Kallikrein - Revision history

Michal Harel at 09:12, 8 September 2019

Michal Harel — Sun, 08 Sep 2019 09:12:32 GMT

←Older revision		Revision as of 09:12, 8 September 2019
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	</StructureSection>		</StructureSection>

-	== 3D Structures of kallikrein ==
-
-	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-	{{#tree:id=OrganizedByTopic\|openlevels=0\|
-
-	*Kallikrein 1
-
-	**[[1gvz]] – KLK - horse <br />
-	**[[2pka]] – pKLK - pig <br />
-	**[[2kai]] – pKLK + BPTI <br />
-	**[[1hia]] – pKLK + hirustasin <br />
-
-	*Kallikrein 2
-
-	**[[4nfe]] – hKLK + inhibitor - human <br />
-	**[[4nff]] – hKLK + PPACK <br />
-
-	*Kallikrein 4
-
-	**[[6nvb]] – hKLK <br />
-	**[[4kga]] – hKLK + Ni<br />
-	**[[2bdg]] – hKLK + aminobenzamidine + Ni <br />
-	**[[2bdh]] – hKLK + aminobenzamidine + Zn<br />
-	**[[2bdi]] – hKLK + aminobenzamidine + Co<br />
-	**[[4k1e]], [[4kel]], [[4k8y]], [[6o21]] – hKLK + trypsin inhibitor <br />
-	**[[6kbr]] – hKLK + SPINK2 inhibitor <br />
-
-	*Kallikrein 5
-
-	**[[2psx]] – hKLK catalytic domain + leupeptin<br />
-	**[[2psy]] – hKLK catalytic domain + leupeptin + Zn<br />
-	**[[6qfe]] – hKLK + inhibitor <br />
-
-	*Kallikrein 6
-
-	**[[1gvl]] – hKLK (mutant) <br />
-	**[[1l2e]], [[1lo6]] – hKLK + inhibitor <br />
-	**[[3vfe]], [[4d8n]], [[6qff]], [[6qfg]], [[6qfh]], [[6qf9]], [[6qfa]], [[6qfb]], [[6qfc]] – hKLK (mutant) + inhibitor <br />
-	**[[5nx1]], [[5nx3]] – hKLK + amyloid-b A4 protein<br />
-
-	*Kallikrein 7
-
-	**[[3bsq]] – hKLK <br />
-	**[[2qxg]], [[2qxh]], [[2qxi]], [[2qxj]] – hKLK + chymotriptic determinant <br />
-	**[[5fah]], [[5y9l]], [[5yjk]] – hKLK + inhibitor<br />
-	**[[5zfh]] – mKLK - mouse<br />
-	**[[5zfi]], [[6ahs]] – mKLK + inhibitor<br />
-
-	*Kallikrein 8
-
-	**[[5ms3]] – hKLK <br />
-	**[[5ms4]] – hKLK + inhibitor<br />
-
-	*Kallikrein 10
-
-	**[[5lpf]] – hKLK <br />
-	**[[5lpe]] – hKLK + Zn<br />
-
-	*Kallikrein 13
-
-	**[[1ao5]] – KLK - mouse<br />
-
-	*Plasma kallikrein
-
-	**[[6o1g]], [[6i44]] – hKLK + inhibitor<br />
-	**[[4ogx]], [[4ogy]] – hKLK light chain (mutant) + antibody <br />
-	**[[5f8z]] – hKLK light chain (mutant) + Pkalin-1 <br />
-	**[[5f8t]] – hKLK light chain (mutant) + Pkalin-2 <br />
-	**[[5f8x]] – hKLK light chain (mutant) + Pkalin-3 <br />
-	**[[5tjx]], [[2anw]], [[2any]], [[6o1s]] – hKLK light chain (mutant) + inhibitor <br />
-	**[[5gvt]] – mKLK protease domain (mutant) <br />
-	**[[6a8o]] – mKLK protease domain + inhibitor<br />
-
-	*Tissue kallikrein (KLK 1)
-
-	**[[1spj]] – hKLK (mutant) <br />
-	}}
	== References ==		== References ==
	<references/>		<references/>

	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 09:11, 8 September 2019

Michal Harel — Sun, 08 Sep 2019 09:11:21 GMT

←Older revision		Revision as of 09:11, 8 September 2019
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	== Structural highlights ==		== Structural highlights ==
	KLK being a serine protease contains the <scene name='59/595822/Cv/5'>Ser, His, Asp catalytic triad and the Gly, Ser oxyanion hole</scene><ref>PMID:16950394</ref>. Water molecules shown as red spheres.		KLK being a serine protease contains the <scene name='59/595822/Cv/5'>Ser, His, Asp catalytic triad and the Gly, Ser oxyanion hole</scene><ref>PMID:16950394</ref>. Water molecules shown as red spheres.
		+
		+	== 3D Structures of kallikrein ==
		+	[[Kallikrein 3D structures]]
		+
	</StructureSection>		</StructureSection>

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	*Kallikrein 4		*Kallikrein 4

		+	**[[6nvb]] – hKLK <br />
	**[[4kga]] – hKLK + Ni<br />		**[[4kga]] – hKLK + Ni<br />
	**[[2bdg]] – hKLK + aminobenzamidine + Ni <br />		**[[2bdg]] – hKLK + aminobenzamidine + Ni <br />
	**[[2bdh]] – hKLK + aminobenzamidine + Zn<br />		**[[2bdh]] – hKLK + aminobenzamidine + Zn<br />
	**[[2bdi]] – hKLK + aminobenzamidine + Co<br />		**[[2bdi]] – hKLK + aminobenzamidine + Co<br />
-	**[[4k1e]], [[4kel]], [[4k8y]] – hKLK + trypsin inhibitor <br />	+	**[[4k1e]], [[4kel]], [[4k8y]], [[6o21]] – hKLK + trypsin inhibitor <br />
		+	**[[6kbr]] – hKLK + SPINK2 inhibitor <br />

	*Kallikrein 5		*Kallikrein 5
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	**[[2psx]] – hKLK catalytic domain + leupeptin<br />		**[[2psx]] – hKLK catalytic domain + leupeptin<br />
	**[[2psy]] – hKLK catalytic domain + leupeptin + Zn<br />		**[[2psy]] – hKLK catalytic domain + leupeptin + Zn<br />
		+	**[[6qfe]] – hKLK + inhibitor <br />

	*Kallikrein 6		*Kallikrein 6
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	**[[1gvl]] – hKLK (mutant) <br />		**[[1gvl]] – hKLK (mutant) <br />
	**[[1l2e]], [[1lo6]] – hKLK + inhibitor <br />		**[[1l2e]], [[1lo6]] – hKLK + inhibitor <br />
-	**[[3vfe]], [[4d8n]] – hKLK (mutant) + inhibitor <br />	+	**[[3vfe]], [[4d8n]], [[6qff]], [[6qfg]], [[6qfh]], [[6qf9]], [[6qfa]], [[6qfb]], [[6qfc]] – hKLK (mutant) + inhibitor <br />
	**[[5nx1]], [[5nx3]] – hKLK + amyloid-b A4 protein<br />		**[[5nx1]], [[5nx3]] – hKLK + amyloid-b A4 protein<br />

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	**[[5fah]], [[5y9l]], [[5yjk]] – hKLK + inhibitor<br />		**[[5fah]], [[5y9l]], [[5yjk]] – hKLK + inhibitor<br />
	**[[5zfh]] – mKLK - mouse<br />		**[[5zfh]] – mKLK - mouse<br />
-	**[[5zfi]] – mKLK + inhibitor<br />	+	**[[5zfi]], [[6ahs]] – mKLK + inhibitor<br />

	*Kallikrein 8		*Kallikrein 8
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	*Plasma kallikrein		*Plasma kallikrein

		+	**[[6o1g]], [[6i44]] – hKLK + inhibitor<br />
	**[[4ogx]], [[4ogy]] – hKLK light chain (mutant) + antibody <br />		**[[4ogx]], [[4ogy]] – hKLK light chain (mutant) + antibody <br />
	**[[5f8z]] – hKLK light chain (mutant) + Pkalin-1 <br />		**[[5f8z]] – hKLK light chain (mutant) + Pkalin-1 <br />
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	**[[5f8x]] – hKLK light chain (mutant) + Pkalin-3 <br />		**[[5f8x]] – hKLK light chain (mutant) + Pkalin-3 <br />
	**[[5tjx]], [[2anw]], [[2any]], [[6o1s]] – hKLK light chain (mutant) + inhibitor <br />		**[[5tjx]], [[2anw]], [[2any]], [[6o1s]] – hKLK light chain (mutant) + inhibitor <br />
-	**[[5gvt]] – mKLK ~~light chain~~ (mutant) + <br />	+	**[[5gvt]] – mKLK protease domain (mutant) <br />
		+	**[[6a8o]] – mKLK protease domain + inhibitor<br />

	*Tissue kallikrein (KLK 1)		*Tissue kallikrein (KLK 1)

Alexander Berchansky at 10:37, 1 July 2019

Alexander Berchansky — Mon, 01 Jul 2019 10:37:22 GMT

←Older revision		Revision as of 10:37, 1 July 2019
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	== Structural highlights ==		== Structural highlights ==
-	KLK being a serine protease contains the <scene name='59/595822/Cv/4'>Ser, His, Asp catalytic triad and the Gly, Ser oxyanion hole</scene><ref>PMID:16950394</ref>. Water molecules shown as red spheres.	+	KLK being a serine protease contains the <scene name='59/595822/Cv/5'>Ser, His, Asp catalytic triad and the Gly, Ser oxyanion hole</scene><ref>PMID:16950394</ref>. Water molecules shown as red spheres.
	</StructureSection>		</StructureSection>

Joel L. Sussman at 19:49, 19 March 2019

Joel L. Sussman — Tue, 19 Mar 2019 19:49:40 GMT

←Older revision		Revision as of 19:49, 19 March 2019
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	**[[5f8t]] – hKLK light chain (mutant) + Pkalin-2 <br />		**[[5f8t]] – hKLK light chain (mutant) + Pkalin-2 <br />
	**[[5f8x]] – hKLK light chain (mutant) + Pkalin-3 <br />		**[[5f8x]] – hKLK light chain (mutant) + Pkalin-3 <br />
-	**[[5tjx]], [[2anw]], [[2any]], [[~~5tz9~~]] – hKLK light chain (mutant) + inhibitor <br />	+	**[[5tjx]], [[2anw]], [[2any]], [[6o1s]] – hKLK light chain (mutant) + inhibitor <br />
	**[[5gvt]] – mKLK light chain (mutant) + <br />		**[[5gvt]] – mKLK light chain (mutant) + <br />

Joel L. Sussman at 07:03, 25 July 2018

Joel L. Sussman — Wed, 25 Jul 2018 07:03:46 GMT

←Older revision		Revision as of 07:03, 25 July 2018
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-	<StructureSection load='~~2bdh~~' size='340' side='right' caption='Structure of human kallikrein 4 complex with p-aminobenzamidine and Zn+2 ion (grey) (PDB code [[2bdh]])' scene='59/595822/Cv/1'>	+	<StructureSection load='' size='340' side='right' caption='Structure of human kallikrein 4 complex with p-aminobenzamidine and Zn+2 ion (grey) (PDB code [[2bdh]])' scene='59/595822/Cv/1'>

	== Function ==		== Function ==

Michal Harel at 09:20, 24 July 2018

Michal Harel — Tue, 24 Jul 2018 09:20:01 GMT

←Older revision		Revision as of 09:20, 24 July 2018
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	*'''KLK5''' and '''KLK7''' regulate cell shedding.<br />		*'''KLK5''' and '''KLK7''' regulate cell shedding.<br />
	*'''KLK6''' regulates immune cells survival.<br />		*'''KLK6''' regulates immune cells survival.<br />
		+	*'''KLK8''' is involved inproteolytic cascade in the skin.<br />
	*'''plasma KLK''' cleaves Arg and Lys in kininogen to release bradykinin.<br />		*'''plasma KLK''' cleaves Arg and Lys in kininogen to release bradykinin.<br />
	*'''Tissue KLK''' is expressed throughout the body.<br />		*'''Tissue KLK''' is expressed throughout the body.<br />

	== Disease ==		== Disease ==
-	Activation of the plasma KLK pathway may contribute to diabetic macular edema<ref>PMID:20535647</ref>. KLK6 is implicated in carcinogenesis, Alzheimer and Parkinson diseases<ref>PMID:16800739</ref>.<br />.	+	Activation of the plasma KLK pathway may contribute to diabetic macular edema<ref>PMID:20535647</ref>. KLK6 is implicated in carcinogenesis, Alzheimer and Parkinson diseases<ref>PMID:16800739</ref>. KLK8 processes papilloma virus fascilitating their entry to host cells<ref>PMID:25926655</ref>.<br />.

	== Structural highlights ==		== Structural highlights ==
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	**[[1l2e]], [[1lo6]] – hKLK + inhibitor <br />		**[[1l2e]], [[1lo6]] – hKLK + inhibitor <br />
	**[[3vfe]], [[4d8n]] – hKLK (mutant) + inhibitor <br />		**[[3vfe]], [[4d8n]] – hKLK (mutant) + inhibitor <br />
		+	**[[5nx1]], [[5nx3]] – hKLK + amyloid-b A4 protein<br />

	*Kallikrein 7		*Kallikrein 7
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	**[[3bsq]] – hKLK <br />		**[[3bsq]] – hKLK <br />
	**[[2qxg]], [[2qxh]], [[2qxi]], [[2qxj]] – hKLK + chymotriptic determinant <br />		**[[2qxg]], [[2qxh]], [[2qxi]], [[2qxj]] – hKLK + chymotriptic determinant <br />
-	**[[5fah]] – hKLK + inhibitor<br />	+	**[[5fah]], [[5y9l]], [[5yjk]] – hKLK + inhibitor<br />
		+	**[[5zfh]] – mKLK - mouse<br />
		+	**[[5zfi]] – mKLK + inhibitor<br />
		+
		+	*Kallikrein 8
		+
		+	**[[5ms3]] – hKLK <br />
		+	**[[5ms4]] – hKLK + inhibitor<br />

	*Kallikrein 10		*Kallikrein 10
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	**[[5f8t]] – hKLK light chain (mutant) + Pkalin-2 <br />		**[[5f8t]] – hKLK light chain (mutant) + Pkalin-2 <br />
	**[[5f8x]] – hKLK light chain (mutant) + Pkalin-3 <br />		**[[5f8x]] – hKLK light chain (mutant) + Pkalin-3 <br />
-	**[[5tjx]], [[2anw]], [[2any]] – hKLK light chain (mutant) + inhibitor <br />	+	**[[5tjx]], [[2anw]], [[2any]], [[5tz9]] – hKLK light chain (mutant) + inhibitor <br />
		+	**[[5gvt]] – mKLK light chain (mutant) + <br />

	*Tissue kallikrein (KLK 1)		*Tissue kallikrein (KLK 1)

Michal Harel at 10:06, 27 June 2017

Michal Harel — Tue, 27 Jun 2017 10:06:32 GMT

←Older revision		Revision as of 10:06, 27 June 2017
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	**[[4nfe]] – hKLK + inhibitor - human <br />		**[[4nfe]] – hKLK + inhibitor - human <br />
		+	**[[4nff]] – hKLK + PPACK <br />

	*Kallikrein 4		*Kallikrein 4
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	**[[3bsq]] – hKLK <br />		**[[3bsq]] – hKLK <br />
	**[[2qxg]], [[2qxh]], [[2qxi]], [[2qxj]] – hKLK + chymotriptic determinant <br />		**[[2qxg]], [[2qxh]], [[2qxi]], [[2qxj]] – hKLK + chymotriptic determinant <br />
		+	**[[5fah]] – hKLK + inhibitor<br />
		+
		+	*Kallikrein 10
		+
		+	**[[5lpf]] – hKLK <br />
		+	**[[5lpe]] – hKLK + Zn<br />

	*Kallikrein 13		*Kallikrein 13
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	*Plasma kallikrein		*Plasma kallikrein

-	**[[~~2anw~~]], [[~~2any~~]] – hKLK ~~catalytic domain~~ (mutant) + ~~benzamidine~~ <br />	+	**[[4ogx]], [[4ogy]] – hKLK light chain (mutant) + antibody <br />
-	**[[~~4ogx~~]], [[~~4ogy~~]] – hKLK ~~catalytic domain~~ (mutant) + ~~antibody~~ <br />	+	**[[5f8z]] – hKLK light chain (mutant) + Pkalin-1 <br />
		+	**[[5f8t]] – hKLK light chain (mutant) + Pkalin-2 <br />
		+	**[[5f8x]] – hKLK light chain (mutant) + Pkalin-3 <br />
		+	**[[5tjx]], [[2anw]], [[2any]] – hKLK light chain (mutant) + inhibitor <br />

	*Tissue kallikrein (KLK 1)		*Tissue kallikrein (KLK 1)

Alexander Berchansky at 12:22, 10 April 2016

Alexander Berchansky — Sun, 10 Apr 2016 12:22:05 GMT

←Older revision		Revision as of 12:22, 10 April 2016
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	== Structural highlights ==		== Structural highlights ==
-	KLK being a serine protease contains the Ser, His, Asp catalytic triad and the Gly, Ser oxyanion hole<ref>PMID:16950394</ref>.	+	KLK being a serine protease contains the <scene name='59/595822/Cv/4'>Ser, His, Asp catalytic triad and the Gly, Ser oxyanion hole</scene><ref>PMID:16950394</ref>. Water molecules shown as red spheres.
	</StructureSection>		</StructureSection>

Alexander Berchansky at 12:03, 10 April 2016

Alexander Berchansky — Sun, 10 Apr 2016 12:03:30 GMT

←Older revision		Revision as of 12:03, 10 April 2016
Line 1:		Line 1:
-	<StructureSection load='2bdh' size='340' side='right' caption='Structure of human kallikrein 4 complex with p-aminobenzamidine and Zn+2 ion (grey) (PDB code [[2bdh]])' scene=''>	+	<StructureSection load='2bdh' size='340' side='right' caption='Structure of human kallikrein 4 complex with p-aminobenzamidine and Zn+2 ion (grey) (PDB code [[2bdh]])' scene='59/595822/Cv/1'>

	== Function ==		== Function ==

Michal Harel at 08:19, 6 April 2016

Michal Harel — Wed, 06 Apr 2016 08:19:50 GMT

←Older revision		Revision as of 08:19, 6 April 2016
Line 9:		Line 9:
	*'''KLK5''' and '''KLK7''' regulate cell shedding.<br />		*'''KLK5''' and '''KLK7''' regulate cell shedding.<br />
	*'''KLK6''' regulates immune cells survival.<br />		*'''KLK6''' regulates immune cells survival.<br />
		+	*'''plasma KLK''' cleaves Arg and Lys in kininogen to release bradykinin.<br />
		+	*'''Tissue KLK''' is expressed throughout the body.<br />

	== Disease ==		== Disease ==