NSAID Pharmacokinetics - Revision history http://52.214.119.220/wiki/index.php?title=NSAID_Pharmacokinetics&action=history Revision history for this page on the wiki en MediaWiki 1.11.2 Sun, 12 Apr 2026 07:43:03 GMT David Canner at 16:39, 11 December 2010 http://52.214.119.220/wiki/index.php?title=NSAID_Pharmacokinetics&diff=1155905&oldid=prev <p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 16:39, 11 December 2010</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 207:</td> <td colspan="2" class="diff-lineno">Line 207:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Diclofenac (Voltaren)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Diclofenac (Voltaren)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>|}</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>|}</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>For references, see: [[Treatments:NSAID References|References]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>For references <ins style="color: red; font-weight: bold; text-decoration: none;">for NSAID Pharmacokinetics</ins>, see: [[Treatments:NSAID References|References]]</div></td></tr> </table> Sat, 11 Dec 2010 16:39:53 GMT David Canner http://52.214.119.220/wiki/index.php/Talk:NSAID_Pharmacokinetics David Canner at 16:39, 11 December 2010 http://52.214.119.220/wiki/index.php?title=NSAID_Pharmacokinetics&diff=1155904&oldid=prev <p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 16:39, 11 December 2010</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 92:</td> <td colspan="2" class="diff-lineno">Line 92:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 18.7</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 18.7</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 4.77</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 4.77</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Acetylsalicylic Acid (Aspirin)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">.25</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 8-11</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 8-11</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 11.2</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 11.2</div></td></tr> </table> Sat, 11 Dec 2010 16:39:17 GMT David Canner http://52.214.119.220/wiki/index.php/Talk:NSAID_Pharmacokinetics David Canner at 16:36, 11 December 2010 http://52.214.119.220/wiki/index.php?title=NSAID_Pharmacokinetics&diff=1155903&oldid=prev <p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 16:36, 11 December 2010</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 32:</td> <td colspan="2" class="diff-lineno">Line 32:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Nabumetone (Relafen)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Nabumetone (Relafen)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetaminophen (Paracetamol)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetaminophen (Paracetamol)</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Mefanamic Acid (Ponstel)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">22</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Ketorolac (Toradol)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Ketorolac (Toradol)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Rofecoxib (Vioxx)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Rofecoxib (Vioxx)</div></td></tr> <tr><td colspan="2" class="diff-lineno">Line 66:</td> <td colspan="2" class="diff-lineno">Line 66:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Nabumetone (Relafen)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Nabumetone (Relafen)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetaminophen (Paracetamol)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetaminophen (Paracetamol)</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Mefanamic Acid (Ponstel)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">90</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Ketorolac (Toradol)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Ketorolac (Toradol)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Rofecoxib (Vioxx)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Rofecoxib (Vioxx)</div></td></tr> <tr><td colspan="2" class="diff-lineno">Line 83:</td> <td colspan="2" class="diff-lineno">Line 83:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Nabumetone (Relafen)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Nabumetone (Relafen)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetaminophen (Paracetamol)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetaminophen (Paracetamol)</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Mefanamic Acid (Ponstel)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">90</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Ketorolac (Toradol)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Ketorolac (Toradol)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Rofecoxib (Vioxx)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Rofecoxib (Vioxx)</div></td></tr> <tr><td colspan="2" class="diff-lineno">Line 100:</td> <td colspan="2" class="diff-lineno">Line 100:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Nabumetone (Relafen)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Nabumetone (Relafen)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetaminophen (Paracetamol)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetaminophen (Paracetamol)</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Mefanamic Acid (Ponstel)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">2-4</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Ketorolac (Toradol)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Ketorolac (Toradol)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Rofecoxib (Vioxx)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Rofecoxib (Vioxx)</div></td></tr> <tr><td colspan="2" class="diff-lineno">Line 122:</td> <td colspan="2" class="diff-lineno">Line 122:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Diclofenac (Voltaren)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Diclofenac (Voltaren)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>|-</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>|-</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! [[Pharmacokinetics#Inhibitory_Concentration_.28IC50.29|IC&lt;sub&gt;50&lt;/sub&gt;]] COX-1 (nM)</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! [[Pharmacokinetics#Inhibitory_Concentration_.28IC50.29|IC&lt;sub&gt;50&lt;/sub&gt;]] COX-1 (nM) <ins style="color: red; font-weight: bold; text-decoration: none;">in Whole Blood</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">38000</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">Ibuprofen (Advil)</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">32000</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">Naproxen </ins>(<ins style="color: red; font-weight: bold; text-decoration: none;">Aleve</ins>)</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">! Flurbiprofen </del>(<del style="color: red; font-weight: bold; text-decoration: none;">Ansaid</del>)</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">440</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">ASPRIN</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">! 4400</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">150000</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">! 25400</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">! 140</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">1900</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 15000</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 15000</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Sulindac (Clinoril)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">2900</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Oxaprozin (Daypro)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">278000</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">680000</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">42000</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">82000</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">1900</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Acetaminophen (Paracetamol)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">110</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Mefanamic Acid (Ponstel)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">63000</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Ketorolac (Toradol)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">140</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">! &gt;1000000</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">! 30</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>|-</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>|-</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! [[Pharmacokinetics#Inhibitory_Concentration_.28IC50.29|IC&lt;sub&gt;50&lt;/sub&gt;]] COX-2 (nM)</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! [[Pharmacokinetics#Inhibitory_Concentration_.28IC50.29|IC&lt;sub&gt;50&lt;/sub&gt;]] COX-2 (nM) <ins style="color: red; font-weight: bold; text-decoration: none;">in Whole Blood</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">117000</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">Ibuprofen (Advil)</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">235000</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">Naproxen </ins>(<ins style="color: red; font-weight: bold; text-decoration: none;">Aleve</ins>)</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">! Flurbiprofen </del>(<del style="color: red; font-weight: bold; text-decoration: none;">Ansaid</del>)</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">6420</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">ASPRIN</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">13900</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">5</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">329</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">40</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">50</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Sulindac (Clinoril)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">55000</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Oxaprozin (Daypro)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">37000</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">660000</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">930</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">&gt;1000000</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">187000</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Acetaminophen (Paracetamol)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">11000</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Mefanamic Acid (Ponstel)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">160</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Ketorolac (Toradol)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">! 60</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">500</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">840</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">10</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">50</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>|-</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>|-</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! [[Pharmacokinetics#Clearance_.28Cl.29|Clearance]] (L/h)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! [[Pharmacokinetics#Clearance_.28Cl.29|Clearance]] (L/h)</div></td></tr> <tr><td colspan="2" class="diff-lineno">Line 168:</td> <td colspan="2" class="diff-lineno">Line 168:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Nabumetone (Relafen)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Nabumetone (Relafen)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetaminophen (Paracetamol)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetaminophen (Paracetamol)</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Mefanamic Acid (Ponstel)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">21.23</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Ketorolac (Toradol)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Ketorolac (Toradol)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Rofecoxib (Vioxx)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Rofecoxib (Vioxx)</div></td></tr> <tr><td colspan="2" class="diff-lineno">Line 185:</td> <td colspan="2" class="diff-lineno">Line 185:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Nabumetone (Relafen)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Nabumetone (Relafen)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetaminophen (Paracetamol)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetaminophen (Paracetamol)</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Mefanamic Acid (Ponstel)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">500</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Ketorolac (Toradol)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Ketorolac (Toradol)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Rofecoxib (Vioxx)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Rofecoxib (Vioxx)</div></td></tr> <tr><td colspan="2" class="diff-lineno">Line 202:</td> <td colspan="2" class="diff-lineno">Line 202:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Nabumetone (Relafen)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Nabumetone (Relafen)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetaminophen (Paracetamol)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetaminophen (Paracetamol)</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Mefanamic Acid </del>(<del style="color: red; font-weight: bold; text-decoration: none;">Ponstel</del>)</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">Hepatic </ins>(<ins style="color: red; font-weight: bold; text-decoration: none;">CYP2C9</ins>)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Ketorolac (Toradol)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Ketorolac (Toradol)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Rofecoxib (Vioxx)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Rofecoxib (Vioxx)</div></td></tr> </table> Sat, 11 Dec 2010 16:36:50 GMT David Canner http://52.214.119.220/wiki/index.php/Talk:NSAID_Pharmacokinetics David Canner at 16:09, 11 December 2010 http://52.214.119.220/wiki/index.php?title=NSAID_Pharmacokinetics&diff=1155900&oldid=prev <p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 16:09, 11 December 2010</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 15:</td> <td colspan="2" class="diff-lineno">Line 15:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Nabumetone (Relafen)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Nabumetone (Relafen)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetaminophen (Paracetamol)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetaminophen (Paracetamol)</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Mefanamic </del>Acid (Ponstel)</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">Mefenamic </ins>Acid (Ponstel)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Ketorolac (Toradol)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Ketorolac (Toradol)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Rofecoxib (Vioxx)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Rofecoxib (Vioxx)</div></td></tr> </table> Sat, 11 Dec 2010 16:09:34 GMT David Canner http://52.214.119.220/wiki/index.php/Talk:NSAID_Pharmacokinetics David Canner at 19:55, 9 December 2010 http://52.214.119.220/wiki/index.php?title=NSAID_Pharmacokinetics&diff=1155324&oldid=prev <p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 19:55, 9 December 2010</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 93:</td> <td colspan="2" class="diff-lineno">Line 93:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 4.77</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 4.77</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetylsalicylic Acid (Aspirin)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetylsalicylic Acid (Aspirin)</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Valdecoxib (Bextra)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">8-11</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 11.2</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 11.2</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 7.8</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 7.8</div></td></tr> <tr><td colspan="2" class="diff-lineno">Line 123:</td> <td colspan="2" class="diff-lineno">Line 123:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>|-</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>|-</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! [[Pharmacokinetics#Inhibitory_Concentration_.28IC50.29|IC&lt;sub&gt;50&lt;/sub&gt;]] COX-1 (nM)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! [[Pharmacokinetics#Inhibitory_Concentration_.28IC50.29|IC&lt;sub&gt;50&lt;/sub&gt;]] COX-1 (nM)</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">18</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">38000</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">11</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">32000</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Flurbiprofen (Ansaid)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Flurbiprofen (Ansaid)</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">342</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">ASPRIN</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Valdecoxib (Bextra)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">150000</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Celecoxib (Celebrex)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">15000</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Sulindac (Clinoril)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Sulindac (Clinoril)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Oxaprozin (Daypro)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Oxaprozin (Daypro)</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Piroxicam (Feldene)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">680000</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Nabumetone (Relafen)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">82000</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetaminophen (Paracetamol)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetaminophen (Paracetamol)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Mefanamic Acid (Ponstel)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Mefanamic Acid (Ponstel)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Ketorolac (Toradol)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Ketorolac (Toradol)</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Rofecoxib (Vioxx)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">&gt;1000000</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Diclofenac (Voltaren)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">30</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>|-</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>|-</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! [[Pharmacokinetics#Inhibitory_Concentration_.28IC50.29|IC&lt;sub&gt;50&lt;/sub&gt;]] COX-2 (nM)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! [[Pharmacokinetics#Inhibitory_Concentration_.28IC50.29|IC&lt;sub&gt;50&lt;/sub&gt;]] COX-2 (nM)</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">1030</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">117000</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">1015</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">235000</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Flurbiprofen (Ansaid)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Flurbiprofen (Ansaid)</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">&gt;5000</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">ASPRIN</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Valdecoxib (Bextra)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">5</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Celecoxib (Celebrex)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">40</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Sulindac (Clinoril)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Sulindac (Clinoril)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Oxaprozin (Daypro)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Oxaprozin (Daypro)</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Piroxicam (Feldene)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">660000</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Nabumetone (Relafen)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">&gt;1000000</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetaminophen (Paracetamol)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetaminophen (Paracetamol)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Mefanamic Acid (Ponstel)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Mefanamic Acid (Ponstel)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Ketorolac (Toradol)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Ketorolac (Toradol)</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Rofecoxib (Vioxx)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">500</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Diclofenac (Voltaren)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">10</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>|-</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>|-</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! [[Pharmacokinetics#Clearance_.28Cl.29|Clearance]] (L/h)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! [[Pharmacokinetics#Clearance_.28Cl.29|Clearance]] (L/h)</div></td></tr> <tr><td colspan="2" class="diff-lineno">Line 161:</td> <td colspan="2" class="diff-lineno">Line 161:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Flurbiprofen (Ansaid)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Flurbiprofen (Ansaid)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetylsalicylic Acid (Aspirin)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetylsalicylic Acid (Aspirin)</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Valdecoxib (Bextra)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">6</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 27.7</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 27.7</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 4.1</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 4.1</div></td></tr> </table> Thu, 09 Dec 2010 19:55:26 GMT David Canner http://52.214.119.220/wiki/index.php/Talk:NSAID_Pharmacokinetics David Canner at 19:41, 9 December 2010 http://52.214.119.220/wiki/index.php?title=NSAID_Pharmacokinetics&diff=1155319&oldid=prev <p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 19:41, 9 December 2010</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 23:</td> <td colspan="2" class="diff-lineno">Line 23:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 1.3</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 1.3</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! .92</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! .92</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! 2.<del style="color: red; font-weight: bold; text-decoration: none;">29</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! 2.<ins style="color: red; font-weight: bold; text-decoration: none;">3</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetylsalicylic Acid (Aspirin)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetylsalicylic Acid (Aspirin)</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! 2.<del style="color: red; font-weight: bold; text-decoration: none;">94</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! 2.<ins style="color: red; font-weight: bold; text-decoration: none;">9</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 2.8</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 2.8</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Sulindac (Clinoril)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">3.4</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Oxaprozin (Daypro)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Oxaprozin (Daypro)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Piroxicam (Feldene)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Piroxicam (Feldene)</div></td></tr> <tr><td colspan="2" class="diff-lineno">Line 43:</td> <td colspan="2" class="diff-lineno">Line 43:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetylsalicylic Acid (Aspirin)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetylsalicylic Acid (Aspirin)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 340</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 340</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">614)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">705</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Sulindac (Clinoril)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Sulindac (Clinoril)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Oxaprozin (Daypro)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Oxaprozin (Daypro)</div></td></tr> <tr><td colspan="2" class="diff-lineno">Line 95:</td> <td colspan="2" class="diff-lineno">Line 95:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Valdecoxib (Bextra)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Valdecoxib (Bextra)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 11.2</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 11.2</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Sulindac (Clinoril)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">7.8</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Oxaprozin (Daypro)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Oxaprozin (Daypro)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Piroxicam (Feldene)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Piroxicam (Feldene)</div></td></tr> <tr><td colspan="2" class="diff-lineno">Line 163:</td> <td colspan="2" class="diff-lineno">Line 163:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Valdecoxib (Bextra)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Valdecoxib (Bextra)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 27.7</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 27.7</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Sulindac (Clinoril)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">4.1</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Oxaprozin (Daypro)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Oxaprozin (Daypro)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Piroxicam (Feldene)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Piroxicam (Feldene)</div></td></tr> <tr><td colspan="2" class="diff-lineno">Line 180:</td> <td colspan="2" class="diff-lineno">Line 180:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 20</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 20</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 200</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 200</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Sulindac (Clinoril)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">200</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Oxaprozin (Daypro)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Oxaprozin (Daypro)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Piroxicam (Feldene)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Piroxicam (Feldene)</div></td></tr> </table> Thu, 09 Dec 2010 19:41:18 GMT David Canner http://52.214.119.220/wiki/index.php/Talk:NSAID_Pharmacokinetics David Canner at 19:30, 9 December 2010 http://52.214.119.220/wiki/index.php?title=NSAID_Pharmacokinetics&diff=1155317&oldid=prev <p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 19:30, 9 December 2010</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 58:</td> <td colspan="2" class="diff-lineno">Line 58:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 95</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 95</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 96</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 96</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Acetylsalicylic Acid (Aspirin)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">99</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 83</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 83</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Celecoxib (Celebrex)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Celecoxib (Celebrex)</div></td></tr> <tr><td colspan="2" class="diff-lineno">Line 192:</td> <td colspan="2" class="diff-lineno">Line 192:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Metabolism</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Metabolism</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Hepatic (CYP2C9)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Hepatic (CYP2C9)</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Naproxen</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">Hepatic (CYP2C9)</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Hepatic (CYP2C9)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Hepatic (CYP2C9)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetylsalicylic Acid (Aspirin)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetylsalicylic Acid (Aspirin)</div></td></tr> </table> Thu, 09 Dec 2010 19:30:38 GMT David Canner http://52.214.119.220/wiki/index.php/Talk:NSAID_Pharmacokinetics David Canner at 19:27, 9 December 2010 http://52.214.119.220/wiki/index.php?title=NSAID_Pharmacokinetics&diff=1155314&oldid=prev <p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 19:27, 9 December 2010</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 26:</td> <td colspan="2" class="diff-lineno">Line 26:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetylsalicylic Acid (Aspirin)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetylsalicylic Acid (Aspirin)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 2.94</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 2.94</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Celecoxib (Celebrex)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">2.8</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Sulindac (Clinoril)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Sulindac (Clinoril)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Oxaprozin (Daypro)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Oxaprozin (Daypro)</div></td></tr> <tr><td colspan="2" class="diff-lineno">Line 43:</td> <td colspan="2" class="diff-lineno">Line 43:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetylsalicylic Acid (Aspirin)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetylsalicylic Acid (Aspirin)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 340</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 340</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Celecoxib (Celebrex</del>)</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">614</ins>)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Sulindac (Clinoril)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Sulindac (Clinoril)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Oxaprozin (Daypro)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Oxaprozin (Daypro)</div></td></tr> <tr><td colspan="2" class="diff-lineno">Line 77:</td> <td colspan="2" class="diff-lineno">Line 77:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 99</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 99</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 98</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 98</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Celecoxib (Celebrex)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">97</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Sulindac (Clinoril)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Sulindac (Clinoril)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Oxaprozin (Daypro)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Oxaprozin (Daypro)</div></td></tr> <tr><td colspan="2" class="diff-lineno">Line 94:</td> <td colspan="2" class="diff-lineno">Line 94:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetylsalicylic Acid (Aspirin)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetylsalicylic Acid (Aspirin)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Valdecoxib (Bextra)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Valdecoxib (Bextra)</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Celecoxib (Celebrex)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">11.2</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Sulindac (Clinoril)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Sulindac (Clinoril)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Oxaprozin (Daypro)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Oxaprozin (Daypro)</div></td></tr> <tr><td colspan="2" class="diff-lineno">Line 111:</td> <td colspan="2" class="diff-lineno">Line 111:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetylsalicylic Acid (Aspirin)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetylsalicylic Acid (Aspirin)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 7548</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 7548</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Celecoxib (Celebrex)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">6930</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Sulindac (Clinoril)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Sulindac (Clinoril)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Oxaprozin (Daypro)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Oxaprozin (Daypro)</div></td></tr> <tr><td colspan="2" class="diff-lineno">Line 162:</td> <td colspan="2" class="diff-lineno">Line 162:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetylsalicylic Acid (Aspirin)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetylsalicylic Acid (Aspirin)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Valdecoxib (Bextra)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Valdecoxib (Bextra)</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Celecoxib (Celebrex)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">27.7</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Sulindac (Clinoril)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Sulindac (Clinoril)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Oxaprozin (Daypro)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Oxaprozin (Daypro)</div></td></tr> <tr><td colspan="2" class="diff-lineno">Line 179:</td> <td colspan="2" class="diff-lineno">Line 179:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetylsalicylic Acid (Aspirin)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetylsalicylic Acid (Aspirin)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 20</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 20</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Celecoxib (Celebrex)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">200</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Sulindac (Clinoril)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Sulindac (Clinoril)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Oxaprozin (Daypro)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Oxaprozin (Daypro)</div></td></tr> <tr><td colspan="2" class="diff-lineno">Line 196:</td> <td colspan="2" class="diff-lineno">Line 196:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetylsalicylic Acid (Aspirin)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetylsalicylic Acid (Aspirin)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Hepatic (CYP3A4 &amp; CYP2C9)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Hepatic (CYP3A4 &amp; CYP2C9)</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Celecoxib </del>(<del style="color: red; font-weight: bold; text-decoration: none;">Celebrex</del>)</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">Hepatic </ins>(<ins style="color: red; font-weight: bold; text-decoration: none;">CYP2C9</ins>)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Sulindac (Clinoril)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Sulindac (Clinoril)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Oxaprozin (Daypro)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Oxaprozin (Daypro)</div></td></tr> </table> Thu, 09 Dec 2010 19:27:10 GMT David Canner http://52.214.119.220/wiki/index.php/Talk:NSAID_Pharmacokinetics David Canner at 19:19, 9 December 2010 http://52.214.119.220/wiki/index.php?title=NSAID_Pharmacokinetics&diff=1155313&oldid=prev <p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 19:19, 9 December 2010</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 57:</td> <td colspan="2" class="diff-lineno">Line 57:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 49-73</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 49-73</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 95</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 95</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Flurbiprofen (Ansaid)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">96</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetylsalicylic Acid (Aspirin)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetylsalicylic Acid (Aspirin)</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Valdecoxib (Bextra)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">83</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Celecoxib (Celebrex)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Celecoxib (Celebrex)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Sulindac (Clinoril)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Sulindac (Clinoril)</div></td></tr> <tr><td colspan="2" class="diff-lineno">Line 74:</td> <td colspan="2" class="diff-lineno">Line 74:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 99</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 99</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 99</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 99</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Flurbiprofen (Ansaid)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">99</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Acetylsalicylic Acid (Aspirin)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">99</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Valdecoxib (Bextra)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">98</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Celecoxib (Celebrex)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Celecoxib (Celebrex)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Sulindac (Clinoril)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Sulindac (Clinoril)</div></td></tr> <tr><td colspan="2" class="diff-lineno">Line 192:</td> <td colspan="2" class="diff-lineno">Line 192:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Metabolism</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Metabolism</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Hepatic (CYP2C9)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Hepatic (CYP2C9)</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! Naproxen <del style="color: red; font-weight: bold; text-decoration: none;">(Aleve)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! Naproxen</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Flurbiprofen </del>(<del style="color: red; font-weight: bold; text-decoration: none;">Ansaid</del>)</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">Hepatic </ins>(<ins style="color: red; font-weight: bold; text-decoration: none;">CYP2C9</ins>)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetylsalicylic Acid (Aspirin)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetylsalicylic Acid (Aspirin)</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Valdecoxib </del>(<del style="color: red; font-weight: bold; text-decoration: none;">Bextra</del>)</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">Hepatic </ins>(<ins style="color: red; font-weight: bold; text-decoration: none;">CYP3A4 &amp; CYP2C9</ins>)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Celecoxib (Celebrex)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Celecoxib (Celebrex)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Sulindac (Clinoril)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Sulindac (Clinoril)</div></td></tr> </table> Thu, 09 Dec 2010 19:19:55 GMT David Canner http://52.214.119.220/wiki/index.php/Talk:NSAID_Pharmacokinetics David Canner at 19:13, 9 December 2010 http://52.214.119.220/wiki/index.php?title=NSAID_Pharmacokinetics&diff=1155310&oldid=prev <p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 19:13, 9 December 2010</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 25:</td> <td colspan="2" class="diff-lineno">Line 25:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 2.29</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 2.29</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetylsalicylic Acid (Aspirin)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetylsalicylic Acid (Aspirin)</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Valdecoxib (Bextra)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">2.94</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Celecoxib (Celebrex)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Celecoxib (Celebrex)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Sulindac (Clinoril)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Sulindac (Clinoril)</div></td></tr> <tr><td colspan="2" class="diff-lineno">Line 42:</td> <td colspan="2" class="diff-lineno">Line 42:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 19670</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 19670</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetylsalicylic Acid (Aspirin)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetylsalicylic Acid (Aspirin)</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Valdecoxib (Bextra)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">340</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Celecoxib (Celebrex)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Celecoxib (Celebrex)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Sulindac (Clinoril)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Sulindac (Clinoril)</div></td></tr> <tr><td colspan="2" class="diff-lineno">Line 110:</td> <td colspan="2" class="diff-lineno">Line 110:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 124320</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 124320</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetylsalicylic Acid (Aspirin)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetylsalicylic Acid (Aspirin)</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Valdecoxib (Bextra)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">7548</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Celecoxib (Celebrex)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Celecoxib (Celebrex)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Sulindac (Clinoril)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Sulindac (Clinoril)</div></td></tr> <tr><td colspan="2" class="diff-lineno">Line 178:</td> <td colspan="2" class="diff-lineno">Line 178:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 150</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! 150</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetylsalicylic Acid (Aspirin)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Acetylsalicylic Acid (Aspirin)</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>! <del style="color: red; font-weight: bold; text-decoration: none;">Valdecoxib (Bextra)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>! <ins style="color: red; font-weight: bold; text-decoration: none;">20</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Celecoxib (Celebrex)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Celecoxib (Celebrex)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Sulindac (Clinoril)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>! Sulindac (Clinoril)</div></td></tr> </table> Thu, 09 Dec 2010 19:13:51 GMT David Canner http://52.214.119.220/wiki/index.php/Talk:NSAID_Pharmacokinetics