PDZ and LIM domain protein - Revision history

Michal Harel at 09:48, 21 August 2023

Michal Harel — Mon, 21 Aug 2023 09:48:13 GMT

←Older revision		Revision as of 09:48, 21 August 2023
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	**[[2q3g]] – hPDLIM PDZ domain + β-tropomysin C terminal <br />		**[[2q3g]] – hPDLIM PDZ domain + β-tropomysin C terminal <br />
		+	**[[7rm8]] – hPDLIM PDZ domain + SNX17 peptide - NMR <br />

	*PDLIM		*PDLIM

Michal Harel at 08:00, 16 August 2018

Michal Harel — Thu, 16 Aug 2018 08:00:19 GMT

←Older revision		Revision as of 08:00, 16 August 2018
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	**[[1v5l]] – mPDLIM PDZ domain - NMR<br />		**[[1v5l]] – mPDLIM PDZ domain - NMR<br />
	**[[1x64]] – mPDLIM LIM domain - NMR<br />		**[[1x64]] – mPDLIM LIM domain - NMR<br />
		+	**[[4ydp]] - hPDLIM PDZ domain <br />

	*PDLIM4		*PDLIM4

Michal Harel at 10:24, 15 June 2016

Michal Harel — Wed, 15 Jun 2016 10:24:06 GMT

←Older revision		Revision as of 10:24, 15 June 2016
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	<StructureSection load='2pa1' size='350' side='right' caption='Structure of PDZ and LIM domain protein 2 PDZ domain with C-terminal of β-tropomyosin and Cl- ions (PDB entry [[2pa1]])' scene=''>		<StructureSection load='2pa1' size='350' side='right' caption='Structure of PDZ and LIM domain protein 2 PDZ domain with C-terminal of β-tropomyosin and Cl- ions (PDB entry [[2pa1]])' scene=''>
	== Function ==		== Function ==
-	'''PDZ and LIM domain proteins''' (PDLIM) contain PDZ and LIM domains. PDLIM binds α-actinin via its PDZ domain and other proteins via its LIM domain. PDLIM is implicated in cardiac and skeletal muscle structure<ref>PMID:17767364</ref>~~.<br /> For details on PDLIM1 see [[Group:MUZIC:ALP]]~~.<br />For details on PDLIM see [[Group:MUZIC:ZASP]] and [[Group:MUZIC:Enigma Family]].	+	'''PDZ and LIM domain proteins''' (PDLIM) contain PDZ and LIM domains. PDLIM binds α-actinin via its PDZ domain and other proteins via its LIM domain. PDLIM is implicated in cardiac and skeletal muscle structure<ref>PMID:17767364</ref>.<br /> For details on PDLIM see [[Group:MUZIC:ZASP]] and [[Group:MUZIC:Enigma Family]].

-	*'''PDLIM1''' promotes cell attachment at the cytoskeleton.<br />	+	*'''PDLIM1''' promotes cell attachment at the cytoskeleton. For details see [[Group:MUZIC:ALP]].<br />
	*'''PDLIM2''' may have a role in bringing proteins to the cytoskeleton.<br />		*'''PDLIM2''' may have a role in bringing proteins to the cytoskeleton.<br />
	*'''PDLIM3''' may have a role in organizing actin filament arrays within muscle cells.<br />		*'''PDLIM3''' may have a role in organizing actin filament arrays within muscle cells.<br />

Michal Harel at 10:22, 15 June 2016

Michal Harel — Wed, 15 Jun 2016 10:22:26 GMT

←Older revision		Revision as of 10:22, 15 June 2016
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	<StructureSection load='2pa1' size='350' side='right' caption='Structure of PDZ and LIM domain protein 2 PDZ domain with C-terminal of β-tropomyosin and Cl- ions (PDB entry [[2pa1]])' scene=''>		<StructureSection load='2pa1' size='350' side='right' caption='Structure of PDZ and LIM domain protein 2 PDZ domain with C-terminal of β-tropomyosin and Cl- ions (PDB entry [[2pa1]])' scene=''>
	== Function ==		== Function ==
-	'''PDZ and LIM domain proteins''' (PDLIM) contain PDZ and LIM domains. PDLIM binds α-actinin via its PDZ domain and other proteins via its LIM domain. PDLIM is implicated in cardiac and skeletal muscle structure.<br /> For details on PDLIM1 see [[Group:MUZIC:ALP]].<br />For details on PDLIM see [[Group:MUZIC:ZASP]] and [[Group:MUZIC:Enigma Family]].	+	'''PDZ and LIM domain proteins''' (PDLIM) contain PDZ and LIM domains. PDLIM binds α-actinin via its PDZ domain and other proteins via its LIM domain. PDLIM is implicated in cardiac and skeletal muscle structure<ref>PMID:17767364</ref>.<br /> For details on PDLIM1 see [[Group:MUZIC:ALP]].<br />For details on PDLIM see [[Group:MUZIC:ZASP]] and [[Group:MUZIC:Enigma Family]].

	*'''PDLIM1''' promotes cell attachment at the cytoskeleton.<br />		*'''PDLIM1''' promotes cell attachment at the cytoskeleton.<br />
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	**[[1rgw]] – hPDLIM PDZ domain - NMR<br />		**[[1rgw]] – hPDLIM PDZ domain - NMR<br />
	}}		}}
		+	== References ==
		+	<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 10:17, 15 June 2016

Michal Harel — Wed, 15 Jun 2016 10:17:32 GMT

←Older revision		Revision as of 10:17, 15 June 2016
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	<StructureSection load='2pa1' size='350' side='right' caption='Structure of PDZ and LIM domain protein 2 PDZ domain with C-terminal of β-tropomyosin and Cl- ions (PDB entry [[2pa1]])' scene=''>		<StructureSection load='2pa1' size='350' side='right' caption='Structure of PDZ and LIM domain protein 2 PDZ domain with C-terminal of β-tropomyosin and Cl- ions (PDB entry [[2pa1]])' scene=''>
-		+	== Function ==
	'''PDZ and LIM domain proteins''' (PDLIM) contain PDZ and LIM domains. PDLIM binds α-actinin via its PDZ domain and other proteins via its LIM domain. PDLIM is implicated in cardiac and skeletal muscle structure.<br /> For details on PDLIM1 see [[Group:MUZIC:ALP]].<br />For details on PDLIM see [[Group:MUZIC:ZASP]] and [[Group:MUZIC:Enigma Family]].		'''PDZ and LIM domain proteins''' (PDLIM) contain PDZ and LIM domains. PDLIM binds α-actinin via its PDZ domain and other proteins via its LIM domain. PDLIM is implicated in cardiac and skeletal muscle structure.<br /> For details on PDLIM1 see [[Group:MUZIC:ALP]].<br />For details on PDLIM see [[Group:MUZIC:ZASP]] and [[Group:MUZIC:Enigma Family]].

	*'''PDLIM1''' promotes cell attachment at the cytoskeleton.<br />		*'''PDLIM1''' promotes cell attachment at the cytoskeleton.<br />
	*'''PDLIM2''' may have a role in bringing proteins to the cytoskeleton.<br />		*'''PDLIM2''' may have a role in bringing proteins to the cytoskeleton.<br />
		+	*'''PDLIM3''' may have a role in organizing actin filament arrays within muscle cells.<br />
		+	*'''PDLIM4''' is a Zn+2 ion binding protein.<br />
	*'''PDLIM5''' has important role in heart development by scaffolding PKC to the Z-disk region.<br />		*'''PDLIM5''' has important role in heart development by scaffolding PKC to the Z-disk region.<br />
	*'''PDLIM7''' is an adaptor protein localizing the LIM-binding proteins to muscle tissues.<br />		*'''PDLIM7''' is an adaptor protein localizing the LIM-binding proteins to muscle tissues.<br />

Michal Harel at 10:13, 15 June 2016

Michal Harel — Wed, 15 Jun 2016 10:13:52 GMT

←Older revision		Revision as of 10:13, 15 June 2016
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	'''PDZ and LIM domain proteins''' (PDLIM) contain PDZ and LIM domains. PDLIM binds α-actinin via its PDZ domain and other proteins via its LIM domain. PDLIM is implicated in cardiac and skeletal muscle structure.<br /> For details on PDLIM1 see [[Group:MUZIC:ALP]].<br />For details on PDLIM see [[Group:MUZIC:ZASP]] and [[Group:MUZIC:Enigma Family]].		'''PDZ and LIM domain proteins''' (PDLIM) contain PDZ and LIM domains. PDLIM binds α-actinin via its PDZ domain and other proteins via its LIM domain. PDLIM is implicated in cardiac and skeletal muscle structure.<br /> For details on PDLIM1 see [[Group:MUZIC:ALP]].<br />For details on PDLIM see [[Group:MUZIC:ZASP]] and [[Group:MUZIC:Enigma Family]].
		+
		+	*'''PDLIM1''' promotes cell attachment at the cytoskeleton.<br />
		+	*'''PDLIM2''' may have a role in bringing proteins to the cytoskeleton.<br />
		+	*'''PDLIM5''' has important role in heart development by scaffolding PKC to the Z-disk region.<br />
		+	*'''PDLIM7''' is an adaptor protein localizing the LIM-binding proteins to muscle tissues.<br />
		+
		+	== Relevance ==
		+	PDLIM2 may contribute to cancer cells migratory capacity. PDLIM5 overexpression promotes the development of heart hypertrophy.<br />
	</StructureSection>		</StructureSection>

Michal Harel at 09:42, 3 February 2016

Michal Harel — Wed, 03 Feb 2016 09:42:12 GMT

←Older revision		Revision as of 09:42, 3 February 2016
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	<StructureSection load='2pa1' size='350' side='right' caption='Structure of PDZ and LIM domain protein 2 PDZ domain with C-terminal of β-tropomyosin and Cl- ions (PDB entry [[2pa1]])' scene=''>		<StructureSection load='2pa1' size='350' side='right' caption='Structure of PDZ and LIM domain protein 2 PDZ domain with C-terminal of β-tropomyosin and Cl- ions (PDB entry [[2pa1]])' scene=''>

-	'''PDZ and LIM domain proteins''' (PDLIM) contain PDZ and LIM domains. PDLIM binds α-actinin via its PDZ domain and other proteins via its LIM domain. PDLIM is implicated in cardiac and skeletal muscle structure.<br /> For details on PDLIM1 see [[Group:MUZIC:ALP]].<br />For details on PDLIM see [[Group:MUZIC:ZASP]] and [[Group:~~MUZICEnigma~~ Family]].	+	'''PDZ and LIM domain proteins''' (PDLIM) contain PDZ and LIM domains. PDLIM binds α-actinin via its PDZ domain and other proteins via its LIM domain. PDLIM is implicated in cardiac and skeletal muscle structure.<br /> For details on PDLIM1 see [[Group:MUZIC:ALP]].<br />For details on PDLIM see [[Group:MUZIC:ZASP]] and [[Group:MUZIC:Enigma Family]].
	</StructureSection>		</StructureSection>

Michal Harel at 09:41, 3 February 2016

Michal Harel — Wed, 03 Feb 2016 09:41:28 GMT

←Older revision		Revision as of 09:41, 3 February 2016
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	<StructureSection load='2pa1' size='350' side='right' caption='Structure of PDZ and LIM domain protein 2 PDZ domain with C-terminal of β-tropomyosin and Cl- ions (PDB entry [[2pa1]])' scene=''>		<StructureSection load='2pa1' size='350' side='right' caption='Structure of PDZ and LIM domain protein 2 PDZ domain with C-terminal of β-tropomyosin and Cl- ions (PDB entry [[2pa1]])' scene=''>

-	'''PDZ and LIM domain proteins''' (PDLIM) contain PDZ and LIM domains. PDLIM binds α-actinin via its PDZ domain and other proteins via its LIM domain. PDLIM is implicated in cardiac and skeletal muscle structure.<br /> For details on PDLIM1 see [[Group:MUZIC:ALP]].<br />For details on PDLIM see [[Group:MUZIC:ZASP]].	+	'''PDZ and LIM domain proteins''' (PDLIM) contain PDZ and LIM domains. PDLIM binds α-actinin via its PDZ domain and other proteins via its LIM domain. PDLIM is implicated in cardiac and skeletal muscle structure.<br /> For details on PDLIM1 see [[Group:MUZIC:ALP]].<br />For details on PDLIM see [[Group:MUZIC:ZASP]] and [[Group:MUZICEnigma Family]].
	</StructureSection>		</StructureSection>

Michal Harel at 11:43, 6 January 2016

Michal Harel — Wed, 06 Jan 2016 11:43:59 GMT

←Older revision		Revision as of 11:43, 6 January 2016
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	<StructureSection load='2pa1' size='350' side='right' caption='Structure of PDZ and LIM domain protein 2 PDZ domain with C-terminal of β-tropomyosin and Cl- ions (PDB entry [[2pa1]])' scene=''>		<StructureSection load='2pa1' size='350' side='right' caption='Structure of PDZ and LIM domain protein 2 PDZ domain with C-terminal of β-tropomyosin and Cl- ions (PDB entry [[2pa1]])' scene=''>

-	'''PDZ and LIM domain proteins''' (PDLIM) contain PDZ and LIM domains. PDLIM binds α-actinin via its PDZ domain and other proteins via its LIM domain. PDLIM is implicated in cardiac and skeletal muscle structure. For details on PDLIM1 see [[Group:MUZIC:ALP]].	+	'''PDZ and LIM domain proteins''' (PDLIM) contain PDZ and LIM domains. PDLIM binds α-actinin via its PDZ domain and other proteins via its LIM domain. PDLIM is implicated in cardiac and skeletal muscle structure.<br /> For details on PDLIM1 see [[Group:MUZIC:ALP]].<br />For details on PDLIM see [[Group:MUZIC:ZASP]].
	</StructureSection>		</StructureSection>

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	**[[2q3g]] – hPDLIM PDZ domain + β-tropomysin C terminal <br />		**[[2q3g]] – hPDLIM PDZ domain + β-tropomysin C terminal <br />
		+
		+	*PDLIM
		+
		+	**[[1rgw]] – hPDLIM PDZ domain - NMR<br />
	}}		}}
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 10:51, 7 May 2015

Michal Harel — Thu, 07 May 2015 10:51:39 GMT

←Older revision		Revision as of 10:51, 7 May 2015
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	*PDLIM4		*PDLIM4

		+	**[[4q2o]] – hPDLIM <br />
	**[[2v1w]] – hPDLIM + α-actinin C terminal <br />		**[[2v1w]] – hPDLIM + α-actinin C terminal <br />
	**[[2eeg]] – hPDLIM PDZ domain - NMR<br />		**[[2eeg]] – hPDLIM PDZ domain - NMR<br />