Phosphoglucose isomerase - Revision history

Alexander Berchansky at 15:06, 10 December 2019

Alexander Berchansky — Tue, 10 Dec 2019 15:06:21 GMT

←Older revision		Revision as of 15:06, 10 December 2019
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	<StructureSection load='' size='350' side='right' scene='48/481605/Cv/2' caption='Rabbit phosphoglucose isomerase dimer complex with fructose-6-phosphate, [[1hox]]'>		<StructureSection load='' size='350' side='right' scene='48/481605/Cv/2' caption='Rabbit phosphoglucose isomerase dimer complex with fructose-6-phosphate, [[1hox]]'>
	== Function ==		== Function ==
-	'''Phosphoglucose isomerase''' (PGI) or '''glucose-6-phosphate isomerase''' catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate<ref>PMID:25811607</ref>. The encoded protein is also referred to as '''autocrine motility factor''' (AMF) based on an additional function as a '''tumor-secreted cytokine''' and '''angiogenic factor'''. PGI is part of the glycolysis cycle. For more details see [[Phosphoglucoisomerase]].	+	'''Phosphoglucose isomerase''' (PGI) or '''glucose-6-phosphate isomerase''' catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate<ref>PMID:25811607</ref>. The encoded protein is also referred to as '''autocrine motility factor''' (AMF) based on an additional function as a '''tumor-secreted cytokine''' and '''angiogenic factor''' (see [[Growth factors]]). PGI is part of the glycolysis cycle. For more details see [[Phosphoglucoisomerase]].

	== Disease ==		== Disease ==

Alexander Berchansky at 15:05, 10 December 2019

Alexander Berchansky — Tue, 10 Dec 2019 15:05:05 GMT

←Older revision		Revision as of 15:05, 10 December 2019
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	<StructureSection load='' size='350' side='right' scene='48/481605/Cv/2' caption='Rabbit phosphoglucose isomerase dimer complex with fructose-6-phosphate, [[1hox]]'>		<StructureSection load='' size='350' side='right' scene='48/481605/Cv/2' caption='Rabbit phosphoglucose isomerase dimer complex with fructose-6-phosphate, [[1hox]]'>
	== Function ==		== Function ==
-	'''Phosphoglucose isomerase''' (PGI) or '''glucose-6-phosphate isomerase''' catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate<ref>PMID:25811607</ref>~~. PGI is part of the glycolysis cycle. For more details see [[Phosphoglucoisomerase]]~~. The encoded protein is also referred to as autocrine motility factor (AMF) based on an additional function as a tumor-secreted cytokine and angiogenic factor.	+	'''Phosphoglucose isomerase''' (PGI) or '''glucose-6-phosphate isomerase''' catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate<ref>PMID:25811607</ref>. The encoded protein is also referred to as '''autocrine motility factor''' (AMF) based on an additional function as a '''tumor-secreted cytokine''' and '''angiogenic factor'''. PGI is part of the glycolysis cycle. For more details see [[Phosphoglucoisomerase]].

	== Disease ==		== Disease ==

Alexander Berchansky at 15:01, 10 December 2019

Alexander Berchansky — Tue, 10 Dec 2019 15:01:36 GMT

←Older revision		Revision as of 15:01, 10 December 2019
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	<StructureSection load='' size='350' side='right' scene='48/481605/Cv/2' caption='Rabbit phosphoglucose isomerase dimer complex with fructose-6-phosphate, [[1hox]]'>		<StructureSection load='' size='350' side='right' scene='48/481605/Cv/2' caption='Rabbit phosphoglucose isomerase dimer complex with fructose-6-phosphate, [[1hox]]'>
	== Function ==		== Function ==
-	'''Phosphoglucose isomerase''' (PGI) or '''glucose-6-phosphate isomerase''' catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate<ref>PMID:25811607</ref>. PGI is part of the glycolysis cycle. For more details see [[Phosphoglucoisomerase]].	+	'''Phosphoglucose isomerase''' (PGI) or '''glucose-6-phosphate isomerase''' catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate<ref>PMID:25811607</ref>. PGI is part of the glycolysis cycle. For more details see [[Phosphoglucoisomerase]]. The encoded protein is also referred to as autocrine motility factor (AMF) based on an additional function as a tumor-secreted cytokine and angiogenic factor.

	== Disease ==		== Disease ==

Michal Harel at 11:46, 17 November 2019

Michal Harel — Sun, 17 Nov 2019 11:46:06 GMT

←Older revision		Revision as of 11:46, 17 November 2019
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	</StructureSection>		</StructureSection>
-	== 3D Structures of phosphoglucose isomerase ==

-	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-	{{#tree:id=OrganizedByTopic\|openlevels=0\|
-
-	*'''Phosphoglucose isomerase'''
-
-	**[[1iat]], [[1jlh]], [[1jiq]] – hPGI – human<br />
-	**[[1dqr]], [[1hm5]], [[1n8t]] – rPGI – rabbit<br />
-	**[[1u0e]], [[2cvp]] – mPGI – mouse<br />
-	**[[2pgi]], [[1b0z]] – GsPGI – ''Geobacillus stearothermophilus''<br />
-	**[[1qxj]], [[1x8e]], [[3sxw]] – PfPGI – ''Pyrococcus furiosus''<br />
-	**[[4lul]] - PfPGI (mutant) <br />
-	**[[1j3p]], [[1j3q]] – TlPGI – ''Thermococcus litoralis''<br />
-	**[[1q50]] – LmPGI – ''Leishmania Mexicana''<br />
-	**[[2q8n]] – PGI – ''Thermotoga maritima''<br />
-	**[[3hjb]] – PGI – ''Vibrio cholera''<br />
-	**[[3ifs]] – PGI – ''Bacillus anthracis''<br />
-	**[[2wu8]] – PGI – ''Mycobacterium tuberculosis''<br />
-	**[[3ljk]] – FtPGI (mutant) – ''Francisella tularensis''<br />
-	**[[3nbu]] – PGI – ''Escherichia coli''<br />
-	**[[3qki]] – PlfPGI – ''Plasmodium falciparum''<br />
-	**[[4em6]] – PGI – ''Brucella melitensis''<br />
-	**[[1tzb]] – PaPGI – ''Pyrobaculum aerophilum''<br />
-	**[[6bzb]] – EaPGI – ''Elizabethkingia anophelis''<br />
-
-	*Phosphoglucose isomerase complex with fructose-6-phosphate
-
-	**[[1hox]] – rPGI + fructose-6-phosphate<br />
-	**[[2cxs]], [[2cxt]] - mPGI + fructose-6-phosphate<br />
-	**[[1t10]] - LmPGI + fructose-6-phosphate<br />
-	**[[2gc2]] - PfPGI + fructose-6-phosphate<br />
-	**[[4lum]] - PfPGI (mutant) + fructose-6-phosphate<br />
-	**[[3m5p]] - FtPGI (mutant) + fructose-6-phosphate<br />
-	**[[3pr3]] - PlfPGI + fructose-6-phosphate<br />
-	**[[1x9h]] - PaPGI + fructose-6-phosphate<br />
-
-	*Phosphoglucose isomerase complex with sorbitol-6-phosphate
-
-	**[[1xtb]] - rPGI + sorbitol-6-phosphate<br />
-	**[[2cxq]] - mPGI + sorbitol-6-phosphate<br />
-	**[[2gc1]] - PfPGI + sorbitol-6-phosphate<br />
-
-	*Phosphoglucose isomerase complex with phosphoarabinose
-
-	**[[1nuh]] - hPGI + phosphoarabinose<br />
-	**[[1gzd]], [[1gzv]] – PGI + phosphoarabinose – pig<br />
-	**[[1koj]] – rPGI + phosphoarabinose derivative<br />
-	**[[2cxp]] – mPGI + phosphoarabinose<br >
-	**[[1c7r]] - GsPGI + phosphoarabinose<br />
-	**[[1qxr]], [[1x7n]], [[1x82]] - PfPGI + phosphoarabinose<br />
-	**[[4luk]], [[4lta]] - PfPGI (mutant) + phosphoarabinose<br />
-	**[[2gc0]] - PfPGI + phosphoarabinose derivative<br />
-	**[[1tzc]] - PaPGI + phosphoarabinose<br />
-
-	*Phosphoglucose isomerase complex with gluconate-6-phosphate
-
-	**[[2cxr]] - mPGI + gluconate-6-phosphate<br />
-	**[[1qy4]] - PfPGI + gluconate-6-phosphate<br />
-	**[[1j3r]] - TlPGI + gluconate-6-phosphate<br />
-	**[[3q7i]] - FtPGI (mutant) + gluconate-6-phosphate<br />
-
-	*Phosphoglucose isomerase complex with glucose-6-phosphate
-
-	**[[1u0f]] - mPGI + glucose-6-phosphate<br />
-	**[[1x9i]] - PaPGI + glucose-6-phosphate<br />
-	**[[6bzc]] - EaPGI + glucose-6-phosphate<br />
-	**[[3ff1]] - PGI + glucose-6-phosphate – ''Staphylococcus aureus''<br />
-	**[[2o2c]] - TbPGI + glucose-6-phosphate – ''Trypanosoma brucei''<br />
-	**[[3ujh]] - PGI + glucose-6-phosphate – ''Toxoplasma gondii''<br />
-	**[[6otu]] - PGI + glucose-6-phosphate – ''Chlamydia trachomatis''<br />
-
-	*Other phosphoglucose isomerase binary complexes
-
-	**[[1iri]] – hPGI + erythrose-4-phosphate<br />
-	**[[1g98]] – rPGI + transition state analog<br />
-	**[[2cxn]], [[2cxu]] – mPGI + phosphate<br />
-	**[[1u0g]], [[2cxo]] - mPGI + erythrose-4-phosphate<br />
-	**[[2o2d]] – TbPGI + citrate<br />
-	**[[3q88]] – FtPGI (mutant) + ribose bisphosphate<br />
-	**[[1c7q]] – GsPGI + phosphate inhibitor<br />
-	**[[2gc3]] - PfPGI + mannose-6-phosphate<br />
-
-	}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 11:45, 17 November 2019

Michal Harel — Sun, 17 Nov 2019 11:45:04 GMT

←Older revision		Revision as of 11:45, 17 November 2019
Line 7:		Line 7:
	== Structural highlights ==		== Structural highlights ==
	Rabbit <scene name='48/481605/Cv/6'>PGI active site containing the substrate D-fructose 6-phosphate shows the substrate interacting mainly with residues of one subunit</scene><ref>PMID:11425306</ref>. Water molecules are shown as red spheres.		Rabbit <scene name='48/481605/Cv/6'>PGI active site containing the substrate D-fructose 6-phosphate shows the substrate interacting mainly with residues of one subunit</scene><ref>PMID:11425306</ref>. Water molecules are shown as red spheres.
		+
		+	== 3D Structures of phosphoglucose isomerase ==
		+	[[Phosphoglucose isomerase 3D structures]]
		+
	</StructureSection>		</StructureSection>
	== 3D Structures of phosphoglucose isomerase ==		== 3D Structures of phosphoglucose isomerase ==
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	*'''Phosphoglucose isomerase'''		*'''Phosphoglucose isomerase'''

-	**[[2pgi]], [[1b0z]] – GsPGI – ''Geobacillus stearothermophilus''<br />
-	**[[1dqr]], [[1hm5]], [[1n8t]] – rPGI – rabbit<br />
	**[[1iat]], [[1jlh]], [[1jiq]] – hPGI – human<br />		**[[1iat]], [[1jlh]], [[1jiq]] – hPGI – human<br />
		+	**[[1dqr]], [[1hm5]], [[1n8t]] – rPGI – rabbit<br />
		+	**[[1u0e]], [[2cvp]] – mPGI – mouse<br />
		+	**[[2pgi]], [[1b0z]] – GsPGI – ''Geobacillus stearothermophilus''<br />
	**[[1qxj]], [[1x8e]], [[3sxw]] – PfPGI – ''Pyrococcus furiosus''<br />		**[[1qxj]], [[1x8e]], [[3sxw]] – PfPGI – ''Pyrococcus furiosus''<br />
	**[[4lul]] - PfPGI (mutant) <br />		**[[4lul]] - PfPGI (mutant) <br />
	**[[1j3p]], [[1j3q]] – TlPGI – ''Thermococcus litoralis''<br />		**[[1j3p]], [[1j3q]] – TlPGI – ''Thermococcus litoralis''<br />
	**[[1q50]] – LmPGI – ''Leishmania Mexicana''<br />		**[[1q50]] – LmPGI – ''Leishmania Mexicana''<br />
-	**[[1u0e]], [[2cvp]] – mPGI – mouse<br />
	**[[2q8n]] – PGI – ''Thermotoga maritima''<br />		**[[2q8n]] – PGI – ''Thermotoga maritima''<br />
	**[[3hjb]] – PGI – ''Vibrio cholera''<br />		**[[3hjb]] – PGI – ''Vibrio cholera''<br />
Line 32:		Line 36:
	**[[4em6]] – PGI – ''Brucella melitensis''<br />		**[[4em6]] – PGI – ''Brucella melitensis''<br />
	**[[1tzb]] – PaPGI – ''Pyrobaculum aerophilum''<br />		**[[1tzb]] – PaPGI – ''Pyrobaculum aerophilum''<br />
		+	**[[6bzb]] – EaPGI – ''Elizabethkingia anophelis''<br />

	*Phosphoglucose isomerase complex with fructose-6-phosphate		*Phosphoglucose isomerase complex with fructose-6-phosphate

	**[[1hox]] – rPGI + fructose-6-phosphate<br />		**[[1hox]] – rPGI + fructose-6-phosphate<br />
		+	**[[2cxs]], [[2cxt]] - mPGI + fructose-6-phosphate<br />
	**[[1t10]] - LmPGI + fructose-6-phosphate<br />		**[[1t10]] - LmPGI + fructose-6-phosphate<br />
	**[[2gc2]] - PfPGI + fructose-6-phosphate<br />		**[[2gc2]] - PfPGI + fructose-6-phosphate<br />
	**[[4lum]] - PfPGI (mutant) + fructose-6-phosphate<br />		**[[4lum]] - PfPGI (mutant) + fructose-6-phosphate<br />
-	**[[2cxs]], [[2cxt]] - mPGI + fructose-6-phosphate<br />
	**[[3m5p]] - FtPGI (mutant) + fructose-6-phosphate<br />		**[[3m5p]] - FtPGI (mutant) + fructose-6-phosphate<br />
	**[[3pr3]] - PlfPGI + fructose-6-phosphate<br />		**[[3pr3]] - PlfPGI + fructose-6-phosphate<br />
Line 47:		Line 52:

	**[[1xtb]] - rPGI + sorbitol-6-phosphate<br />		**[[1xtb]] - rPGI + sorbitol-6-phosphate<br />
-	**[[2gc1]] - PfPGI + sorbitol-6-phosphate<br />
	**[[2cxq]] - mPGI + sorbitol-6-phosphate<br />		**[[2cxq]] - mPGI + sorbitol-6-phosphate<br />
		+	**[[2gc1]] - PfPGI + sorbitol-6-phosphate<br />

	*Phosphoglucose isomerase complex with phosphoarabinose		*Phosphoglucose isomerase complex with phosphoarabinose

		+	**[[1nuh]] - hPGI + phosphoarabinose<br />
	**[[1gzd]], [[1gzv]] – PGI + phosphoarabinose – pig<br />		**[[1gzd]], [[1gzv]] – PGI + phosphoarabinose – pig<br />
		+	**[[1koj]] – rPGI + phosphoarabinose derivative<br />
		+	**[[2cxp]] – mPGI + phosphoarabinose<br >
	**[[1c7r]] - GsPGI + phosphoarabinose<br />		**[[1c7r]] - GsPGI + phosphoarabinose<br />
-	**[[2cxp]] – mPGI + phosphoarabinose<br />
-	**[[1nuh]] - hPGI + phosphoarabinose<br />
	**[[1qxr]], [[1x7n]], [[1x82]] - PfPGI + phosphoarabinose<br />		**[[1qxr]], [[1x7n]], [[1x82]] - PfPGI + phosphoarabinose<br />
	**[[4luk]], [[4lta]] - PfPGI (mutant) + phosphoarabinose<br />		**[[4luk]], [[4lta]] - PfPGI (mutant) + phosphoarabinose<br />
-	**[[1tzc]] - PaPGI + phosphoarabinose<br />
	**[[2gc0]] - PfPGI + phosphoarabinose derivative<br />		**[[2gc0]] - PfPGI + phosphoarabinose derivative<br />
-	**[[~~1koj~~]] ~~– rPGI~~ + phosphoarabinose ~~derivative~~	+	**[[1tzc]] - PaPGI + phosphoarabinose<br />

	*Phosphoglucose isomerase complex with gluconate-6-phosphate		*Phosphoglucose isomerase complex with gluconate-6-phosphate

		+	**[[2cxr]] - mPGI + gluconate-6-phosphate<br />
	**[[1qy4]] - PfPGI + gluconate-6-phosphate<br />		**[[1qy4]] - PfPGI + gluconate-6-phosphate<br />
	**[[1j3r]] - TlPGI + gluconate-6-phosphate<br />		**[[1j3r]] - TlPGI + gluconate-6-phosphate<br />
-	**[[2cxr]] - mPGI + gluconate-6-phosphate<br />
	**[[3q7i]] - FtPGI (mutant) + gluconate-6-phosphate<br />		**[[3q7i]] - FtPGI (mutant) + gluconate-6-phosphate<br />

Line 73:		Line 78:
	**[[1u0f]] - mPGI + glucose-6-phosphate<br />		**[[1u0f]] - mPGI + glucose-6-phosphate<br />
	**[[1x9i]] - PaPGI + glucose-6-phosphate<br />		**[[1x9i]] - PaPGI + glucose-6-phosphate<br />
		+	**[[6bzc]] - EaPGI + glucose-6-phosphate<br />
	**[[3ff1]] - PGI + glucose-6-phosphate – ''Staphylococcus aureus''<br />		**[[3ff1]] - PGI + glucose-6-phosphate – ''Staphylococcus aureus''<br />
	**[[2o2c]] - TbPGI + glucose-6-phosphate – ''Trypanosoma brucei''<br />		**[[2o2c]] - TbPGI + glucose-6-phosphate – ''Trypanosoma brucei''<br />
	**[[3ujh]] - PGI + glucose-6-phosphate – ''Toxoplasma gondii''<br />		**[[3ujh]] - PGI + glucose-6-phosphate – ''Toxoplasma gondii''<br />
		+	**[[6otu]] - PGI + glucose-6-phosphate – ''Chlamydia trachomatis''<br />

	*Other phosphoglucose isomerase binary complexes		*Other phosphoglucose isomerase binary complexes

-	**[[~~2o2d~~]] – ~~TbPGI~~ + ~~citrate~~<br />	+	**[[1iri]] – hPGI + erythrose-4-phosphate<br />
		+	**[[1g98]] – rPGI + transition state analog<br />
		+	**[[2cxn]], [[2cxu]] – mPGI + phosphate<br />
	**[[1u0g]], [[2cxo]] - mPGI + erythrose-4-phosphate<br />		**[[1u0g]], [[2cxo]] - mPGI + erythrose-4-phosphate<br />
		+	**[[2o2d]] – TbPGI + citrate<br />
	**[[3q88]] – FtPGI (mutant) + ribose bisphosphate<br />		**[[3q88]] – FtPGI (mutant) + ribose bisphosphate<br />
	**[[1c7q]] – GsPGI + phosphate inhibitor<br />		**[[1c7q]] – GsPGI + phosphate inhibitor<br />
-	**[[2cxn]], [[2cxu]] – mPGI + phosphate<br />
-	**[[1g98]] – rPGI + transition state analog<br />
	**[[2gc3]] - PfPGI + mannose-6-phosphate<br />		**[[2gc3]] - PfPGI + mannose-6-phosphate<br />
-	**[[1iri]] – hPGI + erythrose-4-phosphate<br />	+
	}}		}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Alexander Berchansky at 12:25, 1 August 2019

Alexander Berchansky — Thu, 01 Aug 2019 12:25:52 GMT

←Older revision		Revision as of 12:25, 1 August 2019
Line 6:		Line 6:
	Increased expression of PGI enhances colorectal cancer metastasis<ref>PMID:19787266</ref>.		Increased expression of PGI enhances colorectal cancer metastasis<ref>PMID:19787266</ref>.
	== Structural highlights ==		== Structural highlights ==
-	Rabbit <scene name='48/481605/Cv/5'>PGI active site containing the substrate D-fructose 6-phosphate shows the substrate interacting mainly with residues of one subunit</scene><ref>PMID:11425306</ref>. Water molecules shown as red spheres.	+	Rabbit <scene name='48/481605/Cv/6'>PGI active site containing the substrate D-fructose 6-phosphate shows the substrate interacting mainly with residues of one subunit</scene><ref>PMID:11425306</ref>. Water molecules are shown as red spheres.
	</StructureSection>		</StructureSection>
	== 3D Structures of phosphoglucose isomerase ==		== 3D Structures of phosphoglucose isomerase ==

Michal Harel at 09:46, 19 August 2018

Michal Harel — Sun, 19 Aug 2018 09:46:37 GMT

←Older revision		Revision as of 09:46, 19 August 2018
Line 1:		Line 1:
	<StructureSection load='' size='350' side='right' scene='48/481605/Cv/2' caption='Rabbit phosphoglucose isomerase dimer complex with fructose-6-phosphate, [[1hox]]'>		<StructureSection load='' size='350' side='right' scene='48/481605/Cv/2' caption='Rabbit phosphoglucose isomerase dimer complex with fructose-6-phosphate, [[1hox]]'>
	== Function ==		== Function ==
-	'''Phosphoglucose isomerase''' (PGI) catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate<ref>PMID:25811607</ref>. PGI is part of the glycolysis cycle. For more details see [[Phosphoglucoisomerase]].	+	'''Phosphoglucose isomerase''' (PGI) or '''glucose-6-phosphate isomerase''' catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate<ref>PMID:25811607</ref>. PGI is part of the glycolysis cycle. For more details see [[Phosphoglucoisomerase]].

	== Disease ==		== Disease ==

Michal Harel at 09:44, 19 August 2018

Michal Harel — Sun, 19 Aug 2018 09:44:18 GMT

←Older revision		Revision as of 09:44, 19 August 2018
Line 1:		Line 1:
-	<StructureSection load='' size='~~450~~' side='right' scene='48/481605/Cv/2' caption='Rabbit phosphoglucose isomerase dimer complex with fructose-6-phosphate, [[1hox]]'>	+	<StructureSection load='' size='350' side='right' scene='48/481605/Cv/2' caption='Rabbit phosphoglucose isomerase dimer complex with fructose-6-phosphate, [[1hox]]'>
	== Function ==		== Function ==
	'''Phosphoglucose isomerase''' (PGI) catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate<ref>PMID:25811607</ref>. PGI is part of the glycolysis cycle. For more details see [[Phosphoglucoisomerase]].		'''Phosphoglucose isomerase''' (PGI) catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate<ref>PMID:25811607</ref>. PGI is part of the glycolysis cycle. For more details see [[Phosphoglucoisomerase]].

Joel L. Sussman at 12:35, 21 October 2017

Joel L. Sussman — Sat, 21 Oct 2017 12:35:25 GMT

←Older revision		Revision as of 12:35, 21 October 2017
Line 1:		Line 1:
-	<StructureSection load='~~1hox~~' size='450' side='right' scene='48/481605/Cv/2' caption='Rabbit phosphoglucose isomerase dimer complex with fructose-6-phosphate, [[1hox]]'>	+	<StructureSection load='' size='450' side='right' scene='48/481605/Cv/2' caption='Rabbit phosphoglucose isomerase dimer complex with fructose-6-phosphate, [[1hox]]'>
	== Function ==		== Function ==
	'''Phosphoglucose isomerase''' (PGI) catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate<ref>PMID:25811607</ref>. PGI is part of the glycolysis cycle. For more details see [[Phosphoglucoisomerase]].		'''Phosphoglucose isomerase''' (PGI) catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate<ref>PMID:25811607</ref>. PGI is part of the glycolysis cycle. For more details see [[Phosphoglucoisomerase]].

Alexander Berchansky at 09:16, 5 September 2016

Alexander Berchansky — Mon, 05 Sep 2016 09:16:30 GMT

←Older revision		Revision as of 09:16, 5 September 2016
Line 6:		Line 6:
	Increased expression of PGI enhances colorectal cancer metastasis<ref>PMID:19787266</ref>.		Increased expression of PGI enhances colorectal cancer metastasis<ref>PMID:19787266</ref>.
	== Structural highlights ==		== Structural highlights ==
-	Rabbit <scene name='48/481605/Cv/5'>PGI active site containing the substrate D-fructose 6-phosphate shows the substrate interacting mainly with residues of one subunit</scene><ref>PMID:11425306</ref>.	+	Rabbit <scene name='48/481605/Cv/5'>PGI active site containing the substrate D-fructose 6-phosphate shows the substrate interacting mainly with residues of one subunit</scene><ref>PMID:11425306</ref>. Water molecules shown as red spheres.
	</StructureSection>		</StructureSection>
	== 3D Structures of phosphoglucose isomerase ==		== 3D Structures of phosphoglucose isomerase ==