Pikachurin - Revision history

Rajesh Pal at 05:40, 8 October 2016

Rajesh Pal — Sat, 08 Oct 2016 05:40:08 GMT

←Older revision		Revision as of 05:40, 8 October 2016
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	== References ==		== References ==
-	1) Hu H, Li J, Zhang Z, Yu M . "Pikachurin interaction with dystroglycan is diminished by defective O-mannosyl glycosylation in congenital muscular dystrophy models and rescued by LARGE overexpression". Neurosci. Lett. 489 (1): 10–5.	+
		+	1) Hu H, Li J, Zhang Z, Yu M . "Pikachurin interaction with dystroglycan is diminished by defective O-mannosyl glycosylation in congenital muscular dystrophy models and rescued by LARGE overexpression". Neurosci. Lett. 489 (1): 10–5.

	2)http://www.uniprot.org/uniprot/Q63HQ2		2)http://www.uniprot.org/uniprot/Q63HQ2

	3)Sato S1, Omori Y, Katoh K, Kondo M, Kanagawa M, Miyata K, Funabiki K, Koyasu T, Kajimura N, Miyoshi T, Sawai H, Kobayashi K, Tani A, Toda T, Usukura J, Tano Y, Fujikado T, Furukawa T.Pikachurin, a dystroglycan ligand, is essential for photoreceptor ribbon synapse formation.Nat Neurosci. 2008 Aug;11(8):923-31. doi: 10.1038/nn.2160. Epub 2008 Jul 20.		3)Sato S1, Omori Y, Katoh K, Kondo M, Kanagawa M, Miyata K, Funabiki K, Koyasu T, Kajimura N, Miyoshi T, Sawai H, Kobayashi K, Tani A, Toda T, Usukura J, Tano Y, Fujikado T, Furukawa T.Pikachurin, a dystroglycan ligand, is essential for photoreceptor ribbon synapse formation.Nat Neurosci. 2008 Aug;11(8):923-31. doi: 10.1038/nn.2160. Epub 2008 Jul 20.

Rajesh Pal at 05:35, 8 October 2016

Rajesh Pal — Sat, 08 Oct 2016 05:35:41 GMT

←Older revision		Revision as of 05:35, 8 October 2016
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	Pikachurin protein has a dual function of photoreceptor visual synapse formation and visual perception.		Pikachurin protein has a dual function of photoreceptor visual synapse formation and visual perception.
-	~~[[Image:nn0808-857-F1.jpg]]~~	+

	== Disease ==		== Disease ==
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	== References ==		== References ==
-	1)Hu H, Li J, Zhang Z, Yu M ~~(February 2011)~~. "Pikachurin interaction with dystroglycan is diminished by defective O-mannosyl glycosylation in congenital muscular dystrophy models and rescued by LARGE overexpression". Neurosci. Lett. 489 (1): 10–5.	+	1) Hu H, Li J, Zhang Z, Yu M . "Pikachurin interaction with dystroglycan is diminished by defective O-mannosyl glycosylation in congenital muscular dystrophy models and rescued by LARGE overexpression". Neurosci. Lett. 489 (1): 10–5.

	2)http://www.uniprot.org/uniprot/Q63HQ2		2)http://www.uniprot.org/uniprot/Q63HQ2
-	<references/>

	3)Sato S1, Omori Y, Katoh K, Kondo M, Kanagawa M, Miyata K, Funabiki K, Koyasu T, Kajimura N, Miyoshi T, Sawai H, Kobayashi K, Tani A, Toda T, Usukura J, Tano Y, Fujikado T, Furukawa T.Pikachurin, a dystroglycan ligand, is essential for photoreceptor ribbon synapse formation.Nat Neurosci. 2008 Aug;11(8):923-31. doi: 10.1038/nn.2160. Epub 2008 Jul 20.		3)Sato S1, Omori Y, Katoh K, Kondo M, Kanagawa M, Miyata K, Funabiki K, Koyasu T, Kajimura N, Miyoshi T, Sawai H, Kobayashi K, Tani A, Toda T, Usukura J, Tano Y, Fujikado T, Furukawa T.Pikachurin, a dystroglycan ligand, is essential for photoreceptor ribbon synapse formation.Nat Neurosci. 2008 Aug;11(8):923-31. doi: 10.1038/nn.2160. Epub 2008 Jul 20.

Rajesh Pal at 05:34, 8 October 2016

Rajesh Pal — Sat, 08 Oct 2016 05:34:31 GMT

←Older revision		Revision as of 05:34, 8 October 2016
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		+	==Introduction==
		+	Synapse formation is very important for mammalian CNS to function properly. Information is transferred from photoreceptors present in the eye to bipolar and horizontal cells at the specialized synapse known as ribbon synapse.Pikachurin is an extracellular retinal protein which helps in precise interaction and signal transmission between ribbon synapse and bipolar dendrites.
		+
	== Function ==		== Function ==

-	~~Has~~ a dual function of photoreceptor visual synapse formation and visual perception.	+	Pikachurin protein has a dual function of photoreceptor visual synapse formation and visual perception.
		+	[[Image:nn0808-857-F1.jpg]]

	== Disease ==		== Disease ==
Line 13:		Line 17:
	2)http://www.uniprot.org/uniprot/Q63HQ2		2)http://www.uniprot.org/uniprot/Q63HQ2
	<references/>		<references/>
		+
		+	3)Sato S1, Omori Y, Katoh K, Kondo M, Kanagawa M, Miyata K, Funabiki K, Koyasu T, Kajimura N, Miyoshi T, Sawai H, Kobayashi K, Tani A, Toda T, Usukura J, Tano Y, Fujikado T, Furukawa T.Pikachurin, a dystroglycan ligand, is essential for photoreceptor ribbon synapse formation.Nat Neurosci. 2008 Aug;11(8):923-31. doi: 10.1038/nn.2160. Epub 2008 Jul 20.

Rajesh Pal at 21:53, 7 October 2016

Rajesh Pal — Fri, 07 Oct 2016 21:53:31 GMT

←Older revision		Revision as of 21:53, 7 October 2016
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	== Function ==		== Function ==

-	Has a dual function of photoreceptor visual synapse formation and visual perception	+	Has a dual function of photoreceptor visual synapse formation and visual perception.

	== Disease ==		== Disease ==

Rajesh Pal at 21:51, 7 October 2016

Rajesh Pal — Fri, 07 Oct 2016 21:51:37 GMT

←Older revision		Revision as of 21:51, 7 October 2016
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-
-
	== Function ==		== Function ==

-	Has a ~~Dual~~ function of photoreceptor visual synapse formation and visual perception	+	Has a dual function of photoreceptor visual synapse formation and visual perception

	== Disease ==		== Disease ==

-	Visual ~~Impairments~~ were seen in mice with deleted pikachurin gene. Congenital muscular dystrophies (CMD) such as muscle-eye-brain disease caused by defective glycosylation of α-dystroglycan (α-DG) exhibit defective photoreceptor synaptic function.	+	Visual impairments were seen in mice with deleted pikachurin gene. Congenital muscular dystrophies (CMD) such as muscle-eye-brain disease caused by defective glycosylation of α-dystroglycan (α-DG) exhibit defective photoreceptor synaptic function.

Rajesh Pal at 21:51, 7 October 2016

Rajesh Pal — Fri, 07 Oct 2016 21:51:04 GMT

←Older revision		Revision as of 21:51, 7 October 2016
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-	==PIKACHURIN==
-


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	== References ==		== References ==
	1)Hu H, Li J, Zhang Z, Yu M (February 2011). "Pikachurin interaction with dystroglycan is diminished by defective O-mannosyl glycosylation in congenital muscular dystrophy models and rescued by LARGE overexpression". Neurosci. Lett. 489 (1): 10–5.		1)Hu H, Li J, Zhang Z, Yu M (February 2011). "Pikachurin interaction with dystroglycan is diminished by defective O-mannosyl glycosylation in congenital muscular dystrophy models and rescued by LARGE overexpression". Neurosci. Lett. 489 (1): 10–5.
		+
	2)http://www.uniprot.org/uniprot/Q63HQ2		2)http://www.uniprot.org/uniprot/Q63HQ2
	<references/>		<references/>

Rajesh Pal at 21:50, 7 October 2016

Rajesh Pal — Fri, 07 Oct 2016 21:50:20 GMT

←Older revision		Revision as of 21:50, 7 October 2016
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-	==PIKACHURIN ~~GENE~~==	+	==PIKACHURIN==



-	== Function ==~~Has a Dual function of photoreceptor visual synapse formation and visual perception~~	+	== Function ==

-	~~== Disease ==Visual Impairments were seen in mice with deleted pikachurin gene. Congenital muscular dystrophies (CMD) such as muscle-eye-brain disease caused by defective glycosylation~~ of ~~α-dystroglycan (α-DG) exhibit defective~~ photoreceptor ~~synaptic function.~~	+	Has a Dual function of photoreceptor visual synapse formation and visual perception

-	== ~~Relevance~~ ==	+	== Disease ==

-	~~== Structural highlights ==~~	+	Visual Impairments were seen in mice with deleted pikachurin gene. Congenital muscular dystrophies (CMD) such as muscle-eye-brain disease caused by defective glycosylation of α-dystroglycan (α-DG) exhibit defective photoreceptor synaptic function.

-	This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

-	</StructureSection>
	== References ==		== References ==
	1)Hu H, Li J, Zhang Z, Yu M (February 2011). "Pikachurin interaction with dystroglycan is diminished by defective O-mannosyl glycosylation in congenital muscular dystrophy models and rescued by LARGE overexpression". Neurosci. Lett. 489 (1): 10–5.		1)Hu H, Li J, Zhang Z, Yu M (February 2011). "Pikachurin interaction with dystroglycan is diminished by defective O-mannosyl glycosylation in congenital muscular dystrophy models and rescued by LARGE overexpression". Neurosci. Lett. 489 (1): 10–5.
	2)http://www.uniprot.org/uniprot/Q63HQ2		2)http://www.uniprot.org/uniprot/Q63HQ2
	<references/>		<references/>

Rajesh Pal at 21:48, 7 October 2016

Rajesh Pal — Fri, 07 Oct 2016 21:48:18 GMT

←Older revision		Revision as of 21:48, 7 October 2016
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	==PIKACHURIN GENE==		==PIKACHURIN GENE==

-	~~This is a default text for your page '''Pikachurin'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.~~	+
-	You may include any references to papers as in: Hu H, Li J, Zhang Z, Yu M (February 2011). "Pikachurin interaction with dystroglycan is diminished by defective O-mannosyl glycosylation in congenital muscular dystrophy models and rescued by LARGE overexpression". Neurosci. Lett. 489 (1): 10–5.	+
-	~~http://www.uniprot.org/uniprot/Q63HQ2.~~	+

	== Function ==Has a Dual function of photoreceptor visual synapse formation and visual perception		== Function ==Has a Dual function of photoreceptor visual synapse formation and visual perception
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	</StructureSection>		</StructureSection>
	== References ==		== References ==
		+	1)Hu H, Li J, Zhang Z, Yu M (February 2011). "Pikachurin interaction with dystroglycan is diminished by defective O-mannosyl glycosylation in congenital muscular dystrophy models and rescued by LARGE overexpression". Neurosci. Lett. 489 (1): 10–5.
		+	2)http://www.uniprot.org/uniprot/Q63HQ2
	<references/>		<references/>

Rajesh Pal at 21:46, 7 October 2016

Rajesh Pal — Fri, 07 Oct 2016 21:46:11 GMT

←Older revision		Revision as of 21:46, 7 October 2016
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-	==PIKACHURIN GENE== 0	+	==PIKACHURIN GENE==
-	~~<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>~~	+
	This is a default text for your page '''Pikachurin'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.		This is a default text for your page '''Pikachurin'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
	You may include any references to papers as in: Hu H, Li J, Zhang Z, Yu M (February 2011). "Pikachurin interaction with dystroglycan is diminished by defective O-mannosyl glycosylation in congenital muscular dystrophy models and rescued by LARGE overexpression". Neurosci. Lett. 489 (1): 10–5.		You may include any references to papers as in: Hu H, Li J, Zhang Z, Yu M (February 2011). "Pikachurin interaction with dystroglycan is diminished by defective O-mannosyl glycosylation in congenital muscular dystrophy models and rescued by LARGE overexpression". Neurosci. Lett. 489 (1): 10–5.

Rajesh Pal at 21:44, 7 October 2016

Rajesh Pal — Fri, 07 Oct 2016 21:44:54 GMT

←Older revision		Revision as of 21:44, 7 October 2016
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-	==~~Your Heading Here (maybe something like 'Structure')~~== 0	+	==PIKACHURIN GENE== 0
	<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>		<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
	This is a default text for your page '''Pikachurin'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.		This is a default text for your page '''Pikachurin'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
-	You may include any references to papers as in: ~~the use of JSmol~~ in ~~Proteopedia <ref>DOI 10~~.~~1002~~/~~ijch~~.~~201300024<~~/~~ref> or to the article describing Jmol <ref>PMID:21638687<~~/~~ref> to the rescue~~.	+	You may include any references to papers as in: Hu H, Li J, Zhang Z, Yu M (February 2011). "Pikachurin interaction with dystroglycan is diminished by defective O-mannosyl glycosylation in congenital muscular dystrophy models and rescued by LARGE overexpression". Neurosci. Lett. 489 (1): 10–5.
		+	http://www.uniprot.org/uniprot/Q63HQ2.

	== Function ==Has a Dual function of photoreceptor visual synapse formation and visual perception		== Function ==Has a Dual function of photoreceptor visual synapse formation and visual perception

-	== Disease ==Visual Impairments were seen in mice with deleted pikachurin gene. ~~Pikachurin also plays very role in congenital~~ muscular dystrophies(CMD) ~~because any defect in the function can cause Muscle~~-eye-brain disease.	+	== Disease ==Visual Impairments were seen in mice with deleted pikachurin gene. Congenital muscular dystrophies (CMD) such as muscle-eye-brain disease caused by defective glycosylation of α-dystroglycan (α-DG) exhibit defective photoreceptor synaptic function.

	== Relevance ==		== Relevance ==