Phospholamban - Revision history

Michal Harel at 07:59, 5 October 2020

Michal Harel — Mon, 05 Oct 2020 07:59:20 GMT

←Older revision		Revision as of 07:59, 5 October 2020
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	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}		Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

-	[[1plp]] – hPLB cytoplasmic domain – human - NMR <br />	+	[[1plp]] – hPLB cytoplasmic domain 1-24 – human - NMR <br />
-	[[1zll]], [[2hyn]] – hPLB - NMR <br />	+	[[6mqu]] – hPLB transmembrane domain 1-33 <br />
		+	[[1zll]], [[2hyn]] – hPLB 1-52 - NMR <br />
	[[1fjk]], [[1fjp]] – PLB – pig - NMR <br />		[[1fjk]], [[1fjp]] – PLB – pig - NMR <br />
	[[1n7l]], [[2lpf]] – rPLB (mutant) – rabbit - NMR <br />		[[1n7l]], [[2lpf]] – rPLB (mutant) – rabbit - NMR <br />

Michal Harel at 22:44, 21 October 2017

Michal Harel — Sat, 21 Oct 2017 22:44:24 GMT

←Older revision		Revision as of 22:44, 21 October 2017
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	== References ==		== References ==
	<references/>		<references/>
		+	[[Category:Topic Page]]

Michal Harel at 09:05, 5 September 2017

Michal Harel — Tue, 05 Sep 2017 09:05:44 GMT

←Older revision		Revision as of 09:05, 5 September 2017
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	[[2m3b]] – rPLB - NMR <br />		[[2m3b]] – rPLB - NMR <br />
	[[2kb7]], [[2kyv]] – PLB – ''Escherichia coli'' - NMR <br />		[[2kb7]], [[2kyv]] – PLB – ''Escherichia coli'' - NMR <br />
		+	[[1yod]] – PLB - synthetic <br />
	[[4kyt]] – dPLB (mutant) + calcium pump – dog <br />		[[4kyt]] – dPLB (mutant) + calcium pump – dog <br />
	[[4y3u]] – dPLB + calcium pump <br />		[[4y3u]] – dPLB + calcium pump <br />

Michal Harel at 09:16, 28 June 2016

Michal Harel — Tue, 28 Jun 2016 09:16:41 GMT

←Older revision		Revision as of 09:16, 28 June 2016
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	PLB is a key protein in the cardiac diastolic function<ref>PMID:23907041</ref>.		PLB is a key protein in the cardiac diastolic function<ref>PMID:23907041</ref>.
-
-	== Structural highlights ==

	</StructureSection>		</StructureSection>

Michal Harel at 09:13, 28 June 2016

Michal Harel — Tue, 28 Jun 2016 09:13:08 GMT

←Older revision		Revision as of 09:13, 28 June 2016
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	== Function ==		== Function ==

-	'''Phospholamban''' (PLB) is a 52-amino acid membrane protein that regulates the Ca+2 pump in cardiac and skeletal muscle cells. PLB functions as a homopentamer and is an inhibitor of Ca+2-ATPase in its unphosphorylated state. When PLB is phosphorylated by protein kinase A, it dissociates from Ca+2-ATPase and its inhibitory function is lost resulting in increase of ATPase activity.	+	'''Phospholamban''' (PLB) is a 52-amino acid membrane protein that regulates the Ca+2 pump in cardiac and skeletal muscle cells. PLB functions as a homopentamer and is an inhibitor of Ca+2-ATPase in its unphosphorylated state. When PLB is phosphorylated by protein kinase A, it dissociates from Ca+2-ATPase and its inhibitory function is lost resulting in increase of ATPase activity<ref>PMID:16317512</ref>.

	== Disease ==		== Disease ==

-	Mutations in PLB cause cardiomyopathy.	+	Mutations in PLB cause cardiomyopathy<ref>PMID:21167350</ref>.

	== Relevance ==		== Relevance ==

-	PLB is a key protein in the cardiac diastolic function.	+	PLB is a key protein in the cardiac diastolic function<ref>PMID:23907041</ref>.

	== Structural highlights ==		== Structural highlights ==

Michal Harel at 12:00, 10 January 2016

Michal Harel — Sun, 10 Jan 2016 12:00:09 GMT

←Older revision		Revision as of 12:00, 10 January 2016
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	<StructureSection load='4y3u' size='340' side='right' caption='Dog phospholamban (green and pink) complex with calcium pump (grey) and K+ ion (purple) (PDB code [[4y3u]])' scene=''>		<StructureSection load='4y3u' size='340' side='right' caption='Dog phospholamban (green and pink) complex with calcium pump (grey) and K+ ion (purple) (PDB code [[4y3u]])' scene=''>
-	'''Phospholamban''' (PLB) is a 52-amino acid membrane protein that regulates the Ca+2 pump in cardiac and skeletal muscle cells. PLB functions as a homopentamer and is an inhibitor of Ca+2-ATPase in its unphosphorylated state. When PLB is phosphorylated by protein kinase A, it dissociates from Ca+2-ATPase and its inhibitory function is lost resulting in increase of ATPase activity.
-
	== Function ==		== Function ==
		+
		+	'''Phospholamban''' (PLB) is a 52-amino acid membrane protein that regulates the Ca+2 pump in cardiac and skeletal muscle cells. PLB functions as a homopentamer and is an inhibitor of Ca+2-ATPase in its unphosphorylated state. When PLB is phosphorylated by protein kinase A, it dissociates from Ca+2-ATPase and its inhibitory function is lost resulting in increase of ATPase activity.

	== Disease ==		== Disease ==

Michal Harel at 10:12, 13 July 2015

Michal Harel — Mon, 13 Jul 2015 10:12:44 GMT

←Older revision		Revision as of 10:12, 13 July 2015
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-		+	<StructureSection load='4y3u' size='340' side='right' caption='Dog phospholamban (green and pink) complex with calcium pump (grey) and K+ ion (purple) (PDB code [[4y3u]])' scene=''>
-	<StructureSection load='4y3u' size='340' side='right' caption='Dog phospholamban complex with calcium pump (PDB code [[4y3u]])' scene=''>	+	'''Phospholamban''' (PLB) is a 52-amino acid membrane protein that regulates the Ca+2 pump in cardiac and skeletal muscle cells. PLB functions as a homopentamer and is an inhibitor of Ca+2-ATPase in its unphosphorylated state. When PLB is phosphorylated by protein kinase A, it dissociates from Ca+2-ATPase and its inhibitory function is lost resulting in increase of ATPase activity.
-	Phospholamban (PLB) is a 52-amino acid membrane protein that regulates the Ca+2 pump in cardiac and skeletal muscle cells. PLB functions as a homopentamer and is an inhibitor of Ca+2-ATPase in its unphosphorylated state. When PLB is phosphorylated by protein kinase A, it dissociates from Ca+2-ATPase and its inhibitory function is lost resulting in increase of ATPase activity.	+

	== Function ==		== Function ==

Michal Harel: New page: Phospholamban (PLB) is a 52-amino acid membrane p...

Michal Harel — Mon, 13 Jul 2015 10:09:55 GMT

New page: <StructureSection load='4y3u' size='340' side='right' caption='Dog phospholamban complex with calcium pump (PDB code 4y3u)' scene=''> Phospholamban (PLB) is a 52-amino acid membrane p...

New page

<StructureSection load='4y3u' size='340' side='right' caption='Dog phospholamban complex with calcium pump (PDB code [[4y3u]])' scene=''>
Phospholamban (PLB) is a 52-amino acid membrane protein that regulates the Ca+2 pump in cardiac and skeletal muscle cells. PLB functions as a homopentamer and is an inhibitor of Ca+2-ATPase in its unphosphorylated state. When PLB is phosphorylated by protein kinase A, it dissociates from Ca+2-ATPase and its inhibitory function is lost resulting in increase of ATPase activity.

== Function ==

== Disease ==

Mutations in PLB cause cardiomyopathy.

== Relevance ==

PLB is a key protein in the cardiac diastolic function.

== Structural highlights ==

</StructureSection>

== 3D Structures of phospholamban ==

Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

[[1plp]] – hPLB cytoplasmic domain – human - NMR 
[[1zll]], [[2hyn]] – hPLB - NMR 
[[1fjk]], [[1fjp]] – PLB – pig - NMR 
[[1n7l]], [[2lpf]] – rPLB (mutant) – rabbit - NMR 
[[2m3b]] – rPLB - NMR 
[[2kb7]], [[2kyv]] – PLB – ''Escherichia coli'' - NMR 
[[4kyt]] – dPLB (mutant) + calcium pump – dog 
[[4y3u]] – dPLB + calcium pump 

== References ==
<references/>