Integrin - Revision history

Michal Harel at 10:25, 29 August 2019

Michal Harel — Thu, 29 Aug 2019 10:25:04 GMT

←Older revision		Revision as of 10:25, 29 August 2019
Line 17:		Line 17:
	</StructureSection>		</StructureSection>

-	==3D structures of integrin==
-
-	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-	{{#tree:id=OrganizedByTopic\|openlevels=0\|
-
-	*IG CR3
-
-	**[[1ido]] – hIG I domain + Mg – human<br />
-	**[[1jlm]] - hIG I domain + Mn<br />
-
-	*IG CD11a or IG α-L
-
-	**[[1lfa]] - hIG I domain + Mn<br />
-	**[[1zon]] - hIG I domain<br />
-	**[[1zoo]], [[1zop]], [[3f74]] - hIG I domain + Mg<br />
-	**[[1mq9]] - hIG I domain (mutant) + Mn<br />
-	**[[1mjn]] - hIG I domain (mutant) + Mg<br />
-	**[[1mqa]] - hIG I domain (mutant) <br />
-	**[[2k8o]] – hIG cytoplasmic domain (mutant) – NMR<BR />
-
-	*''IG CD11a complexes''
-
-	**[[1cqp]] - hIG I domain + lovastatin + Mg<br />
-	**[[1mq8]], [[3bn3]], [[3tcx]] - hIG I domain (mutant) + intracellular adhesion molecule + Mg<br />
-	**[[1t0p]] - hIG I domain + intracellular adhesion molecule-3 + Mg<br />
-	**[[1rd4]], [[2ica]], [[3bqm]], [[3bqn]], [[3e2m]] - hIG I domain + inhibitor<br />
-	**[[2o7n]], [[3m6f]] - hIG I domain + antagonist<br />
-	**[[1xdd]], [[1xdg]], [[1xuo]] - hIG I domain + inhibitor + Mg<br />
-	**[[4ixd]] - hIG I domain + activator + Mg<br />
-	**[[3f78]] - hIG I domain + anesthetic + Mg<br />
-	**[[3eoa]], [[3eob]] - hIG I domain + antibody<br />
-	**[[3hi6]] - hIG I domain (mutant) + antibody + Mn<br />
-
-	*IG CD11b
-
-	**[[1bho]] - hIG I domain + Mg<br />
-	**[[1bhq]] - hIG I domain + Cd<br />
-	**[[1m1u]] - hIG I domain (mutant) + Ca<br />
-	**[[1n9z]] - hIG I domain (mutant) + Mg<br />
-	**[[1idn]], [[1na5]] - hIG I domain<br />
-	**[[1mf7]] - hIG I domain (mutant)
-
-	*IG CD11c
-
-	**[[1n3y]] - hIG I domain (mutant)
-
-	*IG α-1 (CD49a)
-
-	**[[1ck4]] - rIG I domain – rat<br />
-	**[[4a0q]] - hIG I domain (mutant) + Mg<br />
-	**[[2l8s]] - hIG transmembrane domain – NMR<BR />
-	**[[5hgj]] - hIG VWFA domain<br />
-	**[[1mhp]] - rIG I domain (mutant) + antibody + Mn<br />
-	**[[2b2x]] - rIG I domain (mutant) + antibody + Mg<br />
-	**[[2m32]] - hIG I domain + collagen peptide<br />
-
-	*IG α-2 (CD49b)
-
-	**[[4bj3]], [[5e6x]], [[5e6v]] - hIG I domain<br />
-	**[[1dzi]], [[4bj3]] - hIG I domain + collagen peptide<br />
-	**[[1v7p]] - hIG I domain (mutant) + EMS16 + Mn<br />
-	**[[5thp]], [[6nd8]], [[6nd9]], [[6nda]], [[6ndb]], [[6ndc]], [[6ndd]], [[6nde]], [[6ndf]], [[6ndg]], [[6ndh]] - hIG residues 170-366 + rhodocetin <br />
-
-	*IG α-2b
-
-	**[[2k1a]] - hIG transmembrane domain – NMR<BR />
-
-	*IG α-1 β-1 (CD49a-CD49b)
-
-	**[[1qc5]], [[1qcy]] - hIG I domain (mutant) + Mg<br />
-	**[[1pt6]] - hIG I domain + Mg<br />
-
-	*IG α-2 (CD49b) β
-
-	**[[5hj2]] - hIG I domain<br />
-	**[[1aox]] - hIG I domain (mutant) + Mg<br />
-	**[[2k1a]] - hIG transmembrane domain – NMR<br />
-
-	*IG α-2b β-3 (CD61)
-
-	**[[1kup]], [[1kuz]] – hIG proximal domain – NMR<BR />
-	**[[1m8o]] - hIG cytoplasmic domain – NMR<BR />
-	**[[4cak]] – hIG – Cryo-EM<br />
-	**[[2k9j]], [[2knc]] - hIG transmembrane domain – NMR<BR />
-	**[[1tye]], [[3fcu]], [[3fcs]] – hIG + Mg<br />
-	**[[3fc3]] – hIG (mutant) + Mg<br />
-	**[[2vc2]], [[2vdk]], [[2vdl]], [[3nid]], [[3nif]], [[3nig]], [[3zdx]], [[3zdy]], [[3zdz]], [[3ze0]], [[3ze1]], [[3ze2]], [[5hdb]] – hIG headpiece + antibody + Mg<br />
-	**[[4z7q]], [[4z7o]], [[4z7n]] – hIG headpiece + antibody + Mg + tetrapeptide<br />
-	**[[2vdm]], [[2vdn]], [[3t3m]], [[3t3p]] – hIG headpiece + antibody + antagonist + Mg<br />
-	**[[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]] – hIG headpiece + antibody + fibrinogen peptide + Mg<br />
-
-	*IG α-4
-
-	**[[4irz]] - hIG + antibody <br />
-
-	*IG α-4 (CD49d) β-7
-
-	**[[3v4p]] - hIG headpiece (mutant) + antibody + Mg<br />
-	**[[3v4v]] - hIG headpiece (mutant) + antibody + inhibitor + Mg<br />
-
-	*IG α-5 (CD49e) β-1 (CD29)
-
-	**[[4wjk]] - hIG headpiece (mutant) + Mg<br />
-	**[[4wk0]], [[4wk2]], [[4wk4]] - hIG headpiece (mutant) + peptide + Mg<br />
-	**[[3vi3]] - hIG headpiece + antibody + Mg<br />
-	**[[3vi4]] - hIG headpiece + antibody + peptide + Mg<br />
-
-	*IG α-5 (CD49e) β-3 (CD61) ectodomain
-
-	**[[3ije]], [[1m1x]], [[4g1e]], [[4g1m]], [[1u8c]] – hIG + cation<br />
-	**[[4mmx]], [[4mmy]], [[4mmz]] - hIG + Mn + fibronectin domain 10<br />
-	**[[4o02]], [[6avu]], [[6avr]], [[6avq]] - hIG + antibody<br />
-	**[[1jv2]] - hIG + platelet membrane glycoprotein IIIA + Ca<br />
-	**[[1l5g]] - hIG + tripeptide + Mn<br />
-
-	*IG α-5 β-6
-
-	**[[4um8]] – hIG headpiece (mutant) + Ni<br />
-	**[[5ffg]] – hIG headpiece + Ca<br />
-	**[[4um9]] – hIG headpiece (mutant) + Mg + transforming growth factor β 3<br />
-	**[[5neu]], [[5net]], [[5ner]], [[5nem]] – hIG headpiece + foot-and-mouth virus – Cryo EM<br />
-	**[[5ffo]] – hIG headpiece + TGF-beta-1<br />
-
-	*IG α-L
-
-	**[[4ixd]] – hIG I domain<br />
-	**[[5e6s]], [[5e6r]] – hIG AI, headpiece,pocket domains + Mg<br />
-	**[[2m3e]] – hIG transmembrane domain - NMR<br />
-
-	*IG α-L β-2
-
-	**[[5e6u]] – hIG headpiece (mutant) + Ni<br />
-
-	*IG α-M
-
-	**[[3q3g]], [[3qa3]] – hIG + antibody<br />
-	**[[4m76]] – hIG + complement C3<br />
-	**[[2lke]], [[2lkj]] – hIG cytoplasmic domain – NMR<BR />
-	**[[4xw2]] – hIG + simvastatin<br />
-
-	*IG α-V β-8
-
-	**[[6djp]] – hIG + antibody – Cryo EM<br />
-
-	*IG α-X
-
-	**[[2luv]] – hIG cytoplasmic domain – NMR<BR />
-
-	*IG α-X β-2 (CD18)
-
-	**[[3k6s]], [[3k71]], [[3k72]], [[5es4]] – hIG + Mg<br />
-	**[[4neh]], [[4nen]] – hIG (mutant) + Mg<br />
-
-	*IG β-1D
-
-	**[[3g9w]] – hIG cytoplasmic tail + talin 2 F2-F3 domain<br />
-
-	*IG β-2 (CD18)
-
-	**[[2p26]], [[2p28]], [[5e6w]] – hIG phe2 + phe3 domains<br />
-	**[[1yuk]] – hIG chain A PSI domain + chain B I-EGF domain<br />
-	**[[5zaz]] – hIG transmembrane domain - NMR<br />
-
-	*IG β-3 (CD61)
-
-	**[[1s4x]], [[2kv9]], [[2ljd]], [[2lje]], [[2ljf]] – hIG cytoplasmic domain – NMR<BR />
-	**[[2rmz]], [[2rn0]] – hIG transmembrane domain – NMR<BR />
-	**[[2l91]] - hIG transmembrane domain (mutant) – NMR<BR />
-	**[[2l1c]] – hIG cytoplasmic tail + SHC<br />
-	**[[2mtp]] – hIG cytoplasmic tail (mutant) + hIG α-2 β peptide+ filamin rod domain<br />
-
-	*IG β-4 (CD104; Gp150)
-
-	**[[2f7q]], [[3f7r]], [[1qg3]], [[3f7q]], [[4wtw]], [[4wtx]] - hIG fibronectin type III domain<br />
-	**[[2yrz]] – hIG fibronectin type III domain – NMR<BR />
-	**[[3f7p]], [[4q58]] - hIG fibronectin type III domain + plectin-1 <br />
-	**[[6gvl]] - hIG fibronectin type III domain + dystonin<br />
-	**[[6gvk]] - hIG fibronectin type III domain (mutant) + dystonin<br />
-	**[[3fq4]], [[3fso]], [[3h6a]] – hIG Calx-β domain<br />
-	**[[6hyf]] - rIG fibronectin type III domain <br />
-
-	*IG β-7
-
-	**[[2brq]], [[2jf1]] – hIG cytoplasmic tail + filamin rod domain<br />
-
-	}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 10:23, 29 August 2019

Michal Harel — Thu, 29 Aug 2019 10:23:53 GMT

←Older revision		Revision as of 10:23, 29 August 2019
Line 12:		Line 12:

	<scene name='51/516472/Cv/4'>Mg/Cl coordination site</scene>. Water molecules shown as red spheres.		<scene name='51/516472/Cv/4'>Mg/Cl coordination site</scene>. Water molecules shown as red spheres.
		+
		+	==3D structures of integrin==
		+	[[Integrin 3D structures]]
	</StructureSection>		</StructureSection>

Line 75:		Line 78:
	**[[1dzi]], [[4bj3]] - hIG I domain + collagen peptide<br />		**[[1dzi]], [[4bj3]] - hIG I domain + collagen peptide<br />
	**[[1v7p]] - hIG I domain (mutant) + EMS16 + Mn<br />		**[[1v7p]] - hIG I domain (mutant) + EMS16 + Mn<br />
-	**[[5thp]] - hIG residues 170-366 + rhodocetin <br />	+	**[[5thp]], [[6nd8]], [[6nd9]], [[6nda]], [[6ndb]], [[6ndc]], [[6ndd]], [[6nde]], [[6ndf]], [[6ndg]], [[6ndh]] - hIG residues 170-366 + rhodocetin <br />

	*IG α-2b		*IG α-2b
Line 153:		Line 156:
	**[[2lke]], [[2lkj]] – hIG cytoplasmic domain – NMR<BR />		**[[2lke]], [[2lkj]] – hIG cytoplasmic domain – NMR<BR />
	**[[4xw2]] – hIG + simvastatin<br />		**[[4xw2]] – hIG + simvastatin<br />
		+
		+	*IG α-V β-8
		+
		+	**[[6djp]] – hIG + antibody – Cryo EM<br />

	*IG α-X		*IG α-X
Line 171:		Line 178:
	**[[2p26]], [[2p28]], [[5e6w]] – hIG phe2 + phe3 domains<br />		**[[2p26]], [[2p28]], [[5e6w]] – hIG phe2 + phe3 domains<br />
	**[[1yuk]] – hIG chain A PSI domain + chain B I-EGF domain<br />		**[[1yuk]] – hIG chain A PSI domain + chain B I-EGF domain<br />
		+	**[[5zaz]] – hIG transmembrane domain - NMR<br />

	*IG β-3 (CD61)		*IG β-3 (CD61)
Line 180:		Line 188:
	**[[2mtp]] – hIG cytoplasmic tail (mutant) + hIG α-2 β peptide+ filamin rod domain<br />		**[[2mtp]] – hIG cytoplasmic tail (mutant) + hIG α-2 β peptide+ filamin rod domain<br />

-	*IG β-4 (CD104)	+	*IG β-4 (CD104; Gp150)

	**[[2f7q]], [[3f7r]], [[1qg3]], [[3f7q]], [[4wtw]], [[4wtx]] - hIG fibronectin type III domain<br />		**[[2f7q]], [[3f7r]], [[1qg3]], [[3f7q]], [[4wtw]], [[4wtx]] - hIG fibronectin type III domain<br />
	**[[2yrz]] – hIG fibronectin type III domain – NMR<BR />		**[[2yrz]] – hIG fibronectin type III domain – NMR<BR />
	**[[3f7p]], [[4q58]] - hIG fibronectin type III domain + plectin-1 <br />		**[[3f7p]], [[4q58]] - hIG fibronectin type III domain + plectin-1 <br />
-	**[[3fq4]], [[3fso]], [[3h6a]] – hIG Calx-β domain	+	**[[6gvl]] - hIG fibronectin type III domain + dystonin<br />
		+	**[[6gvk]] - hIG fibronectin type III domain (mutant) + dystonin<br />
		+	**[[3fq4]], [[3fso]], [[3h6a]] – hIG Calx-β domain<br />
		+	**[[6hyf]] - rIG fibronectin type III domain <br />

	*IG β-7		*IG β-7

Alexander Berchansky at 13:02, 29 May 2019

Alexander Berchansky — Wed, 29 May 2019 13:02:27 GMT

←Older revision		Revision as of 13:02, 29 May 2019
Line 11:		Line 11:
	The interactions of integrin with ligands are dependent on the presence of divalent ions<ref>PMID:10961914</ref>.		The interactions of integrin with ligands are dependent on the presence of divalent ions<ref>PMID:10961914</ref>.

-	<scene name='51/516472/Cv/3'>Mg/Cl coordination site</scene>. Water molecules shown as red spheres.	+	<scene name='51/516472/Cv/4'>Mg/Cl coordination site</scene>. Water molecules shown as red spheres.
	</StructureSection>		</StructureSection>

Michal Harel at 09:49, 22 July 2018

Michal Harel — Sun, 22 Jul 2018 09:49:43 GMT

←Older revision		Revision as of 09:49, 22 July 2018
Line 121:		Line 121:
	**[[3vi4]] - hIG headpiece + antibody + peptide + Mg<br />		**[[3vi4]] - hIG headpiece + antibody + peptide + Mg<br />

-	*IG α-5 (CD49e) β-3 (CD61)	+	*IG α-5 (CD49e) β-3 (CD61) ectodomain

-	**[[3ije]] ~~– hIG + Ca<br />~~	+	**[[3ije]], [[1m1x]], [[4g1e]], [[4g1m]], [[1u8c]] – hIG + cation<br />
-	**[[1m1x]] - hIG ~~extracellular domain~~ + Mn<br />	+	**[[4mmx]], [[4mmy]], [[4mmz]] - hIG + Mn + fibronectin domain 10<br />
-	**[[4mmx]], [[4mmy]], [[4mmz]] - hIG ~~extracellular domain~~ + Mn + fibronectin domain 10<br />	+	**[[4o02]], [[6avu]], [[6avr]], [[6avq]] - hIG + antibody<br />
-	**[[4o02]], [[6avu]], [[6avr]], [[6avq]] - hIG ~~extracellular domain~~ + antibody~~<br />~~	+	**[[1jv2]] - hIG + platelet membrane glycoprotein IIIA + Ca<br />
-	**[[1u8c]] – hIG psi domain + Ca<br />	+	**[[1l5g]] - hIG + tripeptide + Mn<br />
-	**[[1jv2]] - hIG ~~I domain~~ + platelet membrane glycoprotein IIIA + Ca<br />	+
-	**[[1l5g]] - hIG ~~I domain~~ + tripeptide + Mn<br />	+

	*IG α-5 β-6		*IG α-5 β-6
Line 164:		Line 162:
	**[[3k6s]], [[3k71]], [[3k72]], [[5es4]] – hIG + Mg<br />		**[[3k6s]], [[3k71]], [[3k72]], [[5es4]] – hIG + Mg<br />
	**[[4neh]], [[4nen]] – hIG (mutant) + Mg<br />		**[[4neh]], [[4nen]] – hIG (mutant) + Mg<br />
-
-	*IG α-V β-3
-
-	**[[4g1e]], [[4g1m]] – hIG + Ni<br />

	*IG β-1D		*IG β-1D

Michal Harel at 09:39, 22 July 2018

Michal Harel — Sun, 22 Jul 2018 09:39:08 GMT

←Older revision		Revision as of 09:39, 22 July 2018
Line 75:		Line 75:
	**[[1dzi]], [[4bj3]] - hIG I domain + collagen peptide<br />		**[[1dzi]], [[4bj3]] - hIG I domain + collagen peptide<br />
	**[[1v7p]] - hIG I domain (mutant) + EMS16 + Mn<br />		**[[1v7p]] - hIG I domain (mutant) + EMS16 + Mn<br />
		+	**[[5thp]] - hIG residues 170-366 + rhodocetin <br />

	*IG α-2b		*IG α-2b
Line 87:		Line 88:
	*IG α-2 (CD49b) β		*IG α-2 (CD49b) β

		+	**[[5hj2]] - hIG I domain<br />
	**[[1aox]] - hIG I domain (mutant) + Mg<br />		**[[1aox]] - hIG I domain (mutant) + Mg<br />
-	**[[~~1s4w]], [[1dpk]] - hIG cytoplasmic domain - NMR<BR />~~	+	**[[2k1a]] - hIG transmembrane domain – NMR<br />
-	**[[1dpq]] - hIG ~~cytoplasmic~~ domain ~~(mutant)~~ – NMR<br />	+

	*IG α-2b β-3 (CD61)		*IG α-2b β-3 (CD61)
Line 125:		Line 126:
	**[[1m1x]] - hIG extracellular domain + Mn<br />		**[[1m1x]] - hIG extracellular domain + Mn<br />
	**[[4mmx]], [[4mmy]], [[4mmz]] - hIG extracellular domain + Mn + fibronectin domain 10<br />		**[[4mmx]], [[4mmy]], [[4mmz]] - hIG extracellular domain + Mn + fibronectin domain 10<br />
-	**[[4o02]] - hIG extracellular domain ~~+ Mn~~ + antibody<br />	+	**[[4o02]], [[6avu]], [[6avr]], [[6avq]] - hIG extracellular domain + antibody<br />
	**[[1u8c]] – hIG psi domain + Ca<br />		**[[1u8c]] – hIG psi domain + Ca<br />
	**[[1jv2]] - hIG I domain + platelet membrane glycoprotein IIIA + Ca<br />		**[[1jv2]] - hIG I domain + platelet membrane glycoprotein IIIA + Ca<br />
Line 135:		Line 136:
	**[[5ffg]] – hIG headpiece + Ca<br />		**[[5ffg]] – hIG headpiece + Ca<br />
	**[[4um9]] – hIG headpiece (mutant) + Mg + transforming growth factor β 3<br />		**[[4um9]] – hIG headpiece (mutant) + Mg + transforming growth factor β 3<br />
		+	**[[5neu]], [[5net]], [[5ner]], [[5nem]] – hIG headpiece + foot-and-mouth virus – Cryo EM<br />
		+	**[[5ffo]] – hIG headpiece + TGF-beta-1<br />

	*IG α-L		*IG α-L
Line 172:		Line 175:
	*IG β-2 (CD18)		*IG β-2 (CD18)

-	**[[2p26]], [[2p28]] – hIG phe2 + phe3 domains<br />	+	**[[2p26]], [[2p28]], [[5e6w]] – hIG phe2 + phe3 domains<br />
	**[[1yuk]] – hIG chain A PSI domain + chain B I-EGF domain<br />		**[[1yuk]] – hIG chain A PSI domain + chain B I-EGF domain<br />

Michal Harel at 10:24, 19 June 2017

Michal Harel — Mon, 19 Jun 2017 10:24:19 GMT

←Older revision		Revision as of 10:24, 19 June 2017
Line 65:		Line 65:
	**[[4a0q]] - hIG I domain (mutant) + Mg<br />		**[[4a0q]] - hIG I domain (mutant) + Mg<br />
	**[[2l8s]] - hIG transmembrane domain – NMR<BR />		**[[2l8s]] - hIG transmembrane domain – NMR<BR />
		+	**[[5hgj]] - hIG VWFA domain<br />
	**[[1mhp]] - rIG I domain (mutant) + antibody + Mn<br />		**[[1mhp]] - rIG I domain (mutant) + antibody + Mn<br />
	**[[2b2x]] - rIG I domain (mutant) + antibody + Mg<br />		**[[2b2x]] - rIG I domain (mutant) + antibody + Mg<br />
Line 71:		Line 72:
	*IG α-2 (CD49b)		*IG α-2 (CD49b)

		+	**[[4bj3]], [[5e6x]], [[5e6v]] - hIG I domain<br />
	**[[1dzi]], [[4bj3]] - hIG I domain + collagen peptide<br />		**[[1dzi]], [[4bj3]] - hIG I domain + collagen peptide<br />
	**[[1v7p]] - hIG I domain (mutant) + EMS16 + Mn<br />		**[[1v7p]] - hIG I domain (mutant) + EMS16 + Mn<br />
Line 97:		Line 99:
	**[[1tye]], [[3fcu]], [[3fcs]] – hIG + Mg<br />		**[[1tye]], [[3fcu]], [[3fcs]] – hIG + Mg<br />
	**[[3fc3]] – hIG (mutant) + Mg<br />		**[[3fc3]] – hIG (mutant) + Mg<br />
-	**[[2vc2]], [[2vdk]], [[2vdl]], [[3nid]], [[3nif]], [[3nig]], [[3zdx]], [[3zdy]], [[3zdz]], [[3ze0]], [[3ze1]], [[3ze2]] – hIG headpiece + antibody + Mg<br />	+	**[[2vc2]], [[2vdk]], [[2vdl]], [[3nid]], [[3nif]], [[3nig]], [[3zdx]], [[3zdy]], [[3zdz]], [[3ze0]], [[3ze1]], [[3ze2]], [[5hdb]] – hIG headpiece + antibody + Mg<br />
		+	**[[4z7q]], [[4z7o]], [[4z7n]] – hIG headpiece + antibody + Mg + tetrapeptide<br />
	**[[2vdm]], [[2vdn]], [[3t3m]], [[3t3p]] – hIG headpiece + antibody + antagonist + Mg<br />		**[[2vdm]], [[2vdn]], [[3t3m]], [[3t3p]] – hIG headpiece + antibody + antagonist + Mg<br />
	**[[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]] – hIG headpiece + antibody + fibrinogen peptide + Mg<br />		**[[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]] – hIG headpiece + antibody + fibrinogen peptide + Mg<br />
Line 130:		Line 133:

	**[[4um8]] – hIG headpiece (mutant) + Ni<br />		**[[4um8]] – hIG headpiece (mutant) + Ni<br />
		+	**[[5ffg]] – hIG headpiece + Ca<br />
	**[[4um9]] – hIG headpiece (mutant) + Mg + transforming growth factor β 3<br />		**[[4um9]] – hIG headpiece (mutant) + Mg + transforming growth factor β 3<br />

Line 135:		Line 139:

	**[[4ixd]] – hIG I domain<br />		**[[4ixd]] – hIG I domain<br />
		+	**[[5e6s]], [[5e6r]] – hIG AI, headpiece,pocket domains + Mg<br />
	**[[2m3e]] – hIG transmembrane domain - NMR<br />		**[[2m3e]] – hIG transmembrane domain - NMR<br />
		+
		+	*IG α-L β-2
		+
		+	**[[5e6u]] – hIG headpiece (mutant) + Ni<br />

	*IG α-M		*IG α-M
Line 142:		Line 151:
	**[[4m76]] – hIG + complement C3<br />		**[[4m76]] – hIG + complement C3<br />
	**[[2lke]], [[2lkj]] – hIG cytoplasmic domain – NMR<BR />		**[[2lke]], [[2lkj]] – hIG cytoplasmic domain – NMR<BR />
		+	**[[4xw2]] – hIG + simvastatin<br />

	*IG α-X		*IG α-X
Line 149:		Line 159:
	*IG α-X β-2 (CD18)		*IG α-X β-2 (CD18)

-	**[[3k6s]], [[3k71]], [[3k72]] – hIG + Mg<br />	+	**[[3k6s]], [[3k71]], [[3k72]], [[5es4]] – hIG + Mg<br />
	**[[4neh]], [[4nen]] – hIG (mutant) + Mg<br />		**[[4neh]], [[4nen]] – hIG (mutant) + Mg<br />

Alexander Berchansky at 11:42, 5 April 2016

Alexander Berchansky — Tue, 05 Apr 2016 11:42:09 GMT

←Older revision		Revision as of 11:42, 5 April 2016
Line 10:		Line 10:
	== Structural highlights ==		== Structural highlights ==
	The interactions of integrin with ligands are dependent on the presence of divalent ions<ref>PMID:10961914</ref>.		The interactions of integrin with ligands are dependent on the presence of divalent ions<ref>PMID:10961914</ref>.
		+
		+	<scene name='51/516472/Cv/3'>Mg/Cl coordination site</scene>. Water molecules shown as red spheres.
	</StructureSection>		</StructureSection>

Alexander Berchansky at 11:28, 5 April 2016

Alexander Berchansky — Tue, 05 Apr 2016 11:28:38 GMT

←Older revision		Revision as of 11:28, 5 April 2016
Line 1:		Line 1:
-	<StructureSection load='1zoo' size='400' side='right' caption='Structure of human integrin CD11a I domain dimer complex with Mg+2 (light green) and Cl- (dark green) ions (PDB entry [[1zoo]])' scene=''>	+	<StructureSection load='1zoo' size='400' side='right' caption='Structure of human integrin CD11a I domain dimer complex with Mg+2 (light green) and Cl- (dark green) ions (PDB entry [[1zoo]])' scene='51/516472/Cv/1'>
	== Function ==		== Function ==
	'''Integrins''' (IG) are receptors which mediate the attachment between cells and between cells and the extracellular matrix. They are involved in cellular signaling and cell cycle<ref>PMID:10961914</ref>. IGs contain α and β chain. IG subunits span the cell membrane. Both subunits bind divalent cations some of which bind the ligands which interact with IG. Some IGs contain an insertion domain named I domain. For more details see [[Molecular Playground/IntegrinBeta1]].		'''Integrins''' (IG) are receptors which mediate the attachment between cells and between cells and the extracellular matrix. They are involved in cellular signaling and cell cycle<ref>PMID:10961914</ref>. IGs contain α and β chain. IG subunits span the cell membrane. Both subunits bind divalent cations some of which bind the ligands which interact with IG. Some IGs contain an insertion domain named I domain. For more details see [[Molecular Playground/IntegrinBeta1]].

Michal Harel at 10:21, 29 March 2016

Michal Harel — Tue, 29 Mar 2016 10:21:55 GMT

←Older revision		Revision as of 10:21, 29 March 2016
Line 7:		Line 7:
	==Disease ==		==Disease ==
	Defective integrin is the cause of the skin disease epidermolysis bullosa, of congenital muscular dystrophy. Overexpression of integrin is correlated with some types of cancer and enhanced bone resorption in osteoporosis<ref>PMID:8976799</ref>. Defective integrin is involved in periodontal diseases<ref>PMID:24662197</ref>.		Defective integrin is the cause of the skin disease epidermolysis bullosa, of congenital muscular dystrophy. Overexpression of integrin is correlated with some types of cancer and enhanced bone resorption in osteoporosis<ref>PMID:8976799</ref>. Defective integrin is involved in periodontal diseases<ref>PMID:24662197</ref>.
		+
		+	== Structural highlights ==
		+	The interactions of integrin with ligands are dependent on the presence of divalent ions<ref>PMID:10961914</ref>.
	</StructureSection>		</StructureSection>

Michal Harel at 10:03, 29 March 2016

Michal Harel — Tue, 29 Mar 2016 10:03:35 GMT

←Older revision		Revision as of 10:03, 29 March 2016
Line 1:		Line 1:
-	<StructureSection load='1zoo' size='400' side='right' caption='Structure of human ~~integrein~~ CD11a I domain dimer complex with Mg+2 (light green) and Cl- (dark green) ions (PDB entry [[1zoo]])' scene=''>	+	<StructureSection load='1zoo' size='400' side='right' caption='Structure of human integrin CD11a I domain dimer complex with Mg+2 (light green) and Cl- (dark green) ions (PDB entry [[1zoo]])' scene=''>
-		+	== Function ==
-	'''Integrins''' (IG) are receptors which mediate the attachment between cells ~~or to~~ extracellular matrix. They are involved in cellular signaling and cell cycle. IGs contain α and β chain. IG subunits span the cell membrane. Both subunits bind divalent cations some of which bind the ligands which interact with IG. Some IGs contain an insertion domain named I domain. For more details see [[Molecular Playground/IntegrinBeta1]].	+	'''Integrins''' (IG) are receptors which mediate the attachment between cells and between cells and the extracellular matrix. They are involved in cellular signaling and cell cycle<ref>PMID:10961914</ref>. IGs contain α and β chain. IG subunits span the cell membrane. Both subunits bind divalent cations some of which bind the ligands which interact with IG. Some IGs contain an insertion domain named I domain. For more details see [[Molecular Playground/IntegrinBeta1]].

	For some details on the interaction of a targeting peptide with integrin see [[Molecular Playground/Targeting Peptide]].		For some details on the interaction of a targeting peptide with integrin see [[Molecular Playground/Targeting Peptide]].
		+
		+	==Disease ==
		+	Defective integrin is the cause of the skin disease epidermolysis bullosa, of congenital muscular dystrophy. Overexpression of integrin is correlated with some types of cancer and enhanced bone resorption in osteoporosis<ref>PMID:8976799</ref>. Defective integrin is involved in periodontal diseases<ref>PMID:24662197</ref>.
	</StructureSection>		</StructureSection>

Line 177:		Line 180:

	}}		}}
		+	== References ==
		+	<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]