Inhibitory neurosteroids - Revision history

Michal Harel at 09:03, 12 January 2023

Michal Harel — Thu, 12 Jan 2023 09:03:00 GMT

←Older revision		Revision as of 09:03, 12 January 2023
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-	<StructureSection load='5osb' size='340' side='right' caption='Mouse GLIC-GABAA receptor complex with corticosterone derivative, acetate and Cl- ion (PDB code [[5osb]])''>	+	<StructureSection load='5osb' size='340' side='right' caption='Mouse GLIC-GABAA receptor complex with corticosterone derivative, acetate and Cl- ion (PDB code [[5osb]])'>
	These [[neurosteroids]] exert inhibitory actions on neurotransmission. They act as positive allosteric modulators of the [[GABAA receptor]] (especially δ subunit-containing isoforms), and possess, in no particular order, antidepressant, anxiolytic, stress-reducing, rewarding, prosocial, antiaggressive, prosexual, sedative, pro-sleep, cognitive and memory-impairing, analgesic, anesthetic, anticonvulsant, neuroprotective, and neurogenic effects.		These [[neurosteroids]] exert inhibitory actions on neurotransmission. They act as positive allosteric modulators of the [[GABAA receptor]] (especially δ subunit-containing isoforms), and possess, in no particular order, antidepressant, anxiolytic, stress-reducing, rewarding, prosocial, antiaggressive, prosexual, sedative, pro-sleep, cognitive and memory-impairing, analgesic, anesthetic, anticonvulsant, neuroprotective, and neurogenic effects.

Michal Harel at 09:02, 12 January 2023

Michal Harel — Thu, 12 Jan 2023 09:02:41 GMT

←Older revision		Revision as of 09:02, 12 January 2023
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-	<StructureSection load='5osb' size='340' side='right' caption=''>	+	<StructureSection load='5osb' size='340' side='right' caption='Mouse GLIC-GABAA receptor complex with corticosterone derivative, acetate and Cl- ion (PDB code [[5osb]])''>
	These [[neurosteroids]] exert inhibitory actions on neurotransmission. They act as positive allosteric modulators of the [[GABAA receptor]] (especially δ subunit-containing isoforms), and possess, in no particular order, antidepressant, anxiolytic, stress-reducing, rewarding, prosocial, antiaggressive, prosexual, sedative, pro-sleep, cognitive and memory-impairing, analgesic, anesthetic, anticonvulsant, neuroprotective, and neurogenic effects.		These [[neurosteroids]] exert inhibitory actions on neurotransmission. They act as positive allosteric modulators of the [[GABAA receptor]] (especially δ subunit-containing isoforms), and possess, in no particular order, antidepressant, anxiolytic, stress-reducing, rewarding, prosocial, antiaggressive, prosexual, sedative, pro-sleep, cognitive and memory-impairing, analgesic, anesthetic, anticonvulsant, neuroprotective, and neurogenic effects.

Alexander Berchansky at 13:17, 26 December 2021

Alexander Berchansky — Sun, 26 Dec 2021 13:17:49 GMT

←Older revision		Revision as of 13:17, 26 December 2021
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	<StructureSection load='5osb' size='340' side='right' caption=''>		<StructureSection load='5osb' size='340' side='right' caption=''>
-	These neurosteroids exert inhibitory actions on neurotransmission. They act as positive allosteric modulators of the [[GABAA receptor]] (especially δ subunit-containing isoforms), and possess, in no particular order, antidepressant, anxiolytic, stress-reducing, rewarding, prosocial, antiaggressive, prosexual, sedative, pro-sleep, cognitive and memory-impairing, analgesic, anesthetic, anticonvulsant, neuroprotective, and neurogenic effects.	+	These [[neurosteroids]] exert inhibitory actions on neurotransmission. They act as positive allosteric modulators of the [[GABAA receptor]] (especially δ subunit-containing isoforms), and possess, in no particular order, antidepressant, anxiolytic, stress-reducing, rewarding, prosocial, antiaggressive, prosexual, sedative, pro-sleep, cognitive and memory-impairing, analgesic, anesthetic, anticonvulsant, neuroprotective, and neurogenic effects.

	Major examples include <scene name='89/896619/Cv/7'>tetrahydrodeoxycorticosterone</scene> (THDOC; from [[5osb]]), the androstane 3α-androstanediol, the cholestane cholesterol and the pregnanes pregnanolone (eltanolone), allopregnanolone (3α,5α-THP).		Major examples include <scene name='89/896619/Cv/7'>tetrahydrodeoxycorticosterone</scene> (THDOC; from [[5osb]]), the androstane 3α-androstanediol, the cholestane cholesterol and the pregnanes pregnanolone (eltanolone), allopregnanolone (3α,5α-THP).

Alexander Berchansky at 13:12, 26 December 2021

Alexander Berchansky — Sun, 26 Dec 2021 13:12:31 GMT

←Older revision		Revision as of 13:12, 26 December 2021
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	<StructureSection load='5osb' size='340' side='right' caption=''>		<StructureSection load='5osb' size='340' side='right' caption=''>
-	~~This is a default text for your page '''Inhibitory~~ neurosteroids~~'''. Click above~~ on ~~'''edit this page''' to modify~~. ~~Be careful with~~ the ~~<~~ and ~~> signs.~~	+	These neurosteroids exert inhibitory actions on neurotransmission. They act as positive allosteric modulators of the [[GABAA receptor]] (especially δ subunit-containing isoforms), and possess, in no particular order, antidepressant, anxiolytic, stress-reducing, rewarding, prosocial, antiaggressive, prosexual, sedative, pro-sleep, cognitive and memory-impairing, analgesic, anesthetic, anticonvulsant, neuroprotective, and neurogenic effects.
-	~~You may include any references to papers as~~ in~~: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue~~.	+

-	~~== Function ==~~	+	Major examples include <scene name='89/896619/Cv/7'>tetrahydrodeoxycorticosterone</scene> (THDOC; from [[5osb]]), the androstane 3α-androstanediol, the cholestane cholesterol and the pregnanes pregnanolone (eltanolone), allopregnanolone (3α,5α-THP).
-		+
-	~~== Disease ==~~	+
-		+
-	~~== Relevance ==~~	+
-		+
-	~~== Structural highlights ==~~	+
-		+
-	~~This is a sample scene created with SAT to~~ <scene name="/12/~~3456~~/~~Sample/1"~~>~~color~~</scene> ~~by Group~~, and ~~another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of~~ the ~~protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes~~.	+

	</StructureSection>		</StructureSection>
	== References ==		== References ==
	<references/>		<references/>

Alexander Berchansky: New page: This is a default text for your page '''Inhibitory neurosteroids'''. Click above on '''edit this page''' to modify. Be car...

Alexander Berchansky — Sun, 26 Dec 2021 13:11:42 GMT

New page: <StructureSection load='5osb' size='340' side='right' caption=''> This is a default text for your page '''Inhibitory neurosteroids'''. Click above on '''edit this page''' to modify. Be car...

New page

<StructureSection load='5osb' size='340' side='right' caption=''>
This is a default text for your page '''Inhibitory neurosteroids'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>