Liver X receptor - Revision history

Michal Harel at 09:34, 12 January 2023

Michal Harel — Thu, 12 Jan 2023 09:34:29 GMT

←Older revision		Revision as of 09:34, 12 January 2023
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	'''Liver X receptors''' (LXR) are ligand-activated transcription factors of the nuclear receptor family. There are two LXR isoforms α and β which form heterodimers with retinoic X receptor upon activation and bind to the LXR response element found in the promoter region of the target genes<ref>PMID:19258656</ref>. LXR is a lipogenic transcription factor<ref>PMID:17107947</ref>. LXRs modulate the expression of genes in cholesterol and lipid metabolism in response to changes in cellular cholesterol status.		'''Liver X receptors''' (LXR) are ligand-activated transcription factors of the nuclear receptor family. There are two LXR isoforms α and β which form heterodimers with retinoic X receptor upon activation and bind to the LXR response element found in the promoter region of the target genes<ref>PMID:19258656</ref>. LXR is a lipogenic transcription factor<ref>PMID:17107947</ref>. LXRs modulate the expression of genes in cholesterol and lipid metabolism in response to changes in cellular cholesterol status.
		+
		+	See also [[Intracellular receptors]]

	== Disease ==		== Disease ==

Michal Harel at 10:31, 31 August 2020

Michal Harel — Mon, 31 Aug 2020 10:31:59 GMT

←Older revision		Revision as of 10:31, 31 August 2020
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	* Liver X receptor β		* Liver X receptor β

-	**[[1upv]], [[1upw]], [[5jy3]], [[3kfc]], [[4rak]] – hLXR LBD + agonist<br />	+	**[[1upv]], [[1upw]], [[5jy3]], [[3kfc]], [[4rak]], [[6s4n]], [[6s4t]], [[6s4u]], [[6s5k]] – hLXR LBD + agonist<br />
		+	**[[6k9g]], [[6k9h]], [[6k9m]] – hLXR LBD (mutant) + agonist <br />
	**[[1pq6]], [[1pqc]], [[1pq9]] – hLXR LBD + ligand<br />		**[[1pq6]], [[1pqc]], [[1pq9]] – hLXR LBD + ligand<br />
	**[[6jio]] – hLXR LBD (mutant) + ligand<br />		**[[6jio]] – hLXR LBD (mutant) + ligand<br />

Michal Harel at 10:05, 22 October 2019

Michal Harel — Tue, 22 Oct 2019 10:05:51 GMT

←Older revision		Revision as of 10:05, 22 October 2019
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	* Liver X receptor α		* Liver X receptor α

-	**[[2acl]] – mLXR + retinoic X receptor α + agonist – mouse <br />	+	**[[5avl]], [[5avl]], [[5hjs]], [[3ipq]], [[3ips]], [[3ipu]] – hLXR LBD + NCOA-1 peptide + agonist - human<br />
-	**[[5avl]], [[5avl]], [[5hjs]], [[3ipq]], [[3ips]], [[3ipu]] – hLXR LBD + NCOA-1 peptide + agonist<br />	+
	**[[1uhl]] – hLXR LBD + retinoic X receptor β + NCOA-2 <br />		**[[1uhl]] – hLXR LBD + retinoic X receptor β + NCOA-2 <br />
		+	**[[2acl]] – mLXR + retinoic X receptor α + agonist – mouse <br />

	* Liver X receptor β		* Liver X receptor β

-	**[[1upv]], [[1upw]], [[5jy3]], [[3kfc]], [[4rak]] – hLXR LBD + agonist ~~– human~~<br />	+	**[[1upv]], [[1upw]], [[5jy3]], [[3kfc]], [[4rak]] – hLXR LBD + agonist<br />
	**[[1pq6]], [[1pqc]], [[1pq9]] – hLXR LBD + ligand<br />		**[[1pq6]], [[1pqc]], [[1pq9]] – hLXR LBD + ligand<br />
		+	**[[6jio]] – hLXR LBD (mutant) + ligand<br />
	**[[5i4v]] – hLXR LBD + retinoic X receptor β + agonist <br />		**[[5i4v]] – hLXR LBD + retinoic X receptor β + agonist <br />
	**[[5kyj]], [[5kya]] – hLXR LBD + retinoic X receptor β + modulator <br />		**[[5kyj]], [[5kya]] – hLXR LBD + retinoic X receptor β + modulator <br />

Joel L. Sussman at 14:41, 30 July 2018

Joel L. Sussman — Mon, 30 Jul 2018 14:41:52 GMT

←Older revision		Revision as of 14:41, 30 July 2018
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-	<StructureSection load='~~5kya~~' size='350' side='right' caption='Human liver X receptor β ligand binding domain (deepskyblue) complex with retinoic X receptor β (green) and modulator (PDB code [[5kya]])' scene='77/776388/Cv/1'>	+	<StructureSection load='' size='350' side='right' caption='Human liver X receptor β ligand binding domain (deepskyblue) complex with retinoic X receptor β (green) and modulator (PDB code [[5kya]])' scene='77/776388/Cv/1'>

Michal Harel at 09:56, 30 July 2018

Michal Harel — Mon, 30 Jul 2018 09:56:55 GMT

←Older revision		Revision as of 09:56, 30 July 2018
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	**[[5hjp]] – hLXR LBD + retinoic X receptor β + agonist<br />		**[[5hjp]] – hLXR LBD + retinoic X receptor β + agonist<br />
	**[[4nqa]] – hLXR LBD + retinoic X receptor β + NCOA-2 peptide + DNA <br />		**[[4nqa]] – hLXR LBD + retinoic X receptor β + NCOA-2 peptide + DNA <br />
-	**[[4dk7]], [[4dk8]] – hLXR LBD + NCOA-1 peptide + agonist<br />	+	**[[4dk7]], [[4dk8]], [[5avi]] – hLXR LBD + NCOA-1 peptide + agonist<br />
	**[[1p8d]] – hLXR LBD + NCOA-1 peptide + cholesterol derivative<br />		**[[1p8d]] – hLXR LBD + NCOA-1 peptide + cholesterol derivative<br />
		+	**[[3l0e]] – hLXR LBD + NCOA-2 peptide + inhibitor<br />
	}}		}}
	== References ==		== References ==

Michal Harel at 09:51, 30 July 2018

Michal Harel — Mon, 30 Jul 2018 09:51:15 GMT

←Older revision		Revision as of 09:51, 30 July 2018
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-	<StructureSection load='5kya' size='~~400~~' side='right' caption='Human liver X receptor β ligand binding domain (deepskyblue) complex with retinoic X receptor β (green) and modulator (PDB code [[5kya]])' scene='77/776388/Cv/1'>	+	<StructureSection load='5kya' size='350' side='right' caption='Human liver X receptor β ligand binding domain (deepskyblue) complex with retinoic X receptor β (green) and modulator (PDB code [[5kya]])' scene='77/776388/Cv/1'>

Alexander Berchansky at 13:39, 5 February 2018

Alexander Berchansky — Mon, 05 Feb 2018 13:39:50 GMT

←Older revision		Revision as of 13:39, 5 February 2018
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	== Structural highlights ==		== Structural highlights ==

-	<scene name='77/776388/Cv/2'>Human liver X receptor β ligand binding domain complex with retinoic X receptor β and modulator</scene>. LXR <scene name='77/776388/Cv/4'>modulator binds to the LXR</scene> in the LXR/retinoic X receptor β heterodimer in a hydrophobic pocket<ref>PMID:27599745</ref>.	+	<scene name='77/776388/Cv/2'>Human liver X receptor β ligand binding domain complex with retinoic X receptor β and modulator</scene>. LXR <scene name='77/776388/Cv/4'>modulator binds to the LXR</scene> in the LXR/retinoic X receptor β heterodimer in a hydrophobic <scene name='77/776388/Cv/5'>pocket</scene><ref>PMID:27599745</ref>.
	</StructureSection>		</StructureSection>
	== 3D Structures of liver X receptor ==		== 3D Structures of liver X receptor ==

Alexander Berchansky at 13:36, 5 February 2018

Alexander Berchansky — Mon, 05 Feb 2018 13:36:04 GMT

←Older revision		Revision as of 13:36, 5 February 2018
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	== Structural highlights ==		== Structural highlights ==

-	<scene name='77/776388/Cv/2'>Human liver X receptor β ligand binding domain complex with retinoic X receptor β and modulator</scene>. LXR modulator binds to the LXR in the LXR/retinoic X receptor β heterodimer in a hydrophobic pocket<ref>PMID:27599745</ref>.	+	<scene name='77/776388/Cv/2'>Human liver X receptor β ligand binding domain complex with retinoic X receptor β and modulator</scene>. LXR <scene name='77/776388/Cv/4'>modulator binds to the LXR</scene> in the LXR/retinoic X receptor β heterodimer in a hydrophobic pocket<ref>PMID:27599745</ref>.
	</StructureSection>		</StructureSection>
	== 3D Structures of liver X receptor ==		== 3D Structures of liver X receptor ==

Alexander Berchansky at 13:16, 5 February 2018

Alexander Berchansky — Mon, 05 Feb 2018 13:16:52 GMT

←Older revision		Revision as of 13:16, 5 February 2018
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	== Structural highlights ==		== Structural highlights ==

-	LXR modulator binds to the LXR in the LXR/retinoic X receptor β heterodimer in a hydrophobic pocket<ref>PMID:27599745</ref>.	+	<scene name='77/776388/Cv/2'>Human liver X receptor β ligand binding domain complex with retinoic X receptor β and modulator</scene>. LXR modulator binds to the LXR in the LXR/retinoic X receptor β heterodimer in a hydrophobic pocket<ref>PMID:27599745</ref>.
	</StructureSection>		</StructureSection>
	== 3D Structures of liver X receptor ==		== 3D Structures of liver X receptor ==

Alexander Berchansky at 12:49, 5 February 2018

Alexander Berchansky — Mon, 05 Feb 2018 12:49:15 GMT

←Older revision		Revision as of 12:49, 5 February 2018
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-	<StructureSection load='5kya' size='~~340~~' side='right' caption='Human liver X receptor β ligand binding domain (~~grey~~) complex with retinoic X receptor β (green) and modulator (PDB code [[5kya]])' scene=''>	+	<StructureSection load='5kya' size='400' side='right' caption='Human liver X receptor β ligand binding domain (deepskyblue) complex with retinoic X receptor β (green) and modulator (PDB code [[5kya]])' scene='77/776388/Cv/1'>