Moesin - Revision history

Michal Harel at 08:18, 2 July 2023

Michal Harel — Sun, 02 Jul 2023 08:18:25 GMT

←Older revision		Revision as of 08:18, 2 July 2023
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	[[3u8z]] - hMO FERM domain 1-296 - human <br />		[[3u8z]] - hMO FERM domain 1-296 - human <br />
		+	[[8cit]], [[8ciu]] - hMO FERM domain (mutant) <br />
	[[1ef1]] - hMO FERM domain + C-terminal domain 487-576<br />		[[1ef1]] - hMO FERM domain + C-terminal domain 487-576<br />
	[[1e5w]] - hMO FERM domain + 1st helix 297-345 <br />		[[1e5w]] - hMO FERM domain + 1st helix 297-345 <br />
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	[[6txs]] - hMO FERM+helical linker domains + CD44 peptide<br />		[[6txs]] - hMO FERM+helical linker domains + CD44 peptide<br />
	[[1sgh]] - hMO FERM domain + EBP50 peptide <br />		[[1sgh]] - hMO FERM domain + EBP50 peptide <br />
		+	[[8cir]], [[8cis]] - hMO FERM domain + peptide <br />
	[[4yl8]] - MO FERM domain + Crumbs C-terminal peptide - mouse <br />		[[4yl8]] - MO FERM domain + Crumbs C-terminal peptide - mouse <br />
	[[2i1k]], [[2i1j]] - MO - armyworm <br />		[[2i1k]], [[2i1j]] - MO - armyworm <br />

Michal Harel at 09:05, 4 November 2021

Michal Harel — Thu, 04 Nov 2021 09:05:05 GMT

←Older revision		Revision as of 09:05, 4 November 2021
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	[[6txs]] - hMO FERM+helical linker domains + CD44 peptide<br />		[[6txs]] - hMO FERM+helical linker domains + CD44 peptide<br />
	[[1sgh]] - hMO FERM domain + EBP50 peptide <br />		[[1sgh]] - hMO FERM domain + EBP50 peptide <br />
-	[[2i1k]], [[2i1j]] - MO - armyworm <br />
	[[4yl8]] - MO FERM domain + Crumbs C-terminal peptide - mouse <br />		[[4yl8]] - MO FERM domain + Crumbs C-terminal peptide - mouse <br />
		+	[[2i1k]], [[2i1j]] - MO - armyworm <br />

	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Alexander Berchansky at 14:20, 15 October 2020

Alexander Berchansky — Thu, 15 Oct 2020 14:20:34 GMT

←Older revision		Revision as of 14:20, 15 October 2020
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	== Structural highlights ==		== Structural highlights ==

-	The 3D structure of the complex between FERM domain of the actin-binding moesin and the C-tail domain of cell polarity protein Crumbs shows that the interaction between the 2 proteins involves <scene name='86/864718/Cv/2'>very few residues</scene><ref>PMID:25792740</ref>.	+	The 3D structure of the complex between FERM domain of the actin-binding moesin and the C-tail domain of cell polarity protein Crumbs shows that the interaction between the 2 proteins involves <scene name='86/864718/Cv/3'>very few residues</scene><ref>PMID:25792740</ref>.

	</StructureSection>		</StructureSection>

Alexander Berchansky at 14:18, 15 October 2020

Alexander Berchansky — Thu, 15 Oct 2020 14:18:09 GMT

←Older revision		Revision as of 14:18, 15 October 2020
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	== Structural highlights ==		== Structural highlights ==

-	The 3D structure of the complex between FERM domain of the actin-binding moesin and the C-tail domain of cell polarity protein Crumbs shows that the interaction between the 2 proteins involves very few residues<ref>PMID:25792740</ref>.	+	The 3D structure of the complex between FERM domain of the actin-binding moesin and the C-tail domain of cell polarity protein Crumbs shows that the interaction between the 2 proteins involves <scene name='86/864718/Cv/2'>very few residues</scene><ref>PMID:25792740</ref>.

	</StructureSection>		</StructureSection>

Alexander Berchansky at 14:12, 15 October 2020

Alexander Berchansky — Thu, 15 Oct 2020 14:12:19 GMT

←Older revision		Revision as of 14:12, 15 October 2020
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-	<StructureSection load='4yl8' size='~~340~~' side='right' caption='Mouse moesin FERM domain (~~grey~~) complex with Crumbs C-terminal peptide (~~green~~), glycerol and I- ions (purple) (PDB code [[4yl8]]).' scene=''>	+	<StructureSection load='4yl8' size='400' side='right' caption='Mouse moesin FERM domain (green) complex with Crumbs C-terminal peptide (magenta), glycerol and I- ions (purple) (PDB code [[4yl8]]).' scene='86/864718/Cv/1'>

	== Function ==		== Function ==

-	'''Moesin''' ('''M'''embrane-'''O'''rganizing '''E'''xtension '''S'''pike '''P'''rotein) is a member of the ERM family (Ezrin-Radixin-Moesin) which is important for organizing membrane domains of effector T cells<ref>PMID:28287407</ref>. It plays a role in modification of the actin cytoskeleton<ref>PMID:28851405</ref>.	+	'''Moesin''' ('''M'''embrane-'''O'''rganizing '''E'''xtension '''S'''pike '''P'''rotein) is a member of the ERM family (Ezrin-Radixin-Moesin) which is important for organizing membrane domains of effector T cells<ref>PMID:28287407</ref>. It plays a role in modification of the actin cytoskeleton<ref>PMID:28851405</ref>.

	== Disease ==		== Disease ==

Michal Harel at 08:38, 15 October 2020

Michal Harel — Thu, 15 Oct 2020 08:38:18 GMT

←Older revision		Revision as of 08:38, 15 October 2020
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-	<StructureSection load='4yl8' size='340' side='right' caption='Mouse moesin FERM domain (grey) complex with Crumbs C-terminal (green), glycerol and I- ions (purple) (PDB code [[4yl8]]).' scene=''>	+	<StructureSection load='4yl8' size='340' side='right' caption='Mouse moesin FERM domain (grey) complex with Crumbs C-terminal peptide (green), glycerol and I- ions (purple) (PDB code [[4yl8]]).' scene=''>

	== Function ==		== Function ==
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	[[1sgh]] - hMO FERM domain + EBP50 peptide <br />		[[1sgh]] - hMO FERM domain + EBP50 peptide <br />
	[[2i1k]], [[2i1j]] - MO - armyworm <br />		[[2i1k]], [[2i1j]] - MO - armyworm <br />
-	[[4yl8]] - MO FERM domain + Crumbs - mouse <br />	+	[[4yl8]] - MO FERM domain + Crumbs C-terminal peptide - mouse <br />

	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 08:36, 15 October 2020

Michal Harel — Thu, 15 Oct 2020 08:36:59 GMT

←Older revision		Revision as of 08:36, 15 October 2020
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	[[1sgh]] - hMO FERM domain + EBP50 peptide <br />		[[1sgh]] - hMO FERM domain + EBP50 peptide <br />
	[[2i1k]], [[2i1j]] - MO - armyworm <br />		[[2i1k]], [[2i1j]] - MO - armyworm <br />
-	[[4yl8]] - MO + Crumbs - mouse <br />	+	[[4yl8]] - MO FERM domain + Crumbs - mouse <br />

	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 08:35, 15 October 2020

Michal Harel — Thu, 15 Oct 2020 08:35:29 GMT

←Older revision		Revision as of 08:35, 15 October 2020
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-	<StructureSection load='4yl8' size='340' side='right' caption='~~Caption for this structure~~' scene=''>	+	<StructureSection load='4yl8' size='340' side='right' caption='Mouse moesin FERM domain (grey) complex with Crumbs C-terminal (green), glycerol and I- ions (purple) (PDB code [[4yl8]]).' scene=''>

	== Function ==		== Function ==
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	== Structural highlights ==		== Structural highlights ==

-		+	The 3D structure of the complex between FERM domain of the actin-binding moesin and the C-tail domain of cell polarity protein Crumbs shows that the interaction between the 2 proteins involves very few residues<ref>PMID:25792740</ref>.

	</StructureSection>		</StructureSection>

	==3D structures of moesin==		==3D structures of moesin==
		+
		+	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

	[[3u8z]] - hMO FERM domain 1-296 - human <br />		[[3u8z]] - hMO FERM domain 1-296 - human <br />
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	== References ==		== References ==
	<references/>		<references/>
		+	[[Category:Topic Page]]

Michal Harel at 08:20, 15 October 2020

Michal Harel — Thu, 15 Oct 2020 08:20:53 GMT

←Older revision		Revision as of 08:20, 15 October 2020
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-		+	<StructureSection load='4yl8' size='340' side='right' caption='Caption for this structure' scene=''>
-	<StructureSection load='~~1sgh~~' size='340' side='right' caption='Caption for this structure' scene=''>	+

	== Function ==		== Function ==
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	[[1sgh]] - hMO FERM domain + EBP50 peptide <br />		[[1sgh]] - hMO FERM domain + EBP50 peptide <br />
	[[2i1k]], [[2i1j]] - MO - armyworm <br />		[[2i1k]], [[2i1j]] - MO - armyworm <br />
-	[[4yl8]] - MO + Crumbs - ~~''Drosophila melanogaster''~~ <br />	+	[[4yl8]] - MO + Crumbs - mouse <br />

	== References ==		== References ==
	<references/>		<references/>

Michal Harel: New page: == Function == '''Moesin''' ('''M'''embrane-'''O'''rganizing '''E'''xtension '''S'''...

Michal Harel — Thu, 15 Oct 2020 08:11:04 GMT

New page: <StructureSection load='1sgh' size='340' side='right' caption='Caption for this structure' scene=''> == Function == '''Moesin''' ('''M'''embrane-'''O'''rganizing '''E'''xtension '''S'''...

New page

<StructureSection load='1sgh' size='340' side='right' caption='Caption for this structure' scene=''>

== Function ==

'''Moesin''' ('''M'''embrane-'''O'''rganizing '''E'''xtension '''S'''pike '''P'''rotein) is a member of the ERM family (Ezrin-Radixin-Moesin) which is important for organizing membrane domains of effector T cells<ref>PMID:28287407</ref>. It plays a role in modification of the actin cytoskeleton<ref>PMID:28851405</ref>.

== Disease ==

Moesin is involved in the regulation of cell adhesion, polarity and migration by cross-linking between the actin cytoskeleton and plasma membrane and thus regulates hepatic fibrosis<ref>PMID:31860744</ref>.

== Relevance ==

Reduction of moesin expression in Drosophila brain resulted in prevention of long term memory formation.

== Structural highlights ==

</StructureSection>

==3D structures of moesin==

[[3u8z]] - hMO FERM domain 1-296 - human 
[[1ef1]] - hMO FERM domain + C-terminal domain 487-576 
[[1e5w]] - hMO FERM domain + 1st helix 297-345 
[[6txq]] - hMO FERM+helical linker domains - Cryo EM 
[[6txs]] - hMO FERM+helical linker domains + CD44 peptide 
[[1sgh]] - hMO FERM domain + EBP50 peptide 
[[2i1k]], [[2i1j]] - MO - armyworm 
[[4yl8]] - MO + Crumbs - ''Drosophila melanogaster'' 

== References ==
<references/>