NADH peroxidase - Revision history

Alexander Berchansky at 12:24, 21 July 2019

Alexander Berchansky — Sun, 21 Jul 2019 12:24:50 GMT

←Older revision		Revision as of 12:24, 21 July 2019
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	'''NADH peroxidase''' (NPO) catalyzes the conversion of NADH to NAD+ using hydrogen peroxide. See [[NAD]]. NPO eliminates the potentially toxic hydrogen peroxide and defends the cell against H<sub>2</sub>O<sub>2</sub>-mediated oxidative stress<ref>PMID:8425532</ref>. NPO provides an additional pathway for regeneration of NAD+ which is essential to the fermentative metabolism. FAD is the cofactor in this reaction.		'''NADH peroxidase''' (NPO) catalyzes the conversion of NADH to NAD+ using hydrogen peroxide. See [[NAD]]. NPO eliminates the potentially toxic hydrogen peroxide and defends the cell against H<sub>2</sub>O<sub>2</sub>-mediated oxidative stress<ref>PMID:8425532</ref>. NPO provides an additional pathway for regeneration of NAD+ which is essential to the fermentative metabolism. FAD is the cofactor in this reaction.
-	*<scene name='48/486476/Cv/4'>NAD binding site</scene>.	+	*<scene name='48/486476/Cv/13'>NAD binding site</scene>. Water molrcules are shown as red spheres.
-	*<scene name='48/486476/Cv/8'>NAD/FAD interactions</scene>.	+	*<scene name='48/486476/Cv/14'>NAD/FAD interactions</scene>.
-	*<scene name='48/486476/Cv/7'>FAD binding site</scene>.	+	*<scene name='48/486476/Cv/15'>FAD binding site</scene>.
-	*<scene name='48/486476/Cv/9'>Whole binding site</scene>.	+	*<scene name='48/486476/Cv/16'>Whole binding site</scene>.
-	*<scene name='48/486476/Cv/11'>NAD binding pocket</scene>.	+	*<scene name='48/486476/Cv/17'>NAD binding pocket</scene>.
-	*<scene name='48/486476/Cv/12'>FAD binding pocket</scene>.	+	*<scene name='48/486476/Cv/18'>FAD binding pocket</scene>.
	</StructureSection>		</StructureSection>
	==3D structures of NADH peroxidase==		==3D structures of NADH peroxidase==

Joel L. Sussman at 16:36, 20 October 2017

Joel L. Sussman — Fri, 20 Oct 2017 16:36:58 GMT

←Older revision		Revision as of 16:36, 20 October 2017
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-	<StructureSection load='~~2npx~~' size='450' side='right' scene='48/486476/Cv/1' caption='NADH peroxidase containing FAD complex with NAD, [[2npx]]'>	+	<StructureSection load='' size='450' side='right' scene='48/486476/Cv/1' caption='NADH peroxidase containing FAD complex with NAD, [[2npx]]'>

	'''NADH peroxidase''' (NPO) catalyzes the conversion of NADH to NAD+ using hydrogen peroxide. See [[NAD]]. NPO eliminates the potentially toxic hydrogen peroxide and defends the cell against H<sub>2</sub>O<sub>2</sub>-mediated oxidative stress<ref>PMID:8425532</ref>. NPO provides an additional pathway for regeneration of NAD+ which is essential to the fermentative metabolism. FAD is the cofactor in this reaction.		'''NADH peroxidase''' (NPO) catalyzes the conversion of NADH to NAD+ using hydrogen peroxide. See [[NAD]]. NPO eliminates the potentially toxic hydrogen peroxide and defends the cell against H<sub>2</sub>O<sub>2</sub>-mediated oxidative stress<ref>PMID:8425532</ref>. NPO provides an additional pathway for regeneration of NAD+ which is essential to the fermentative metabolism. FAD is the cofactor in this reaction.

Michal Harel at 15:24, 20 October 2017

Michal Harel — Fri, 20 Oct 2017 15:24:27 GMT

←Older revision		Revision as of 15:24, 20 October 2017
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	== References ==		== References ==
	<references/>		<references/>
		+	[[Category:Topic Page]]

Alexander Berchansky at 12:10, 10 August 2017

Alexander Berchansky — Thu, 10 Aug 2017 12:10:14 GMT

←Older revision		Revision as of 12:10, 10 August 2017
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	*<scene name='48/486476/Cv/7'>FAD binding site</scene>.		*<scene name='48/486476/Cv/7'>FAD binding site</scene>.
	*<scene name='48/486476/Cv/9'>Whole binding site</scene>.		*<scene name='48/486476/Cv/9'>Whole binding site</scene>.
		+	*<scene name='48/486476/Cv/11'>NAD binding pocket</scene>.
		+	*<scene name='48/486476/Cv/12'>FAD binding pocket</scene>.
	</StructureSection>		</StructureSection>
	==3D structures of NADH peroxidase==		==3D structures of NADH peroxidase==

Alexander Berchansky at 12:02, 10 August 2017

Alexander Berchansky — Thu, 10 Aug 2017 12:02:16 GMT

←Older revision		Revision as of 12:02, 10 August 2017
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	'''NADH peroxidase''' (NPO) catalyzes the conversion of NADH to NAD+ using hydrogen peroxide. See [[NAD]]. NPO eliminates the potentially toxic hydrogen peroxide and defends the cell against H<sub>2</sub>O<sub>2</sub>-mediated oxidative stress<ref>PMID:8425532</ref>. NPO provides an additional pathway for regeneration of NAD+ which is essential to the fermentative metabolism. FAD is the cofactor in this reaction.		'''NADH peroxidase''' (NPO) catalyzes the conversion of NADH to NAD+ using hydrogen peroxide. See [[NAD]]. NPO eliminates the potentially toxic hydrogen peroxide and defends the cell against H<sub>2</sub>O<sub>2</sub>-mediated oxidative stress<ref>PMID:8425532</ref>. NPO provides an additional pathway for regeneration of NAD+ which is essential to the fermentative metabolism. FAD is the cofactor in this reaction.
		+	*<scene name='48/486476/Cv/4'>NAD binding site</scene>.
		+	*<scene name='48/486476/Cv/8'>NAD/FAD interactions</scene>.
		+	*<scene name='48/486476/Cv/7'>FAD binding site</scene>.
		+	*<scene name='48/486476/Cv/9'>Whole binding site</scene>.
	</StructureSection>		</StructureSection>
	==3D structures of NADH peroxidase==		==3D structures of NADH peroxidase==

Alexander Berchansky at 10:56, 10 August 2017

Alexander Berchansky — Thu, 10 Aug 2017 10:56:51 GMT

←Older revision		Revision as of 10:56, 10 August 2017
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-	<StructureSection load='2npx' size='450' side='right' scene='' caption='NADH peroxidase containing FAD complex with NAD, [[2npx]]'>	+	<StructureSection load='2npx' size='450' side='right' scene='48/486476/Cv/1' caption='NADH peroxidase containing FAD complex with NAD, [[2npx]]'>

	'''NADH peroxidase''' (NPO) catalyzes the conversion of NADH to NAD+ using hydrogen peroxide. See [[NAD]]. NPO eliminates the potentially toxic hydrogen peroxide and defends the cell against H<sub>2</sub>O<sub>2</sub>-mediated oxidative stress<ref>PMID:8425532</ref>. NPO provides an additional pathway for regeneration of NAD+ which is essential to the fermentative metabolism. FAD is the cofactor in this reaction.		'''NADH peroxidase''' (NPO) catalyzes the conversion of NADH to NAD+ using hydrogen peroxide. See [[NAD]]. NPO eliminates the potentially toxic hydrogen peroxide and defends the cell against H<sub>2</sub>O<sub>2</sub>-mediated oxidative stress<ref>PMID:8425532</ref>. NPO provides an additional pathway for regeneration of NAD+ which is essential to the fermentative metabolism. FAD is the cofactor in this reaction.

Alexander Berchansky at 10:54, 10 August 2017

Alexander Berchansky — Thu, 10 Aug 2017 10:54:41 GMT

←Older revision		Revision as of 10:54, 10 August 2017
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-	~~{{STRUCTURE_2npx\| PDB~~=2npx ~~\| SIZE~~=~~350\| SCENE~~= \|right~~\|CAPTION~~=NADH peroxidase containing FAD complex with NAD, [[2npx]] }}	+	<StructureSection load='2npx' size='450' side='right' scene='' caption='NADH peroxidase containing FAD complex with NAD, [[2npx]]'>
-		+

	'''NADH peroxidase''' (NPO) catalyzes the conversion of NADH to NAD+ using hydrogen peroxide. See [[NAD]]. NPO eliminates the potentially toxic hydrogen peroxide and defends the cell against H<sub>2</sub>O<sub>2</sub>-mediated oxidative stress<ref>PMID:8425532</ref>. NPO provides an additional pathway for regeneration of NAD+ which is essential to the fermentative metabolism. FAD is the cofactor in this reaction.		'''NADH peroxidase''' (NPO) catalyzes the conversion of NADH to NAD+ using hydrogen peroxide. See [[NAD]]. NPO eliminates the potentially toxic hydrogen peroxide and defends the cell against H<sub>2</sub>O<sub>2</sub>-mediated oxidative stress<ref>PMID:8425532</ref>. NPO provides an additional pathway for regeneration of NAD+ which is essential to the fermentative metabolism. FAD is the cofactor in this reaction.
-		+	</StructureSection>
	==3D structures of NADH peroxidase==		==3D structures of NADH peroxidase==

Michal Harel at 08:40, 5 May 2016

Michal Harel — Thu, 05 May 2016 08:40:28 GMT

←Older revision		Revision as of 08:40, 5 May 2016
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	{{STRUCTURE_2npx\| PDB=2npx \| SIZE=350\| SCENE= \|right\|CAPTION=NADH peroxidase containing FAD complex with NAD, [[2npx]] }}		{{STRUCTURE_2npx\| PDB=2npx \| SIZE=350\| SCENE= \|right\|CAPTION=NADH peroxidase containing FAD complex with NAD, [[2npx]] }}

-	~~<!--~~	+
-	~~Please use the "3D" button above this box to insert a Jmol applet (molecule) on this page.~~	+	'''NADH peroxidase''' (NPO) catalyzes the conversion of NADH to NAD+ using hydrogen peroxide. See [[NAD]]. NPO eliminates the potentially toxic hydrogen peroxide and defends the cell against H<sub>2</sub>O<sub>2</sub>-mediated oxidative stress<ref>PMID:8425532</ref>. NPO provides an additional pathway for regeneration of NAD+ which is essential to the fermentative metabolism. FAD is the cofactor in this reaction.
-	~~Or use the four-green-boxes-button to insert scrollable text adjacent~~	+
-	~~to a Jmol applet. Check out the other buttons as well!~~	+
-	~~-->~~	+
-	'''NADH peroxidase''' (NPO) catalyzes the conversion of NADH to NAD+ using hydrogen peroxide. See [[NAD]]. NPO eliminates the potentially toxic hydrogen peroxide and defends the cell against ~~H2O2~~-mediated oxidative stress. NPO provides an additional pathway for regeneration of NAD+ which is essential to the fermentative metabolism. FAD is the cofactor in this reaction.	+

	==3D structures of NADH peroxidase==		==3D structures of NADH peroxidase==
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	[[2npx]] – EfNPO + NAD<br />		[[2npx]] – EfNPO + NAD<br />
	[[1nhp]], [[1nhq]], [[1nhr]], [[1nhs]], [[1f8w]] – EfNPO (mutant)		[[1nhp]], [[1nhq]], [[1nhr]], [[1nhs]], [[1f8w]] – EfNPO (mutant)
		+
		+	== References ==
		+	<references/>

Michal Harel at 08:40, 16 February 2016

Michal Harel — Tue, 16 Feb 2016 08:40:31 GMT

←Older revision		Revision as of 08:40, 16 February 2016
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-	{{STRUCTURE_2npx\| PDB=2npx \| SIZE=~~400~~\| SCENE= \|right\|CAPTION=NADH peroxidase containing FAD complex with NAD, [[2npx]] }}	+	{{STRUCTURE_2npx\| PDB=2npx \| SIZE=350\| SCENE= \|right\|CAPTION=NADH peroxidase containing FAD complex with NAD, [[2npx]] }}

	<!--		<!--
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	to a Jmol applet. Check out the other buttons as well!		to a Jmol applet. Check out the other buttons as well!
	-->		-->
-	'''NADH peroxidase''' (NPO) catalyzes the conversion of NADH to NAD+ using hydrogen peroxide. NPO eliminates the potentially toxic hydrogen peroxide and defends the cell against H2O2-mediated oxidative stress. NPO provides an additional pathway for regeneration of NAD+ which is essential to the fermentative metabolism. FAD is the cofactor in this reaction.	+	'''NADH peroxidase''' (NPO) catalyzes the conversion of NADH to NAD+ using hydrogen peroxide. See [[NAD]]. NPO eliminates the potentially toxic hydrogen peroxide and defends the cell against H2O2-mediated oxidative stress. NPO provides an additional pathway for regeneration of NAD+ which is essential to the fermentative metabolism. FAD is the cofactor in this reaction.

	==3D structures of NADH peroxidase==		==3D structures of NADH peroxidase==

Michal Harel at 07:31, 19 March 2012

Michal Harel — Mon, 19 Mar 2012 07:31:35 GMT

←Older revision		Revision as of 07:31, 19 March 2012
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-	{{STRUCTURE_2npx\| PDB=2npx \| SIZE=400\| SCENE= \|right\|CAPTION=NADH peroxidase complex with NAD, [[2npx]] }}	+	{{STRUCTURE_2npx\| PDB=2npx \| SIZE=400\| SCENE= \|right\|CAPTION=NADH peroxidase containing FAD complex with NAD, [[2npx]] }}

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