], [[6eqs]] – zSIRT5 + inhibitor + Zn 
**[[5ojo]] – zSIRT5 + CPS1 peptide + Zn 

*SIRT6

**[[3k35]] – hSIRT6 + ADP-ribose + Zn 
**[[5x16]] – hSIRT6 + oxolan derivative + Zn 
**[[6hoy]] – hSIRT6 + ADP-ribose + trichostatin + Zn 
**[[3pki]], [[3pkj]] – hSIRT6 (mutant) + ADP-ribose derivative + Zn 
**[[3zg6]] – hSIRT6 + acetyl lysine peptide + ADP-ribose + Zn 
**[[5mgn]], [[5mfz]], [[5mfp]], [[5mf6]] – hSIRT6 + activator + Zn 
**[[5y2f]] – hSIRT6 + peptide activator + Zn 

*SIRT7

**[[5iqz]] – hSIRT7 N-terminal 

}}

[[Category:Topic Page]]

←Older revision		Revision as of 09:11, 23 September 2021
Line 11:		Line 11:
	**[[3hgq]], [[3hgt]] – hHDAC1 subunit 3<br />		**[[3hgq]], [[3hgt]] – hHDAC1 subunit 3<br />
	**[[5icn]] – hHDAC1 + MTA1 + peptide<br />		**[[5icn]] – hHDAC1 + MTA1 + peptide<br />
		+	**[[7ao8]], [[7ao9]] – hHDAC1 + MTA1 + MBD2 – Cryo EM<br />
		+	**[[7aoa]] – hHDAC1 + MTA1 + MBD2 + RBBP4 – Cryo EM<br />
	**[[6z2j]], [[6z2k]] – hHDAC1 + DNTTIP1 + Midac deacetylase – Cryo EM<br />		**[[6z2j]], [[6z2k]] – hHDAC1 + DNTTIP1 + Midac deacetylase – Cryo EM<br />
	**[[5j8j]] – yHDAC1 residues 457-698 – yeast<br />		**[[5j8j]] – yHDAC1 residues 457-698 – yeast<br />
		+	**[[6z6f]], [[6z6h]], [[6z6o]], [[6z6p]] – yHDAC1 – Cryo EM<br />

	*HDAC2		*HDAC2
Line 18:		Line 21:
	**[[3max]] – hHDAC2 + amide derivative <br />		**[[3max]] – hHDAC2 + amide derivative <br />
	**[[4lxz]], [[6g3o]] – hHDAC2 core domain + SAHA<br />		**[[4lxz]], [[6g3o]] – hHDAC2 core domain + SAHA<br />
-	**[[4ly1]], [[5iwg]], [[5ix0]], [[6wbz]], [[6wbw]], [[6xdm]], [[6xeb]], [[6xec]] – hHDAC2 core domain + inhibitor<br />	+	**[[4ly1]], [[5iwg]], [[5ix0]], [[6wbz]], [[6wbw]], [[6xdm]], [[6xeb]], [[6xec]], [[7js8]], [[7kbh]], [[7kbg]], [[7ltg]], [[7ltk]], [[7ltl]], [[7mot]], [[7mox]], [[7moy]] – hHDAC2 core domain + inhibitor<br />
		+	**[[6whn]], [[6who]], [[6whq]], [[6whz]], [[6wi3]], [[7mos]], [[7moz]] – hHDAC2 core domain + peptide macrocycle<br />

	*HDAC3		*HDAC3
Line 30:		Line 34:
	**[[4qa1]], [[4qa2]], [[4qa3]], [[4qa4]] - hHDAC8 (mutant) + inhibitor<br />		**[[4qa1]], [[4qa2]], [[4qa3]], [[4qa4]] - hHDAC8 (mutant) + inhibitor<br />
	**[[1t64]], [[3f0r]], [[5ths]] – hHDAC8 + trichostatin A <br />		**[[1t64]], [[3f0r]], [[5ths]] – hHDAC8 + trichostatin A <br />
-	**[[5tht]], [[5thu]], [[5thv]], [[5dc5]], [[5d1b]] - hHDAC8 (mutant) + amide derivative<br />	+	**[[5tht]], [[5thu]], [[5thv]], [[5dc5]], [[5d1b]], [[7jvw]] - hHDAC8 (mutant) + amide derivative<br />
	**[[1t67]], [[1w22]], [[1vkg]], [[3f07]], [[6oda]], [[6odb]], [[6odc]] - hHDAC8 + amide derivative<br />		**[[1t67]], [[1w22]], [[1vkg]], [[3f07]], [[6oda]], [[6odb]], [[6odc]] - hHDAC8 + amide derivative<br />
	**[[1t69]] - hHDAC8 + SAHA<br />		**[[1t69]] - hHDAC8 + SAHA<br />
-	**[[4qa0]] - hHDAC8 (mutant) + SAHA<br />	+	**[[4qa0]], [[7jvu]] - hHDAC8 (mutant) + SAHA<br />
	**[[5fcw]], [[5fue]] - hHDAC8 + hydroxamate<br />		**[[5fcw]], [[5fue]] - hHDAC8 + hydroxamate<br />
	**[[5vi6]] - hHDAC8 + trapoxin A<br />		**[[5vi6]] - hHDAC8 + trapoxin A<br />
	**[[2v5w]] – hHDAC8 + tripeptide substrate<br />		**[[2v5w]] – hHDAC8 + tripeptide substrate<br />
-	**[[4qa5]], [[4qa6]], [[4qa7]], [[3ewf]], [[5dc8]], [[5dc7]], [[5dc6]], [[5d1d]], [[5d1c]] - hHDAC8 (mutant) + tetrapeptide substrate<br />	+	**[[4qa5]], [[4qa6]], [[4qa7]], [[3ewf]], [[5dc8]], [[5dc7]], [[5dc6]], [[5d1d]], [[5d1c]], [[7jvv]], [[7p3s]] - hHDAC8 (mutant) + tetrapeptide substrate<br />
	**[[3rqd]] - hHDAC8 + largazole<br />		**[[3rqd]] - hHDAC8 + largazole<br />
	**[[4rn0]], [[4rn1]], [[4rn2]] - hHDAC8 (mutant) + largazole analog<br />		**[[4rn0]], [[4rn1]], [[4rn2]] - hHDAC8 (mutant) + largazole analog<br />
Line 47:		Line 51:
	**[[2v5x]] - hHDAC8 (mutant) + octanediamide derivative<br />		**[[2v5x]] - hHDAC8 (mutant) + octanediamide derivative<br />
	**[[4bz5]] – SmHDAC8 – ''Schistosoma mansoni''<br />		**[[4bz5]] – SmHDAC8 – ''Schistosoma mansoni''<br />
-	**[[4bz7]], [[4bz8]], [[4bz9]], [[4cqf]], [[6hsz]], [[6ht8]], [[6htg]], [[6hth]], [[6hti]], [[6htt]], [[6htz]], [[6hu0]], [[6hu1]], [[6hu2]], [[6hu3]], [[6hsh]], [[6hrq]], [[6hqy]], [[6tld]] – SmHDAC8 + inhibitor<br />	+	**[[4bz7]], [[4bz8]], [[4bz9]], [[4cqf]], [[6hsz]], [[6ht8]], [[6htg]], [[6hth]], [[6hti]], [[6htt]], [[6htz]], [[6hu0]], [[6hu1]], [[6hu2]], [[6hu3]], [[6hsh]], [[6hrq]], [[6hqy]], [[6tld]], [[7p3s]] – SmHDAC8 + inhibitor<br />
	**[[6hsk]], [[6hsf]], [[6hsg]] – SmHDAC8 (mutant) + inhibitor<br />		**[[6hsk]], [[6hsf]], [[6hsg]] – SmHDAC8 (mutant) + inhibitor<br />
	**[[4bz6]], [[6gxw]], [[6gxu]], [[6gxa]], [[6gx3]], [[6fu1]] – SmHDAC8 + SAHA derivative<br />		**[[4bz6]], [[6gxw]], [[6gxu]], [[6gxa]], [[6gx3]], [[6fu1]] – SmHDAC8 + SAHA derivative<br />
Line 80:		Line 84:
	*HDAC10 or polyamine deacetylase 10		*HDAC10 or polyamine deacetylase 10

-	**[[6ufn]], [[6ufo]], [[6uhu]], [[6uhv]], [[6uii]], [[6uij]], [[6uil]], [[6uim]], [[6wbq]], [[6wdv]], [[6wdw]], [[6wdx]], [[6wdy]] – zHDAC10 + inhibitor ~~- zebrafish~~<br />	+	**[[7kuv]] – zHDAC10 - zebrafish<br />
-	**[[6vnq]] – zHDAC10 (mutant) + inhibitor <br />	+	**[[6ufn]], [[6ufo]], [[6uhu]], [[6uhv]], [[6uii]], [[6uij]], [[6uil]], [[6uim]], [[6wbq]], [[6wdv]], [[6wdw]], [[6wdx]], [[6wdy]] – zHDAC10 + inhibitor<br />
		+	**[[6vnq]], [[7kuq]], [[7kur]], [[7kus]], [[7kut]] – zHDAC10 (mutant) + inhibitor <br />

	*HDAC		*HDAC
Line 101:		Line 106:
	**[[5kh3]], [[5kh7]], [[5kh9]], [[5b8d]], [[6ce6]], [[6ce8]], [[6cea]], [[6cec]], [[6ced]], [[6cee]], [[6cef]], [[5wpb]], [[5wbn]] – hHDAC6 zinc finger + inhibitor<br />		**[[5kh3]], [[5kh7]], [[5kh9]], [[5b8d]], [[6ce6]], [[6ce8]], [[6cea]], [[6cec]], [[6ced]], [[6cee]], [[6cef]], [[5wpb]], [[5wbn]] – hHDAC6 zinc finger + inhibitor<br />
	**[[5eem]] – zHDAC6 catalytic domain<br />		**[[5eem]] – zHDAC6 catalytic domain<br />
-	**[[6cgp]], [[5wgm]], [[5wgl]], [[5wgi]], [[5wgk]], [[5g0j]], [[5g0i]], [[5g0h]], [[5g0g]], [[5g0f]], [[5efh]], [[5efg]], [[5efb]], [[5ef7]], [[5ef8]], [[5een]], [[5eek]], [[5eef]], [[6mr5]], [[6dvo]], [[6dvn]], [[6dvm]], [[6dvl]], [[6cw8]], [[6pye]], [[6pzo]], [[6pzr]], [[6pzs]], [[6pzu]], [[6q0z]], [[6r0k]], [[6thv]], [[6uo2]], [[6uo3]], [[6uo5]], [[6vnr]] – zHDAC6 catalytic domain + inhibitor <br />	+	**[[6cgp]], [[5wgm]], [[5wgl]], [[5wgi]], [[5wgk]], [[5g0j]], [[5g0i]], [[5g0h]], [[5g0g]], [[5g0f]], [[5efh]], [[5efg]], [[5efb]], [[5ef7]], [[5ef8]], [[5een]], [[5eek]], [[5eef]], [[6mr5]], [[6dvo]], [[6dvn]], [[6dvm]], [[6dvl]], [[6cw8]], [[6pye]], [[6pzo]], [[6pzr]], [[6pzs]], [[6pzu]], [[6q0z]], [[6r0k]], [[6tcy]], [[6thv]], [[6uo2]], [[6uo3]], [[6uo5]], [[6uo7]], [[6v79]], [[6v7a]], [[6vnr]], [[6zw1]], [[7jom]] – zHDAC6 catalytic domain + inhibitor <br />
-	**[[6uo4]], [[6uo7]], [[6uob]], [[6uoc]] – zHDAC6 catalytic domain (mutant) + inhibitor <br />	+	**[[6uo4]], [[6uo7]], [[6uob]], [[6uoc]], [[6wyo]] – zHDAC6 catalytic domain (mutant) + inhibitor <br />
	**[[5eei]], [[6css]], [[6csr]], [[6csq]], [[6csp]], [[5w5k]] – zHDAC6 catalytic domain + SAHA derivative<br />		**[[5eei]], [[6css]], [[6csr]], [[6csq]], [[6csp]], [[5w5k]] – zHDAC6 catalytic domain + SAHA derivative<br />
		+	**[[6wyp]], [[6wyq]] – zHDAC6 catalytic domain (mutant) + SAHA derivative<br />
		+	**[[6wsj]] – zHDAC6 catalytic domain + peptide <br />
	**[[5efn]], [[5efk]], [[53fj]] – zHDAC6 catalytic domain (mutant) + peptide <br />		**[[5efn]], [[5efk]], [[53fj]] – zHDAC6 catalytic domain (mutant) + peptide <br />

←Older revision		Revision as of 08:33, 19 August 2020
Line 132:		Line 132:
	**[[4l3o]], [[4y6l]], [[4y6o]] – hSIRT2 + acetyl lysine peptide + Zn<br />		**[[4l3o]], [[4y6l]], [[4y6o]] – hSIRT2 + acetyl lysine peptide + Zn<br />
	**[[4x3o]], [[4x3p]] – hSIRT2 + myristoyl peptide + Zn<br />		**[[4x3o]], [[4x3p]] – hSIRT2 + myristoyl peptide + Zn<br />
-	**[[4rmg]], [[5dy4]], [[5dy5]], [[5y5n]], [[5mat]] – hSIRT2 + inhibitor + Zn<br />	+	**[[4rmg]], [[5dy4]], [[5dy5]], [[5y5n]], [[5mat]], [[6nr0]] – hSIRT2 + inhibitor + Zn<br />
		+	**[[6qcn]] – hSIRT2 + ADP-ribose + quercetin derivative + Zn<br />
	**[[5d7p]], [[5d7q]], [[5mar]] – hSIRT2 + inhibitor + ADP-ribose + Zn<br />		**[[5d7p]], [[5d7q]], [[5mar]] – hSIRT2 + inhibitor + ADP-ribose + Zn<br />
	**[[4rmh]], [[4rmi]] – hSIRT2 + acetyl lysine peptide + inhibitor + Zn<br />		**[[4rmh]], [[4rmi]] – hSIRT2 + acetyl lysine peptide + inhibitor + Zn<br />
Line 148:		Line 149:
	**[[3gls]] – hSIRT3 (mutant) + Zn<br />		**[[3gls]] – hSIRT3 (mutant) + Zn<br />
	**[[3glu]], [[5ytk]], [[5y4h]] – hSIRT3 + peptide + Zn<br />		**[[3glu]], [[5ytk]], [[5y4h]] – hSIRT3 + peptide + Zn<br />
		+	**[[6iso]] – hSIRT3 + histone peptide + Zn<br />
	**[[5bwo]], [[5bwn]] – hSIRT3 + palmitoyl H3K9 peptide + Zn<br />		**[[5bwo]], [[5bwn]] – hSIRT3 + palmitoyl H3K9 peptide + Zn<br />
	**[[5bwl]] – hSIRT3 + succinyl peptide + Zn<br />		**[[5bwl]] – hSIRT3 + succinyl peptide + Zn<br />
Line 184:		Line 186:
	**[[5x16]] – hSIRT6 + oxolan derivative + Zn<br />		**[[5x16]] – hSIRT6 + oxolan derivative + Zn<br />
	**[[6hoy]] – hSIRT6 + ADP-ribose + trichostatin + Zn<br />		**[[6hoy]] – hSIRT6 + ADP-ribose + trichostatin + Zn<br />
		+	**[[6qcd]], [[6qce]], [[6qch]], [[6qcj]] – hSIRT6 + ADP-ribose + quercetin derivative + Zn<br />
	**[[3pki]], [[3pkj]] – hSIRT6 (mutant) + ADP-ribose derivative + Zn<br />		**[[3pki]], [[3pkj]] – hSIRT6 (mutant) + ADP-ribose derivative + Zn<br />
	**[[3zg6]] – hSIRT6 + acetyl lysine peptide + ADP-ribose + Zn<br />		**[[3zg6]] – hSIRT6 + acetyl lysine peptide + ADP-ribose + Zn<br />