SAICAR synthetase - Revision history

Michal Harel at 11:18, 9 March 2022

Michal Harel — Wed, 09 Mar 2022 11:18:23 GMT

←Older revision		Revision as of 11:18, 9 March 2022
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	**[[1a48]] – ySAI - yeast<br />		**[[1a48]] – ySAI - yeast<br />
-	**[[3r9r]] – ~~SAI~~ – ''Mycobacterium abscessus'' <br />	+	**[[3r9r]], [[6yvq]] – MaSAI – ''Mycobacterium abscessus'' <br />
	**[[3kre]] – SAI – ''Ehrlichia chaffeensis'' <br />		**[[3kre]] – SAI – ''Ehrlichia chaffeensis'' <br />
	**[[1kut]] – SAI – ''Thermotoga maritima''<br />		**[[1kut]] – SAI – ''Thermotoga maritima''<br />
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	**[[2gqr]] – EcSAI + ADP – ''Escherichia coli''<br />		**[[2gqr]] – EcSAI + ADP – ''Escherichia coli''<br />
	**[[2gqs]] – EcSAI + ADP + AICAR <br />		**[[2gqs]] – EcSAI + ADP + AICAR <br />
		+	**[[6yy6]], [[6yy7]], [[6yy8]], [[6yy9]], [[6yya]], [[6yyb]], [[6yyc]], [[6yyd]], [[6z0q]], [[6z0r]] – MaSAI + inhibitor<br />
		+	**[[6yx3]] – MaSAI + ATP <br />

	*SAICAR synthetase type-1		*SAICAR synthetase type-1

Alexander Berchansky at 12:43, 1 September 2019

Alexander Berchansky — Sun, 01 Sep 2019 12:43:20 GMT

←Older revision		Revision as of 12:43, 1 September 2019
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	== Structural highlights ==		== Structural highlights ==
-	SAI structure shows <scene name='74/749400/Cv/2'>two domains</scene>. The <scene name='74/749400/Cv/9'>active site is located in a hydrophilic tunnel</scene> between the 2 domains and contains <scene name='74/749400/Cv/4'>ADP</scene>, <scene name='74/749400/Cv/6'>aspartic acid</scene> and <scene name='74/749400/Cv/7'>aminoimidazole-ribonucleotide (AIR)</scene><ref>PMID:24598753</ref>. Residues are colored according to {{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}. Water molecules shown as red spheres.	+	SAI structure shows <scene name='74/749400/Cv/10'>two domains</scene>. The <scene name='74/749400/Cv/11'>active site is located in a hydrophilic tunnel</scene> between the 2 domains and contains <scene name='74/749400/Cv/12'>ADP</scene>, <scene name='74/749400/Cv/13'>aspartic acid</scene> and <scene name='74/749400/Cv/14'>aminoimidazole-ribonucleotide (AIR)</scene><ref>PMID:24598753</ref>. Residues are colored according to {{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}. Water molecules are shown as red spheres.
-	*<scene name='74/749400/Cv/3'>Surface representation of hydrophilic tunnel</scene>.	+	*<scene name='74/749400/Cv/15'>Surface representation of hydrophilic tunnel</scene>.
-	*<scene name='74/749400/Cv/5'>Mg coordination site</scene>.	+	*<scene name='74/749400/Cv/16'>Mg coordination site</scene>.
-	*<scene name='74/749400/Cv/8'>Whole active site</scene>.	+	*<scene name='74/749400/Cv/17'>Whole active site</scene>.

	</StructureSection>		</StructureSection>

Michal Harel at 16:55, 17 September 2018

Michal Harel — Mon, 17 Sep 2018 16:55:31 GMT

←Older revision		Revision as of 16:55, 17 September 2018
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-	<StructureSection load='' size='~~450~~' side='right' caption='SAICAR synthetase complex with aminoimidazole-ribonucleotide, ADP, TRIS, aspartate, acetate, Mg+2 and Cl- ions (PDB code [[4fe2]]) ' scene='74/749400/Cv/1'>	+	<StructureSection load='' size='350' side='right' caption='SAICAR synthetase complex with aminoimidazole-ribonucleotide, ADP, TRIS, aspartate, acetate, Mg+2 and Cl- ions (PDB code [[4fe2]]) ' scene='74/749400/Cv/1'>

	== Function ==		== Function ==

Joel L. Sussman at 11:06, 25 October 2017

Joel L. Sussman — Wed, 25 Oct 2017 11:06:02 GMT

←Older revision		Revision as of 11:06, 25 October 2017
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-	<StructureSection load='~~4fe2~~' size='450' side='right' caption='SAICAR synthetase complex with aminoimidazole-ribonucleotide, ADP, TRIS, aspartate, acetate, Mg+2 and Cl- ions (PDB code [[4fe2]]) ' scene='74/749400/Cv/1'>	+	<StructureSection load='' size='450' side='right' caption='SAICAR synthetase complex with aminoimidazole-ribonucleotide, ADP, TRIS, aspartate, acetate, Mg+2 and Cl- ions (PDB code [[4fe2]]) ' scene='74/749400/Cv/1'>

	== Function ==		== Function ==

Michal Harel at 10:13, 25 October 2017

Michal Harel — Wed, 25 Oct 2017 10:13:09 GMT

←Older revision		Revision as of 10:13, 25 October 2017
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	== References ==		== References ==
	<references/>		<references/>
		+	[[Category:Topic Page]]

Alexander Berchansky at 14:55, 27 December 2016

Alexander Berchansky — Tue, 27 Dec 2016 14:55:55 GMT

←Older revision		Revision as of 14:55, 27 December 2016
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	*<scene name='74/749400/Cv/3'>Surface representation of hydrophilic tunnel</scene>.		*<scene name='74/749400/Cv/3'>Surface representation of hydrophilic tunnel</scene>.
	*<scene name='74/749400/Cv/5'>Mg coordination site</scene>.		*<scene name='74/749400/Cv/5'>Mg coordination site</scene>.
-	*<scene name='74/749400/Cv/8'>Whole ~~binding~~ site</scene>.	+	*<scene name='74/749400/Cv/8'>Whole active site</scene>.

	</StructureSection>		</StructureSection>

Alexander Berchansky at 14:53, 27 December 2016

Alexander Berchansky — Tue, 27 Dec 2016 14:53:31 GMT

←Older revision		Revision as of 14:53, 27 December 2016
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	== Structural highlights ==		== Structural highlights ==
-	SAI structure shows <scene name='74/749400/Cv/2'>two domains</scene>. The <scene name='74/749400/Cv/9'>active site is located in a hydrophilic tunnel</scene> between the 2 domains and contains <scene name='74/749400/Cv/4'>ADP</scene>, <scene name='74/749400/Cv/6'>aspartic acid</scene> and <scene name='74/749400/Cv/7'>aminoimidazole-ribonucleotide (AIR)</scene><ref>PMID:24598753</ref>. {{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}. Water molecules shown as red spheres.	+	SAI structure shows <scene name='74/749400/Cv/2'>two domains</scene>. The <scene name='74/749400/Cv/9'>active site is located in a hydrophilic tunnel</scene> between the 2 domains and contains <scene name='74/749400/Cv/4'>ADP</scene>, <scene name='74/749400/Cv/6'>aspartic acid</scene> and <scene name='74/749400/Cv/7'>aminoimidazole-ribonucleotide (AIR)</scene><ref>PMID:24598753</ref>. Residues are colored according to {{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}. Water molecules shown as red spheres.
	*<scene name='74/749400/Cv/3'>Surface representation of hydrophilic tunnel</scene>.		*<scene name='74/749400/Cv/3'>Surface representation of hydrophilic tunnel</scene>.
	*<scene name='74/749400/Cv/5'>Mg coordination site</scene>.		*<scene name='74/749400/Cv/5'>Mg coordination site</scene>.

Alexander Berchansky at 14:52, 27 December 2016

Alexander Berchansky — Tue, 27 Dec 2016 14:52:33 GMT

←Older revision		Revision as of 14:52, 27 December 2016
Line 5:		Line 5:

	== Structural highlights ==		== Structural highlights ==
-	SAI structure shows <scene name='74/749400/Cv/2'>two domains</scene>. The <scene name='74/749400/Cv/3'>active site is located in a hydrophilic tunnel</scene> between the 2 domains and contains <scene name='74/749400/Cv/4'>ADP</scene>, <scene name='74/749400/Cv/6'>aspartic acid</scene> and <scene name='74/749400/Cv/7'>aminoimidazole-ribonucleotide (AIR)</scene><ref>PMID:24598753</ref>. <scene name='74/749400/Cv/5'>Mg coordination site</scene>. <scene name='74/749400/Cv/8'>Whole binding site</scene>.	+	SAI structure shows <scene name='74/749400/Cv/2'>two domains</scene>. The <scene name='74/749400/Cv/9'>active site is located in a hydrophilic tunnel</scene> between the 2 domains and contains <scene name='74/749400/Cv/4'>ADP</scene>, <scene name='74/749400/Cv/6'>aspartic acid</scene> and <scene name='74/749400/Cv/7'>aminoimidazole-ribonucleotide (AIR)</scene><ref>PMID:24598753</ref>. {{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}. Water molecules shown as red spheres.
		+	*<scene name='74/749400/Cv/3'>Surface representation of hydrophilic tunnel</scene>.
		+	*<scene name='74/749400/Cv/5'>Mg coordination site</scene>.
		+	*<scene name='74/749400/Cv/8'>Whole binding site</scene>.

	</StructureSection>		</StructureSection>

Alexander Berchansky at 14:43, 27 December 2016

Alexander Berchansky — Tue, 27 Dec 2016 14:43:16 GMT

←Older revision		Revision as of 14:43, 27 December 2016
Line 5:		Line 5:

	== Structural highlights ==		== Structural highlights ==
-	SAI structure shows <scene name='74/749400/Cv/2'>two domains</scene>. The <scene name='74/749400/Cv/3'>active site is located in a hydrophilic tunnel</scene> between the 2 domains and contains ADP, aspartic acid and aminoimidazole-ribonucleotide (AIR)<ref>PMID:24598753</ref>.	+	SAI structure shows <scene name='74/749400/Cv/2'>two domains</scene>. The <scene name='74/749400/Cv/3'>active site is located in a hydrophilic tunnel</scene> between the 2 domains and contains <scene name='74/749400/Cv/4'>ADP</scene>, <scene name='74/749400/Cv/6'>aspartic acid</scene> and <scene name='74/749400/Cv/7'>aminoimidazole-ribonucleotide (AIR)</scene><ref>PMID:24598753</ref>. <scene name='74/749400/Cv/5'>Mg coordination site</scene>. <scene name='74/749400/Cv/8'>Whole binding site</scene>.

	</StructureSection>		</StructureSection>

Alexander Berchansky at 13:26, 27 December 2016

Alexander Berchansky — Tue, 27 Dec 2016 13:26:32 GMT

←Older revision		Revision as of 13:26, 27 December 2016
Line 5:		Line 5:

	== Structural highlights ==		== Structural highlights ==
-	SAI structure shows two domains. The active site is located in a hydrophilic tunnel between the 2 domains and contains ADP, aspartic acid and aminoimidazole-ribonucleotide (AIR)<ref>PMID:24598753</ref>.	+	SAI structure shows <scene name='74/749400/Cv/2'>two domains</scene>. The <scene name='74/749400/Cv/3'>active site is located in a hydrophilic tunnel</scene> between the 2 domains and contains ADP, aspartic acid and aminoimidazole-ribonucleotide (AIR)<ref>PMID:24598753</ref>.

	</StructureSection>		</StructureSection>