Obscurin - Revision history

Michal Harel at 08:54, 17 August 2023

Michal Harel — Thu, 17 Aug 2023 08:54:14 GMT

←Older revision		Revision as of 08:54, 17 August 2023
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	**[[2e7b]] - hObs 6th Ig domain residues 8-97 – human - NMR<BR />		**[[2e7b]] - hObs 6th Ig domain residues 8-97 – human - NMR<BR />
	**[[2eo1]] - hObs Ig domain residues 69-163 – NMR<br />		**[[2eo1]] - hObs Ig domain residues 69-163 – NMR<br />
-	**[[2dm7]] - hObs ~~14th~~ Ig domain residues ~~1157~~-~~1251~~ – NMR<br />	+	**[[7r68]] - hObs 12th Ig domain residues 1071-1162 – NMR<br />
		+	**[[2dm7]], [[7r67]] - hObs 13th Ig domain residues 1161-1254 – NMR<br />
	**[[2gqh]] - hObs 15th Ig domain residues 1253-1346 – NMR<br />		**[[2gqh]] - hObs 15th Ig domain residues 1253-1346 – NMR<br />
	**[[2eny]] - hObs Ig domain residues 2735-2825 – NMR<BR />		**[[2eny]] - hObs Ig domain residues 2735-2825 – NMR<BR />
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	**[[2n56]] - hObs 59th Ig domain residues 4430-4524 – NMR<br />		**[[2n56]] - hObs 59th Ig domain residues 4430-4524 – NMR<br />
	**[[1v1c]] - hObs SH3 domain residues 5601-5668 – NMR<BR />		**[[1v1c]] - hObs SH3 domain residues 5601-5668 – NMR<BR />
		+	**[[8ak2]] - DmObs kinase domain residues 3186-3480 – ''Drosophila melanogaster''<br />
		+	**[[8ak3]] - DmObs kinase domain + ADP<br />

	*Obscurin-like protein 1		*Obscurin-like protein 1

Michal Harel at 09:49, 15 September 2020

Michal Harel — Tue, 15 Sep 2020 09:49:40 GMT

←Older revision		Revision as of 09:49, 15 September 2020
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	**[[2e7b]] - hObs 6th Ig domain residues 8-97 – human - NMR<BR />		**[[2e7b]] - hObs 6th Ig domain residues 8-97 – human - NMR<BR />
		+	**[[2eo1]] - hObs Ig domain residues 69-163 – NMR<br />
	**[[2dm7]] - hObs 14th Ig domain residues 1157-1251 – NMR<br />		**[[2dm7]] - hObs 14th Ig domain residues 1157-1251 – NMR<br />
	**[[2gqh]] - hObs 15th Ig domain residues 1253-1346 – NMR<br />		**[[2gqh]] - hObs 15th Ig domain residues 1253-1346 – NMR<br />
Line 38:		Line 39:
	*Obscurin-like protein 1		*Obscurin-like protein 1

		+	**[[5fm5]] - hObsL 3rd Ig domain residues 251-339 + myomesin-1<br />
	**[[2e6q]] - hObsL Ig domain residues 615-713 – NMR<BR />		**[[2e6q]] - hObsL Ig domain residues 615-713 – NMR<BR />
	**[[2e6p]] - hObsL Ig domain residues 714-804 – NMR<BR />		**[[2e6p]] - hObsL Ig domain residues 714-804 – NMR<BR />
-	**[[3knb]], [[2wp3]], [[2wwm]], [[4c4k]] – ~~hObs~~ N terminal residues 1-105 + titin M10 domain <br />	+	**[[2lvc]] - hObsL 6th Ig domain residues 805-892 – NMR<br />
-	**[[~~4uow~~]] ~~- hObs~~ residues ~~26829-26925~~+ titin M10 domain<br />	+	**[[2lu7]] - hObsL 11th Ig domain residues 1277-1357 – NMR<br />
-	**[[~~2wwk~~]] ~~– hObs N terminal~~ residues 1-~~105 (mutant)~~ + titin M10 domain<br />	+	**[[3knb]], [[2wp3]], [[2wwm]], [[4c4k]] – hObsL N terminal residues 1-105 + titin M10 domain <br />
		+	**[[2wwk]] – hObsL N terminal residues (mutant) + titin M10 domain<br />
		+	**[[4uow]] - hObsL residues 26829-26925 + titin M10 domain<br />
		+
	}}		}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 08:48, 12 November 2019

Michal Harel — Tue, 12 Nov 2019 08:48:01 GMT

←Older revision		Revision as of 08:48, 12 November 2019
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	**[[2edq]] - hObs Ig domain residues 3713-3806 – NMR<BR />		**[[2edq]] - hObs Ig domain residues 3713-3806 – NMR<BR />
	**[[2edl]] - hObs Ig domain residues 3801-3897 – NMR<BR />		**[[2edl]] - hObs Ig domain residues 3801-3897 – NMR<BR />
		+	**[[6mg9]] - hObs 57th Ig domain residues 4247-4338 – NMR<br />
	**[[2mwc]], [[4rsv]] - hObs 58th Ig domain residues 4337-4429 – NMR<br />		**[[2mwc]], [[4rsv]] - hObs 58th Ig domain residues 4337-4429 – NMR<br />
	**[[5tzm]] - hObs 59th Ig domain residues 4946-5036 <br />		**[[5tzm]] - hObs 59th Ig domain residues 4946-5036 <br />

Michal Harel at 09:50, 15 August 2018

Michal Harel — Wed, 15 Aug 2018 09:50:34 GMT

←Older revision		Revision as of 09:50, 15 August 2018
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	**[[2eny]] - hObs Ig domain residues 2735-2825 – NMR<BR />		**[[2eny]] - hObs Ig domain residues 2735-2825 – NMR<BR />
	**[[2edf]] - hObs 2nd Ig domain residues 2826-2915 – NMR<BR />		**[[2edf]] - hObs 2nd Ig domain residues 2826-2915 – NMR<BR />
-	**[[2dku]] - hObs Ig domain residues 2915-3004 – NMR<br />	+	**[[2dku]] - hObs 3rd Ig domain residues 2915-3004 – NMR<br />
	**[[2cr6]] - hObs Ig domain residues 2998-3100 – NMR<BR />		**[[2cr6]] - hObs Ig domain residues 2998-3100 – NMR<BR />
	**[[2yz8]] - hObs 32nd Ig domain residues 3184-3273 <br />		**[[2yz8]] - hObs 32nd Ig domain residues 3184-3273 <br />
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	**[[2edq]] - hObs Ig domain residues 3713-3806 – NMR<BR />		**[[2edq]] - hObs Ig domain residues 3713-3806 – NMR<BR />
	**[[2edl]] - hObs Ig domain residues 3801-3897 – NMR<BR />		**[[2edl]] - hObs Ig domain residues 3801-3897 – NMR<BR />
-	**[[2mwc]], [[4rsv]] - hObs Ig domain residues 4337-4429 – NMR<br />	+	**[[2mwc]], [[4rsv]] - hObs 58th Ig domain residues 4337-4429 – NMR<br />
-	**[[2n56]] - hObs Ig domain residues ~~4330~~-4524 – NMR<br />	+	**[[5tzm]] - hObs 59th Ig domain residues 4946-5036 <br />
		+	**[[2n56]] - hObs 59th Ig domain residues 4430-4524 – NMR<br />
	**[[1v1c]] - hObs SH3 domain residues 5601-5668 – NMR<BR />		**[[1v1c]] - hObs SH3 domain residues 5601-5668 – NMR<BR />

Michal Harel at 10:08, 28 August 2017

Michal Harel — Mon, 28 Aug 2017 10:08:07 GMT

←Older revision		Revision as of 10:08, 28 August 2017
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-
	<StructureSection load='2yz8' size='350' side='right' caption='Human obscurin of 32th IG-like domain residues 3184-3273 (PDB entry [[2yz8]])' scene=''>		<StructureSection load='2yz8' size='350' side='right' caption='Human obscurin of 32th IG-like domain residues 3184-3273 (PDB entry [[2yz8]])' scene=''>
	== Function ==		== Function ==
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	**[[2edq]] - hObs Ig domain residues 3713-3806 – NMR<BR />		**[[2edq]] - hObs Ig domain residues 3713-3806 – NMR<BR />
	**[[2edl]] - hObs Ig domain residues 3801-3897 – NMR<BR />		**[[2edl]] - hObs Ig domain residues 3801-3897 – NMR<BR />
		+	**[[2mwc]], [[4rsv]] - hObs Ig domain residues 4337-4429 – NMR<br />
		+	**[[2n56]] - hObs Ig domain residues 4330-4524 – NMR<br />
	**[[1v1c]] - hObs SH3 domain residues 5601-5668 – NMR<BR />		**[[1v1c]] - hObs SH3 domain residues 5601-5668 – NMR<BR />

Michal Harel at 10:00, 28 August 2017

Michal Harel — Mon, 28 Aug 2017 10:00:53 GMT

←Older revision		Revision as of 10:00, 28 August 2017
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-	{{STRUCTURE_2yz8\| PDB=2yz8 \| SIZE=400\| SCENE= \|right\|CAPTION=Human obscurin of 32th IG-like domain residues 3184-3273 [[2yz8]] }}

		+	<StructureSection load='2yz8' size='350' side='right' caption='Human obscurin of 32th IG-like domain residues 3184-3273 (PDB entry [[2yz8]])' scene=''>
	== Function ==		== Function ==
	'''Obscurin''' (Obs) or '''KIAA1556''' is a giant sarcomeric signalling protein expressed in striated muscles. Other giant proteins in the family include titin and nebulin. It is a multidomain protein containing adhesion modules and signaling domains. These domains include: 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with PH domain and 2 serine/thereonine kinase domains.		'''Obscurin''' (Obs) or '''KIAA1556''' is a giant sarcomeric signalling protein expressed in striated muscles. Other giant proteins in the family include titin and nebulin. It is a multidomain protein containing adhesion modules and signaling domains. These domains include: 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with PH domain and 2 serine/thereonine kinase domains.
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	== Disease ==		== Disease ==
	Mutations of Obs are found in hypertrophy cardiomyopathy<ref>PMID:17716621</ref>.		Mutations of Obs are found in hypertrophy cardiomyopathy<ref>PMID:17716621</ref>.
-		+	</StructureSection>
	==3D structures of obscurin==		==3D structures of obscurin==

Michal Harel at 09:06, 7 June 2016

Michal Harel — Tue, 07 Jun 2016 09:06:16 GMT

←Older revision		Revision as of 09:06, 7 June 2016
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	{{STRUCTURE_2yz8\| PDB=2yz8 \| SIZE=400\| SCENE= \|right\|CAPTION=Human obscurin of 32th IG-like domain residues 3184-3273 [[2yz8]] }}		{{STRUCTURE_2yz8\| PDB=2yz8 \| SIZE=400\| SCENE= \|right\|CAPTION=Human obscurin of 32th IG-like domain residues 3184-3273 [[2yz8]] }}

-	~~<!--~~	+	== Function ==
-	~~Please use the "3D" button above this box to insert a Jmol applet (molecule) on this page.~~	+
-	~~Or use the four-green-boxes-button to insert scrollable text adjacent~~	+
-	~~to a Jmol applet. Check out the other buttons as well!~~	+
-	~~-->~~	+
	'''Obscurin''' (Obs) or '''KIAA1556''' is a giant sarcomeric signalling protein expressed in striated muscles. Other giant proteins in the family include titin and nebulin. It is a multidomain protein containing adhesion modules and signaling domains. These domains include: 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with PH domain and 2 serine/thereonine kinase domains.		'''Obscurin''' (Obs) or '''KIAA1556''' is a giant sarcomeric signalling protein expressed in striated muscles. Other giant proteins in the family include titin and nebulin. It is a multidomain protein containing adhesion modules and signaling domains. These domains include: 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with PH domain and 2 serine/thereonine kinase domains.
	Obscurin binds small ankyrin 1 which is part of the sarcoplasmic reticulum membrane. It associates with the contractile apparatus via binding to titin and sarcomeric myosin. Obscurin is assumed to play a key role in modulating the organization and assembly of sarcomeric reticulum and the myofibril<ref>PMID:17012262</ref>.		Obscurin binds small ankyrin 1 which is part of the sarcoplasmic reticulum membrane. It associates with the contractile apparatus via binding to titin and sarcomeric myosin. Obscurin is assumed to play a key role in modulating the organization and assembly of sarcomeric reticulum and the myofibril<ref>PMID:17012262</ref>.

	For more details see [[Group:MUZIC:Obscurin]].		For more details see [[Group:MUZIC:Obscurin]].
		+
		+	== Disease ==
		+	Mutations of Obs are found in hypertrophy cardiomyopathy<ref>PMID:17716621</ref>.

	==3D structures of obscurin==		==3D structures of obscurin==

Michal Harel at 08:59, 7 June 2016

Michal Harel — Tue, 07 Jun 2016 08:59:38 GMT

←Older revision		Revision as of 08:59, 7 June 2016
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	-->		-->
	'''Obscurin''' (Obs) or '''KIAA1556''' is a giant sarcomeric signalling protein expressed in striated muscles. Other giant proteins in the family include titin and nebulin. It is a multidomain protein containing adhesion modules and signaling domains. These domains include: 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with PH domain and 2 serine/thereonine kinase domains.		'''Obscurin''' (Obs) or '''KIAA1556''' is a giant sarcomeric signalling protein expressed in striated muscles. Other giant proteins in the family include titin and nebulin. It is a multidomain protein containing adhesion modules and signaling domains. These domains include: 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with PH domain and 2 serine/thereonine kinase domains.
-	Obscurin binds small ankyrin 1 which is part of the sarcoplasmic reticulum membrane. It associates with the contractile apparatus via binding to titin and sarcomeric myosin. Obscurin is assumed to play a key role in modulating the organization and assembly of sarcomeric reticulum and the myofibril. For more details see [[Group:MUZIC:Obscurin]].	+	Obscurin binds small ankyrin 1 which is part of the sarcoplasmic reticulum membrane. It associates with the contractile apparatus via binding to titin and sarcomeric myosin. Obscurin is assumed to play a key role in modulating the organization and assembly of sarcomeric reticulum and the myofibril<ref>PMID:17012262</ref>.
		+
		+	For more details see [[Group:MUZIC:Obscurin]].

	==3D structures of obscurin==		==3D structures of obscurin==
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	**[[2wwk]] – hObs N terminal residues 1-105 (mutant) + titin M10 domain<br />		**[[2wwk]] – hObs N terminal residues 1-105 (mutant) + titin M10 domain<br />
	}}		}}
		+	== References ==
		+	<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 09:25, 7 May 2015

Michal Harel — Thu, 07 May 2015 09:25:30 GMT

←Older revision		Revision as of 09:25, 7 May 2015
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	to a Jmol applet. Check out the other buttons as well!		to a Jmol applet. Check out the other buttons as well!
	-->		-->
-	'''Obscurin''' (Obs) is a giant sarcomeric signalling protein expressed in striated muscles. Other giant proteins in the family include titin and nebulin. It is a multidomain protein containing adhesion modules and signaling domains. These domains include: 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with PH domain and 2 serine/thereonine kinase domains.	+	'''Obscurin''' (Obs) or '''KIAA1556''' is a giant sarcomeric signalling protein expressed in striated muscles. Other giant proteins in the family include titin and nebulin. It is a multidomain protein containing adhesion modules and signaling domains. These domains include: 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with PH domain and 2 serine/thereonine kinase domains.
	Obscurin binds small ankyrin 1 which is part of the sarcoplasmic reticulum membrane. It associates with the contractile apparatus via binding to titin and sarcomeric myosin. Obscurin is assumed to play a key role in modulating the organization and assembly of sarcomeric reticulum and the myofibril. For more details see [[Group:MUZIC:Obscurin]].		Obscurin binds small ankyrin 1 which is part of the sarcoplasmic reticulum membrane. It associates with the contractile apparatus via binding to titin and sarcomeric myosin. Obscurin is assumed to play a key role in modulating the organization and assembly of sarcomeric reticulum and the myofibril. For more details see [[Group:MUZIC:Obscurin]].

Line 17:		Line 17:

	**[[2e7b]] - hObs 6th Ig domain residues 8-97 – human - NMR<BR />		**[[2e7b]] - hObs 6th Ig domain residues 8-97 – human - NMR<BR />
		+	**[[2dm7]] - hObs 14th Ig domain residues 1157-1251 – NMR<br />
		+	**[[2gqh]] - hObs 15th Ig domain residues 1253-1346 – NMR<br />
	**[[2eny]] - hObs Ig domain residues 2735-2825 – NMR<BR />		**[[2eny]] - hObs Ig domain residues 2735-2825 – NMR<BR />
	**[[2edf]] - hObs 2nd Ig domain residues 2826-2915 – NMR<BR />		**[[2edf]] - hObs 2nd Ig domain residues 2826-2915 – NMR<BR />
		+	**[[2dku]] - hObs Ig domain residues 2915-3004 – NMR<br />
	**[[2cr6]] - hObs Ig domain residues 2998-3100 – NMR<BR />		**[[2cr6]] - hObs Ig domain residues 2998-3100 – NMR<BR />
	**[[2yz8]] - hObs 32nd Ig domain residues 3184-3273 <br />		**[[2yz8]] - hObs 32nd Ig domain residues 3184-3273 <br />
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	**[[2e6q]] - hObsL Ig domain residues 615-713 – NMR<BR />		**[[2e6q]] - hObsL Ig domain residues 615-713 – NMR<BR />
	**[[2e6p]] - hObsL Ig domain residues 714-804 – NMR<BR />		**[[2e6p]] - hObsL Ig domain residues 714-804 – NMR<BR />
-	**[[3knb]], [[2wp3]], [[2wwm]] – hObs N terminal residues 1-105 + titin M10 domain <br />	+	**[[3knb]], [[2wp3]], [[2wwm]], [[4c4k]] – hObs N terminal residues 1-105 + titin M10 domain <br />
		+	**[[4uow]] - hObs residues 26829-26925+ titin M10 domain<br />
	**[[2wwk]] – hObs N terminal residues 1-105 (mutant) + titin M10 domain<br />		**[[2wwk]] – hObs N terminal residues 1-105 (mutant) + titin M10 domain<br />
	}}		}}
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 07:44, 2 December 2014

Michal Harel — Tue, 02 Dec 2014 07:44:21 GMT

←Older revision		Revision as of 07:44, 2 December 2014
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	==3D structures of obscurin==		==3D structures of obscurin==

-	~~[[2e7b]]~~ - ~~hObs 6th Ig domain residues 8~~-~~97 – human - NMR<BR />~~	+	{{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-	~~[[2eny]] - hObs Ig domain residues 2735-2825 – NMR<BR />~~	+	{{#tree:id=OrganizedByTopic\|openlevels=0\|
-	~~[[2edf]] - hObs 2nd Ig domain residues 2826-2915 – NMR<BR />~~	+
-	~~[[2cr6]] - hObs Ig domain residues 2998-3100 – NMR<BR />~~	+
-	~~[[2yz8]] - hObs 32nd Ig domain residues 3184-3273 <br />~~	+
-	~~[[2edr]] - hObs Ig domain residues 3361-3449 – NMR<BR />~~	+
-	~~[[2edt]] - hObs Ig domain residues 3449-3537 – NMR<BR />~~	+
-	~~[[2edw]] - hObs I-set domain residues 3537-3630 – NMR<BR />~~	+
-	~~[[2edh]] – hObs PDZ domain residues 3614-3713 – NMR<BR />~~	+
-	~~[[2edq]] - hObs Ig domain residues 3713-3806 – NMR<BR />~~	+
-	~~[[2edl]] - hObs Ig domain residues 3801-3897 – NMR<BR />~~	+
-	~~[[1v1c]] - hObs SH3 domain residues 5601-5668 – NMR<BR />~~	+

-	~~===~~Obscurin~~-like protein 1===~~	+	*Obscurin

-	[[~~2e6q~~]] - ~~hObsL~~ Ig domain residues ~~615~~-~~713~~ – NMR<BR />	+	**[[2e7b]] - hObs 6th Ig domain residues 8-97 – human - NMR<BR />
-	[[~~2e6p~~]] - ~~hObsL~~ Ig domain residues ~~714~~-~~804~~ – NMR<BR />	+	**[[2eny]] - hObs Ig domain residues 2735-2825 – NMR<BR />
-	[[~~3knb~~]], [[~~2wp3~~]], [[~~2wwm~~]] – hObs ~~N terminal~~ residues 1-~~105 + titin M10~~ domain <br />	+	**[[2edf]] - hObs 2nd Ig domain residues 2826-2915 – NMR<BR />
-	[[~~2wwk~~]] – hObs ~~N terminal~~ residues 1-~~105 (mutant) + titin M10~~ domain<br />	+	**[[2cr6]] - hObs Ig domain residues 2998-3100 – NMR<BR />
		+	**[[2yz8]] - hObs 32nd Ig domain residues 3184-3273 <br />
		+	**[[2edr]] - hObs Ig domain residues 3361-3449 – NMR<BR />
		+	**[[2edt]] - hObs Ig domain residues 3449-3537 – NMR<BR />
		+	**[[2edw]] - hObs I-set domain residues 3537-3630 – NMR<BR />
		+	**[[2edh]] – hObs PDZ domain residues 3614-3713 – NMR<BR />
		+	**[[2edq]] - hObs Ig domain residues 3713-3806 – NMR<BR />
		+	**[[2edl]] - hObs Ig domain residues 3801-3897 – NMR<BR />
		+	**[[1v1c]] - hObs SH3 domain residues 5601-5668 – NMR<BR />

		+	*Obscurin-like protein 1
		+
		+	**[[2e6q]] - hObsL Ig domain residues 615-713 – NMR<BR />
		+	**[[2e6p]] - hObsL Ig domain residues 714-804 – NMR<BR />
		+	**[[3knb]], [[2wp3]], [[2wwm]] – hObs N terminal residues 1-105 + titin M10 domain <br />
		+	**[[2wwk]] – hObs N terminal residues 1-105 (mutant) + titin M10 domain<br />
		+	}}
	[[Category:Topic Page]]		[[Category:Topic Page]]