Insulin-like growth factor binding protein - Revision history

Michal Harel at 09:26, 29 August 2019

Michal Harel — Thu, 29 Aug 2019 09:26:23 GMT

←Older revision		Revision as of 09:26, 29 August 2019
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	</StructureSection>		</StructureSection>
-	==3D structures of insulin-like growth factor binding protein==
-	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-	{{#tree:id=OrganizedByTopic\|openlevels=0\|
-	*IGF binding protein 1

-	**[[1zt3]], [[1zt5]] – hIGFBP C terminal + IGF I – human <br />
-	**[[2dsq]] – hIGFBP C terminal + hIGFBP-4 N terminal + IGF I <br />
-
-	*IGF binding protein 2
-
-	**[[2h7t]] – hIGFBP C terminal – NMR<br />
-
-	*IGF binding protein 4
-
-	**[[1wqj]], [[2dsp]] – hIGFBP binding domain + IGF I <br />
-	**[[2dsr]] – hIGFBP N terminal + C terminal + IGF I <br />
-
-	*IGF binding protein 5
-
-	**[[1boe]] – hIGFBP binding domain + IGF I – NMR<br />
-	**[[1h59]] – hIGFBP binding domain + IGF I <br />
-
-	*IGF binding protein 6
-
-	**[[1rmj]] – hIGFBP C terminal – NMR<br />
-	**[[2jm2]] – hIGFBP N terminal – NMR<br />
-	}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 09:25, 29 August 2019

Michal Harel — Thu, 29 Aug 2019 09:25:30 GMT

←Older revision		Revision as of 09:25, 29 August 2019
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	*IGFBP-4 overexpression inhibits the growth of colon and prostate cancer cells<ref>PMID:16685432</ref>.<br />		*IGFBP-4 overexpression inhibits the growth of colon and prostate cancer cells<ref>PMID:16685432</ref>.<br />
	*IGFBP-1 is closely related to risk factors for diabetes and cardiovascular disease<ref>PMID:11317665</ref>.		*IGFBP-1 is closely related to risk factors for diabetes and cardiovascular disease<ref>PMID:11317665</ref>.
		+
		+	==3D structures of insulin-like growth factor binding protein==
		+	[[Insulin-like growth factor binding protein 3D structures]]

	</StructureSection>		</StructureSection>

Michal Harel at 22:04, 19 October 2017

Michal Harel — Thu, 19 Oct 2017 22:04:37 GMT

←Older revision		Revision as of 22:04, 19 October 2017
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	== References ==		== References ==
	<references/>		<references/>
		+	[[Category:Topic Page]]

Michal Harel at 08:10, 29 March 2016

Michal Harel — Tue, 29 Mar 2016 08:10:58 GMT

←Older revision		Revision as of 08:10, 29 March 2016
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	*IGFBP-4 overexpression inhibits the growth of colon and prostate cancer cells<ref>PMID:16685432</ref>.<br />		*IGFBP-4 overexpression inhibits the growth of colon and prostate cancer cells<ref>PMID:16685432</ref>.<br />
	*IGFBP-1 is closely related to risk factors for diabetes and cardiovascular disease<ref>PMID:11317665</ref>.		*IGFBP-1 is closely related to risk factors for diabetes and cardiovascular disease<ref>PMID:11317665</ref>.
-
-	== Relevance ==
-
-	== Structural highlights ==

	</StructureSection>		</StructureSection>

Michal Harel at 08:01, 29 March 2016

Michal Harel — Tue, 29 Mar 2016 08:01:43 GMT

←Older revision		Revision as of 08:01, 29 March 2016
Line 1:		Line 1:
-	<StructureSection load='2dsp' size='340' side='right' caption='~~Caption for this structure~~' scene=''>	+	<StructureSection load='2dsp' size='340' side='right' caption='Insulin-like growth factor binding protein N terminal (green) complex with Insulin-like growth factor I (wheat) (PDB code [[2dsp]])' scene=''>
	== Function ==		== Function ==
	Insulin-like growth factor binding protein (IGFBP) are 7 homologous proteins which bind insulin-like growth factor I (IGF I)<ref>PMID:10605625</ref>. The N-terminal of IGFBP is the domain which binds IGF I.		Insulin-like growth factor binding protein (IGFBP) are 7 homologous proteins which bind insulin-like growth factor I (IGF I)<ref>PMID:10605625</ref>. The N-terminal of IGFBP is the domain which binds IGF I.

	== Disease ==		== Disease ==
-	*IGFBP-3 and IGFBP-6 show inhibition of angiogenesis and promotion of cancer cell migration<ref>PMID:23126425</ref>,<ref>PMID:9815544</ref. <br />	+	*IGFBP-3 and IGFBP-6 show inhibition of angiogenesis and promotion of cancer cell migration<ref>PMID:23126425</ref>,<ref>PMID:9815544</ref>. <br />
	*IGFBP-3 level is decreased in patients with inflammatory bowel disease<ref>PMID:15844718</ref>.<br />		*IGFBP-3 level is decreased in patients with inflammatory bowel disease<ref>PMID:15844718</ref>.<br />
	*IGFBP-4 overexpression inhibits the growth of colon and prostate cancer cells<ref>PMID:16685432</ref>.<br />		*IGFBP-4 overexpression inhibits the growth of colon and prostate cancer cells<ref>PMID:16685432</ref>.<br />

Michal Harel at 07:57, 29 March 2016

Michal Harel — Tue, 29 Mar 2016 07:57:27 GMT

←Older revision		Revision as of 07:57, 29 March 2016
Line 1:		Line 1:
-		+	<StructureSection load='2dsp' size='340' side='right' caption='Caption for this structure' scene=''>
-	<StructureSection load='~~1stp~~' size='340' side='right' caption='Caption for this structure' scene=''>	+
	== Function ==		== Function ==
-	Insulin-like growth factor binding protein (IGFBP) are 7 homologous proteins which bind insulin-like growth factor I<ref>PMID:10605625</ref> .	+	Insulin-like growth factor binding protein (IGFBP) are 7 homologous proteins which bind insulin-like growth factor I (IGF I)<ref>PMID:10605625</ref>. The N-terminal of IGFBP is the domain which binds IGF I.

	== Disease ==		== Disease ==
		+	*IGFBP-3 and IGFBP-6 show inhibition of angiogenesis and promotion of cancer cell migration<ref>PMID:23126425</ref>,<ref>PMID:9815544</ref. <br />
		+	*IGFBP-3 level is decreased in patients with inflammatory bowel disease<ref>PMID:15844718</ref>.<br />
		+	*IGFBP-4 overexpression inhibits the growth of colon and prostate cancer cells<ref>PMID:16685432</ref>.<br />
		+	*IGFBP-1 is closely related to risk factors for diabetes and cardiovascular disease<ref>PMID:11317665</ref>.

	== Relevance ==		== Relevance ==

Michal Harel: New page: == Function == Insulin-like growth factor binding protein (IGFBP) are 7 homologous pro...

Michal Harel — Tue, 29 Mar 2016 07:39:36 GMT

New page: <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> == Function == Insulin-like growth factor binding protein (IGFBP) are 7 homologous pro...

New page

<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
== Function ==
Insulin-like growth factor binding protein (IGFBP) are 7 homologous proteins which bind insulin-like growth factor I<ref>PMID:10605625</ref> .

== Disease ==

== Relevance ==

== Structural highlights ==

</StructureSection>
==3D structures of insulin-like growth factor binding protein==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
*IGF binding protein 1

**[[1zt3]], [[1zt5]] – hIGFBP C terminal + IGF I – human 
**[[2dsq]] – hIGFBP C terminal + hIGFBP-4 N terminal + IGF I 

*IGF binding protein 2

**[[2h7t]] – hIGFBP C terminal – NMR 

*IGF binding protein 4

**[[1wqj]], [[2dsp]] – hIGFBP binding domain + IGF I 
**[[2dsr]] – hIGFBP N terminal + C terminal + IGF I 

*IGF binding protein 5

**[[1boe]] – hIGFBP binding domain + IGF I – NMR 
**[[1h59]] – hIGFBP binding domain + IGF I 

*IGF binding protein 6

**[[1rmj]] – hIGFBP C terminal – NMR 
**[[2jm2]] – hIGFBP N terminal – NMR 
}}
== References ==
<references/>