Phenylpyruvate decarboxylase - Revision history

Alexander Berchansky at 12:36, 31 July 2019

Alexander Berchansky — Wed, 31 Jul 2019 12:36:23 GMT

←Older revision		Revision as of 12:36, 31 July 2019
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	== Structural highlights ==		== Structural highlights ==
	PPDC active site contains the ThDP cofactor and the phenypyruvate substrate<ref>PMID:17905741</ref>.		PPDC active site contains the ThDP cofactor and the phenypyruvate substrate<ref>PMID:17905741</ref>.
-	*<scene name='46/468226/Cv/3'>ThDP cofactor/phenypyruvate substrate binding site</scene>. Water molecules shown as red spheres.	+	*<scene name='46/468226/Cv/6'>ThDP cofactor/phenypyruvate substrate binding site</scene>. Water molecules are shown as red spheres.
-	*<scene name='46/468226/Cv/5'>Mg coordination site</scene>.	+	*<scene name='46/468226/Cv/7'>Mg coordination site</scene>.
	</StructureSection>		</StructureSection>
	== 3D Structures of phenylpyruvate decarboxylase ==		== 3D Structures of phenylpyruvate decarboxylase ==

Michal Harel at 08:53, 19 December 2016

Michal Harel — Mon, 19 Dec 2016 08:53:27 GMT

←Older revision		Revision as of 08:53, 19 December 2016
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-	<StructureSection load='2q5o' size='~~450~~' side='right' scene='46/468226/Cv/1' caption='Phenylpyruvate decarboxylase dimer complex with phenylpyruvate, deaza-ThDP and Mg+2 (green) ion [[2q5o]]'>	+	<StructureSection load='2q5o' size='350' side='right' scene='46/468226/Cv/1' caption='Phenylpyruvate decarboxylase dimer complex with phenylpyruvate, deaza-ThDP and Mg+2 (green) ion [[2q5o]]'>

	== Function ==		== Function ==

Alexander Berchansky at 10:11, 8 September 2016

Alexander Berchansky — Thu, 08 Sep 2016 10:11:06 GMT

←Older revision		Revision as of 10:11, 8 September 2016
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	== Structural highlights ==		== Structural highlights ==
-	PPDC active site contains the ThDP cofactor and the phenypyruvate substrate<ref>PMID:17905741</ref>~~. Water molecules shown as red spheres~~.	+	PPDC active site contains the ThDP cofactor and the phenypyruvate substrate<ref>PMID:17905741</ref>.
-	*<scene name='46/468226/Cv/3'>ThDP cofactor/phenypyruvate substrate binding site</scene>.	+	*<scene name='46/468226/Cv/3'>ThDP cofactor/phenypyruvate substrate binding site</scene>. Water molecules shown as red spheres.
	*<scene name='46/468226/Cv/5'>Mg coordination site</scene>.		*<scene name='46/468226/Cv/5'>Mg coordination site</scene>.
	</StructureSection>		</StructureSection>

Alexander Berchansky at 10:10, 8 September 2016

Alexander Berchansky — Thu, 08 Sep 2016 10:10:43 GMT

←Older revision		Revision as of 10:10, 8 September 2016
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	== Structural highlights ==		== Structural highlights ==
-	PPDC active site contains the ThDP cofactor and the phenypyruvate substrate<ref>PMID:17905741</ref>.	+	PPDC active site contains the ThDP cofactor and the phenypyruvate substrate<ref>PMID:17905741</ref>. Water molecules shown as red spheres.
-	*<scene name='46/468226/Cv/3'>ThDP cofactor binding site</scene>.	+	*<scene name='46/468226/Cv/3'>ThDP cofactor/phenypyruvate substrate binding site</scene>.
	*<scene name='46/468226/Cv/5'>Mg coordination site</scene>.		*<scene name='46/468226/Cv/5'>Mg coordination site</scene>.
	</StructureSection>		</StructureSection>

Alexander Berchansky at 10:09, 8 September 2016

Alexander Berchansky — Thu, 08 Sep 2016 10:09:26 GMT

←Older revision		Revision as of 10:09, 8 September 2016
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	== Structural highlights ==		== Structural highlights ==
	PPDC active site contains the ThDP cofactor and the phenypyruvate substrate<ref>PMID:17905741</ref>.		PPDC active site contains the ThDP cofactor and the phenypyruvate substrate<ref>PMID:17905741</ref>.
		+	*<scene name='46/468226/Cv/3'>ThDP cofactor binding site</scene>.
		+	*<scene name='46/468226/Cv/5'>Mg coordination site</scene>.
	</StructureSection>		</StructureSection>
	== 3D Structures of phenylpyruvate decarboxylase ==		== 3D Structures of phenylpyruvate decarboxylase ==

Alexander Berchansky at 09:21, 8 September 2016

Alexander Berchansky — Thu, 08 Sep 2016 09:21:06 GMT

←Older revision		Revision as of 09:21, 8 September 2016
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-	<StructureSection load='2q5o' size='450' side='right' scene='' caption='Phenylpyruvate decarboxylase dimer complex with phenylpyruvate, deaza-ThDP and Mg+2 (green) ion [[2q5o]]'>	+	<StructureSection load='2q5o' size='450' side='right' scene='46/468226/Cv/1' caption='Phenylpyruvate decarboxylase dimer complex with phenylpyruvate, deaza-ThDP and Mg+2 (green) ion [[2q5o]]'>

	== Function ==		== Function ==

Alexander Berchansky at 09:13, 8 September 2016

Alexander Berchansky — Thu, 08 Sep 2016 09:13:37 GMT

←Older revision		Revision as of 09:13, 8 September 2016
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-	~~{{STRUCTURE_2q5o\| PDB~~=2q5o ~~\| SIZE~~=~~400\| SCENE~~= \|right~~\|CAPTION~~=Phenylpyruvate decarboxylase dimer complex with phenylpyruvate, deaza-ThDP and Mg+2 (green) ion [[2q5o]] }}	+	<StructureSection load='2q5o' size='450' side='right' scene='' caption='Phenylpyruvate decarboxylase dimer complex with phenylpyruvate, deaza-ThDP and Mg+2 (green) ion [[2q5o]]'>
		+
	== Function ==		== Function ==
	'''Phenylpyruvate decarboxylase''' (PPDC) catalyzes the conversion of phenylpyruvate to phenylacetaldehyde. PPDC participates in phenylalanine and tryptophan metabolism<ref>PMID:12902239</ref>. PPDC is a thiamine diphosphate (ThDP) (i.e., vitamin B1)-dependent enzyme.		'''Phenylpyruvate decarboxylase''' (PPDC) catalyzes the conversion of phenylpyruvate to phenylacetaldehyde. PPDC participates in phenylalanine and tryptophan metabolism<ref>PMID:12902239</ref>. PPDC is a thiamine diphosphate (ThDP) (i.e., vitamin B1)-dependent enzyme.
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	== Structural highlights ==		== Structural highlights ==
	PPDC active site contains the ThDP cofactor and the phenypyruvate substrate<ref>PMID:17905741</ref>.		PPDC active site contains the ThDP cofactor and the phenypyruvate substrate<ref>PMID:17905741</ref>.
-		+	</StructureSection>
	== 3D Structures of phenylpyruvate decarboxylase ==		== 3D Structures of phenylpyruvate decarboxylase ==

Michal Harel at 08:21, 23 June 2016

Michal Harel — Thu, 23 Jun 2016 08:21:34 GMT

←Older revision		Revision as of 08:21, 23 June 2016
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	{{STRUCTURE_2q5o\| PDB=2q5o \| SIZE=400\| SCENE= \|right\|CAPTION=Phenylpyruvate decarboxylase dimer complex with phenylpyruvate, deaza-ThDP and Mg+2 (green) ion [[2q5o]] }}		{{STRUCTURE_2q5o\| PDB=2q5o \| SIZE=400\| SCENE= \|right\|CAPTION=Phenylpyruvate decarboxylase dimer complex with phenylpyruvate, deaza-ThDP and Mg+2 (green) ion [[2q5o]] }}
		+	== Function ==
		+	'''Phenylpyruvate decarboxylase''' (PPDC) catalyzes the conversion of phenylpyruvate to phenylacetaldehyde. PPDC participates in phenylalanine and tryptophan metabolism<ref>PMID:12902239</ref>. PPDC is a thiamine diphosphate (ThDP) (i.e., vitamin B1)-dependent enzyme.

-	~~'''Phenylpyruvate decarboxylase''' (~~PPDC~~) catalyzes~~ the ~~conversion of phenylpyruvate to phenylacetaldehyde. PPDC participates in phenylalanine~~ and ~~tryptophan metabolism~~<ref>PMID:~~12902239~~</ref>.	+	== Structural highlights ==
-		+	PPDC active site contains the ThDP cofactor and the phenypyruvate substrate<ref>PMID:17905741</ref>.

	== 3D Structures of phenylpyruvate decarboxylase ==		== 3D Structures of phenylpyruvate decarboxylase ==

Michal Harel at 08:02, 23 June 2016

Michal Harel — Thu, 23 Jun 2016 08:02:18 GMT

←Older revision		Revision as of 08:02, 23 June 2016
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	{{STRUCTURE_2q5o\| PDB=2q5o \| SIZE=400\| SCENE= \|right\|CAPTION=Phenylpyruvate decarboxylase dimer complex with phenylpyruvate, deaza-ThDP and Mg+2 (green) ion [[2q5o]] }}		{{STRUCTURE_2q5o\| PDB=2q5o \| SIZE=400\| SCENE= \|right\|CAPTION=Phenylpyruvate decarboxylase dimer complex with phenylpyruvate, deaza-ThDP and Mg+2 (green) ion [[2q5o]] }}

-	'''Phenylpyruvate decarboxylase''' (PPDC) catalyzes the conversion of phenylpyruvate to phenylacetaldehyde. PPDC participates in phenylalanine and tryptophan metabolism.	+	'''Phenylpyruvate decarboxylase''' (PPDC) catalyzes the conversion of phenylpyruvate to phenylacetaldehyde. PPDC participates in phenylalanine and tryptophan metabolism<ref>PMID:12902239</ref>.

-	{{TOC limit\|limit=2}}

	== 3D Structures of phenylpyruvate decarboxylase ==		== 3D Structures of phenylpyruvate decarboxylase ==
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	[[2q5q]] - AbPPDC + deaza-ThDP + phenylvalerate		[[2q5q]] - AbPPDC + deaza-ThDP + phenylvalerate

-		+	== References ==
		+	<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 11:55, 29 December 2013

Michal Harel — Sun, 29 Dec 2013 11:55:12 GMT

←Older revision		Revision as of 11:55, 29 December 2013
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-	{{STRUCTURE_2q5o\| PDB=2q5o \| SIZE=400\| SCENE= \|right\|CAPTION=Phenylpyruvate decarboxylase dimer complex with phenylpyruvate ~~and~~ deaza-ThDP, [[2q5o]] }}	+	{{STRUCTURE_2q5o\| PDB=2q5o \| SIZE=400\| SCENE= \|right\|CAPTION=Phenylpyruvate decarboxylase dimer complex with phenylpyruvate, deaza-ThDP and Mg+2 (green) ion [[2q5o]] }}

	'''Phenylpyruvate decarboxylase''' (PPDC) catalyzes the conversion of phenylpyruvate to phenylacetaldehyde. PPDC participates in phenylalanine and tryptophan metabolism.		'''Phenylpyruvate decarboxylase''' (PPDC) catalyzes the conversion of phenylpyruvate to phenylacetaldehyde. PPDC participates in phenylalanine and tryptophan metabolism.