Ralf Stephan: /* Available structures */ +1

Ralf Stephan — Sun, 22 Feb 2009 10:46:14 GMT

Available structures - +1

←Older revision		Revision as of 10:46, 22 February 2009
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	* from ''E. coli'' K12:		* from ''E. coli'' K12:
	** the [[glycerol-3-phosphate transporter]] ([[1pw4]])		** the [[glycerol-3-phosphate transporter]] ([[1pw4]])
-	** the [[multidrug resistance protein]] D ([[2gfp]])	+	** the [[multidrug resistance protein]] EmrD ([[2gfp]])
	** the [[Lactose Permease\|lactose permease]] ([[1pv7]], [[2cfp]], [[2cfq]], [[2v8n]])		** the [[Lactose Permease\|lactose permease]] ([[1pv7]], [[2cfp]], [[2cfq]], [[2v8n]])
		+	* from ''Clostridum phytofermentans'': the sugar transporter ([[3brs]])

	== Weblinks ==		== Weblinks ==

Ralf Stephan: New page: '''Major Facilitators''' are membrane proteins that help with both influx and outflux of specific small molecules. They are neither passive channels, nor do they active pumping, like the A...

Ralf Stephan — Sat, 14 Feb 2009 16:04:54 GMT

New page: '''Major Facilitators''' are membrane proteins that help with both influx and outflux of specific small molecules. They are neither passive channels, nor do they active pumping, like the A...

New page

'''Major Facilitators''' are membrane proteins that help with both influx and outflux of specific small molecules. They are neither passive channels, nor do they active pumping, like the ATPases. Like a rocker-switch, they tilt between the two states 'outside open' and 'inside open'. This tilting (or switching) is triggered when a molecule has docked inside, and it transports the molecule to the other side. There are major facilitator uniporters, symporters, and antiporters. Antiporters usually transport a second, different, molecule, when switching back in the opposite direction. In 2009, there is still no structure data that would clearly show the transport process in major facilitators.

== Classification ==
TCDB, the most sophisticated classification of transport proteins to date, classifies the major facilitators as family 2.A.1 in the clan of '''secondary active [[porters]]'''.

== Available structures ==
The family has about 10,000 sequenced members from all living organisms. There are, however, only a few protein structures resolved.
* from ''E. coli'' K12:
** the [[glycerol-3-phosphate transporter]] ([[1pw4]])
** the [[multidrug resistance protein]] D ([[2gfp]])
** the [[Lactose Permease|lactose permease]] ([[1pv7]], [[2cfp]], [[2cfq]], [[2v8n]])

== Weblinks ==
*[http://www.tcdb.org/ The TCDB database]
*[http://www.tcdb.org/tcdb/subclass2.php?tc=2.A.1 TCDB: 2.A.1 The Major Facilitator Superfamily (MFS)]
*[http://www.tcdb.org/pdb_structure.php TCDB: Transport proteins with PDB structures]

Major Facilitators - Revision history

Ralf Stephan: /* Available structures */ +1

Ralf Stephan: New page: '''Major Facilitators''' are membrane proteins that help with both influx and outflux of specific small molecules. They are neither passive channels, nor do they active pumping, like the A...