Leucine transporter - Revision history

Michal Harel at 08:26, 17 October 2021

Michal Harel — Sun, 17 Oct 2021 08:26:01 GMT

←Older revision		Revision as of 08:26, 17 October 2021
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	[[3mpn]], [[3mpq]] – AaLeuT (mutant) + Leu + Na + halide<br />		[[3mpn]], [[3mpq]] – AaLeuT (mutant) + Leu + Na + halide<br />
	[[3f3e]], [[3usg]], [[3usj]], [[3usi]], [[3usk]] – AaLeuT + Leu + Na <br />		[[3f3e]], [[3usg]], [[3usj]], [[3usi]], [[3usk]] – AaLeuT + Leu + Na <br />
-	[[4fxz]], [[3gjc]] – AaLeuT (mutant) + Leu + Na <br />	+	[[4fxz]], [[3gjc]], [[6nle]] – AaLeuT (mutant) + Leu + Na <br />
-	[[3f48]], [[3f4j]], [[3f3a]], [[3f3c]], [[3f3d]], [[3f4i]] – AaLeuT + amino acid + Na <br />	+	[[3f48]], [[3f4j]], [[3f3a]], [[3f3c]], [[3f3d]], [[3f4i]], [[6xwm]] – AaLeuT + amino acid + Na <br />
-	[[3qs4]], [[3qs5]], [[3qs6]], [[4fy0]], [[3tu0]], [[3usl]], [[3uso]], [[3usm]] – AaLeuT (mutant) + amino acid + Na <br />	+	[[3qs4]], [[3qs5]], [[3qs6]], [[4fy0]], [[3tu0]], [[3usl]], [[3uso]], [[3usm]], [[7lqj]], [[7lqk]], [[7lql]] – AaLeuT (mutant) + amino acid + Na <br />
	[[3tt1]] – AaLeuT (mutant) + Na + antibody<br />		[[3tt1]] – AaLeuT (mutant) + Na + antibody<br />
	[[3tt3]] – AaLeuT (mutant) + antibody<br />		[[3tt3]] – AaLeuT (mutant) + antibody<br />

Alexander Berchansky at 10:53, 4 July 2019

Alexander Berchansky — Thu, 04 Jul 2019 10:53:51 GMT

←Older revision		Revision as of 10:53, 4 July 2019
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	== Structural highlights ==		== Structural highlights ==
-	*<scene name='56/564069/Cv/2'>Leucine transporter complex with leucine, lipid membrane fragments and Na+ ions</scene>.	+	*<scene name='56/564069/Cv/6'>Leucine transporter complex with leucine, lipid membrane fragments and Na+ ions</scene>.
-	*The <scene name='56/564069/Cv/3'>leucine binding pocket of LeuT contains 2 Na+ ions</scene><ref>PMID:22245965</ref>.	+	*The <scene name='56/564069/Cv/7'>leucine binding pocket of LeuT contains 2 Na+ ions</scene><ref>PMID:22245965</ref>.
-	*<scene name='56/564069/Cv/4'>Leucine binding pocket</scene>.	+	*<scene name='56/564069/Cv/8'>Leucine binding pocket</scene>.
	==3D structures of leucine transporter==		==3D structures of leucine transporter==

Michal Harel at 13:38, 20 October 2017

Michal Harel — Fri, 20 Oct 2017 13:38:43 GMT

←Older revision		Revision as of 13:38, 20 October 2017
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	== References ==		== References ==
	<references/>		<references/>
		+	[[Category:Topic Page]]

Joel L. Sussman at 10:25, 9 August 2017

Joel L. Sussman — Wed, 09 Aug 2017 10:25:30 GMT

←Older revision		Revision as of 10:25, 9 August 2017
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-	<StructureSection load='~~3usg~~' size='450' side='right' caption='Structure of leucine transporter complex with leucine, lipid membrane fragments and Na+ ions (purple) (PDB entry [[3usg]])' scene='56/564069/Cv/1' pspeed='8'>	+	<StructureSection load='' size='450' side='right' caption='Structure of leucine transporter complex with leucine, lipid membrane fragments and Na+ ions (purple) (PDB entry [[3usg]])' scene='56/564069/Cv/1' pspeed='8'>
	== Function ==		== Function ==
	'''Leucine transporter''' (LeuT) is a membrane protein which is comprised of 12 transmembrane helices forming a channel. LeuT clears the synapse after signal transduction. LeuT utilizes the electrochemical potential gradient of Na+ ions across the membrane to catalyze the uptake of leucine. <scene name='56/564069/Cv/5'>The LeuT is a homodimer</scene><ref>PMID:15980244</ref>.		'''Leucine transporter''' (LeuT) is a membrane protein which is comprised of 12 transmembrane helices forming a channel. LeuT clears the synapse after signal transduction. LeuT utilizes the electrochemical potential gradient of Na+ ions across the membrane to catalyze the uptake of leucine. <scene name='56/564069/Cv/5'>The LeuT is a homodimer</scene><ref>PMID:15980244</ref>.

Alexander Berchansky at 10:49, 8 August 2017

Alexander Berchansky — Tue, 08 Aug 2017 10:49:48 GMT

←Older revision		Revision as of 10:49, 8 August 2017
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	<StructureSection load='3usg' size='450' side='right' caption='Structure of leucine transporter complex with leucine, lipid membrane fragments and Na+ ions (purple) (PDB entry [[3usg]])' scene='56/564069/Cv/1' pspeed='8'>		<StructureSection load='3usg' size='450' side='right' caption='Structure of leucine transporter complex with leucine, lipid membrane fragments and Na+ ions (purple) (PDB entry [[3usg]])' scene='56/564069/Cv/1' pspeed='8'>
	== Function ==		== Function ==
-	'''Leucine transporter''' (LeuT) is a membrane protein which is comprised of 12 transmembrane helices forming a channel. LeuT clears the synapse after signal transduction. LeuT utilizes the electrochemical potential gradient of Na+ ions across the membrane to catalyze the uptake of leucine. The LeuT is a homodimer<ref>PMID:15980244</ref>.	+	'''Leucine transporter''' (LeuT) is a membrane protein which is comprised of 12 transmembrane helices forming a channel. LeuT clears the synapse after signal transduction. LeuT utilizes the electrochemical potential gradient of Na+ ions across the membrane to catalyze the uptake of leucine. <scene name='56/564069/Cv/5'>The LeuT is a homodimer</scene><ref>PMID:15980244</ref>.

	==Relevance ==		==Relevance ==

Alexander Berchansky at 10:39, 8 August 2017

Alexander Berchansky — Tue, 08 Aug 2017 10:39:50 GMT

←Older revision		Revision as of 10:39, 8 August 2017
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	== Structural highlights ==		== Structural highlights ==
-	<scene name='56/564069/Cv/2'>Leucine transporter complex with leucine, lipid membrane fragments and Na+ ions</scene>. The <scene name='56/564069/Cv/3'>leucine binding pocket of LeuT contains 2 Na+ ions</scene><ref>PMID:22245965</ref>.	+	*<scene name='56/564069/Cv/2'>Leucine transporter complex with leucine, lipid membrane fragments and Na+ ions</scene>.
		+	*The <scene name='56/564069/Cv/3'>leucine binding pocket of LeuT contains 2 Na+ ions</scene><ref>PMID:22245965</ref>.
		+	*<scene name='56/564069/Cv/4'>Leucine binding pocket</scene>.
	==3D structures of leucine transporter==		==3D structures of leucine transporter==

Alexander Berchansky at 10:33, 8 August 2017

Alexander Berchansky — Tue, 08 Aug 2017 10:33:30 GMT

←Older revision		Revision as of 10:33, 8 August 2017
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-	<StructureSection load='3usg' size='~~350~~' side='right' caption='Structure of leucine transporter complex with leucine, lipid membrane fragments and Na+ ions (purple) (PDB entry [[3usg]])' scene='56/564069/Cv/1'>	+	<StructureSection load='3usg' size='450' side='right' caption='Structure of leucine transporter complex with leucine, lipid membrane fragments and Na+ ions (purple) (PDB entry [[3usg]])' scene='56/564069/Cv/1' pspeed='8'>
	== Function ==		== Function ==
	'''Leucine transporter''' (LeuT) is a membrane protein which is comprised of 12 transmembrane helices forming a channel. LeuT clears the synapse after signal transduction. LeuT utilizes the electrochemical potential gradient of Na+ ions across the membrane to catalyze the uptake of leucine. The LeuT is a homodimer<ref>PMID:15980244</ref>.		'''Leucine transporter''' (LeuT) is a membrane protein which is comprised of 12 transmembrane helices forming a channel. LeuT clears the synapse after signal transduction. LeuT utilizes the electrochemical potential gradient of Na+ ions across the membrane to catalyze the uptake of leucine. The LeuT is a homodimer<ref>PMID:15980244</ref>.
Line 7:		Line 7:

	== Structural highlights ==		== Structural highlights ==
-	<scene name='56/564069/Cv/2'>Leucine transporter complex with leucine, lipid membrane fragments and Na+ ions</scene>. The leucine binding pocket of LeuT contains 2 Na+ ions<ref>PMID:22245965</ref>.	+	<scene name='56/564069/Cv/2'>Leucine transporter complex with leucine, lipid membrane fragments and Na+ ions</scene>. The <scene name='56/564069/Cv/3'>leucine binding pocket of LeuT contains 2 Na+ ions</scene><ref>PMID:22245965</ref>.
	==3D structures of leucine transporter==		==3D structures of leucine transporter==

Alexander Berchansky at 10:19, 8 August 2017

Alexander Berchansky — Tue, 08 Aug 2017 10:19:21 GMT

←Older revision		Revision as of 10:19, 8 August 2017
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-	<StructureSection load='3usg' size='350' side='right' caption='Structure of leucine transporter complex with leucine, lipid membrane fragments and Na+ ~~ion~~ (purple) (PDB entry [[3usg]])' scene='56/564069/Cv/1'>	+	<StructureSection load='3usg' size='350' side='right' caption='Structure of leucine transporter complex with leucine, lipid membrane fragments and Na+ ions (purple) (PDB entry [[3usg]])' scene='56/564069/Cv/1'>
	== Function ==		== Function ==
	'''Leucine transporter''' (LeuT) is a membrane protein which is comprised of 12 transmembrane helices forming a channel. LeuT clears the synapse after signal transduction. LeuT utilizes the electrochemical potential gradient of Na+ ions across the membrane to catalyze the uptake of leucine. The LeuT is a homodimer<ref>PMID:15980244</ref>.		'''Leucine transporter''' (LeuT) is a membrane protein which is comprised of 12 transmembrane helices forming a channel. LeuT clears the synapse after signal transduction. LeuT utilizes the electrochemical potential gradient of Na+ ions across the membrane to catalyze the uptake of leucine. The LeuT is a homodimer<ref>PMID:15980244</ref>.
Line 7:		Line 7:

	== Structural highlights ==		== Structural highlights ==
-	The leucine binding pocket of LeuT contains 2 Na+ ions<ref>PMID:22245965</ref>.	+	<scene name='56/564069/Cv/2'>Leucine transporter complex with leucine, lipid membrane fragments and Na+ ions</scene>. The leucine binding pocket of LeuT contains 2 Na+ ions<ref>PMID:22245965</ref>.
	==3D structures of leucine transporter==		==3D structures of leucine transporter==

Alexander Berchansky at 10:13, 8 August 2017

Alexander Berchansky — Tue, 08 Aug 2017 10:13:47 GMT

←Older revision		Revision as of 10:13, 8 August 2017
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-	<StructureSection load='3usg' size='350' side='right' caption='Structure of leucine transporter complex with leucine, lipid membrane fragments and Na+ ion (purple) (PDB entry [[3usg]])' scene=''>	+	<StructureSection load='3usg' size='350' side='right' caption='Structure of leucine transporter complex with leucine, lipid membrane fragments and Na+ ion (purple) (PDB entry [[3usg]])' scene='56/564069/Cv/1'>
	== Function ==		== Function ==
	'''Leucine transporter''' (LeuT) is a membrane protein which is comprised of 12 transmembrane helices forming a channel. LeuT clears the synapse after signal transduction. LeuT utilizes the electrochemical potential gradient of Na+ ions across the membrane to catalyze the uptake of leucine. The LeuT is a homodimer<ref>PMID:15980244</ref>.		'''Leucine transporter''' (LeuT) is a membrane protein which is comprised of 12 transmembrane helices forming a channel. LeuT clears the synapse after signal transduction. LeuT utilizes the electrochemical potential gradient of Na+ ions across the membrane to catalyze the uptake of leucine. The LeuT is a homodimer<ref>PMID:15980244</ref>.

Michal Harel at 07:17, 11 April 2016

Michal Harel — Mon, 11 Apr 2016 07:17:23 GMT

←Older revision		Revision as of 07:17, 11 April 2016
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	LeuT is the target of many antidepressant and recreational drugs.		LeuT is the target of many antidepressant and recreational drugs.

		+	== Structural highlights ==
		+	The leucine binding pocket of LeuT contains 2 Na+ ions<ref>PMID:22245965</ref>.
	==3D structures of leucine transporter==		==3D structures of leucine transporter==