Krebs cycle step 3 - Revision history

Alexander Berchansky at 09:22, 18 December 2019

Alexander Berchansky — Wed, 18 Dec 2019 09:22:25 GMT

←Older revision		Revision as of 09:22, 18 December 2019
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-	<h2>Step three of the Krebs Cycle: Isocitrate ~~Dehydrogenase~~</h2>	+	<h2>Step three of the Krebs Cycle: [[Isocitrate dehydrogenase]]</h2>

	[[Image:isocitrate_3.jpg]]		[[Image:isocitrate_3.jpg]]
	<p>Figure: Formation of α-ketoglutarate</p>		<p>Figure: Formation of α-ketoglutarate</p>

-	<p>Like the second step of the Krebs cycle, the third reaction (see Figure) is a two-step reaction sequence. In the first step,	+	<p>Like the second step of the [[Citric Acid Cycle\|Krebs cycle]], the third reaction (see Figure) is a two-step reaction sequence. In the first step,
	the secondary OH group of isocitrate (highlighted in yellow) is oxidised by the coenzyme NAD<sup>+</sup>, and a ketone is formed. At this point it becomes apparent why citrate was previously isomerised to isocitrate: Without		the secondary OH group of isocitrate (highlighted in yellow) is oxidised by the coenzyme NAD<sup>+</sup>, and a ketone is formed. At this point it becomes apparent why citrate was previously isomerised to isocitrate: Without
	this step, the oxidation would not have taken place, since tertiary alcohols can not be oxidised. In the second step of the		this step, the oxidation would not have taken place, since tertiary alcohols can not be oxidised. In the second step of the
	reaction, the intermediate product is decarboxylated and thus CO<sub>2</sub> (in green) and		reaction, the intermediate product is decarboxylated and thus CO<sub>2</sub> (in green) and
	α-ketoglutarate, the salt of α-ketoglutaric acid, are released. With this step, the carbon chain is shortened for the first time because α-ketoglutarate has a C5 body. </p>		α-ketoglutarate, the salt of α-ketoglutaric acid, are released. With this step, the carbon chain is shortened for the first time because α-ketoglutarate has a C5 body. </p>

Jaime Prilusky: Sandbox Oldenburg06 moved to Krebs cycle step 3

Jaime Prilusky — Sun, 03 Aug 2014 21:33:33 GMT

Sandbox Oldenburg06 moved to Krebs cycle step 3

←Older revision

Revision as of 21:33, 3 August 2014

Verena Pietzner: New page:

Step three of the Krebs Cycle: Isocitrate Dehydrogenase

Image:isocitrate_3.jpg

Figure: Formation of α-ketoglutarate

Like the second step of the Krebs cycle, ...

Verena Pietzner — Mon, 28 Jul 2014 07:33:00 GMT

New page: <h2>Step three of the Krebs Cycle: Isocitrate Dehydrogenase</h2> Image:isocitrate_3.jpg <p>Figure: Formation of α-ketoglutarate</p> <p>Like the second step of the Krebs cycle, ...

New page

<h2>Step three of the Krebs Cycle: Isocitrate Dehydrogenase</h2>

[[Image:isocitrate_3.jpg]]
<p>Figure: Formation of α-ketoglutarate</p>

<p>Like the second step of the Krebs cycle, the third reaction (see Figure) is a two-step reaction sequence. In the first step,
the secondary OH group of isocitrate (highlighted in yellow) is oxidised by the coenzyme NAD<sup>+</sup>, and a ketone is formed. At this point it becomes apparent why citrate was previously isomerised to isocitrate: Without
this step, the oxidation would not have taken place, since tertiary alcohols can not be oxidised. In the second step of the
reaction, the intermediate product is decarboxylated and thus CO<sub>2</sub> (in green) and
α-ketoglutarate, the salt of α-ketoglutaric acid, are released. With this step, the carbon chain is shortened for the first time because α-ketoglutarate has a C5 body. </p>