Molecular Playground/ADAM13 - Revision history

Michal Harel at 21:39, 15 January 2012

Michal Harel — Sun, 15 Jan 2012 21:39:09 GMT

←Older revision		Revision as of 21:39, 15 January 2012
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	scene='User:Genevieve_Abbruzzese/Sandbox_1/Adam13homologymodel/1'		scene='User:Genevieve_Abbruzzese/Sandbox_1/Adam13homologymodel/1'
	caption='ADAM13 homology model against ADAM22 [[3g5c]]' />		caption='ADAM13 homology model against ADAM22 [[3g5c]]' />
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Michal Harel — Sun, 15 Jan 2012 21:38:34 GMT

←Older revision		Revision as of 21:38, 15 January 2012
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	'''ADAM13''' is one of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].		'''ADAM13''' is one of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].
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Michal Harel — Sun, 15 Jan 2012 21:38:13 GMT

←Older revision		Revision as of 21:38, 15 January 2012
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	scene='User:Genevieve_Abbruzzese/Sandbox_1/Adam13homologymodel/1'		scene='User:Genevieve_Abbruzzese/Sandbox_1/Adam13homologymodel/1'
	caption='ADAM13 homology model against ADAM22 [[3g5c]]' />		caption='ADAM13 homology model against ADAM22 [[3g5c]]' />
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Michal Harel — Sun, 15 Jan 2012 21:37:40 GMT

←Older revision		Revision as of 21:37, 15 January 2012
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	scene='User:Genevieve_Abbruzzese/Sandbox_1/Adam13homologymodel/1'		scene='User:Genevieve_Abbruzzese/Sandbox_1/Adam13homologymodel/1'
	caption='ADAM13 homology model against ADAM22 [[3g5c]]' />		caption='ADAM13 homology model against ADAM22 [[3g5c]]' />
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Michal Harel — Sun, 15 Jan 2012 21:37:08 GMT

←Older revision		Revision as of 21:37, 15 January 2012
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-	ADAM13 is one of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].	+	'''ADAM13''' is one of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].


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	scene='User:Genevieve_Abbruzzese/Sandbox_1/Adam13homologymodel/1'		scene='User:Genevieve_Abbruzzese/Sandbox_1/Adam13homologymodel/1'
	caption='ADAM13 homology model against ADAM22 [[3g5c]]' />		caption='ADAM13 homology model against ADAM22 [[3g5c]]' />
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Genevieve Abbruzzese — Fri, 10 Dec 2010 21:53:12 GMT

←Older revision		Revision as of 21:53, 10 December 2010
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-		+	ADAM13 is one of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].
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-	~~One~~ of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].	+

Genevieve Abbruzzese — Fri, 10 Dec 2010 18:55:23 GMT

Metalloprotease domain

←Older revision		Revision as of 18:55, 10 December 2010
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-	Most ADAMs contain the canonical metalloprotease active site sequence (HExxHxxGxxH) with a catalytic glutamate residue (shown in red) three Histidine residues (blue) that coordinate a zinc ion (green). ADAMs are known to cleave a variety of proteins present at the cell surface ~~in addition to cell adhesion molecules~~, such as signaling receptors and their ligands to either activate or inactivate ~~the~~ signaling ~~pathway~~. The [http://www-unix.oit.umass.edu/%7Ealfandar/ Alfandari Lab] currently studies the role of the meltrin subfamily of ADAMs in early embryo development.	+	Most ADAMs contain the canonical metalloprotease active site sequence (HExxHxxGxxH) with a catalytic glutamate residue (shown below in red) three Histidine residues (blue) that coordinate a zinc ion (green). In addition to cell adhesion molecules, ADAMs are known to cleave a variety of other biologically important proteins present at the cell surface, such as signaling receptors and their ligands to either activate or inactivate multiple signaling pathways. The [http://www-unix.oit.umass.edu/%7Ealfandar/ Alfandari Lab] currently studies the role of the meltrin subfamily of ADAMs in early embryo development.

Genevieve Abbruzzese — Fri, 10 Dec 2010 06:22:56 GMT

←Older revision		Revision as of 06:22, 10 December 2010
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-	Most ADAMs contain a canonical metalloprotease site (HExxHxxGxxH) with a catalytic glutamate residue (shown in red) three Histidine residues (blue) ~~coordinating~~ a ~~Zinc~~ ion (green). ADAMs are known to cleave a variety of proteins present at the cell surface in addition to cell adhesion molecules, such as signaling receptors and their ligands to either activate or inactivate the signaling pathway. The [http://www-unix.oit.umass.edu/%7Ealfandar/ Alfandari Lab] currently studies the role of the meltrin subfamily of ADAMs in early embryo development.	+	Most ADAMs contain the canonical metalloprotease active site sequence (HExxHxxGxxH) with a catalytic glutamate residue (shown in red) three Histidine residues (blue) that coordinate a zinc ion (green). ADAMs are known to cleave a variety of proteins present at the cell surface in addition to cell adhesion molecules, such as signaling receptors and their ligands to either activate or inactivate the signaling pathway. The [http://www-unix.oit.umass.edu/%7Ealfandar/ Alfandari Lab] currently studies the role of the meltrin subfamily of ADAMs in early embryo development.

Genevieve Abbruzzese — Fri, 10 Dec 2010 06:20:18 GMT

←Older revision		Revision as of 06:20, 10 December 2010
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	<applet size='[450,338]' frame='true' align='right'		<applet size='[450,338]' frame='true' align='right'
	scene='User:Genevieve_Abbruzzese/Sandbox_1/Adam13homologymodel/1'		scene='User:Genevieve_Abbruzzese/Sandbox_1/Adam13homologymodel/1'
-	caption='ADAM13 homology model against ADAM22[[3g5c]]' />	+	caption='ADAM13 homology model against ADAM22 [[3g5c]]' />

Genevieve Abbruzzese — Fri, 10 Dec 2010 06:18:57 GMT

←Older revision		Revision as of 06:18, 10 December 2010
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-		+	{{Template:Molecular Playground animation description}}
	[[Category: Molecular Playground]]		[[Category: Molecular Playground]]