Krebs cycle importance - Revision history

Alexander Berchansky at 15:06, 12 December 2022

Alexander Berchansky — Mon, 12 Dec 2022 15:06:09 GMT

←Older revision		Revision as of 15:06, 12 December 2022
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	*[[Major metabolic pathways converging on the citric acid cycle]]		*[[Major metabolic pathways converging on the citric acid cycle]]
	*[[Citric acid cycle intermediates serve as substrates for biosynthetic processes]]		*[[Citric acid cycle intermediates serve as substrates for biosynthetic processes]]
		+	*[[Gluconeogenesis]]
		+	*[[Cori cycle]]
		+	*[[Glyoxylate cycle]]

Alexander Berchansky at 12:39, 29 September 2022

Alexander Berchansky — Thu, 29 Sep 2022 12:39:37 GMT

←Older revision		Revision as of 12:39, 29 September 2022
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	other substances.</p>		other substances.</p>

		+	*[[Major metabolic pathways converging on the citric acid cycle]]
	*[[Citric acid cycle intermediates serve as substrates for biosynthetic processes]]		*[[Citric acid cycle intermediates serve as substrates for biosynthetic processes]]

Alexander Berchansky at 12:38, 29 September 2022

Alexander Berchansky — Thu, 29 Sep 2022 12:38:37 GMT

←Older revision		Revision as of 12:38, 29 September 2022
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	and amino acids) "drive in" and "drive out " again at the different locations for the synthesis of		and amino acids) "drive in" and "drive out " again at the different locations for the synthesis of
	other substances.</p>		other substances.</p>
		+
		+	*[[Citric acid cycle intermediates serve as substrates for biosynthetic processes]]

Alexander Berchansky at 10:26, 19 December 2019

Alexander Berchansky — Thu, 19 Dec 2019 10:26:22 GMT

←Older revision		Revision as of 10:26, 19 December 2019
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	<h2>The importance of the Krebs Cycle in the metabolism</h2>		<h2>The importance of the Krebs Cycle in the metabolism</h2>

-	<p>Citric Acid Cycle\|The Krebs cycle is the second of three stages of cellular respiration,	+	<p>[[Citric Acid Cycle\|The Krebs cycle]] is the second of three stages of cellular respiration,
	in which glucose, fatty acids and certain amino acids, the so-called <em>fuel molecules</em>, are oxidized		in which glucose, fatty acids and certain amino acids, the so-called <em>fuel molecules</em>, are oxidized
	(see Figure). The oxidation of these molecules is primarily used to transform the energy contained in these molecules into ATP. ATP provides for example energy for muscle contractions		(see Figure). The oxidation of these molecules is primarily used to transform the energy contained in these molecules into ATP. ATP provides for example energy for muscle contractions

Alexander Berchansky at 10:26, 19 December 2019

Alexander Berchansky — Thu, 19 Dec 2019 10:26:07 GMT

←Older revision		Revision as of 10:26, 19 December 2019
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	<h2>The importance of the Krebs Cycle in the metabolism</h2>		<h2>The importance of the Krebs Cycle in the metabolism</h2>

-	<p>The Krebs cycle is the second of three stages of cellular respiration,	+	<p>Citric Acid Cycle\|The Krebs cycle is the second of three stages of cellular respiration,
	in which glucose, fatty acids and certain amino acids, the so-called <em>fuel molecules</em>, are oxidized		in which glucose, fatty acids and certain amino acids, the so-called <em>fuel molecules</em>, are oxidized
	(see Figure). The oxidation of these molecules is primarily used to transform the energy contained in these molecules into ATP. ATP provides for example energy for muscle contractions		(see Figure). The oxidation of these molecules is primarily used to transform the energy contained in these molecules into ATP. ATP provides for example energy for muscle contractions

Jaime Prilusky: Sandbox Oldenburg03 moved to Krebs cycle importance

Jaime Prilusky — Sun, 03 Aug 2014 21:32:03 GMT

Sandbox Oldenburg03 moved to Krebs cycle importance

←Older revision

Revision as of 21:32, 3 August 2014

Verena Pietzner at 07:05, 28 July 2014

Verena Pietzner — Mon, 28 Jul 2014 07:05:28 GMT

←Older revision		Revision as of 07:05, 28 July 2014
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	electrons were used to reduce O<sub>2</sub>. Finally, the electrons that are released in the Krebs Cycle and the transported to the respiratory chain were used there to produce ATP out of ADP and P<sub>i</sub>.</p>		electrons were used to reduce O<sub>2</sub>. Finally, the electrons that are released in the Krebs Cycle and the transported to the respiratory chain were used there to produce ATP out of ADP and P<sub>i</sub>.</p>

-		+	[[Image:Relevance.jpg]]
-	~~<img width=360 height=447 src="bedeutung_image002~~.jpg~~" alt="Citratzyklus Einfach.gif">~~	+	<p>Figure: Overview of the Krebs cycle</p>
-		+
-	<p >Figure: Overview of the Krebs cycle</p>	+

	<p> In addition to the supply of energy from the fuel molecules, the citric acid cycle has other		<p> In addition to the supply of energy from the fuel molecules, the citric acid cycle has other

Verena Pietzner: New page:

The importance of the Krebs Cycle in the metabolism

The Krebs cycle is the second of three stages of cellular respiration, in which glucose, fatty acids and certain amino aci...

Verena Pietzner — Mon, 28 Jul 2014 07:01:25 GMT

New page: <h2>The importance of the Krebs Cycle in the metabolism</h2> The Krebs cycle is the second of three stages of cellular respiration, in which glucose, fatty acids and certain amino aci...

New page

<h2>The importance of the Krebs Cycle in the metabolism</h2>

The Krebs cycle is the second of three stages of cellular respiration,
in which glucose, fatty acids and certain amino acids, the so-called fuel molecules, are oxidized
(see Figure). The oxidation of these molecules is primarily used to transform the energy contained in these molecules into ATP. ATP provides for example energy for muscle contractions
and can therefore be referred to as "energy currency" of the cells. 
Before the fuel molecules can be
inserted in the Krebs Cycle, they must first all be converted into acetyl-CoA. Looking at
the path of a nutrient, such as glucose, the oxidation of the molecule takes place in the glycolysis. The product of the
glycolysis is pyruvate. In a further reaction, which is catalyzed by the enzyme complex pyruvate
dehydrogenase, acetyl-CoA is formed out of pyruvate, which can be introduced into the
citric acid cycle or Krebs Cycle. 
In an eight-step reaction sequence, the acetyl
group of acetyl-CoA is oxidised into two molecules of CO2 (see Figure). These reactions are catalysed
by eight different enzymes. Instead of producing high amounts of ATP, eight electrons were removed from the acetyl group and transferred to
the coenzymes NAD+ and FAD, which are reduced to NADH and FADH2. They are therefore called
electron carrier coenzymes and are used to transport electrons from the Krebs cycle to the respiratory chain.
Through a series of molecules, the reduced coenzymes NADH and FADH2 are oxidised and the released
electrons were used to reduce O2. Finally, the electrons that are released in the Krebs Cycle and the transported to the respiratory chain were used there to produce ATP out of ADP and Pi.

<img width=360 height=447 src="bedeutung_image002.jpg" alt="Citratzyklus Einfach.gif">

Figure: Overview of the Krebs cycle

 In addition to the supply of energy from the fuel molecules, the citric acid cycle has other
important functions. Thus, some of the citric acid cycle are intermediates for other important reactions like the biosynthesis of glucose, fatty acids and amino acids.

Due to the many functions of the citric acid cycle is also considered to be the "central hub of metabolism".
This is because, as most of the absorbed nutrients, the fuel molecules are oxidized ultimately within the Krebs Cycke and its intermediates are used for various biosynthetic pathways. Figuratively, one can look at the
citric acid cycle as a " roundabout" introduce, in which the nutrients (carbohydrates, fatty acids
and amino acids) "drive in" and "drive out " again at the different locations for the synthesis of
other substances.