PI3K/AKT/mTOR signaling pathway - Revision history

Alexander Berchansky at 12:04, 24 April 2022

Alexander Berchansky — Sun, 24 Apr 2022 12:04:32 GMT

←Older revision		Revision as of 12:04, 24 April 2022
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	<StructureSection load='3hhm' size='350' side='right' scene='' caption='PI3K (grey) complex with NISH2 P85α and wortmannin (PDB code [[3hhm]]) '>		<StructureSection load='3hhm' size='350' side='right' scene='' caption='PI3K (grey) complex with NISH2 P85α and wortmannin (PDB code [[3hhm]]) '>
-	The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle. Therefore, it is directly related to cellular quiescence, proliferation, cancer, and longevity. [[PI3K]] activation phosphorylates and activates AKT, localizing it in the plasma membrane. Protein kinase B (PKB), also known as Akt, is the collective name of a set of three [[Serine/threonine protein kinase\|serine/threonine-specific protein kinases]] that play key roles in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription, and cell migration. AKT can have a number of downstream effects such as activating CREB, inhibiting p27, localizing FOXO in the cytoplasm, activating PtdIns-3ps, and activating mTOR, which can affect transcription of p70 or 4EBP1.	+	The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle. Therefore, it is directly related to cellular quiescence, proliferation, cancer, and longevity. [[PI3K]] activation phosphorylates and activates AKT, localizing it in the plasma membrane. Protein kinase B (PKB), also known as Akt, is the collective name of a set of three [[Serine/threonine protein kinase\|serine/threonine-specific protein kinases]] that play key roles in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription, and cell migration. AKT can have a number of downstream effects such as activating CREB, inhibiting p27, localizing FOXO in the cytoplasm, activating PtdIns-3ps, and activating [[mTOR]], which can affect transcription of p70 or 4EBP1.

	</StructureSection>		</StructureSection>
	== References ==		== References ==
	<references/>		<references/>

Alexander Berchansky at 12:02, 24 April 2022

Alexander Berchansky — Sun, 24 Apr 2022 12:02:51 GMT

←Older revision		Revision as of 12:02, 24 April 2022
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	<StructureSection load='3hhm' size='350' side='right' scene='' caption='PI3K (grey) complex with NISH2 P85α and wortmannin (PDB code [[3hhm]]) '>		<StructureSection load='3hhm' size='350' side='right' scene='' caption='PI3K (grey) complex with NISH2 P85α and wortmannin (PDB code [[3hhm]]) '>
-	The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle. Therefore, it is directly related to cellular quiescence, proliferation, cancer, and longevity. [[PI3K]] activation phosphorylates and activates AKT, localizing it in the plasma membrane. AKT can have a number of downstream effects such as activating CREB, inhibiting p27, localizing FOXO in the cytoplasm, activating PtdIns-3ps, and activating mTOR, which can affect transcription of p70 or 4EBP1.	+	The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle. Therefore, it is directly related to cellular quiescence, proliferation, cancer, and longevity. [[PI3K]] activation phosphorylates and activates AKT, localizing it in the plasma membrane. Protein kinase B (PKB), also known as Akt, is the collective name of a set of three [[Serine/threonine protein kinase\|serine/threonine-specific protein kinases]] that play key roles in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription, and cell migration. AKT can have a number of downstream effects such as activating CREB, inhibiting p27, localizing FOXO in the cytoplasm, activating PtdIns-3ps, and activating mTOR, which can affect transcription of p70 or 4EBP1.

	</StructureSection>		</StructureSection>
	== References ==		== References ==
	<references/>		<references/>

Alexander Berchansky at 12:00, 24 April 2022

Alexander Berchansky — Sun, 24 Apr 2022 12:00:41 GMT

←Older revision		Revision as of 12:00, 24 April 2022
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	<StructureSection load='3hhm' size='350' side='right' scene='' caption='PI3K (grey) complex with NISH2 P85α and wortmannin (PDB code [[3hhm]]) '>		<StructureSection load='3hhm' size='350' side='right' scene='' caption='PI3K (grey) complex with NISH2 P85α and wortmannin (PDB code [[3hhm]]) '>
-	The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle. Therefore, it is directly related to cellular quiescence, proliferation, cancer, and longevity. PI3K activation phosphorylates and activates AKT, localizing it in the plasma membrane. AKT can have a number of downstream effects such as activating CREB, inhibiting p27,~~[3]~~ localizing FOXO in the cytoplasm, activating PtdIns-3ps, and activating mTOR~~[3]~~ which can affect transcription of p70 or 4EBP1.	+	The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle. Therefore, it is directly related to cellular quiescence, proliferation, cancer, and longevity. [[PI3K]] activation phosphorylates and activates AKT, localizing it in the plasma membrane. AKT can have a number of downstream effects such as activating CREB, inhibiting p27, localizing FOXO in the cytoplasm, activating PtdIns-3ps, and activating mTOR, which can affect transcription of p70 or 4EBP1.

	</StructureSection>		</StructureSection>
	== References ==		== References ==
	<references/>		<references/>

Alexander Berchansky at 11:59, 24 April 2022

Alexander Berchansky — Sun, 24 Apr 2022 11:59:35 GMT

←Older revision		Revision as of 11:59, 24 April 2022
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	<StructureSection load='3hhm' size='350' side='right' scene='' caption='PI3K (grey) complex with NISH2 P85α and wortmannin (PDB code [[3hhm]]) '>		<StructureSection load='3hhm' size='350' side='right' scene='' caption='PI3K (grey) complex with NISH2 P85α and wortmannin (PDB code [[3hhm]]) '>
-	~~This is a default text for your page '''~~PI3K/AKT/mTOR signaling pathway~~'''~~. ~~Click above on '''edit this page'''~~ to ~~modify~~. ~~Be careful with the <~~ and ~~> signs.~~	+	The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle. Therefore, it is directly related to cellular quiescence, proliferation, cancer, and longevity. PI3K activation phosphorylates and activates AKT, localizing it in the plasma membrane. AKT can have a number of downstream effects such as activating CREB, inhibiting p27,[3] localizing FOXO in the cytoplasm, activating PtdIns-3ps, and activating mTOR[3] which can affect transcription of p70 or 4EBP1.
-	~~You may include any references to papers as~~ in: the ~~use~~ of ~~JSmol~~ in ~~Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to~~ the ~~article describing Jmol <ref>PMID:21638687</ref> to the rescue.~~	+
-		+
-	~~== Function ==~~	+
-		+
-	~~== Disease ==~~	+
-		+
-	~~== Relevance ==~~	+
-		+
-	~~== Structural highlights ==~~	+
-		+
-	~~This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group~~, and ~~another to make <scene name="/12/3456/Sample/2">a transparent representation</scene>~~ of ~~the protein. You can make your own scenes on SAT starting from scratch~~ or ~~loading and editing one of these sample scenes~~.	+

	</StructureSection>		</StructureSection>
	== References ==		== References ==
	<references/>		<references/>

Alexander Berchansky: New page: This is a default text for your page '''P...

Alexander Berchansky — Sun, 24 Apr 2022 11:57:57 GMT

New page: <StructureSection load='3hhm' size='350' side='right' scene='' caption='PI3K (grey) complex with NISH2 P85α and wortmannin (PDB code 3hhm) '> This is a default text for your page '''P...

New page

<StructureSection load='3hhm' size='350' side='right' scene='' caption='PI3K (grey) complex with NISH2 P85α and wortmannin (PDB code [[3hhm]]) '>
This is a default text for your page '''PI3K/AKT/mTOR signaling pathway'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>