Kelch-like protein 3D structures - Revision history

Michal Harel at 07:19, 13 June 2023

Michal Harel — Tue, 13 Jun 2023 07:19:55 GMT

Michal Harel at 06:40, 12 October 2021

Michal Harel — Tue, 12 Oct 2021 06:40:03 GMT

Michal Harel at 09:37, 30 August 2020

Michal Harel — Sun, 30 Aug 2020 09:37:57 GMT

←Older revision		Revision as of 09:37, 30 August 2020
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	**[[3vng]], [[3vnh]], [[6ffm]] – hKeap1 Kelch domain + oxadiazole derivative <br />		**[[3vng]], [[3vnh]], [[6ffm]] – hKeap1 Kelch domain + oxadiazole derivative <br />
-	**[[4ifn]], [[6tym]], [[6typ]], [[6v6z] – hKeap1 Kelch domain + quinoline derivative <br />	+	**[[4ifn]], [[6tym]], [[6typ]], [[6v6z]] – hKeap1 Kelch domain + quinoline derivative <br />
	**[[4l7b]], [[4l7c]], [[4l7d]] [[4n1b]], [[6uf0]] – hKeap1 Kelch domain (mutant) + quinoline derivative <br />		**[[4l7b]], [[4l7c]], [[4l7d]] [[4n1b]], [[6uf0]] – hKeap1 Kelch domain (mutant) + quinoline derivative <br />
	**[[4in4]], [[4zy3]], [[5fnq]], [[5fnr]], [[5fns]], [[5fnt]], [[5fnu]], [[5fzj]], [[5fzn]], [[6hws]], [[6sp1]], [[6sp4]] – hKeap1 Kelch domain + inhibitor <br />		**[[4in4]], [[4zy3]], [[5fnq]], [[5fnr]], [[5fns]], [[5fnt]], [[5fnu]], [[5fzj]], [[5fzn]], [[6hws]], [[6sp1]], [[6sp4]] – hKeap1 Kelch domain + inhibitor <br />

Michal Harel at 09:37, 30 August 2020

Michal Harel — Sun, 30 Aug 2020 09:37:21 GMT

←Older revision		Revision as of 09:37, 30 August 2020
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	**[[2vpj]] – hKLHL12 Kelch domain <br />		**[[2vpj]] – hKLHL12 Kelch domain <br />
		+	**[[6ttk]], [[6v7o]] – hKLHL12 Kelch domain + peptide <br />

	*Kelch-like protein 16 (gigaxonin)		*Kelch-like protein 16 (gigaxonin)
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	**[[1u6d]], [[1zgk]], [[4ifj]], [[6rog]] – hKeap1 Kelch domain <br />		**[[1u6d]], [[1zgk]], [[4ifj]], [[6rog]] – hKeap1 Kelch domain <br />
	**[[3zgd]], [[5wfl]] – hKeap1 Kelch domain (mutant) <br />		**[[3zgd]], [[5wfl]] – hKeap1 Kelch domain (mutant) <br />
-	**[[4cxi]], [[4cxj]] – hKeap1 BTB domain (mutant) <br />	+	**[[4cxi]], [[4cxj]], [[6w68]], [[6w69]] – hKeap1 BTB domain (mutant) <br />
	**[[1x2j]] – mKeap1 Kelch domain <br />		**[[1x2j]] – mKeap1 Kelch domain <br />

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	*Keap1 complex with small molecule		*Keap1 complex with small molecule

-	**[[3vng]], [[3vnh]] – hKeap1 Kelch domain + oxadiazole derivative <br />	+	**[[3vng]], [[3vnh]], [[6ffm]] – hKeap1 Kelch domain + oxadiazole derivative <br />
-	**[[4ifn]] – hKeap1 Kelch domain + quinoline derivative <br />	+	**[[4ifn]], [[6tym]], [[6typ]], [[6v6z] – hKeap1 Kelch domain + quinoline derivative <br />
-	**[[4l7b]], [[4l7c]], [[4l7d]] [[4n1b]] – hKeap1 Kelch domain (mutant) + quinoline derivative <br />	+	**[[4l7b]], [[4l7c]], [[4l7d]] [[4n1b]], [[6uf0]] – hKeap1 Kelch domain (mutant) + quinoline derivative <br />
-	**[[4in4]], [[4zy3]], [[5fnq]], [[5fnr]], [[5fns]], [[5fnt]], [[5fnu]], [[5fzj]], [[5fzn]] – hKeap1 Kelch domain + inhibitor <br />	+	**[[4in4]], [[4zy3]], [[5fnq]], [[5fnr]], [[5fns]], [[5fnt]], [[5fnu]], [[5fzj]], [[5fzn]], [[6hws]], [[6sp1]], [[6sp4]] – hKeap1 Kelch domain + inhibitor <br />
	**[[4iqk]], [[4n1b]], [[5wiy]], [[5whl]], [[5who]] – hKeap1 Kelch domain (mutant) + inhibitor <br />		**[[4iqk]], [[4n1b]], [[5wiy]], [[5whl]], [[5who]] – hKeap1 Kelch domain (mutant) + inhibitor <br />
-	**[[4cxt]] – hKeap1 BTB domain (mutant) + antagonist<br />
	**[[5dad]], [[5daf]] – hKeap1 BTB domain + activator <br />		**[[5dad]], [[5daf]] – hKeap1 BTB domain + activator <br />
	**[[5git]] – hKeap1 BTB domain + inhibitor <br />		**[[5git]] – hKeap1 BTB domain + inhibitor <br />
		+	**[[4cxt]] – hKeap1 BTB domain (mutant) + antagonist<br />
	**[[6qmc]], [[6qmd]], [[6qme]], [[6qmj]], [[6qmk]] – mKeap1 Kelch domain + inhibitor <br />		**[[6qmc]], [[6qmd]], [[6qme]], [[6qmj]], [[6qmk]] – mKeap1 Kelch domain + inhibitor <br />
		+
		+	*Keap1 complex with protein
		+
		+	**[[6w66]] – hKeap1 BTB domain (mutant) + SKP1 + FBXL17<br />
		+	**[[6wcq]] – hKeap1 BTB domain (mutant) + SKP1 + FBXL17 + cullin-1 – Cryo EM<br />

	*Kelch-like protein 20		*Kelch-like protein 20

Michal Harel: New page: == 3D Structures of Kelch-like protein == Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *Kelch-like protein 2 **...

Michal Harel — Sun, 08 Sep 2019 09:52:21 GMT

New page: == 3D Structures of Kelch-like protein == Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *Kelch-like protein 2 **...

New page

== 3D Structures of Kelch-like protein ==

Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|

*Kelch-like protein 2

**[[2xn4]] – hKLHL2 Kelch domain - human 

*Kelch-like protein 3

**[[4chb]], [[4ch9]], [[5nkp]] – hKLHL3 Kelch domain + serine/threonine protein kinas WNK4 peptide 
**[[4hxi]] – hKLHL3 BTB-BACK domain (mutant) + cullin-3 N terminal 

*Kelch-like protein 4

**[[2eqx]] – hKLHL4 BACK domain - NMR 

*Kelch-like protein 5

**[[4asc]] – hKLHL5 Kelch domain 

*Kelch-like protein 7

**[[3ii7]] – hKLHL7 Kelch domain 

*Kelch-like protein 10

**[[2woz]] – KLHL10 Kelch domain - rat 

*Kelch-like protein 11

**[[3i3n]] – hKLHL11 BTB-BACK domain 
**[[4ap2]], [[4apf]] – hKLHL11 BTB-BACK domain + cullin-3 N terminal 

*Kelch-like protein 12

**[[2vpj]] – hKLHL12 Kelch domain 

*Kelch-like protein 16 (gigaxonin)

**[[3hve]] – hKLHL16 
**[[2ppi]] – hKLHL16 BTB domain 

*Kelch-like protein 17 (actinfilin)

**[[6hrl]] – hKLHL17 

*Kelch-like protein 19 (kelch-like ECH-associated protein 1; Keap1)); domains: BTB 48-140; kelch 320-812

**[[1u6d]], [[1zgk]], [[4ifj]], [[6rog]] – hKeap1 Kelch domain 
**[[3zgd]], [[5wfl]] – hKeap1 Kelch domain (mutant) 
**[[4cxi]], [[4cxj]] – hKeap1 BTB domain (mutant) 
**[[1x2j]] – mKeap1 Kelch domain 

*Keap1 complex with peptide

**[[4ifl]], [[2flu]], [[3zgc]] – hKeap1 Kelch domain + NRF2 Neh2 peptide 
**[[5wfv]], [[5wg1]] – hKeap1 Kelch domain (mutant) + NRF2 peptide 
**[[6fmp]], [[6fmq]] – hKeap1 Kelch domain + peptide 
**[[5f72]] – hKeap1 Kelch domain + antibody 
**[[5x54]] – hKeap1 Kelch domain + tetrapeptide 
**[[5nlb]] – hKLHL1 BTB+ 3-BOX domains + CUL-3 
**[[4xmb]] – hKLHL1 Kelch domain + NRF2 activator 
**[[5cgj]] – mKLHL1 Kelch domain + NRF2 activator - mouse 
**[[1x2r]] – mKeap1 Kelch domain + NRF2 Neh2 peptide 
**[[2z32]] – mKeap1 Kelch domain + prothymosin a peptide 
**[[3ade]], [[3wdz]] – mKeap1 Kelch domain + sequestosome-1 peptide 
**[[2dyh]] – mKeap1 Kelch domain + NRF2 residues 22-36 
**[[3wn7]] – mKeap1 Kelch domain + NRF2 residues 17-51 

*Keap1 complex with small molecule

**[[3vng]], [[3vnh]] – hKeap1 Kelch domain + oxadiazole derivative 
**[[4ifn]] – hKeap1 Kelch domain + quinoline derivative 
**[[4l7b]], [[4l7c]], [[4l7d]] [[4n1b]] – hKeap1 Kelch domain (mutant) + quinoline derivative 
**[[4in4]], [[4zy3]], [[5fnq]], [[5fnr]], [[5fns]], [[5fnt]], [[5fnu]], [[5fzj]], [[5fzn]] – hKeap1 Kelch domain + inhibitor 
**[[4iqk]], [[4n1b]], [[5wiy]], [[5whl]], [[5who]] – hKeap1 Kelch domain (mutant) + inhibitor 
**[[4cxt]] – hKeap1 BTB domain (mutant) + antagonist 
**[[5dad]], [[5daf]] – hKeap1 BTB domain + activator 
**[[5git]] – hKeap1 BTB domain + inhibitor 
**[[6qmc]], [[6qmd]], [[6qme]], [[6qmj]], [[6qmk]] – mKeap1 Kelch domain + inhibitor 

*Kelch-like protein 20

**[[5yq4]] – hKLHL20 kelch domain 
**[[6gy5]] – hKLHL20 kelch domain + DAPK1 peptide 

}}

[[Category:Topic Page]]

←Older revision		Revision as of 07:19, 13 June 2023
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	*Kelch-like protein 19 (kelch-like ECH-associated protein 1; Keap1)); domains: BTB 48-140; kelch 320-812		*Kelch-like protein 19 (kelch-like ECH-associated protein 1; Keap1)); domains: BTB 48-140; kelch 320-812

-	**[[1u6d]], [[1zgk]], [[4ifj]], [[6rog]] – hKeap1 Kelch domain <br />	+	**[[1u6d]], [[1zgk]], [[4ifj]], [[6rog]], [[7xot]] – hKeap1 Kelch domain <br />
	**[[3zgd]], [[5wfl]], [[6w67]], [[6w68]], [[6w69]] – hKeap1 Kelch domain (mutant) <br />		**[[3zgd]], [[5wfl]], [[6w67]], [[6w68]], [[6w69]] – hKeap1 Kelch domain (mutant) <br />
-	**[[4cxi]], [[4cxj]], [[6w68]], [[6w69]] – hKeap1 BTB domain (mutant) <br />	+	**[[4cxi]], [[4cxj]], [[6w68]], [[6w69]], [[7exi]] – hKeap1 BTB domain (mutant) <br />
	**[[1x2j]] – mKeap1 Kelch domain <br />		**[[1x2j]] – mKeap1 Kelch domain <br />

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	**[[3vng]], [[3vnh]], [[6ffm]] – hKeap1 Kelch domain + oxadiazole derivative <br />		**[[3vng]], [[3vnh]], [[6ffm]] – hKeap1 Kelch domain + oxadiazole derivative <br />
-	**[[6z6a]] – hKeap1 Kelch domain + macrocycle<br />	+	**[[6z6a]], [[7q5h]], [[7q6q]], [[7q6x]], [[7q8r]], [[7q96]] – hKeap1 Kelch domain + macrocycle<br />
	**[[4ifn]], [[6tym]], [[6typ]], [[6v6z]] – hKeap1 Kelch domain + quinoline derivative <br />		**[[4ifn]], [[6tym]], [[6typ]], [[6v6z]] – hKeap1 Kelch domain + quinoline derivative <br />
	**[[4l7b]], [[4l7c]], [[4l7d]] [[4n1b]], [[6uf0]] – hKeap1 Kelch domain (mutant) + quinoline derivative <br />		**[[4l7b]], [[4l7c]], [[4l7d]] [[4n1b]], [[6uf0]] – hKeap1 Kelch domain (mutant) + quinoline derivative <br />
-	**~~[[4in4]],~~ [[4zy3]], [[5fnq]], [[5fnr]], [[5fns]], [[5fnt]], [[5fnu]], [[5fzj]], [[5fzn]], [[6hws]], [[6sp1]], [[6sp4]] – hKeap1 Kelch domain + inhibitor <br />	+	**[[4zy3]], [[5fnq]], [[5fnr]], [[5fns]], [[5fnt]], [[5fnu]], [[5fzj]], [[5fzn]], [[4in4]], [[6hws]], [[6sp1]], [[6sp4]], [[7xm2]], [[7xm3]], [[7xm4]], [[7xm5]] – hKeap1 Kelch domain + inhibitor <br />
-	**[[~~4iqk~~]], [[~~4n1b~~]], [[5wiy]], [[5whl]], [[5who]] – hKeap1 Kelch domain (mutant) + inhibitor <br />	+	**[[4n1b]], [[4iqk]], [[5wiy]], [[5whl]], [[5who]] – hKeap1 Kelch domain (mutant) + inhibitor <br />
	**[[5dad]], [[5daf]] – hKeap1 BTB domain + activator <br />		**[[5dad]], [[5daf]] – hKeap1 BTB domain + activator <br />
-	**[[5git]] – hKeap1 BTB domain + inhibitor <br />	+	**[[5git]], [[7x4w]], [[7x4x]] – hKeap1 BTB domain + inhibitor <br />
	**[[4cxt]] – hKeap1 BTB domain (mutant) + antagonist<br />		**[[4cxt]] – hKeap1 BTB domain (mutant) + antagonist<br />
	**[[6qmc]], [[6qmd]], [[6qme]], [[6qmj]], [[6qmk]] – mKeap1 Kelch domain + inhibitor <br />		**[[6qmc]], [[6qmd]], [[6qme]], [[6qmj]], [[6qmk]] – mKeap1 Kelch domain + inhibitor <br />
		+	**[[7c60]] – mKeap1 Kelch domain + fumarate derivative<br />

	*Keap1 complex with protein		*Keap1 complex with protein
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	**[[5yq4]] – hKLHL20 kelch domain <br />		**[[5yq4]] – hKLHL20 kelch domain <br />
	**[[6gy5]] – hKLHL20 kelch domain + DAPK1 peptide <br />		**[[6gy5]] – hKLHL20 kelch domain + DAPK1 peptide <br />
		+	**[[8cia]] – hKLHL20 kelch domain + kelch like family member 20 <br />

	}}		}}

	[[Category:Topic Page]]		[[Category:Topic Page]]

←Older revision		Revision as of 06:40, 12 October 2021
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	**[[1u6d]], [[1zgk]], [[4ifj]], [[6rog]] – hKeap1 Kelch domain <br />		**[[1u6d]], [[1zgk]], [[4ifj]], [[6rog]] – hKeap1 Kelch domain <br />
-	**[[3zgd]], [[5wfl]] – hKeap1 Kelch domain (mutant) <br />	+	**[[3zgd]], [[5wfl]], [[6w67]], [[6w68]], [[6w69]] – hKeap1 Kelch domain (mutant) <br />
	**[[4cxi]], [[4cxj]], [[6w68]], [[6w69]] – hKeap1 BTB domain (mutant) <br />		**[[4cxi]], [[4cxj]], [[6w68]], [[6w69]] – hKeap1 BTB domain (mutant) <br />
	**[[1x2j]] – mKeap1 Kelch domain <br />		**[[1x2j]] – mKeap1 Kelch domain <br />
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	*Keap1 complex with peptide		*Keap1 complex with peptide

-	**[[4ifl]], [[2flu]], [[3zgc]] – hKeap1 Kelch domain + NRF2 Neh2 peptide <br />	+	**[[4ifl]], [[2flu]], [[3zgc]], [[7k28]], [[7k29]], [[7k2a]], [[7k2b]], [[7k2c]], [[7k2d]], [[7k2e]], [[7k2f]], [[7k2i]], [[7k2j]], [[7k2l]], [[7k2m]], [[7k2g]], [[7k2h]] [[7k2k]], [[7k2n]], [[7k2o]] [[7k2p]], [[7k2q]] [[7k2r]], [[7k2s]] – hKeap1 Kelch domain + NRF2 Neh2 peptide <br />
	**[[5wfv]], [[5wg1]] – hKeap1 Kelch domain (mutant) + NRF2 peptide <br />		**[[5wfv]], [[5wg1]] – hKeap1 Kelch domain (mutant) + NRF2 peptide <br />
-	**[[6fmp]], [[6fmq]] – hKeap1 Kelch domain + peptide <br />	+	**[[6fmp]], [[6fmq]], [[6t7v]], [[6t7z]], [[6tg8]] – hKeap1 Kelch domain + peptide <br />
	**[[5f72]] – hKeap1 Kelch domain + antibody <br />		**[[5f72]] – hKeap1 Kelch domain + antibody <br />
	**[[5x54]] – hKeap1 Kelch domain + tetrapeptide <br />		**[[5x54]] – hKeap1 Kelch domain + tetrapeptide <br />
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	**[[3vng]], [[3vnh]], [[6ffm]] – hKeap1 Kelch domain + oxadiazole derivative <br />		**[[3vng]], [[3vnh]], [[6ffm]] – hKeap1 Kelch domain + oxadiazole derivative <br />
		+	**[[6z6a]] – hKeap1 Kelch domain + macrocycle<br />
	**[[4ifn]], [[6tym]], [[6typ]], [[6v6z]] – hKeap1 Kelch domain + quinoline derivative <br />		**[[4ifn]], [[6tym]], [[6typ]], [[6v6z]] – hKeap1 Kelch domain + quinoline derivative <br />
	**[[4l7b]], [[4l7c]], [[4l7d]] [[4n1b]], [[6uf0]] – hKeap1 Kelch domain (mutant) + quinoline derivative <br />		**[[4l7b]], [[4l7c]], [[4l7d]] [[4n1b]], [[6uf0]] – hKeap1 Kelch domain (mutant) + quinoline derivative <br />