Insulin-like growth factor - Revision history

Michal Harel at 09:50, 17 January 2024

Michal Harel — Wed, 17 Jan 2024 09:50:01 GMT

←Older revision		Revision as of 09:50, 17 January 2024
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	Inhibition of IGF I influences colon cancer<ref>PMID:11694656</ref>. IGF I has protective effect in neuropathy<ref>PMID:15832492</ref>.		Inhibition of IGF I influences colon cancer<ref>PMID:11694656</ref>. IGF I has protective effect in neuropathy<ref>PMID:15832492</ref>.

-	See also [[Insulin-like growth factor receptor]] and [Insulin-like growth factor 1]].	+	See also [[Insulin-like growth factor receptor]] and [[Insulin-like growth factor 1]].
	</StructureSection>		</StructureSection>

Michal Harel at 09:49, 17 January 2024

Michal Harel — Wed, 17 Jan 2024 09:49:45 GMT

←Older revision		Revision as of 09:49, 17 January 2024
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	Inhibition of IGF I influences colon cancer<ref>PMID:11694656</ref>. IGF I has protective effect in neuropathy<ref>PMID:15832492</ref>.		Inhibition of IGF I influences colon cancer<ref>PMID:11694656</ref>. IGF I has protective effect in neuropathy<ref>PMID:15832492</ref>.

-	See also [[Insulin-like growth factor receptor]].	+	See also [[Insulin-like growth factor receptor]] and [Insulin-like growth factor 1]].
	</StructureSection>		</StructureSection>

Alexander Berchansky at 13:10, 8 June 2023

Alexander Berchansky — Thu, 08 Jun 2023 13:10:03 GMT

←Older revision		Revision as of 13:10, 8 June 2023
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	== Relevance ==		== Relevance ==
	Inhibition of IGF I influences colon cancer<ref>PMID:11694656</ref>. IGF I has protective effect in neuropathy<ref>PMID:15832492</ref>.		Inhibition of IGF I influences colon cancer<ref>PMID:11694656</ref>. IGF I has protective effect in neuropathy<ref>PMID:15832492</ref>.
		+
		+	See also [[Insulin-like growth factor receptor]].
	</StructureSection>		</StructureSection>

Michal Harel at 08:59, 30 May 2023

Michal Harel — Tue, 30 May 2023 08:59:14 GMT

←Older revision		Revision as of 08:59, 30 May 2023
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	**[[6ff3]] - hIGF I + neural ectodermal development factor<br />		**[[6ff3]] - hIGF I + neural ectodermal development factor<br />
	**[[6pyh]] - hIGF I + mIGFI receptor – Cryo EM<br />		**[[6pyh]] - hIGF I + mIGFI receptor – Cryo EM<br />
		+	**[[7wrq]] - hIGF I + IGFBP3 + ALS – Cryo EM<br />
		+	**[[7s0q]] - hIGF I + IGFI receptor + insulin receptor – Cryo EM<br />
		+	**[[8eyr]] - hIGF I 1-195 + IGFI receptor – Cryo EM<br />

	*IGF II residues 25-91		*IGF II residues 25-91
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	**[[1igl]], [[5l3l]], [[5l3m]], [[5l3n]] - hIGF II – NMR<BR />		**[[1igl]], [[5l3l]], [[5l3m]], [[5l3n]] - hIGF II – NMR<BR />
	**[[3e4z]] – hIGF II + insulin-degrading enzyme<BR />		**[[3e4z]] – hIGF II + insulin-degrading enzyme<BR />
		+	**[[3kr3]] - hIGF II + antibody<br />
	**[[6um2]] - hIGF II + bIGFII receptor – Cryo EM<br />		**[[6um2]] - hIGF II + bIGFII receptor – Cryo EM<br />
	**[[6vwg]], [[6vwi]] - hIGF II + IGFI receptor – Cryo EM<br />		**[[6vwg]], [[6vwi]] - hIGF II + IGFI receptor – Cryo EM<br />

Michal Harel at 10:29, 24 August 2020

Michal Harel — Mon, 24 Aug 2020 10:29:02 GMT

←Older revision		Revision as of 10:29, 24 August 2020
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	{{#tree:id=OrganizedByTopic\|openlevels=0\|		{{#tree:id=OrganizedByTopic\|openlevels=0\|

-	*IGF I	+	*IGF I residues 49-118

-	**[[2gf1]], [[3gf1]], [[1b9g]], [[1bqt]] – hIGF I – human – NMR<BR />	+	**[[2gf1]], [[3gf1]], [[1b9g]], [[1bqt]], [[6rva]] – hIGF I – human – NMR<BR />
	**[[3lri]] - hIGF I (mutant) – NMR<BR />		**[[3lri]] - hIGF I (mutant) – NMR<BR />
-	**[[1tgr]] - hIGF I (mutant) <BR />
	**[[1imx]], [[1gzr]], [[1gzy]], [[1gzz]], [[1h02]] - hIGF I<BR />		**[[1imx]], [[1gzr]], [[1gzy]], [[1gzz]], [[1h02]] - hIGF I<BR />
		+	**[[1tgr]] - hIGF I (mutant) <BR />
	**[[1pmx]] – hIGF I + peptide - NMR<BR />		**[[1pmx]] – hIGF I + peptide - NMR<BR />
	**[[1h59]] – hIGF I + IGF binding protein 5<BR />		**[[1h59]] – hIGF I + IGF binding protein 5<BR />
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	**[[2dsq]] - hIGF I + IGF binding protein 4 + IGF binding protein 1<br />		**[[2dsq]] - hIGF I + IGF binding protein 4 + IGF binding protein 1<br />
	**[[4xss]] - hIGF I + insulin receptor + insulin-like growth factor receptor peptide<br />		**[[4xss]] - hIGF I + insulin receptor + insulin-like growth factor receptor peptide<br />
		+	**[[5u8q]] - hIGF I + IGFI receptor + antibody<br />
		+	**[[6ff3]] - hIGF I + neural ectodermal development factor<br />
		+	**[[6pyh]] - hIGF I + mIGFI receptor – Cryo EM<br />

-	*IGF II	+	*IGF II residues 25-91

	**[[1igl]], [[5l3l]], [[5l3m]], [[5l3n]] - hIGF II – NMR<BR />		**[[1igl]], [[5l3l]], [[5l3m]], [[5l3n]] - hIGF II – NMR<BR />
	**[[3e4z]] – hIGF II + insulin-degrading enzyme<BR />		**[[3e4z]] – hIGF II + insulin-degrading enzyme<BR />
-	**[[~~3rk3~~]] – hIGF II + ~~antibody~~	+	**[[6um2]] - hIGF II + bIGFII receptor – Cryo EM<br />
		+	**[[6vwg]], [[6vwi]] - hIGF II + IGFI receptor – Cryo EM<br />
	}}		}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 10:40, 12 January 2020

Michal Harel — Sun, 12 Jan 2020 10:40:50 GMT

←Older revision		Revision as of 10:40, 12 January 2020
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	== Function ==		== Function ==
	'''Insulin-like growth factor''' (IGF) are proteins with high sequence similarity to insulin. IGF are ligands in a complex called the IGF axis, which contains 2 IGF receptors, 6 IGF-binding proteins and IGF-binding protein degrading enzyme<ref>PMID:15797461</ref>.<br />		'''Insulin-like growth factor''' (IGF) are proteins with high sequence similarity to insulin. IGF are ligands in a complex called the IGF axis, which contains 2 IGF receptors, 6 IGF-binding proteins and IGF-binding protein degrading enzyme<ref>PMID:15797461</ref>.<br />
-	* '''IGF I''' is secreted in the liver after stimulation by growth hormone. See details in [[IGF1]]<br />	+	* '''IGF I''' is secreted in the liver after stimulation by growth hormone. See details in [[IGF1]] and [[Igf1 - alec]].<br />
	* '''IGF II''' is required in early development stages.		* '''IGF II''' is required in early development stages.

Michal Harel at 11:11, 2 January 2018

Michal Harel — Tue, 02 Jan 2018 11:11:44 GMT

←Older revision		Revision as of 11:11, 2 January 2018
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	== Function ==		== Function ==
	'''Insulin-like growth factor''' (IGF) are proteins with high sequence similarity to insulin. IGF are ligands in a complex called the IGF axis, which contains 2 IGF receptors, 6 IGF-binding proteins and IGF-binding protein degrading enzyme<ref>PMID:15797461</ref>.<br />		'''Insulin-like growth factor''' (IGF) are proteins with high sequence similarity to insulin. IGF are ligands in a complex called the IGF axis, which contains 2 IGF receptors, 6 IGF-binding proteins and IGF-binding protein degrading enzyme<ref>PMID:15797461</ref>.<br />
-	* '''IGF I''' is secreted in the liver after stimulation by growth hormone.<br />	+	* '''IGF I''' is secreted in the liver after stimulation by growth hormone. See details in [[IGF1]]<br />
	* '''IGF II''' is required in early development stages.		* '''IGF II''' is required in early development stages.

Michal Harel at 08:28, 19 June 2017

Michal Harel — Mon, 19 Jun 2017 08:28:46 GMT

←Older revision		Revision as of 08:28, 19 June 2017
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	**[[2dsp]], [[2dsr]] - hIGF I + IGF binding protein 4<BR />		**[[2dsp]], [[2dsr]] - hIGF I + IGF binding protein 4<BR />
	**[[1wqj]] - hIGF I + IGF binding protein 4<br />		**[[1wqj]] - hIGF I + IGF binding protein 4<br />
-	**[[2dsq]] - hIGF I + IGF binding protein 4 + IGF binding protein 1	+	**[[2dsq]] - hIGF I + IGF binding protein 4 + IGF binding protein 1<br />
		+	**[[4xss]] - hIGF I + insulin receptor + insulin-like growth factor receptor peptide<br />

	*IGF II		*IGF II

-	**[[1igl]] - hIGF II – NMR<BR />	+	**[[1igl]], [[5l3l]], [[5l3m]], [[5l3n]] - hIGF II – NMR<BR />
	**[[3e4z]] – hIGF II + insulin-degrading enzyme<BR />		**[[3e4z]] – hIGF II + insulin-degrading enzyme<BR />
	**[[3rk3]] – hIGF II + antibody		**[[3rk3]] – hIGF II + antibody

Michal Harel at 06:54, 29 March 2016

Michal Harel — Tue, 29 Mar 2016 06:54:09 GMT

←Older revision		Revision as of 06:54, 29 March 2016
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	**[[3rk3]] – hIGF II + antibody		**[[3rk3]] – hIGF II + antibody
	}}		}}
		+	== References ==
		+	<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 06:51, 29 March 2016

Michal Harel — Tue, 29 Mar 2016 06:51:46 GMT

←Older revision		Revision as of 06:51, 29 March 2016
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	<StructureSection load='1gzr' size='400' side='right' caption='Structure of insulin-like growth factor I complex with detergent (PDB entry [[1gzr]])' scene=''>		<StructureSection load='1gzr' size='400' side='right' caption='Structure of insulin-like growth factor I complex with detergent (PDB entry [[1gzr]])' scene=''>

-		+	== Function ==
-	'''Insulin-like growth factor''' (IGF) are proteins with high sequence similarity to insulin. IGF are ligands in a complex called the IGF axis, which contains 2 IGF receptors, 6 IGF-binding proteins and IGF-binding protein degrading enzyme.<br />	+	'''Insulin-like growth factor''' (IGF) are proteins with high sequence similarity to insulin. IGF are ligands in a complex called the IGF axis, which contains 2 IGF receptors, 6 IGF-binding proteins and IGF-binding protein degrading enzyme<ref>PMID:15797461</ref>.<br />
	* '''IGF I''' is secreted in the liver after stimulation by growth hormone.<br />		* '''IGF I''' is secreted in the liver after stimulation by growth hormone.<br />
	* '''IGF II''' is required in early development stages.		* '''IGF II''' is required in early development stages.
		+
		+	== Relevance ==
		+	Inhibition of IGF I influences colon cancer<ref>PMID:11694656</ref>. IGF I has protective effect in neuropathy<ref>PMID:15832492</ref>.
	</StructureSection>		</StructureSection>