Kelch-like protein - Revision history

Michal Harel at 09:56, 8 September 2019

Michal Harel — Sun, 08 Sep 2019 09:56:37 GMT

←Older revision		Revision as of 09:56, 8 September 2019
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	== Function ==		== Function ==
	'''Kelch-like proteins''' (KLHL) contain multiple Kelch motifs. This motif is about 50 residues long and forms a four-stranded β-sheet blade. <scene name='70/706701/Cv/6'>Six to eight such blades form a circular β-propeller domain</scene>. β-propellers are involved in protein-protein interactions. The N-terminal of KLHL contains other protein domains like BTB (Broad-Tramtrack-Bric-a-brac) which is also involved in protein-protein interactions<ref>PMID:23676014</ref>.<br />		'''Kelch-like proteins''' (KLHL) contain multiple Kelch motifs. This motif is about 50 residues long and forms a four-stranded β-sheet blade. <scene name='70/706701/Cv/6'>Six to eight such blades form a circular β-propeller domain</scene>. β-propellers are involved in protein-protein interactions. The N-terminal of KLHL contains other protein domains like BTB (Broad-Tramtrack-Bric-a-brac) which is also involved in protein-protein interactions<ref>PMID:23676014</ref>.<br />
-	*'''KLHL1''' may play a role in organizing the actin cytoskeleton in brain cells.<br />
	*'''KLHL2''' '''KLHL11''' is a component of the cullin-RING based E3 ubiquitin-protein ligase system.<br />		*'''KLHL2''' '''KLHL11''' is a component of the cullin-RING based E3 ubiquitin-protein ligase system.<br />
	*'''KLHL3''' and '''KLHL7''' '''KLHL10''' are substrate-specific adapters of the cullin-RING based E3 ubiquitin-protein ligase system.<br />		*'''KLHL3''' and '''KLHL7''' '''KLHL10''' are substrate-specific adapters of the cullin-RING based E3 ubiquitin-protein ligase system.<br />

Michal Harel at 09:53, 8 September 2019

Michal Harel — Sun, 08 Sep 2019 09:53:11 GMT

←Older revision		Revision as of 09:53, 8 September 2019
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	</StructureSection>		</StructureSection>
-
-	== 3D Structures of Kelch-like protein ==
-
-	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-	{{#tree:id=OrganizedByTopic\|openlevels=0\|
-
-	*Kelch-like protein 2
-
-	**[[2xn4]] – hKLHL2 Kelch domain - human <br />
-
-	*Kelch-like protein 3
-
-	**[[4chb]], [[4ch9]], [[5nkp]] – hKLHL3 Kelch domain + serine/threonine protein kinas WNK4 peptide <br />
-	**[[4hxi]] – hKLHL3 BTB-BACK domain (mutant) + cullin-3 N terminal <br />
-
-	*Kelch-like protein 4
-
-	**[[2eqx]] – hKLHL4 BACK domain - NMR <br />
-
-	*Kelch-like protein 5
-
-	**[[4asc]] – hKLHL5 Kelch domain <br />
-
-	*Kelch-like protein 7
-
-	**[[3ii7]] – hKLHL7 Kelch domain <br />
-
-	*Kelch-like protein 10
-
-	**[[2woz]] – KLHL10 Kelch domain - rat <br />
-
-	*Kelch-like protein 11
-
-	**[[3i3n]] – hKLHL11 BTB-BACK domain <br />
-	**[[4ap2]], [[4apf]] – hKLHL11 BTB-BACK domain + cullin-3 N terminal <br />
-
-	*Kelch-like protein 12
-
-	**[[2vpj]] – hKLHL12 Kelch domain <br />
-
-	*Kelch-like protein 16 (gigaxonin)
-
-	**[[3hve]] – hKLHL16 <br />
-	**[[2ppi]] – hKLHL16 BTB domain <br />
-
-	*Kelch-like protein 17 (actinfilin)
-
-	**[[6hrl]] – hKLHL17 <br />
-
-	*Kelch-like protein 19 (kelch-like ECH-associated protein 1; Keap1)); domains: BTB 48-140; kelch 320-812
-
-	**[[1u6d]], [[1zgk]], [[4ifj]], [[6rog]] – hKeap1 Kelch domain <br />
-	**[[3zgd]], [[5wfl]] – hKeap1 Kelch domain (mutant) <br />
-	**[[4cxi]], [[4cxj]] – hKeap1 BTB domain (mutant) <br />
-	**[[1x2j]] – mKeap1 Kelch domain <br />
-
-	*Keap1 complex with peptide
-
-	**[[4ifl]], [[2flu]], [[3zgc]] – hKeap1 Kelch domain + NRF2 Neh2 peptide <br />
-	**[[5wfv]], [[5wg1]] – hKeap1 Kelch domain (mutant) + NRF2 peptide <br />
-	**[[6fmp]], [[6fmq]] – hKeap1 Kelch domain + peptide <br />
-	**[[5f72]] – hKeap1 Kelch domain + antibody <br />
-	**[[5x54]] – hKeap1 Kelch domain + tetrapeptide <br />
-	**[[5nlb]] – hKLHL1 BTB+ 3-BOX domains + CUL-3 <br />
-	**[[4xmb]] – hKLHL1 Kelch domain + NRF2 activator <br />
-	**[[5cgj]] – mKLHL1 Kelch domain + NRF2 activator - mouse <br />
-	**[[1x2r]] – mKeap1 Kelch domain + NRF2 Neh2 peptide <br />
-	**[[2z32]] – mKeap1 Kelch domain + prothymosin a peptide <br />
-	**[[3ade]], [[3wdz]] – mKeap1 Kelch domain + sequestosome-1 peptide <br />
-	**[[2dyh]] – mKeap1 Kelch domain + NRF2 residues 22-36 <br />
-	**[[3wn7]] – mKeap1 Kelch domain + NRF2 residues 17-51 <br />
-
-	*Keap1 complex with small molecule
-
-	**[[3vng]], [[3vnh]] – hKeap1 Kelch domain + oxadiazole derivative <br />
-	**[[4ifn]] – hKeap1 Kelch domain + quinoline derivative <br />
-	**[[4l7b]], [[4l7c]], [[4l7d]] [[4n1b]] – hKeap1 Kelch domain (mutant) + quinoline derivative <br />
-	**[[4in4]], [[4zy3]], [[5fnq]], [[5fnr]], [[5fns]], [[5fnt]], [[5fnu]], [[5fzj]], [[5fzn]] – hKeap1 Kelch domain + inhibitor <br />
-	**[[4iqk]], [[4n1b]], [[5wiy]], [[5whl]], [[5who]] – hKeap1 Kelch domain (mutant) + inhibitor <br />
-	**[[4cxt]] – hKeap1 BTB domain (mutant) + antagonist<br />
-	**[[5dad]], [[5daf]] – hKeap1 BTB domain + activator <br />
-	**[[5git]] – hKeap1 BTB domain + inhibitor <br />
-	**[[6qmc]], [[6qmd]], [[6qme]], [[6qmj]], [[6qmk]] – mKeap1 Kelch domain + inhibitor <br />
-
-	*Kelch-like protein 20
-
-	**[[5yq4]] – hKLHL20 kelch domain <br />
-	**[[6gy5]] – hKLHL20 kelch domain + DAPK1 peptide <br />
-
-	}}
-
-

	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 09:51, 8 September 2019

Michal Harel — Sun, 08 Sep 2019 09:51:38 GMT

←Older revision		Revision as of 09:51, 8 September 2019
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	== Structural highlights ==		== Structural highlights ==
	The <scene name='70/706701/Cv/7'>interaction of Keap1 with Neh2 is through the first Glu in the latter's ETGE motif</scene><ref>PMID:16507366</ref>. <scene name='70/706701/Cv/8'>All interactions of Keap1 with Neh2</scene>. Water molecules shown as red spheres.		The <scene name='70/706701/Cv/7'>interaction of Keap1 with Neh2 is through the first Glu in the latter's ETGE motif</scene><ref>PMID:16507366</ref>. <scene name='70/706701/Cv/8'>All interactions of Keap1 with Neh2</scene>. Water molecules shown as red spheres.
		+
		+	== 3D Structures of Kelch-like protein ==
		+	[[Kelch-like protein 3D structures]]

	</StructureSection>		</StructureSection>
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	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}		Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
	{{#tree:id=OrganizedByTopic\|openlevels=0\|		{{#tree:id=OrganizedByTopic\|openlevels=0\|
-
-	*Kelch-like protein 1
-
-	**[[4xmb]] – hKLHL1 Kelch domain + NRF2 activator - human <br />
-	**[[5cgj]] – mKLHL1 Kelch domain + NRF2 activator - mouse <br />

	*Kelch-like protein 2		*Kelch-like protein 2

-	**[[2xn4]] – hKLHL2 Kelch domain <br />	+	**[[2xn4]] – hKLHL2 Kelch domain - human <br />

	*Kelch-like protein 3		*Kelch-like protein 3
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	**[[2ppi]] – hKLHL16 BTB domain <br />		**[[2ppi]] – hKLHL16 BTB domain <br />

-	*Kelch-like protein 19 (~~kelch-like ECH-associated protein 1; Keap1~~)	+	*Kelch-like protein 17 (actinfilin)

-	**[[1u6d]], [[1zgk]], [[4ifj]] – hKeap1 Kelch domain <br />	+	**[[6hrl]] – hKLHL17 <br />
-	**[[3zgd]] – hKeap1 Kelch domain (mutant) <br />	+
		+	*Kelch-like protein 19 (kelch-like ECH-associated protein 1; Keap1)); domains: BTB 48-140; kelch 320-812
		+
		+	**[[1u6d]], [[1zgk]], [[4ifj]], [[6rog]] – hKeap1 Kelch domain <br />
		+	**[[3zgd]], [[5wfl]] – hKeap1 Kelch domain (mutant) <br />
	**[[4cxi]], [[4cxj]] – hKeap1 BTB domain (mutant) <br />		**[[4cxi]], [[4cxj]] – hKeap1 BTB domain (mutant) <br />
	**[[1x2j]] – mKeap1 Kelch domain <br />		**[[1x2j]] – mKeap1 Kelch domain <br />
Line 78:		Line 80:
	*Keap1 complex with peptide		*Keap1 complex with peptide

		+	**[[4ifl]], [[2flu]], [[3zgc]] – hKeap1 Kelch domain + NRF2 Neh2 peptide <br />
		+	**[[5wfv]], [[5wg1]] – hKeap1 Kelch domain (mutant) + NRF2 peptide <br />
		+	**[[6fmp]], [[6fmq]] – hKeap1 Kelch domain + peptide <br />
		+	**[[5f72]] – hKeap1 Kelch domain + antibody <br />
		+	**[[5x54]] – hKeap1 Kelch domain + tetrapeptide <br />
		+	**[[5nlb]] – hKLHL1 BTB+ 3-BOX domains + CUL-3 <br />
		+	**[[4xmb]] – hKLHL1 Kelch domain + NRF2 activator <br />
		+	**[[5cgj]] – mKLHL1 Kelch domain + NRF2 activator - mouse <br />
	**[[1x2r]] – mKeap1 Kelch domain + NRF2 Neh2 peptide <br />		**[[1x2r]] – mKeap1 Kelch domain + NRF2 Neh2 peptide <br />
	**[[2z32]] – mKeap1 Kelch domain + prothymosin a peptide <br />		**[[2z32]] – mKeap1 Kelch domain + prothymosin a peptide <br />
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	**[[2dyh]] – mKeap1 Kelch domain + NRF2 residues 22-36 <br />		**[[2dyh]] – mKeap1 Kelch domain + NRF2 residues 22-36 <br />
	**[[3wn7]] – mKeap1 Kelch domain + NRF2 residues 17-51 <br />		**[[3wn7]] – mKeap1 Kelch domain + NRF2 residues 17-51 <br />
-	**[[4ifl]], [[2flu]], [[3zgc]] – hKeap1 Kelch domain + NRF2 Neh2 peptide <br />
-	**[[5nlb]] – hKeap1 BTB+ 3-BOX domains + CUL-3 <br />
-	**[[5f72]] – hKLHL1 Kelch domain + antibody <br />
-	**[[5x54]] – hKLHL1 Kelch domain + tetrapeptide <br />

	*Keap1 complex with small molecule		*Keap1 complex with small molecule
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	**[[4l7b]], [[4l7c]], [[4l7d]] [[4n1b]] – hKeap1 Kelch domain (mutant) + quinoline derivative <br />		**[[4l7b]], [[4l7c]], [[4l7d]] [[4n1b]] – hKeap1 Kelch domain (mutant) + quinoline derivative <br />
	**[[4in4]], [[4zy3]], [[5fnq]], [[5fnr]], [[5fns]], [[5fnt]], [[5fnu]], [[5fzj]], [[5fzn]] – hKeap1 Kelch domain + inhibitor <br />		**[[4in4]], [[4zy3]], [[5fnq]], [[5fnr]], [[5fns]], [[5fnt]], [[5fnu]], [[5fzj]], [[5fzn]] – hKeap1 Kelch domain + inhibitor <br />
-	**[[4iqk]], [[4n1b]] – hKeap1 Kelch domain (mutant) + inhibitor <br />	+	**[[4iqk]], [[4n1b]], [[5wiy]], [[5whl]], [[5who]] – hKeap1 Kelch domain (mutant) + inhibitor <br />
	**[[4cxt]] – hKeap1 BTB domain (mutant) + antagonist<br />		**[[4cxt]] – hKeap1 BTB domain (mutant) + antagonist<br />
	**[[5dad]], [[5daf]] – hKeap1 BTB domain + activator <br />		**[[5dad]], [[5daf]] – hKeap1 BTB domain + activator <br />
		+	**[[5git]] – hKeap1 BTB domain + inhibitor <br />
		+	**[[6qmc]], [[6qmd]], [[6qme]], [[6qmj]], [[6qmk]] – mKeap1 Kelch domain + inhibitor <br />
		+
		+	*Kelch-like protein 20
		+
		+	**[[5yq4]] – hKLHL20 kelch domain <br />
		+	**[[6gy5]] – hKLHL20 kelch domain + DAPK1 peptide <br />

	}}		}}

Alexander Berchansky at 10:50, 1 July 2019

Alexander Berchansky — Mon, 01 Jul 2019 10:50:27 GMT

←Older revision		Revision as of 10:50, 1 July 2019
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	<StructureSection load='' size='450' side='right' caption='Human Kelch-like protein 1 (Keap1) Kelch domain (cyan) complex with NRF2 Neh2 peptide (green) and sulfate (PDB code [[1x2r]])' scene='70/706701/Cv/1'>		<StructureSection load='' size='450' side='right' caption='Human Kelch-like protein 1 (Keap1) Kelch domain (cyan) complex with NRF2 Neh2 peptide (green) and sulfate (PDB code [[1x2r]])' scene='70/706701/Cv/1'>
	== Function ==		== Function ==
-	'''Kelch-like proteins''' (KLHL) contain multiple Kelch motifs. This motif is about 50 residues long and forms a four-stranded β-sheet blade. <scene name='70/706701/Cv/2'>Six to eight such blades form a circular β-propeller domain</scene>. β-propellers are involved in protein-protein interactions. The N-terminal of KLHL contains other protein domains like BTB (Broad-Tramtrack-Bric-a-brac) which is also involved in protein-protein interactions<ref>PMID:23676014</ref>.<br />	+	'''Kelch-like proteins''' (KLHL) contain multiple Kelch motifs. This motif is about 50 residues long and forms a four-stranded β-sheet blade. <scene name='70/706701/Cv/6'>Six to eight such blades form a circular β-propeller domain</scene>. β-propellers are involved in protein-protein interactions. The N-terminal of KLHL contains other protein domains like BTB (Broad-Tramtrack-Bric-a-brac) which is also involved in protein-protein interactions<ref>PMID:23676014</ref>.<br />
	*'''KLHL1''' may play a role in organizing the actin cytoskeleton in brain cells.<br />		*'''KLHL1''' may play a role in organizing the actin cytoskeleton in brain cells.<br />
	*'''KLHL2''' '''KLHL11''' is a component of the cullin-RING based E3 ubiquitin-protein ligase system.<br />		*'''KLHL2''' '''KLHL11''' is a component of the cullin-RING based E3 ubiquitin-protein ligase system.<br />
Line 16:		Line 16:

	== Structural highlights ==		== Structural highlights ==
-	The <scene name='70/706701/Cv/5'>interaction of Keap1 with Neh2 is through the first Glu in the latter's ETGE motif</scene><ref>PMID:16507366</ref>. <scene name='70/706701/Cv/3'>All interactions of Keap1 with Neh2</scene>. Water molecules shown as red spheres.	+	The <scene name='70/706701/Cv/7'>interaction of Keap1 with Neh2 is through the first Glu in the latter's ETGE motif</scene><ref>PMID:16507366</ref>. <scene name='70/706701/Cv/8'>All interactions of Keap1 with Neh2</scene>. Water molecules shown as red spheres.

	</StructureSection>		</StructureSection>

Joel L. Sussman at 16:12, 20 October 2017

Joel L. Sussman — Fri, 20 Oct 2017 16:12:48 GMT

←Older revision		Revision as of 16:12, 20 October 2017
Line 1:		Line 1:
-	<StructureSection load='~~1x2r~~' size='450' side='right' caption='Human Kelch-like protein 1 (Keap1) Kelch domain (cyan) complex with NRF2 Neh2 peptide (green) and sulfate (PDB code [[1x2r]])' scene='70/706701/Cv/1'>	+	<StructureSection load='' size='450' side='right' caption='Human Kelch-like protein 1 (Keap1) Kelch domain (cyan) complex with NRF2 Neh2 peptide (green) and sulfate (PDB code [[1x2r]])' scene='70/706701/Cv/1'>
	== Function ==		== Function ==
	'''Kelch-like proteins''' (KLHL) contain multiple Kelch motifs. This motif is about 50 residues long and forms a four-stranded β-sheet blade. <scene name='70/706701/Cv/2'>Six to eight such blades form a circular β-propeller domain</scene>. β-propellers are involved in protein-protein interactions. The N-terminal of KLHL contains other protein domains like BTB (Broad-Tramtrack-Bric-a-brac) which is also involved in protein-protein interactions<ref>PMID:23676014</ref>.<br />		'''Kelch-like proteins''' (KLHL) contain multiple Kelch motifs. This motif is about 50 residues long and forms a four-stranded β-sheet blade. <scene name='70/706701/Cv/2'>Six to eight such blades form a circular β-propeller domain</scene>. β-propellers are involved in protein-protein interactions. The N-terminal of KLHL contains other protein domains like BTB (Broad-Tramtrack-Bric-a-brac) which is also involved in protein-protein interactions<ref>PMID:23676014</ref>.<br />

Michal Harel at 13:23, 20 October 2017

Michal Harel — Fri, 20 Oct 2017 13:23:51 GMT

←Older revision		Revision as of 13:23, 20 October 2017
Line 104:		Line 104:
	== References ==		== References ==
	<references/>		<references/>
		+	[[Category:Topic Page]]

Michal Harel at 08:28, 28 June 2017

Michal Harel — Wed, 28 Jun 2017 08:28:24 GMT

←Older revision		Revision as of 08:28, 28 June 2017
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	*Kelch-like protein 3		*Kelch-like protein 3

-	**[[4chb]], [[4ch9]] – hKLHL3 Kelch domain + serine/threonine protein kinas WNK4 peptide <br />	+	**[[4chb]], [[4ch9]], [[5nkp]] – hKLHL3 Kelch domain + serine/threonine protein kinas WNK4 peptide <br />
	**[[4hxi]] – hKLHL3 BTB-BACK domain (mutant) + cullin-3 N terminal <br />		**[[4hxi]] – hKLHL3 BTB-BACK domain (mutant) + cullin-3 N terminal <br />

Line 84:		Line 84:
	**[[3wn7]] – mKeap1 Kelch domain + NRF2 residues 17-51 <br />		**[[3wn7]] – mKeap1 Kelch domain + NRF2 residues 17-51 <br />
	**[[4ifl]], [[2flu]], [[3zgc]] – hKeap1 Kelch domain + NRF2 Neh2 peptide <br />		**[[4ifl]], [[2flu]], [[3zgc]] – hKeap1 Kelch domain + NRF2 Neh2 peptide <br />
		+	**[[5nlb]] – hKeap1 BTB+ 3-BOX domains + CUL-3 <br />
		+	**[[5f72]] – hKLHL1 Kelch domain + antibody <br />
		+	**[[5x54]] – hKLHL1 Kelch domain + tetrapeptide <br />

	*Keap1 complex with small molecule		*Keap1 complex with small molecule
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	**[[4ifn]] – hKeap1 Kelch domain + quinoline derivative <br />		**[[4ifn]] – hKeap1 Kelch domain + quinoline derivative <br />
	**[[4l7b]], [[4l7c]], [[4l7d]] [[4n1b]] – hKeap1 Kelch domain (mutant) + quinoline derivative <br />		**[[4l7b]], [[4l7c]], [[4l7d]] [[4n1b]] – hKeap1 Kelch domain (mutant) + quinoline derivative <br />
-	**[[4in4]] – hKeap1 Kelch domain + inhibitor <br />	+	**[[4in4]], [[4zy3]], [[5fnq]], [[5fnr]], [[5fns]], [[5fnt]], [[5fnu]], [[5fzj]], [[5fzn]] – hKeap1 Kelch domain + inhibitor <br />
-	**[[4iqk]] – hKeap1 Kelch domain (mutant) + inhibitor <br />	+	**[[4iqk]], [[4n1b]] – hKeap1 Kelch domain (mutant) + inhibitor <br />
	**[[4cxt]] – hKeap1 BTB domain (mutant) + antagonist<br />		**[[4cxt]] – hKeap1 BTB domain (mutant) + antagonist<br />
		+	**[[5dad]], [[5daf]] – hKeap1 BTB domain + activator <br />

	}}		}}

Alexander Berchansky at 11:30, 14 April 2016

Alexander Berchansky — Thu, 14 Apr 2016 11:30:46 GMT

←Older revision		Revision as of 11:30, 14 April 2016
Line 16:		Line 16:

	== Structural highlights ==		== Structural highlights ==
-	The <scene name='70/706701/Cv/5'>interaction of Keap1 with Neh2 is through the first Glu in the latter's ETGE ~~motifd~~</scene><ref>PMID:16507366</ref>. <scene name='70/706701/Cv/3'>All interactions of Keap1 with Neh2</scene>. Water molecules shown as red spheres.	+	The <scene name='70/706701/Cv/5'>interaction of Keap1 with Neh2 is through the first Glu in the latter's ETGE motif</scene><ref>PMID:16507366</ref>. <scene name='70/706701/Cv/3'>All interactions of Keap1 with Neh2</scene>. Water molecules shown as red spheres.

	</StructureSection>		</StructureSection>

Alexander Berchansky at 11:29, 14 April 2016

Alexander Berchansky — Thu, 14 Apr 2016 11:29:40 GMT

←Older revision		Revision as of 11:29, 14 April 2016
Line 16:		Line 16:

	== Structural highlights ==		== Structural highlights ==
-	The interaction of Keap1 with Neh2 is through the first Glu in the latter's ETGE ~~motif~~<ref>PMID:16507366</ref>.	+	The <scene name='70/706701/Cv/5'>interaction of Keap1 with Neh2 is through the first Glu in the latter's ETGE motifd</scene><ref>PMID:16507366</ref>. <scene name='70/706701/Cv/3'>All interactions of Keap1 with Neh2</scene>. Water molecules shown as red spheres.

	</StructureSection>		</StructureSection>

Alexander Berchansky at 10:58, 14 April 2016

Alexander Berchansky — Thu, 14 Apr 2016 10:58:00 GMT

←Older revision		Revision as of 10:58, 14 April 2016
Line 1:		Line 1:
	<StructureSection load='1x2r' size='450' side='right' caption='Human Kelch-like protein 1 (Keap1) Kelch domain (cyan) complex with NRF2 Neh2 peptide (green) and sulfate (PDB code [[1x2r]])' scene='70/706701/Cv/1'>		<StructureSection load='1x2r' size='450' side='right' caption='Human Kelch-like protein 1 (Keap1) Kelch domain (cyan) complex with NRF2 Neh2 peptide (green) and sulfate (PDB code [[1x2r]])' scene='70/706701/Cv/1'>
	== Function ==		== Function ==
-	'''Kelch-like proteins''' (KLHL) contain multiple Kelch motifs. This motif is about 50 residues long and forms a four-stranded β-sheet blade. Six to eight such blades form a circular β-propeller domain. β-propellers are involved in protein-protein interactions. The N-terminal of KLHL contains other protein domains like BTB (Broad-Tramtrack-Bric-a-brac) which is also involved in protein-protein interactions<ref>PMID:23676014</ref>.<br />	+	'''Kelch-like proteins''' (KLHL) contain multiple Kelch motifs. This motif is about 50 residues long and forms a four-stranded β-sheet blade. <scene name='70/706701/Cv/2'>Six to eight such blades form a circular β-propeller domain</scene>. β-propellers are involved in protein-protein interactions. The N-terminal of KLHL contains other protein domains like BTB (Broad-Tramtrack-Bric-a-brac) which is also involved in protein-protein interactions<ref>PMID:23676014</ref>.<br />
	*'''KLHL1''' may play a role in organizing the actin cytoskeleton in brain cells.<br />		*'''KLHL1''' may play a role in organizing the actin cytoskeleton in brain cells.<br />
	*'''KLHL2''' '''KLHL11''' is a component of the cullin-RING based E3 ubiquitin-protein ligase system.<br />		*'''KLHL2''' '''KLHL11''' is a component of the cullin-RING based E3 ubiquitin-protein ligase system.<br />