Hydroxysteroid dehydrogenase - Revision history

Michal Harel at 10:17, 12 January 2020

Michal Harel — Sun, 12 Jan 2020 10:17:46 GMT

←Older revision		Revision as of 10:17, 12 January 2020
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	* '''20-α HSD''' is involved in the control of progesterone level in pregnancy of mice<ref>PMID:17122075</ref>.<br />		* '''20-α HSD''' is involved in the control of progesterone level in pregnancy of mice<ref>PMID:17122075</ref>.<br />
	* '''11-β HSD''' converts 11-keto products like cortisone to cortisol<ref>PMID:15466942</ref>.<br />		* '''11-β HSD''' converts 11-keto products like cortisone to cortisol<ref>PMID:15466942</ref>.<br />
-	* '''17-β HSD''' is involved in the conversion of androstenedione to testosterone<ref>PMID:9029730</ref>.<br />	+	* '''17-β HSD''' is involved in the conversion of androstenedione to testosterone<ref>PMID:9029730</ref>. See [[Human Keto Acyl Reductase]].<br />
	* '''3-β/17-β HSD''' catalyzes the reversible dehydrogenation of steroid compounds at position 3 and 17<ref>PMID:1309351</ref>.<br />		* '''3-β/17-β HSD''' catalyzes the reversible dehydrogenation of steroid compounds at position 3 and 17<ref>PMID:1309351</ref>.<br />
	[[NAD]] and NADP are cofactors of HSD.		[[NAD]] and NADP are cofactors of HSD.

Michal Harel at 09:57, 27 August 2019

Michal Harel — Tue, 27 Aug 2019 09:57:26 GMT

←Older revision		Revision as of 09:57, 27 August 2019
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	</StructureSection>		</StructureSection>
-	==3D structures of hydroxysteroid dehydrogenase==

-	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-	{{#tree:id=OrganizedByTopic\|openlevels=0\|
-
-	*3-α HSD or AKR1C2
-
-	'''For 3-α HSD type 2 see''' [[Prostaglandin F synthase]]
-
-	**[[1ral]] – rHSD – rat<BR />
-	**[[1fjh]] - CtHSD – ''Comamonas testosterone''<BR />
-	**[[4is2]] – CsHSD – ''Clostridium scindens''<br />
-
-	*''3-α HSD binary complex''
-
-	**[[2fvl]], [[2hdj]] - hHSD + NADP - human<BR />
-	**[[1lwi]] – rHSD + NADP<BR />
-	**[[1fk8]] – CtHSD + NAD<BR />
-	**[[2dkn]] - HSD + NAD – ''Pseudomonas''<BR />
-	**[[4is3]] - CsHSD + NAD<br />
-
-	*''3-α HSD ternary complex''
-
-	**[[4jq1]], [[4jq2]], [[4jq3]], [[4jq4]], [[4jqa]], [[4jtq]], [[4jtr]] - hHSD + NSAID drug + NADP <br />
-	**[[1afs]] - rHSD + hydroxysteroid + NADP<BR />
-
-	*3-α HSD type 3
-
-	**[[2hdj]] - hHSD + NADP<br />
-	**[[1ihi]], [[1j96]] - hHSD + hydroxysteroid + NADP <br />
-	**[[1xjb]] - hHSD + citrate+ acetate + NADP<br />
-	**[[4l1w]] - hHSD + progesterone + NADP<br />
-	**[[4l1x]] - hHSD (mutant) + progesterone + NADP<br />
-	**[[4xo6]], [[4xo7]] – hHSD + NADP + epiandrosterone derivative<br />
-
-	*7-α HSD
-
-	**[[3gaf]] - HSD – ''Brucella melitensis''<BR />
-	**[[1ahh]] – EcHSD + NAD – ''Escherichia coli''<BR />
-	**[[1ahi]], [[1fmc]] – EcHSD + hydroxysteroid + NAD
-
-	*20-α HSD or AKR1C1
-
-	**[[1q5m]] - raHSD + NADP – rabbit
-
-	*''20-α HSD ternary complex''
-
-	**[[1mrq]] – hHSD + hydroxysteroid + NADP<BR />
-	**[[4yvp]] – hHSD + NADP + sulfonylurea derivative<br />
-	**[[3c3u]], [[3nty]] - hHSD + inhibitor + NADP<BR />
-	**[[3gug]] - hHSD (mutant) + inhibitor + NADP<BR />
-	**[[1q13]] - raHSD + hydroxysteroid + NADP<BR />
-
-	*11-β HSD or corticosteroid 11-β-dehydrogenase 1
-
-	**[[1xu7]], [[1xu9]] - hHSD (mutant) + NADP<BR />
-	**[[2pd6]] - hHSD + NAD<BR />
-	**[[3hb4]] - hHSD + inhibitor<BR />
-	**[[3dey]] - hHSD + hydroxysteroid<BR />
-	**[[1y5m]] - mHSD + NADP - mouse<BR />
-	**[[1xse]] - gpHSD catalytic domain + NADP – guinea pig<BR />
-	**[[3dwf]], [[3lz6]] - gpHSD catalytic domain (mutant) + NADP<BR />
-
-	*''11-β HSD ternary complex''
-
-	**[[2bel]] - hHSD 1 + hydroxysteroid + NADP<BR />
-	**[[2irw]], [[2ilt]], [[4bb5]], [[4bb6]] - hHSD 1 + inhibitor + NADP<BR />
-	**[[2rbe]], [[3byz]], [[3bzu]], [[3ch6]], [[3czr]], [[3d3e]], [[3d4n]], [[3d5q]], [[3ey4]], [[3frj]], [[3hfg]], [[3fco]], [[3h6k]], [[3oq1]], [[3pdj]], [[3tfq]], [[3qqp]], [[4c7j]], [[4c7k]], [[4p38]], [[5pgu]], [[5pgv]], [[5pgw]], [[5pgx]], [[5pgy]], [[5pgz]], [[5pii]], [[5pij]] - hHSD 1 (mutant) + inhibitor + NADP<BR />
-	**[[6nj7]] - hHSD 1 + colleic acid + NAP<br />
-	**[[3g49]] - gpHSD catalytic domain + inhibitor + NADP<BR />
-	**[[1y5r]], [[3gmd]] - mHSD 1 + hydroxysteroid + NADP<BR />
-	**[[4k26]] - mHSD 1 + inhibitor + NADP<br />
-	**[[4nmh]] - mHSD 1 (mutant) + inhibitor + NADP<br />
-
-	*17-α HSD or AKR1C21
-
-	**[[2he8]] – mHSD - mouse <br />
-	**[[3fjn]] - mHSD (mutant) <br />
-	**[[2p5n]], [[2he5]], [[2hej]] - mHSD + NADP <br />
-	**[[2ipf]] - mHSD + hydroxysteroid + NADP <br />
-	**[[2ipg]], [[2ipj]] - mHSD (mutant) + hydroxysteroid + NADP<br />
-	**[[3cv6]] - mHSD (mutant) + inhibitor + NADP<br />
-
-	*17-β HSD or estradiol 11-β-dehydrogenase 1
-
-	'''For 17-β HSD type 5 or AKR1C3 see''' [[Prostaglandin F synthase]]
-
-	**[[1bhs]] – hHSD 1 <BR />
-	**[[1s9c]] - hHSD 4 (mutant) <BR />
-	**[[5ics]] – hHSD 14 <BR />
-	**[[3is3]] – ClHSD – ''Cochliobolus lunatus''<BR />
-	**[[3itd]] - ClHSD (mutant)
-
-	*''17-β HSD binary complex''
-
-	**[[1jtv]], [[1yb1]], [[3dhe]], [[1fds]], [[1iol]], [[3klm]], [[3klp]], [[3km0]] - hHSD + hydroxysteroid<br />
-	**[[1fdw]], [[1dht]] - hHSD (mutant) + hydroxysteroid<BR />
-	**[[6mnc]] – hHSD 1 + estrone<br />
-	**[[1fdv]] - hHSD 1 (mutant) + NAD<BR />
-	**[[1qyv]] - hHSD 1 + NADP<BR />
-	**[[1i5r]], [[6dtp]] - hHSD 1 + inhibitor<br />
-	**[[1zbq]] - hHSD 4 + NAD<BR />
-	**[[5l7t]], [[5l7w]], [[5l7y]], [[5icm]], [[5en4]] - hHSD 14 + inhibitor<br />
-	**[[6h0m]], [[6hno]], [[5js6]], [[5jsf]] - hHSD 14 (mutant) + NAD<br />
-	**[[3qwf]] - ClHSD + NADP<BR />
-	**[[4fj0]], [[4fj1]], [[4fj2]], [[4fiz]] – ClHSD + dehydroxy flavonoid inhibitor<br />
-
-	*''17-β HSD ternary complex''
-
-	**[[1qyw]], [[1qyx]], [[1fdt]] - hHSD 1 + hydroxysteroid + NADP<BR />
-	**[[1a27]], [[1fdu]] - hHSD 1 (mutant) + hydroxysteroid + NADP<BR />
-	**[[3hb5]], [[6cge]] - hHSD 1 + inhibitor + NADP<BR />
-	**[[4hfr]], [[4hx5]], [[4iju]], [[4ijv]], [[4ijw]], [[4k1l]], [[6cgc]] - hHSD 1 (mutant) + inhibitor + NADP<br />
-	**[[6mne]] – hHSD 1 + NADP + estrone<br />
-	**[[5o42]], [[5o43]], [[5o6o]], [[5o6x]], [[5o6z]], [[5o72]] - hHSD 14 + inhibitor + NAD<br />
-	**[[5hs6]] - hHSD + NAD + estrone<br />
-	**[[4cql]] - hHSD 8 + carbonyl reductase + NAD<br />
-	**[[4cqm]] - hHSD 8 + carbonyl reductase + NADP<br />
-	**[[5o42]], [[5o43]], [[5o6o]], [[5o6x]], [[5o6z]], [[5o72]] - hHSD 14 + inhibitor + NAD<br />
-	**[[6ffb]], [[6g4l]], [[6gtu]], [[5o7c]] - hHSD 14 (mutant) + inhibitor + NAD<br />
-	**[[6emm]] - hHSD 14 (mutant) + salicilate + NAD<br />
-	**[[5hs6]] - hHSD 14 + NAD + estrone<br />
-	**[[3qwi]], [[3qwh]] - ClHSD + hydroxysteroid + NADP<BR />
-
-	*3-α 20-β HSD
-
-	**[[2hsd]] – SeHSD – ''Streptomyces exfoliates''<BR />
-	**[[1hdc]] – SeHSD + inhibitor
-
-	*Carbonyl reductase/20-β HSD
-
-	**[[1n5d]] - HSD + NADP – pig<br />
-
-	*3-β/17-β HSD
-
-	**[[1hxh ]] - CtHSD
-	}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 09:56, 27 August 2019

Michal Harel — Tue, 27 Aug 2019 09:56:13 GMT

←Older revision		Revision as of 09:56, 27 August 2019
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	== Structural highlights ==		== Structural highlights ==
	The structure of 3-α HSD is that of an <scene name='49/491805/Cv/5'>α/β barrel</scene> with the <scene name='49/491805/Cv/6'>cofactor NADP binding site</scene> at the C-terminal of the barrel<ref>PMID:8718859</ref>. Water molecules shown as red spheres.		The structure of 3-α HSD is that of an <scene name='49/491805/Cv/5'>α/β barrel</scene> with the <scene name='49/491805/Cv/6'>cofactor NADP binding site</scene> at the C-terminal of the barrel<ref>PMID:8718859</ref>. Water molecules shown as red spheres.
		+
		+	==3D structures of hydroxysteroid dehydrogenase==
		+	[[Hydroxysteroid dehydrogenase 3D structures]]

	</StructureSection>		</StructureSection>
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	**[[1q13]] - raHSD + hydroxysteroid + NADP<BR />		**[[1q13]] - raHSD + hydroxysteroid + NADP<BR />

-	*11-β HSD	+	*11-β HSD or corticosteroid 11-β-dehydrogenase 1

	**[[1xu7]], [[1xu9]] - hHSD (mutant) + NADP<BR />		**[[1xu7]], [[1xu9]] - hHSD (mutant) + NADP<BR />
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	**[[2bel]] - hHSD 1 + hydroxysteroid + NADP<BR />		**[[2bel]] - hHSD 1 + hydroxysteroid + NADP<BR />
	**[[2irw]], [[2ilt]], [[4bb5]], [[4bb6]] - hHSD 1 + inhibitor + NADP<BR />		**[[2irw]], [[2ilt]], [[4bb5]], [[4bb6]] - hHSD 1 + inhibitor + NADP<BR />
-	**[[2rbe]], [[3byz]], [[3bzu]], [[3ch6]], [[3czr]], [[3d3e]], [[3d4n]], [[3d5q]], [[3ey4]], [[3frj]], [[3hfg]], [[3fco]], [[3h6k]], [[3oq1]], [[3pdj]], [[3tfq]], [[3qqp]], [[4c7j]], [[4c7k]], [[4p38]] - hHSD 1 (mutant) + inhibitor + NADP<BR />	+	**[[2rbe]], [[3byz]], [[3bzu]], [[3ch6]], [[3czr]], [[3d3e]], [[3d4n]], [[3d5q]], [[3ey4]], [[3frj]], [[3hfg]], [[3fco]], [[3h6k]], [[3oq1]], [[3pdj]], [[3tfq]], [[3qqp]], [[4c7j]], [[4c7k]], [[4p38]], [[5pgu]], [[5pgv]], [[5pgw]], [[5pgx]], [[5pgy]], [[5pgz]], [[5pii]], [[5pij]] - hHSD 1 (mutant) + inhibitor + NADP<BR />
		+	**[[6nj7]] - hHSD 1 + colleic acid + NAP<br />
	**[[3g49]] - gpHSD catalytic domain + inhibitor + NADP<BR />		**[[3g49]] - gpHSD catalytic domain + inhibitor + NADP<BR />
	**[[1y5r]], [[3gmd]] - mHSD 1 + hydroxysteroid + NADP<BR />		**[[1y5r]], [[3gmd]] - mHSD 1 + hydroxysteroid + NADP<BR />
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	**[[3cv6]] - mHSD (mutant) + inhibitor + NADP<br />		**[[3cv6]] - mHSD (mutant) + inhibitor + NADP<br />

-	*17-β HSD	+	*17-β HSD or estradiol 11-β-dehydrogenase 1

	'''For 17-β HSD type 5 or AKR1C3 see''' [[Prostaglandin F synthase]]		'''For 17-β HSD type 5 or AKR1C3 see''' [[Prostaglandin F synthase]]

-	**[[1bhs~~]], [[5ics~~]] – hHSD <BR />	+	**[[1bhs]] – hHSD 1 <BR />
-	**[[1s9c]] - hHSD (mutant) <BR />	+	**[[1s9c]] - hHSD 4 (mutant) <BR />
		+	**[[5ics]] – hHSD 14 <BR />
	**[[3is3]] – ClHSD – ''Cochliobolus lunatus''<BR />		**[[3is3]] – ClHSD – ''Cochliobolus lunatus''<BR />
	**[[3itd]] - ClHSD (mutant)		**[[3itd]] - ClHSD (mutant)
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	*''17-β HSD binary complex''		*''17-β HSD binary complex''

		+	**[[1jtv]], [[1yb1]], [[3dhe]], [[1fds]], [[1iol]], [[3klm]], [[3klp]], [[3km0]] - hHSD + hydroxysteroid<br />
	**[[1fdw]], [[1dht]] - hHSD (mutant) + hydroxysteroid<BR />		**[[1fdw]], [[1dht]] - hHSD (mutant) + hydroxysteroid<BR />
-	**[[~~1jtv~~]]~~, [[1yb1]], [[3dhe]], [[1fds]], [[1iol]], [[3klm]], [[3klp]], [[3km0]] -~~ hHSD + ~~hydroxysteroid~~	+	**[[6mnc]] – hHSD 1 + estrone<br />
-	**[[1fdv]] - hHSD (mutant) + NAD<BR />	+	**[[1fdv]] - hHSD 1 (mutant) + NAD<BR />
-	**[[~~1zbq~~]], [[~~5js6~~]], [[~~5jsf~~]] - hHSD + ~~NAD~~<BR />	+	**[[1qyv]] - hHSD 1 + NADP<BR />
-	**[[~~1qyv~~]] - hHSD + ~~NADP~~<BR />	+	**[[1i5r]], [[6dtp]] - hHSD 1 + inhibitor<br />
-	**~~[[1i5r]],~~ [[5l7t]], [[5l7w]], [[5l7y]], [[5icm]], [[5en4]] - hHSD + inhibitor<br />	+	**[[1zbq]] - hHSD 4 + NAD<BR />
		+	**[[5l7t]], [[5l7w]], [[5l7y]], [[5icm]], [[5en4]] - hHSD 14 + inhibitor<br />
		+	**[[6h0m]], [[6hno]], [[5js6]], [[5jsf]] - hHSD 14 (mutant) + NAD<br />
	**[[3qwf]] - ClHSD + NADP<BR />		**[[3qwf]] - ClHSD + NADP<BR />
	**[[4fj0]], [[4fj1]], [[4fj2]], [[4fiz]] – ClHSD + dehydroxy flavonoid inhibitor<br />		**[[4fj0]], [[4fj1]], [[4fj2]], [[4fiz]] – ClHSD + dehydroxy flavonoid inhibitor<br />
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	**[[1qyw]], [[1qyx]], [[1fdt]] - hHSD 1 + hydroxysteroid + NADP<BR />		**[[1qyw]], [[1qyx]], [[1fdt]] - hHSD 1 + hydroxysteroid + NADP<BR />
	**[[1a27]], [[1fdu]] - hHSD 1 (mutant) + hydroxysteroid + NADP<BR />		**[[1a27]], [[1fdu]] - hHSD 1 (mutant) + hydroxysteroid + NADP<BR />
-	**[[3hb5]] - hHSD 1 + inhibitor + NADP<BR />	+	**[[3hb5]], [[6cge]] - hHSD 1 + inhibitor + NADP<BR />
-	**[[4hfr]], [[4hx5]], [[4iju]], [[4ijv]], [[4ijw]], [[4k1l]] - hHSD 1 (mutant) + inhibitor + NADP<br />	+	**[[4hfr]], [[4hx5]], [[4iju]], [[4ijv]], [[4ijw]], [[4k1l]], [[6cgc]] - hHSD 1 (mutant) + inhibitor + NADP<br />
		+	**[[6mne]] – hHSD 1 + NADP + estrone<br />
	**[[5o42]], [[5o43]], [[5o6o]], [[5o6x]], [[5o6z]], [[5o72]] - hHSD 14 + inhibitor + NAD<br />		**[[5o42]], [[5o43]], [[5o6o]], [[5o6x]], [[5o6z]], [[5o72]] - hHSD 14 + inhibitor + NAD<br />
	**[[5hs6]] - hHSD + NAD + estrone<br />		**[[5hs6]] - hHSD + NAD + estrone<br />
	**[[4cql]] - hHSD 8 + carbonyl reductase + NAD<br />		**[[4cql]] - hHSD 8 + carbonyl reductase + NAD<br />
	**[[4cqm]] - hHSD 8 + carbonyl reductase + NADP<br />		**[[4cqm]] - hHSD 8 + carbonyl reductase + NADP<br />
		+	**[[5o42]], [[5o43]], [[5o6o]], [[5o6x]], [[5o6z]], [[5o72]] - hHSD 14 + inhibitor + NAD<br />
		+	**[[6ffb]], [[6g4l]], [[6gtu]], [[5o7c]] - hHSD 14 (mutant) + inhibitor + NAD<br />
		+	**[[6emm]] - hHSD 14 (mutant) + salicilate + NAD<br />
		+	**[[5hs6]] - hHSD 14 + NAD + estrone<br />
	**[[3qwi]], [[3qwh]] - ClHSD + hydroxysteroid + NADP<BR />		**[[3qwi]], [[3qwh]] - ClHSD + hydroxysteroid + NADP<BR />

Michal Harel at 08:33, 27 August 2019

Michal Harel — Tue, 27 Aug 2019 08:33:03 GMT

←Older revision		Revision as of 08:33, 27 August 2019
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	*''3-α HSD binary complex''		*''3-α HSD binary complex''

		+	**[[2fvl]], [[2hdj]] - hHSD + NADP - human<BR />
	**[[1lwi]] – rHSD + NADP<BR />		**[[1lwi]] – rHSD + NADP<BR />
	**[[1fk8]] – CtHSD + NAD<BR />		**[[1fk8]] – CtHSD + NAD<BR />
-	**[[2fvl]], [[2hdj]] - hHSD + NADP<BR />
	**[[2dkn]] - HSD + NAD – ''Pseudomonas''<BR />		**[[2dkn]] - HSD + NAD – ''Pseudomonas''<BR />
	**[[4is3]] - CsHSD + NAD<br />		**[[4is3]] - CsHSD + NAD<br />
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	*''3-α HSD ternary complex''		*''3-α HSD ternary complex''

		+	**[[4jq1]], [[4jq2]], [[4jq3]], [[4jq4]], [[4jqa]], [[4jtq]], [[4jtr]] - hHSD + NSAID drug + NADP <br />
	**[[1afs]] - rHSD + hydroxysteroid + NADP<BR />		**[[1afs]] - rHSD + hydroxysteroid + NADP<BR />
-	**[[4jq1]], [[4jq2]], [[4jq3]], [[4jq4]], [[4jqa]], [[4jtq]], [[4jtr]] - hHSD + NSAID drug + NADP - human<br />

	*3-α HSD type 3		*3-α HSD type 3
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	**[[1xu7]], [[1xu9]] - hHSD (mutant) + NADP<BR />		**[[1xu7]], [[1xu9]] - hHSD (mutant) + NADP<BR />
	**[[2pd6]] - hHSD + NAD<BR />		**[[2pd6]] - hHSD + NAD<BR />
-	**[[1y5m]] - mHSD + NADP<BR />
-	**[[1xse]] - gpHSD catalytic domain + NADP – guinea pig<BR />
	**[[3hb4]] - hHSD + inhibitor<BR />		**[[3hb4]] - hHSD + inhibitor<BR />
	**[[3dey]] - hHSD + hydroxysteroid<BR />		**[[3dey]] - hHSD + hydroxysteroid<BR />
		+	**[[1y5m]] - mHSD + NADP - mouse<BR />
		+	**[[1xse]] - gpHSD catalytic domain + NADP – guinea pig<BR />
	**[[3dwf]], [[3lz6]] - gpHSD catalytic domain (mutant) + NADP<BR />		**[[3dwf]], [[3lz6]] - gpHSD catalytic domain (mutant) + NADP<BR />

	*''11-β HSD ternary complex''		*''11-β HSD ternary complex''

		+	**[[2bel]] - hHSD 1 + hydroxysteroid + NADP<BR />
		+	**[[2irw]], [[2ilt]], [[4bb5]], [[4bb6]] - hHSD 1 + inhibitor + NADP<BR />
		+	**[[2rbe]], [[3byz]], [[3bzu]], [[3ch6]], [[3czr]], [[3d3e]], [[3d4n]], [[3d5q]], [[3ey4]], [[3frj]], [[3hfg]], [[3fco]], [[3h6k]], [[3oq1]], [[3pdj]], [[3tfq]], [[3qqp]], [[4c7j]], [[4c7k]], [[4p38]] - hHSD 1 (mutant) + inhibitor + NADP<BR />
	**[[3g49]] - gpHSD catalytic domain + inhibitor + NADP<BR />		**[[3g49]] - gpHSD catalytic domain + inhibitor + NADP<BR />
	**[[1y5r]], [[3gmd]] - mHSD 1 + hydroxysteroid + NADP<BR />		**[[1y5r]], [[3gmd]] - mHSD 1 + hydroxysteroid + NADP<BR />
	**[[4k26]] - mHSD 1 + inhibitor + NADP<br />		**[[4k26]] - mHSD 1 + inhibitor + NADP<br />
	**[[4nmh]] - mHSD 1 (mutant) + inhibitor + NADP<br />		**[[4nmh]] - mHSD 1 (mutant) + inhibitor + NADP<br />
-	**[[2bel]] - hHSD 1 + hydroxysteroid + NADP<BR />
-	**[[2irw]], [[2ilt]], [[4bb5]], [[4bb6]] - hHSD 1 + inhibitor + NADP<BR />
-	**[[2rbe]], [[3byz]], [[3bzu]], [[3ch6]], [[3czr]], [[3d3e]], [[3d4n]], [[3d5q]], [[3ey4]], [[3frj]], [[3hfg]], [[3fco]], [[3h6k]], [[3oq1]], [[3pdj]], [[3tfq]], [[3qqp]], [[4c7j]], [[4c7k]], [[4p38]] - hHSD 1 (mutant) + inhibitor + NADP<BR />

	*17-α HSD or AKR1C21		*17-α HSD or AKR1C21
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	*''17-β HSD binary complex''		*''17-β HSD binary complex''

-	**[[3qwf]] - ClHSD + NADP<BR />
-	**[[4fj0]], [[4fj1]], [[4fj2]], [[4fiz]] – ClHSD + dehydroxy flavonoid inhibitor<br />
	**[[1fdw]], [[1dht]] - hHSD (mutant) + hydroxysteroid<BR />		**[[1fdw]], [[1dht]] - hHSD (mutant) + hydroxysteroid<BR />
	**[[1jtv]], [[1yb1]], [[3dhe]], [[1fds]], [[1iol]], [[3klm]], [[3klp]], [[3km0]] - hHSD + hydroxysteroid		**[[1jtv]], [[1yb1]], [[3dhe]], [[1fds]], [[1iol]], [[3klm]], [[3klp]], [[3km0]] - hHSD + hydroxysteroid
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	**[[1qyv]] - hHSD + NADP<BR />		**[[1qyv]] - hHSD + NADP<BR />
	**[[1i5r]], [[5l7t]], [[5l7w]], [[5l7y]], [[5icm]], [[5en4]] - hHSD + inhibitor<br />		**[[1i5r]], [[5l7t]], [[5l7w]], [[5l7y]], [[5icm]], [[5en4]] - hHSD + inhibitor<br />
-		+	**[[3qwf]] - ClHSD + NADP<BR />
		+	**[[4fj0]], [[4fj1]], [[4fj2]], [[4fiz]] – ClHSD + dehydroxy flavonoid inhibitor<br />

	*''17-β HSD ternary complex''		*''17-β HSD ternary complex''

Alexander Berchansky at 13:03, 19 May 2019

Alexander Berchansky — Sun, 19 May 2019 13:03:15 GMT

←Older revision		Revision as of 13:03, 19 May 2019
Line 15:		Line 15:

	== Structural highlights ==		== Structural highlights ==
-	The structure of 3-α HSD is that of an <scene name='49/491805/Cv/4'>α/β barrel</scene> with the <scene name='49/491805/Cv/3'>cofactor NADP binding site</scene> at the C-terminal of the barrel<ref>PMID:8718859</ref>. Water molecules shown as red spheres.	+	The structure of 3-α HSD is that of an <scene name='49/491805/Cv/5'>α/β barrel</scene> with the <scene name='49/491805/Cv/6'>cofactor NADP binding site</scene> at the C-terminal of the barrel<ref>PMID:8718859</ref>. Water molecules shown as red spheres.

	</StructureSection>		</StructureSection>

Michal Harel at 09:49, 18 July 2018

Michal Harel — Wed, 18 Jul 2018 09:49:58 GMT

←Older revision		Revision as of 09:49, 18 July 2018
Line 127:		Line 127:
	**[[3hb5]] - hHSD 1 + inhibitor + NADP<BR />		**[[3hb5]] - hHSD 1 + inhibitor + NADP<BR />
	**[[4hfr]], [[4hx5]], [[4iju]], [[4ijv]], [[4ijw]], [[4k1l]] - hHSD 1 (mutant) + inhibitor + NADP<br />		**[[4hfr]], [[4hx5]], [[4iju]], [[4ijv]], [[4ijw]], [[4k1l]] - hHSD 1 (mutant) + inhibitor + NADP<br />
		+	**[[5o42]], [[5o43]], [[5o6o]], [[5o6x]], [[5o6z]], [[5o72]] - hHSD 14 + inhibitor + NAD<br />
	**[[5hs6]] - hHSD + NAD + estrone<br />		**[[5hs6]] - hHSD + NAD + estrone<br />
	**[[4cql]] - hHSD 8 + carbonyl reductase + NAD<br />		**[[4cql]] - hHSD 8 + carbonyl reductase + NAD<br />

Michal Harel at 08:32, 15 June 2017

Michal Harel — Thu, 15 Jun 2017 08:32:21 GMT

←Older revision		Revision as of 08:32, 15 June 2017
Line 102:		Line 102:
	*17-β HSD		*17-β HSD

-	'''For 17-β HSD type 5 see''' [[Prostaglandin F synthase]]	+	'''For 17-β HSD type 5 or AKR1C3 see''' [[Prostaglandin F synthase]]

-	**[[1bhs]] – hHSD <BR />	+	**[[1bhs]], [[5ics]] – hHSD <BR />
	**[[1s9c]] - hHSD (mutant) <BR />		**[[1s9c]] - hHSD (mutant) <BR />
	**[[3is3]] – ClHSD – ''Cochliobolus lunatus''<BR />		**[[3is3]] – ClHSD – ''Cochliobolus lunatus''<BR />
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	**[[1jtv]], [[1yb1]], [[3dhe]], [[1fds]], [[1iol]], [[3klm]], [[3klp]], [[3km0]] - hHSD + hydroxysteroid		**[[1jtv]], [[1yb1]], [[3dhe]], [[1fds]], [[1iol]], [[3klm]], [[3klp]], [[3km0]] - hHSD + hydroxysteroid
	**[[1fdv]] - hHSD (mutant) + NAD<BR />		**[[1fdv]] - hHSD (mutant) + NAD<BR />
-	**[[1zbq]] - hHSD + NAD<BR />	+	**[[1zbq]], [[5js6]], [[5jsf]] - hHSD + NAD<BR />
	**[[1qyv]] - hHSD + NADP<BR />		**[[1qyv]] - hHSD + NADP<BR />
-	**[[1i5r]] - hHSD + inhibitor	+	**[[1i5r]], [[5l7t]], [[5l7w]], [[5l7y]], [[5icm]], [[5en4]] - hHSD + inhibitor<br />
		+

	*''17-β HSD ternary complex''		*''17-β HSD ternary complex''
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	**[[3hb5]] - hHSD 1 + inhibitor + NADP<BR />		**[[3hb5]] - hHSD 1 + inhibitor + NADP<BR />
	**[[4hfr]], [[4hx5]], [[4iju]], [[4ijv]], [[4ijw]], [[4k1l]] - hHSD 1 (mutant) + inhibitor + NADP<br />		**[[4hfr]], [[4hx5]], [[4iju]], [[4ijv]], [[4ijw]], [[4k1l]] - hHSD 1 (mutant) + inhibitor + NADP<br />
		+	**[[5hs6]] - hHSD + NAD + estrone<br />
	**[[4cql]] - hHSD 8 + carbonyl reductase + NAD<br />		**[[4cql]] - hHSD 8 + carbonyl reductase + NAD<br />
	**[[4cqm]] - hHSD 8 + carbonyl reductase + NADP<br />		**[[4cqm]] - hHSD 8 + carbonyl reductase + NADP<br />

Michal Harel at 11:43, 27 December 2016

Michal Harel — Tue, 27 Dec 2016 11:43:49 GMT

←Older revision		Revision as of 11:43, 27 December 2016
Line 1:		Line 1:
-	<StructureSection load='1lwi' size='~~450~~' side='right' scene='49/491805/Cv/1' caption='Rat 3-α hydroxysteroid dehydrogenase dimer complex with cofactor NADP [[1lwi]]'>	+	<StructureSection load='1lwi' size='350' side='right' scene='49/491805/Cv/1' caption='Rat 3-α hydroxysteroid dehydrogenase dimer complex with cofactor NADP [[1lwi]]'>

	== Function ==		== Function ==
Line 23:		Line 23:
	{{#tree:id=OrganizedByTopic\|openlevels=0\|		{{#tree:id=OrganizedByTopic\|openlevels=0\|

-	*3-α HSD	+	*3-α HSD or AKR1C2

	'''For 3-α HSD type 2 see''' [[Prostaglandin F synthase]]		'''For 3-α HSD type 2 see''' [[Prostaglandin F synthase]]
Line 42:		Line 42:

	**[[1afs]] - rHSD + hydroxysteroid + NADP<BR />		**[[1afs]] - rHSD + hydroxysteroid + NADP<BR />
-	**[[4jq1]], [[4jq2]], [[4jq3]], [[4jq4~~]], [[4jqa~~]], [[4jqa]], [[4jtq]], [[4jtr]] - hHSD + NSAID drug + NADP - human<br />	+	**[[4jq1]], [[4jq2]], [[4jq3]], [[4jq4]], [[4jqa]], [[4jtq]], [[4jtr]] - hHSD + NSAID drug + NADP - human<br />

	*3-α HSD type 3		*3-α HSD type 3
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	**[[4l1w]] - hHSD + progesterone + NADP<br />		**[[4l1w]] - hHSD + progesterone + NADP<br />
	**[[4l1x]] - hHSD (mutant) + progesterone + NADP<br />		**[[4l1x]] - hHSD (mutant) + progesterone + NADP<br />
		+	**[[4xo6]], [[4xo7]] – hHSD + NADP + epiandrosterone derivative<br />

	*7-α HSD		*7-α HSD
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	**[[1ahi]], [[1fmc]] – EcHSD + hydroxysteroid + NAD		**[[1ahi]], [[1fmc]] – EcHSD + hydroxysteroid + NAD

-	*20-α HSD	+	*20-α HSD or AKR1C1

	**[[1q5m]] - raHSD + NADP – rabbit		**[[1q5m]] - raHSD + NADP – rabbit
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	**[[1mrq]] – hHSD + hydroxysteroid + NADP<BR />		**[[1mrq]] – hHSD + hydroxysteroid + NADP<BR />
		+	**[[4yvp]] – hHSD + NADP + sulfonylurea derivative<br />
	**[[3c3u]], [[3nty]] - hHSD + inhibitor + NADP<BR />		**[[3c3u]], [[3nty]] - hHSD + inhibitor + NADP<BR />
	**[[3gug]] - hHSD (mutant) + inhibitor + NADP<BR />		**[[3gug]] - hHSD (mutant) + inhibitor + NADP<BR />
Line 89:		Line 91:
	**[[2rbe]], [[3byz]], [[3bzu]], [[3ch6]], [[3czr]], [[3d3e]], [[3d4n]], [[3d5q]], [[3ey4]], [[3frj]], [[3hfg]], [[3fco]], [[3h6k]], [[3oq1]], [[3pdj]], [[3tfq]], [[3qqp]], [[4c7j]], [[4c7k]], [[4p38]] - hHSD 1 (mutant) + inhibitor + NADP<BR />		**[[2rbe]], [[3byz]], [[3bzu]], [[3ch6]], [[3czr]], [[3d3e]], [[3d4n]], [[3d5q]], [[3ey4]], [[3frj]], [[3hfg]], [[3fco]], [[3h6k]], [[3oq1]], [[3pdj]], [[3tfq]], [[3qqp]], [[4c7j]], [[4c7k]], [[4p38]] - hHSD 1 (mutant) + inhibitor + NADP<BR />

-	*17-α HSD	+	*17-α HSD or AKR1C21

-	**[[3fjn]] - mHSD (mutant) ~~- mouse~~<br />	+	**[[2he8]] – mHSD - mouse <br />
-	**[[2p5n]] - mHSD + NADP <br />	+	**[[3fjn]] - mHSD (mutant) <br />
		+	**[[2p5n]], [[2he5]], [[2hej]] - mHSD + NADP <br />
	**[[2ipf]] - mHSD + hydroxysteroid + NADP <br />		**[[2ipf]] - mHSD + hydroxysteroid + NADP <br />
	**[[2ipg]], [[2ipj]] - mHSD (mutant) + hydroxysteroid + NADP<br />		**[[2ipg]], [[2ipj]] - mHSD (mutant) + hydroxysteroid + NADP<br />

Alexander Berchansky at 09:00, 4 April 2016

Alexander Berchansky — Mon, 04 Apr 2016 09:00:07 GMT

←Older revision		Revision as of 09:00, 4 April 2016
Line 15:		Line 15:

	== Structural highlights ==		== Structural highlights ==
-	The structure of 3-α HSD is that of an α/β barrel with the <scene name='49/491805/Cv/3'>cofactor NADP binding site</scene> at the C-terminal of the barrel<ref>PMID:8718859</ref>.	+	The structure of 3-α HSD is that of an <scene name='49/491805/Cv/4'>α/β barrel</scene> with the <scene name='49/491805/Cv/3'>cofactor NADP binding site</scene> at the C-terminal of the barrel<ref>PMID:8718859</ref>. Water molecules shown as red spheres.

	</StructureSection>		</StructureSection>

Alexander Berchansky at 08:55, 4 April 2016

Alexander Berchansky — Mon, 04 Apr 2016 08:55:56 GMT

←Older revision		Revision as of 08:55, 4 April 2016
Line 1:		Line 1:
-	<StructureSection load='1lwi' size='~~350~~' side='right' scene='49/491805/Cv/1' caption='Rat 3-α hydroxysteroid dehydrogenase dimer complex with cofactor NADP [[1lwi]]'>	+	<StructureSection load='1lwi' size='450' side='right' scene='49/491805/Cv/1' caption='Rat 3-α hydroxysteroid dehydrogenase dimer complex with cofactor NADP [[1lwi]]'>

	== Function ==		== Function ==
Line 15:		Line 15:

	== Structural highlights ==		== Structural highlights ==
-	The structure of 3-α HSD is that of an α/β barrel with the cofactor NADP binding site at the C-terminal of the barrel<ref>PMID:8718859</ref>.	+	The structure of 3-α HSD is that of an α/β barrel with the <scene name='49/491805/Cv/3'>cofactor NADP binding site</scene> at the C-terminal of the barrel<ref>PMID:8718859</ref>.

	</StructureSection>		</StructureSection>