Rhodopsin Structure and Function - Revision history

Alexander Berchansky at 14:35, 31 May 2021

Alexander Berchansky — Mon, 31 May 2021 14:35:58 GMT

←Older revision		Revision as of 14:35, 31 May 2021
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	<scene name='77/778331/Rhodopsin_and_ligand/1'>Rhodopsin and Ligand</scene> This is rhodopsin with 11-cis retinal bound. After 11-cis retinal becomes activated and becomes all-trans, rhodopsin undergoes the conformational change to become metarhodopsin I and then metarhodopsin II which is the fully active form of rhodopsin. Metarhodopsin II then associates with the G protein transducin and the signal cascade can continue.		<scene name='77/778331/Rhodopsin_and_ligand/1'>Rhodopsin and Ligand</scene> This is rhodopsin with 11-cis retinal bound. After 11-cis retinal becomes activated and becomes all-trans, rhodopsin undergoes the conformational change to become metarhodopsin I and then metarhodopsin II which is the fully active form of rhodopsin. Metarhodopsin II then associates with the G protein transducin and the signal cascade can continue.
		+
		+	See also:
		+	*[[Receptor]]
		+	*[[Transmembrane (cell surface) receptors]]
		+	*[[G protein-coupled receptors]]

Michal Harel at 10:37, 5 February 2019

Michal Harel — Tue, 05 Feb 2019 10:37:54 GMT

←Older revision		Revision as of 10:37, 5 February 2019
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-	<StructureSection load='1jfp' size='340' side='right' caption='[[Bovine rhodopsin complex with retinal~~]], pdb~~ code 1jfp]];' scene=''>	+	<StructureSection load='1jfp' size='340' side='right' caption='Bovine rhodopsin complex with retinal (PDB code [[1jfp]])' scene=''>

	==Rhodopsin==		==Rhodopsin==

-	Rhodopsin is a member of the G-protein coupled receptor (GPCR) family. Rhodopsin is the	+	'''Rhodopsin''' is a member of the G-protein coupled receptor (GPCR) family. Rhodopsin is the
	common GPCR structure used to understand functionality of G-protein coupled receptors.		common GPCR structure used to understand functionality of G-protein coupled receptors.
	Rhodopsin is commonly found in the photoreceptors in the retina, specifically in the rod		Rhodopsin is commonly found in the photoreceptors in the retina, specifically in the rod

Karsten Theis at 15:33, 4 January 2019

Karsten Theis — Fri, 04 Jan 2019 15:33:20 GMT

←Older revision		Revision as of 15:33, 4 January 2019
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	== Structural highlights ==		== Structural highlights ==
-	<StructureSection load='1jfp' size='340' side='right' caption='Bovine rhodopsin complex with retinal (PDB code [[1jfp]])'/>
	<scene name='77/778331/Rhodopsin_no_ligand/1'>Rhodopsin protein</scene> Fully functional rhodopsin has the typical GPCR structure of a seven transmembrane helical bundle with the N-terminus on the interior of the rods and the C-terminus in the cytoplasm. The N-terminus is located near the extracellular loops and ends of the transmembrane protein. There are hydrogen bonding between the transmembrane sections and the extracellular loops that are involved in the activation of rhodopsin when a photon is received. The N-terminus is thought to play a role in orientation of the extracellular loops<ref name="Article4">PMID:29042326</ref>. Transmembrane domain 1 and 2 play a role in stabilizing the protein and giving the protein functionality<ref name="Article3">PMID:21352497</ref>. Rhodopsin has two components: opsin (a membrane-bound polypeptide) and 11-cis-retinal (a chromophore that is bound to opsin via a protonated Schiff-base)<ref name="Article5">PMID:12402507</ref>.		<scene name='77/778331/Rhodopsin_no_ligand/1'>Rhodopsin protein</scene> Fully functional rhodopsin has the typical GPCR structure of a seven transmembrane helical bundle with the N-terminus on the interior of the rods and the C-terminus in the cytoplasm. The N-terminus is located near the extracellular loops and ends of the transmembrane protein. There are hydrogen bonding between the transmembrane sections and the extracellular loops that are involved in the activation of rhodopsin when a photon is received. The N-terminus is thought to play a role in orientation of the extracellular loops<ref name="Article4">PMID:29042326</ref>. Transmembrane domain 1 and 2 play a role in stabilizing the protein and giving the protein functionality<ref name="Article3">PMID:21352497</ref>. Rhodopsin has two components: opsin (a membrane-bound polypeptide) and 11-cis-retinal (a chromophore that is bound to opsin via a protonated Schiff-base)<ref name="Article5">PMID:12402507</ref>.

Jason Telford at 14:41, 20 December 2018

Jason Telford — Thu, 20 Dec 2018 14:41:08 GMT

←Older revision		Revision as of 14:41, 20 December 2018
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-	<StructureSection load='1jfp' size='340' side='right' caption='Bovine rhodopsin complex with retinal, pdb code 1jfp;' scene=''>	+	<StructureSection load='1jfp' size='340' side='right' caption='[[Bovine rhodopsin complex with retinal]], pdb code 1jfp]];' scene=''>

	==Rhodopsin==		==Rhodopsin==

Jason Telford at 14:37, 20 December 2018

Jason Telford — Thu, 20 Dec 2018 14:37:55 GMT

←Older revision		Revision as of 14:37, 20 December 2018
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-	<StructureSection load='1jfp' size='340' side='right' caption='[[Bovine rhodopsin complex with retinal]], pdb code 1jfp]];' scene=''>	+	<StructureSection load='1jfp' size='340' side='right' caption='Bovine rhodopsin complex with retinal, pdb code 1jfp;' scene=''>

	==Rhodopsin==		==Rhodopsin==

Jason Telford at 14:37, 20 December 2018

Jason Telford — Thu, 20 Dec 2018 14:37:14 GMT

←Older revision		Revision as of 14:37, 20 December 2018
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-	<StructureSection load='1jfp' size='340' side='right' caption='[[Bovine rhodopsin complex with retinal, ~~pub~~ code 1jfp]];' scene=''>	+	<StructureSection load='1jfp' size='340' side='right' caption='[[Bovine rhodopsin complex with retinal]], pdb code 1jfp]];' scene=''>

	==Rhodopsin==		==Rhodopsin==

Jason Telford at 14:36, 20 December 2018

Jason Telford — Thu, 20 Dec 2018 14:36:52 GMT

←Older revision		Revision as of 14:36, 20 December 2018
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-	<StructureSection load='1jfp' size='340' side='right' caption='[[Bovine rhodopsin complex with retinal]];' scene=''>	+	<StructureSection load='1jfp' size='340' side='right' caption='[[Bovine rhodopsin complex with retinal, pub code 1jfp]];' scene=''>

	==Rhodopsin==		==Rhodopsin==

Jason Telford at 14:35, 20 December 2018

Jason Telford — Thu, 20 Dec 2018 14:35:51 GMT

←Older revision		Revision as of 14:35, 20 December 2018
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-	<StructureSection load='1jfp' size='340' side='right' caption='[[Bovine rhodopsin complex with retinal]]~~, (PDB code [[1jfp]]'&Aring~~;' scene=''>	+	<StructureSection load='1jfp' size='340' side='right' caption='[[Bovine rhodopsin complex with retinal]];' scene=''>

	==Rhodopsin==		==Rhodopsin==

Jason Telford at 14:34, 20 December 2018

Jason Telford — Thu, 20 Dec 2018 14:34:59 GMT

←Older revision		Revision as of 14:34, 20 December 2018
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-	<StructureSection load='1jfp' size='340' side='right' caption='Bovine rhodopsin complex with retinal (PDB code [[1jfp]'])'scene=''>	+	<StructureSection load='1jfp' size='340' side='right' caption='[[Bovine rhodopsin complex with retinal]], (PDB code [[1jfp]]'Å' scene=''>
-		+
	==Rhodopsin==		==Rhodopsin==

Jason Telford at 14:30, 20 December 2018

Jason Telford — Thu, 20 Dec 2018 14:30:40 GMT

←Older revision		Revision as of 14:30, 20 December 2018
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-	<StructureSection load='1jfp' size='340' side='right' caption='Bovine rhodopsin complex with retinal (PDB code [[1jfp]])'scene=''>	+	<StructureSection load='1jfp' size='340' side='right' caption='Bovine rhodopsin complex with retinal (PDB code [[1jfp]'])'scene=''>

	==Rhodopsin==		==Rhodopsin==