Progesterone receptor - Revision history

Michal Harel at 09:29, 18 January 2024

Michal Harel — Thu, 18 Jan 2024 09:29:06 GMT

←Older revision		Revision as of 09:29, 18 January 2024
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	== Relevance ==		== Relevance ==

-	The response to hormone therapy in breast cancer correlates with PR. PR absence in breast tumor cells predicts resistance to hormone therapy <ref>PMID:16234531</ref>. [[Mometasone]] is a potent agonist of PR.	+	The response to hormone therapy in breast cancer correlates with PR. PR absence in breast tumor cells predicts resistance to hormone therapy <ref>PMID:16234531</ref>. [[Mometasone]] is a potent agonist of PR<ref>PMID:15189034</ref>.

	== Structural highlights ==		== Structural highlights ==

Michal Harel at 09:26, 18 January 2024

Michal Harel — Thu, 18 Jan 2024 09:26:14 GMT

←Older revision		Revision as of 09:26, 18 January 2024
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	== Relevance ==		== Relevance ==

-	The response to hormone therapy in breast cancer correlates with PR. PR absence in breast tumor cells predicts resistance to hormone therapy <ref>PMID:16234531</ref>. [[~~Mometasome~~]] is a potent agonist of PR.	+	The response to hormone therapy in breast cancer correlates with PR. PR absence in breast tumor cells predicts resistance to hormone therapy <ref>PMID:16234531</ref>. [[Mometasone]] is a potent agonist of PR.

	== Structural highlights ==		== Structural highlights ==

Michal Harel at 09:25, 18 January 2024

Michal Harel — Thu, 18 Jan 2024 09:25:55 GMT

←Older revision		Revision as of 09:25, 18 January 2024
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	== Relevance ==		== Relevance ==

-	The response to hormone therapy in breast cancer correlates with PR. PR absence in breast tumor cells predicts resistance to hormone therapy <ref>PMID:16234531</ref>.	+	The response to hormone therapy in breast cancer correlates with PR. PR absence in breast tumor cells predicts resistance to hormone therapy <ref>PMID:16234531</ref>. [[Mometasome]] is a potent agonist of PR.

	== Structural highlights ==		== Structural highlights ==

Michal Harel at 09:48, 12 January 2023

Michal Harel — Thu, 12 Jan 2023 09:48:34 GMT

←Older revision		Revision as of 09:48, 12 January 2023
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	<StructureSection load='2w8y' size='350' side='right' caption='Structure of human progesterone receptor ligand-binding domain complex with RU486 and sulfate (PDB entry [[2w8y]])' scene='78/780972/Cv/2'>		<StructureSection load='2w8y' size='350' side='right' caption='Structure of human progesterone receptor ligand-binding domain complex with RU486 and sulfate (PDB entry [[2w8y]])' scene='78/780972/Cv/2'>
-
-	See also [[Intracellular receptors]]

	== Function ==		== Function ==

	'''Progesterone receptor''' (PR) binds to DNA and inhibits transcription. It is [[Nuclear receptors\|nuclear receptor]]. The inhibition terminates when progesterone binds to PR. The ovarian steroid progesterone which is essential for breast development and reproductive behavior, is mediated by PR<ref>PMID:19072517</ref>.		'''Progesterone receptor''' (PR) binds to DNA and inhibits transcription. It is [[Nuclear receptors\|nuclear receptor]]. The inhibition terminates when progesterone binds to PR. The ovarian steroid progesterone which is essential for breast development and reproductive behavior, is mediated by PR<ref>PMID:19072517</ref>.
		+
		+	See also [[Intracellular receptors]]

	== Relevance ==		== Relevance ==

Michal Harel at 09:47, 12 January 2023

Michal Harel — Thu, 12 Jan 2023 09:47:58 GMT

←Older revision		Revision as of 09:47, 12 January 2023
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	<StructureSection load='2w8y' size='350' side='right' caption='Structure of human progesterone receptor ligand-binding domain complex with RU486 and sulfate (PDB entry [[2w8y]])' scene='78/780972/Cv/2'>		<StructureSection load='2w8y' size='350' side='right' caption='Structure of human progesterone receptor ligand-binding domain complex with RU486 and sulfate (PDB entry [[2w8y]])' scene='78/780972/Cv/2'>
		+
		+	See also [[Intracellular receptors]]

	== Function ==		== Function ==

Alexander Berchansky at 13:55, 14 November 2021

Alexander Berchansky — Sun, 14 Nov 2021 13:55:08 GMT

←Older revision		Revision as of 13:55, 14 November 2021
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	== Structural highlights ==		== Structural highlights ==

-	The structure of the complex of the ligand-binding domain of PR with RU486 - an abortion-inducing drug - shows the ligand bound at a similar location to other agonists or partial agonists with a flexible loop of PR being a possible entry route to the <scene name='78/780972/Cv/4'>binding site and several PR-RU486 interactions</scene><ref>PMID:19372222</ref>. Water molecules are shown as red spheres.	+	The structure of the complex of the ligand-binding domain of PR with RU486 - an abortion-inducing drug - shows the ligand bound at a similar location to other agonists or partial agonists with a flexible loop of PR being a possible entry route to the <scene name='78/780972/Cv/4'>binding site and several PR-RU486 interactions</scene><ref>PMID:19372222</ref>. Water molecules are shown as red spheres. <scene name='89/895670/Cv/8'>Human progesterone receptor ligand-binding domain bound with progesterone</scene> ([[1a28]]).
	</StructureSection>		</StructureSection>
	== 3D Structures of progesterone receptor ==		== 3D Structures of progesterone receptor ==

Alexander Berchansky at 19:31, 25 January 2021

Alexander Berchansky — Mon, 25 Jan 2021 19:31:30 GMT

←Older revision		Revision as of 19:31, 25 January 2021
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	== Function ==		== Function ==

-	'''Progesterone receptor''' (PR) binds to DNA and inhibits transcription. The inhibition terminates when progesterone binds to PR. The ovarian steroid progesterone which is essential for breast development and reproductive behavior, is mediated by PR<ref>PMID:19072517</ref>.	+	'''Progesterone receptor''' (PR) binds to DNA and inhibits transcription. It is [[Nuclear receptors\|nuclear receptor]]. The inhibition terminates when progesterone binds to PR. The ovarian steroid progesterone which is essential for breast development and reproductive behavior, is mediated by PR<ref>PMID:19072517</ref>.

	== Relevance ==		== Relevance ==

Michal Harel at 07:30, 7 October 2020

Michal Harel — Wed, 07 Oct 2020 07:30:05 GMT

←Older revision		Revision as of 07:30, 7 October 2020
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	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}		Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
	{{#tree:id=OrganizedByTopic\|openlevels=0\|		{{#tree:id=OrganizedByTopic\|openlevels=0\|
		+
		+	* Progesterone receptor residues 1-125
		+
		+	**[[1ejf]] – hPR - human<br />

	* Progesterone receptor residues 72-195		* Progesterone receptor residues 72-195

-	**[[4x8y]] – hPR ~~- human~~<br />	+	**[[4x8y]] – hPR<br />

	* Progesterone receptor DNA-binding domain residues 399-476		* Progesterone receptor DNA-binding domain residues 399-476

Alexander Berchansky at 13:07, 14 August 2019

Alexander Berchansky — Wed, 14 Aug 2019 13:07:46 GMT

←Older revision		Revision as of 13:07, 14 August 2019
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	== Structural highlights ==		== Structural highlights ==

-	The structure of the complex of the ligand-binding domain of PR with RU486 - an abortion-inducing drug - shows the ligand bound at a similar location to other agonists or partial agonists with a flexible loop of PR being a possible entry route to the <scene name='78/780972/Cv/4'>binding site and several PR-RU486 interactions</scene><ref>PMID:19372222</ref>.	+	The structure of the complex of the ligand-binding domain of PR with RU486 - an abortion-inducing drug - shows the ligand bound at a similar location to other agonists or partial agonists with a flexible loop of PR being a possible entry route to the <scene name='78/780972/Cv/4'>binding site and several PR-RU486 interactions</scene><ref>PMID:19372222</ref>. Water molecules are shown as red spheres.
	</StructureSection>		</StructureSection>
	== 3D Structures of progesterone receptor ==		== 3D Structures of progesterone receptor ==

Michal Harel at 10:24, 26 August 2018

Michal Harel — Sun, 26 Aug 2018 10:24:58 GMT

←Older revision		Revision as of 10:24, 26 August 2018
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	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}		Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
	{{#tree:id=OrganizedByTopic\|openlevels=0\|		{{#tree:id=OrganizedByTopic\|openlevels=0\|
		+
		+	* Progesterone receptor residues 72-195
		+
		+	**[[4x8y]] – hPR - human<br />

	* Progesterone receptor DNA-binding domain residues 399-476		* Progesterone receptor DNA-binding domain residues 399-476

-	**[[2c7a]] – hPR DBD + DNA ~~- human~~<br />	+	**[[2c7a]] – hPR DBD + DNA<br />

	* Progesterone receptor ligand-binding domain residues 673-933		* Progesterone receptor ligand-binding domain residues 673-933