Pyruvate dehydrogenase kinase - Revision history

Michal Harel at 09:20, 4 October 2023

Michal Harel — Wed, 04 Oct 2023 09:20:55 GMT

←Older revision		Revision as of 09:20, 4 October 2023
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	*PDK isozyme 2		*PDK isozyme 2

-	**[[1jm6]] – PDK2 + ADP – rat<br />
	**[[2btz]] – hPDK2 <br />		**[[2btz]] – hPDK2 <br />
	**[[2bu2]] – hPDK2 + benzonitrile derivative + ATP<br />		**[[2bu2]] – hPDK2 + benzonitrile derivative + ATP<br />
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	**[[2bu7]] - hPDK2 + acetamide derivative<br />		**[[2bu7]] - hPDK2 + acetamide derivative<br />
	**[[2bu8]] - hPDK2 + dichloro-acetic acid + ADP<BR />		**[[2bu8]] - hPDK2 + dichloro-acetic acid + ADP<BR />
-	**[[4mp2]], [[4mp7]], [[4mpc]], [[4mpe]], [[4mpn]], [[4v25]], [[4v26]], [[5j6a]], [[5j71]], [[5m4k]], [[5m4m]], [[5m4n]], [[5m4p]], [[6lil]], [[6lio]], [[6lin]], [[6tmz]], [[6tmp]], [[6tmq]], [[6tn0]], [[6tn2]], [[7ebh]], [[7eas]] – hPDK2 + inhibitor<br />	+	**[[4mp2]], [[4mp7]], [[4mpc]], [[4mpe]], [[4mpn]], [[4v25]], [[4v26]], [[5j6a]], [[5j71]], [[5m4k]], [[5m4m]], [[5m4n]], [[5m4p]], [[6lil]], [[6lio]], [[6lin]], [[6tmz]], [[6tmp]], [[6tmq]], [[6tn0]], [[6tn2]], [[7ebh]], [[7eas]], [[7vbu]], [[7vbv]], [[7vbx]] – hPDK2 + inhibitor<br />
-	**[[3crk]], [[3crl]] – hPDK2 + pyruvate dehydrogenase E2	+	**[[3crk]], [[3crl]] – hPDK2 + pyruvate dehydrogenase E2<br />
		+	**[[1jm6]] – PDK2 + ADP – rat<br />

	*PDK isozyme 3		*PDK isozyme 3

Michal Harel at 08:28, 9 February 2022

Michal Harel — Wed, 09 Feb 2022 08:28:03 GMT

←Older revision		Revision as of 08:28, 9 February 2022
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	**[[2bu7]] - hPDK2 + acetamide derivative<br />		**[[2bu7]] - hPDK2 + acetamide derivative<br />
	**[[2bu8]] - hPDK2 + dichloro-acetic acid + ADP<BR />		**[[2bu8]] - hPDK2 + dichloro-acetic acid + ADP<BR />
-	**[[4mp2]], [[4mp7]], [[4mpc]], [[4mpe]], [[4mpn]], [[4v25]], [[4v26]], [[5j6a]], [[5j71]], [[5m4k]], [[5m4m]], [[5m4n]], [[5m4p]], [[6lil]], [[6lio]], [[6lin]], [[6tmz]], [[6tmp]], [[6tmq]], [[6tn0]], [[6tn2]] – hPDK2 + inhibitor<br />	+	**[[4mp2]], [[4mp7]], [[4mpc]], [[4mpe]], [[4mpn]], [[4v25]], [[4v26]], [[5j6a]], [[5j71]], [[5m4k]], [[5m4m]], [[5m4n]], [[5m4p]], [[6lil]], [[6lio]], [[6lin]], [[6tmz]], [[6tmp]], [[6tmq]], [[6tn0]], [[6tn2]], [[7ebh]], [[7eas]] – hPDK2 + inhibitor<br />
	**[[3crk]], [[3crl]] – hPDK2 + pyruvate dehydrogenase E2		**[[3crk]], [[3crl]] – hPDK2 + pyruvate dehydrogenase E2

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	**[[2e0a]] – hPDK4 + AMPPNP<br />		**[[2e0a]] – hPDK4 + AMPPNP<br />
	**[[2zkj]], [[3d2r]] – hPDK4 + ADP<BR />		**[[2zkj]], [[3d2r]] – hPDK4 + ADP<BR />
		+	**[[7ea0]], [[7eat]], [[7ebb]], [[7ebg]] – hPDK4 + inhibitor<br />
	**[[2zdx]], [[2zdy]] – hPDK4 (mutant) + inhibitor		**[[2zdx]], [[2zdy]] – hPDK4 (mutant) + inhibitor
	}}		}}

Michal Harel at 07:29, 14 October 2020

Michal Harel — Wed, 14 Oct 2020 07:29:02 GMT

←Older revision		Revision as of 07:29, 14 October 2020
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	<StructureSection load='' size='350' side='right' caption='Human pyruvate dehydrogenase kinase isozyme 4 dimer complex with AMPPNP and Mg+2 ion (green) (PDB entry [[2e0a]])' scene='48/485629/Cv/1'>		<StructureSection load='' size='350' side='right' caption='Human pyruvate dehydrogenase kinase isozyme 4 dimer complex with AMPPNP and Mg+2 ion (green) (PDB entry [[2e0a]])' scene='48/485629/Cv/1'>
	__TOC__		__TOC__
		+
	== Function ==		== Function ==
	'''Pyruvate dehydrogenase kinase''' (PDK) is part of the pyruvate dehydrogenase complex. This complex is located in the mitochondria and converts pyruvate to acetyl-CoA as part of the citric acid cycle. PDK phosphphorylates serine residues on pyruvate dehydrogenase using ATP. There are 4 isozymes of PDK. The isozymes differ in length, activity and phosphorylation sites<ref>PMID:11486000</ref>. PDK1 is abundant in heart cells. PDK2 is abundant in mitochondria. PDK3 is abundant in testis. PDK4 is abundant in muscle and heart.		'''Pyruvate dehydrogenase kinase''' (PDK) is part of the pyruvate dehydrogenase complex. This complex is located in the mitochondria and converts pyruvate to acetyl-CoA as part of the citric acid cycle. PDK phosphphorylates serine residues on pyruvate dehydrogenase using ATP. There are 4 isozymes of PDK. The isozymes differ in length, activity and phosphorylation sites<ref>PMID:11486000</ref>. PDK1 is abundant in heart cells. PDK2 is abundant in mitochondria. PDK3 is abundant in testis. PDK4 is abundant in muscle and heart.

Michal Harel at 07:28, 14 October 2020

Michal Harel — Wed, 14 Oct 2020 07:28:01 GMT

←Older revision		Revision as of 07:28, 14 October 2020
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	== Structural highlights ==		== Structural highlights ==
	<scene name='48/485629/Cv/11'>The active site cleft of PDK4 binds AMPPNP</scene><ref>PMID:21904029</ref>. Water molecules are shown as red spheres. <scene name='48/485629/Cv/12'>Mg coordination site</scene>.		<scene name='48/485629/Cv/11'>The active site cleft of PDK4 binds AMPPNP</scene><ref>PMID:21904029</ref>. Water molecules are shown as red spheres. <scene name='48/485629/Cv/12'>Mg coordination site</scene>.
-		+	</StructureSection>
	==3D structures of pyruvate dehydrogenase kinase==		==3D structures of pyruvate dehydrogenase kinase==

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	== References ==		== References ==
	<references/>		<references/>
-	~~</StructureSection>~~	+
	[[Category: Topic Page]]		[[Category: Topic Page]]

Michal Harel at 07:26, 14 October 2020

Michal Harel — Wed, 14 Oct 2020 07:26:38 GMT

←Older revision		Revision as of 07:26, 14 October 2020
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	== Structural highlights ==		== Structural highlights ==
	<scene name='48/485629/Cv/11'>The active site cleft of PDK4 binds AMPPNP</scene><ref>PMID:21904029</ref>. Water molecules are shown as red spheres. <scene name='48/485629/Cv/12'>Mg coordination site</scene>.		<scene name='48/485629/Cv/11'>The active site cleft of PDK4 binds AMPPNP</scene><ref>PMID:21904029</ref>. Water molecules are shown as red spheres. <scene name='48/485629/Cv/12'>Mg coordination site</scene>.
-	</StructureSection>

	==3D structures of pyruvate dehydrogenase kinase==		==3D structures of pyruvate dehydrogenase kinase==
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	**[[2bu7]] - hPDK2 + acetamide derivative<br />		**[[2bu7]] - hPDK2 + acetamide derivative<br />
	**[[2bu8]] - hPDK2 + dichloro-acetic acid + ADP<BR />		**[[2bu8]] - hPDK2 + dichloro-acetic acid + ADP<BR />
-	**[[4mp2]], [[4mp7]], [[4mpc]], [[4mpe]], [[4mpn]], [[4v25]], [[4v26]], [[5j6a]], [[5j71]], [[5m4k]], [[5m4m]], [[5m4n]], [[5m4p]] – hPDK2 + inhibitor<br />	+	**[[4mp2]], [[4mp7]], [[4mpc]], [[4mpe]], [[4mpn]], [[4v25]], [[4v26]], [[5j6a]], [[5j71]], [[5m4k]], [[5m4m]], [[5m4n]], [[5m4p]], [[6lil]], [[6lio]], [[6lin]], [[6tmz]], [[6tmp]], [[6tmq]], [[6tn0]], [[6tn2]] – hPDK2 + inhibitor<br />
	**[[3crk]], [[3crl]] – hPDK2 + pyruvate dehydrogenase E2		**[[3crk]], [[3crl]] – hPDK2 + pyruvate dehydrogenase E2

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	== References ==		== References ==
	<references/>		<references/>
		+	</StructureSection>
	[[Category: Topic Page]]		[[Category: Topic Page]]

Michal Harel at 07:17, 14 October 2020

Michal Harel — Wed, 14 Oct 2020 07:17:33 GMT

←Older revision		Revision as of 07:17, 14 October 2020
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	<StructureSection load='' size='350' side='right' caption='Human pyruvate dehydrogenase kinase isozyme 4 dimer complex with AMPPNP and Mg+2 ion (green) (PDB entry [[2e0a]])' scene='48/485629/Cv/1'>		<StructureSection load='' size='350' side='right' caption='Human pyruvate dehydrogenase kinase isozyme 4 dimer complex with AMPPNP and Mg+2 ion (green) (PDB entry [[2e0a]])' scene='48/485629/Cv/1'>
		+	__TOC__
	== Function ==		== Function ==
	'''Pyruvate dehydrogenase kinase''' (PDK) is part of the pyruvate dehydrogenase complex. This complex is located in the mitochondria and converts pyruvate to acetyl-CoA as part of the citric acid cycle. PDK phosphphorylates serine residues on pyruvate dehydrogenase using ATP. There are 4 isozymes of PDK. The isozymes differ in length, activity and phosphorylation sites<ref>PMID:11486000</ref>. PDK1 is abundant in heart cells. PDK2 is abundant in mitochondria. PDK3 is abundant in testis. PDK4 is abundant in muscle and heart.		'''Pyruvate dehydrogenase kinase''' (PDK) is part of the pyruvate dehydrogenase complex. This complex is located in the mitochondria and converts pyruvate to acetyl-CoA as part of the citric acid cycle. PDK phosphphorylates serine residues on pyruvate dehydrogenase using ATP. There are 4 isozymes of PDK. The isozymes differ in length, activity and phosphorylation sites<ref>PMID:11486000</ref>. PDK1 is abundant in heart cells. PDK2 is abundant in mitochondria. PDK3 is abundant in testis. PDK4 is abundant in muscle and heart.

Alexander Berchansky at 13:17, 22 August 2019

Alexander Berchansky — Thu, 22 Aug 2019 13:17:53 GMT

←Older revision		Revision as of 13:17, 22 August 2019
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	== Structural highlights ==		== Structural highlights ==
-	<scene name='48/485629/Cv/9'>The active site cleft of PDK4 binds AMPPNP</scene>.<ref>PMID:21904029</ref> <scene name='48/485629/Cv/10'>Mg coordination site</scene>.	+	<scene name='48/485629/Cv/11'>The active site cleft of PDK4 binds AMPPNP</scene><ref>PMID:21904029</ref>. Water molecules are shown as red spheres. <scene name='48/485629/Cv/12'>Mg coordination site</scene>.
	</StructureSection>		</StructureSection>

Michal Harel at 08:51, 30 August 2018

Michal Harel — Thu, 30 Aug 2018 08:51:40 GMT

←Older revision		Revision as of 08:51, 30 August 2018
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-	<StructureSection load='' size='~~450~~' side='right' caption='Human pyruvate dehydrogenase kinase isozyme 4 dimer complex with AMPPNP and Mg+2 ion (green) (PDB entry [[2e0a]])' scene='48/485629/Cv/1'>	+	<StructureSection load='' size='350' side='right' caption='Human pyruvate dehydrogenase kinase isozyme 4 dimer complex with AMPPNP and Mg+2 ion (green) (PDB entry [[2e0a]])' scene='48/485629/Cv/1'>
	== Function ==		== Function ==
-	'''Pyruvate dehydrogenase kinase''' (PDK) is part of the pyruvate dehydrogenase complex. This complex is located in the mitochondria and converts pyruvate to acetyl-CoA as part of the citric acid cycle. PDK phosphphorylates serine residues on pyruvate dehydrogenase using ATP. There are 4 isozymes of PDK. The isozymes differ in length, activity and phosphorylation sites<ref>PMID:11486000</ref>.	+	'''Pyruvate dehydrogenase kinase''' (PDK) is part of the pyruvate dehydrogenase complex. This complex is located in the mitochondria and converts pyruvate to acetyl-CoA as part of the citric acid cycle. PDK phosphphorylates serine residues on pyruvate dehydrogenase using ATP. There are 4 isozymes of PDK. The isozymes differ in length, activity and phosphorylation sites<ref>PMID:11486000</ref>. PDK1 is abundant in heart cells. PDK2 is abundant in mitochondria. PDK3 is abundant in testis. PDK4 is abundant in muscle and heart.

	== Relevance ==		== Relevance ==
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	**[[2bu7]] - hPDK2 + acetamide derivative<br />		**[[2bu7]] - hPDK2 + acetamide derivative<br />
	**[[2bu8]] - hPDK2 + dichloro-acetic acid + ADP<BR />		**[[2bu8]] - hPDK2 + dichloro-acetic acid + ADP<BR />
-	**[[4mp2]], [[4mp7]], [[4mpc]], [[4mpe]], [[4mpn]], [[4v25]], [[4v26]], [[5j6a]], [[5j71]] – hPDK2 + inhibitor<br />	+	**[[4mp2]], [[4mp7]], [[4mpc]], [[4mpe]], [[4mpn]], [[4v25]], [[4v26]], [[5j6a]], [[5j71]], [[5m4k]], [[5m4m]], [[5m4n]], [[5m4p]] – hPDK2 + inhibitor<br />
	**[[3crk]], [[3crl]] – hPDK2 + pyruvate dehydrogenase E2		**[[3crk]], [[3crl]] – hPDK2 + pyruvate dehydrogenase E2

Joel L. Sussman at 13:46, 23 September 2017

Joel L. Sussman — Sat, 23 Sep 2017 13:46:27 GMT

←Older revision		Revision as of 13:46, 23 September 2017
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-	<StructureSection load='~~2e0a~~' size='450' side='right' caption='Human pyruvate dehydrogenase kinase isozyme 4 dimer complex with AMPPNP and Mg+2 ion (green) (PDB entry [[2e0a]])' scene='48/485629/Cv/1'>	+	<StructureSection load='' size='450' side='right' caption='Human pyruvate dehydrogenase kinase isozyme 4 dimer complex with AMPPNP and Mg+2 ion (green) (PDB entry [[2e0a]])' scene='48/485629/Cv/1'>
	== Function ==		== Function ==
	'''Pyruvate dehydrogenase kinase''' (PDK) is part of the pyruvate dehydrogenase complex. This complex is located in the mitochondria and converts pyruvate to acetyl-CoA as part of the citric acid cycle. PDK phosphphorylates serine residues on pyruvate dehydrogenase using ATP. There are 4 isozymes of PDK. The isozymes differ in length, activity and phosphorylation sites<ref>PMID:11486000</ref>.		'''Pyruvate dehydrogenase kinase''' (PDK) is part of the pyruvate dehydrogenase complex. This complex is located in the mitochondria and converts pyruvate to acetyl-CoA as part of the citric acid cycle. PDK phosphphorylates serine residues on pyruvate dehydrogenase using ATP. There are 4 isozymes of PDK. The isozymes differ in length, activity and phosphorylation sites<ref>PMID:11486000</ref>.

Michal Harel at 17:56, 22 September 2017

Michal Harel — Fri, 22 Sep 2017 17:56:02 GMT

←Older revision		Revision as of 17:56, 22 September 2017
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	**[[2bu7]] - hPDK2 + acetamide derivative<br />		**[[2bu7]] - hPDK2 + acetamide derivative<br />
	**[[2bu8]] - hPDK2 + dichloro-acetic acid + ADP<BR />		**[[2bu8]] - hPDK2 + dichloro-acetic acid + ADP<BR />
-	**[[4mp2]], [[4mp7]], [[4mpc]], [[4mpe]], [[4mpn]], [[4v25]], [[4v26]] – hPDK2 + inhibitor<br />	+	**[[4mp2]], [[4mp7]], [[4mpc]], [[4mpe]], [[4mpn]], [[4v25]], [[4v26]], [[5j6a]], [[5j71]] – hPDK2 + inhibitor<br />
	**[[3crk]], [[3crl]] – hPDK2 + pyruvate dehydrogenase E2		**[[3crk]], [[3crl]] – hPDK2 + pyruvate dehydrogenase E2