Sandbox28 - Revision history

Student at 05:54, 23 March 2009

Student — Mon, 23 Mar 2009 05:54:04 GMT

←Older revision		Revision as of 05:54, 23 March 2009
Line 9:		Line 9:
	There are also two active sites that can be seen here: <scene name='Sandbox28/Active_sites/1'>Active Sites</scene>		There are also two active sites that can be seen here: <scene name='Sandbox28/Active_sites/1'>Active Sites</scene>

-	This view shows a	+	This view of the protein shows an ampiphilic character in regards to the protein containing a hydrophobic core (black) surrounded by hydrophilic surface residues (green) that stretch farther out from the protein than do the hydrophobic elements. This trend occurs throughout the protein for the most part and can be seen in both the alpha and beta structures and can be seen by rotating the protein. <scene name='Sandbox28/X/1'>View 1</scene>.
-	<scene name='Sandbox28/~~Hydrophobicalpha~~/1'>~~hydrophobic element~~</scene> ~~of an alpha helix (in red) on the surface of the protein~~.	+
-		+
	{{STRUCTURE_1h8f \| PDB=1h8f \| SCENE= }}		{{STRUCTURE_1h8f \| PDB=1h8f \| SCENE= }}

Student: /* GLYCOGEN SYNTHASE KINASE 3 BETA */

Student — Wed, 04 Mar 2009 16:46:58 GMT

GLYCOGEN SYNTHASE KINASE 3 BETA

←Older revision		Revision as of 16:46, 4 March 2009
Line 8:		Line 8:
	in the two opposite quadrants and <scene name='Sandbox28/Alpha_helix/1'>alpha helices</scene> in the other two opposite quadrants.		in the two opposite quadrants and <scene name='Sandbox28/Alpha_helix/1'>alpha helices</scene> in the other two opposite quadrants.
	There are also two active sites that can be seen here: <scene name='Sandbox28/Active_sites/1'>Active Sites</scene>		There are also two active sites that can be seen here: <scene name='Sandbox28/Active_sites/1'>Active Sites</scene>
		+
	This view shows a		This view shows a
	<scene name='Sandbox28/Hydrophobicalpha/1'>hydrophobic element</scene> of an alpha helix (in red) on the surface of the protein.		<scene name='Sandbox28/Hydrophobicalpha/1'>hydrophobic element</scene> of an alpha helix (in red) on the surface of the protein.

Student: /* GLYCOGEN SYNTHASE KINASE 3 BETA */

Student — Wed, 04 Mar 2009 16:45:53 GMT

GLYCOGEN SYNTHASE KINASE 3 BETA

←Older revision		Revision as of 16:45, 4 March 2009
Line 7:		Line 7:
	Glycogen Synthase Kinase 3 Beta has <scene name='Sandbox28/Beta_sheets/1'>beta sheet</scene>		Glycogen Synthase Kinase 3 Beta has <scene name='Sandbox28/Beta_sheets/1'>beta sheet</scene>
	in the two opposite quadrants and <scene name='Sandbox28/Alpha_helix/1'>alpha helices</scene> in the other two opposite quadrants.		in the two opposite quadrants and <scene name='Sandbox28/Alpha_helix/1'>alpha helices</scene> in the other two opposite quadrants.
-	There are also two active sites that can be seen here: <scene name='Sandbox28/~~Ac1~~/1'>~~active site 1</scene> <scene name='Sandbox28/Ac2/1'>active site 2~~</scene>	+	There are also two active sites that can be seen here: <scene name='Sandbox28/Active_sites/1'>Active Sites</scene>
-		+
	This view shows a		This view shows a
	<scene name='Sandbox28/Hydrophobicalpha/1'>hydrophobic element</scene> of an alpha helix (in red) on the surface of the protein.		<scene name='Sandbox28/Hydrophobicalpha/1'>hydrophobic element</scene> of an alpha helix (in red) on the surface of the protein.

Student at 07:03, 4 March 2009

Student — Wed, 04 Mar 2009 07:03:23 GMT

←Older revision		Revision as of 07:03, 4 March 2009
Line 1:		Line 1:
		+	This sandbox is in use until June 1, 2009 for UMass Chemistry 490a. Others please do not edit this page. Thanks!
		+
		+	Bejan Hakimi and Brendan Walker 3/4/09
		+
	==GLYCOGEN SYNTHASE KINASE 3 BETA==		==GLYCOGEN SYNTHASE KINASE 3 BETA==

Student at 07:01, 4 March 2009

Student — Wed, 04 Mar 2009 07:01:55 GMT

←Older revision		Revision as of 07:01, 4 March 2009
Line 4:		Line 4:
	in the two opposite quadrants and <scene name='Sandbox28/Alpha_helix/1'>alpha helices</scene> in the other two opposite quadrants.		in the two opposite quadrants and <scene name='Sandbox28/Alpha_helix/1'>alpha helices</scene> in the other two opposite quadrants.
	There are also two active sites that can be seen here: <scene name='Sandbox28/Ac1/1'>active site 1</scene> <scene name='Sandbox28/Ac2/1'>active site 2</scene>		There are also two active sites that can be seen here: <scene name='Sandbox28/Ac1/1'>active site 1</scene> <scene name='Sandbox28/Ac2/1'>active site 2</scene>
		+
		+	This view shows a
		+	<scene name='Sandbox28/Hydrophobicalpha/1'>hydrophobic element</scene> of an alpha helix (in red) on the surface of the protein.

	{{STRUCTURE_1h8f \| PDB=1h8f \| SCENE= }}		{{STRUCTURE_1h8f \| PDB=1h8f \| SCENE= }}

Student at 06:53, 4 March 2009

Student — Wed, 04 Mar 2009 06:53:06 GMT

←Older revision		Revision as of 06:53, 4 March 2009
Line 4:		Line 4:
	in the two opposite quadrants and <scene name='Sandbox28/Alpha_helix/1'>alpha helices</scene> in the other two opposite quadrants.		in the two opposite quadrants and <scene name='Sandbox28/Alpha_helix/1'>alpha helices</scene> in the other two opposite quadrants.
	There are also two active sites that can be seen here: <scene name='Sandbox28/Ac1/1'>active site 1</scene> <scene name='Sandbox28/Ac2/1'>active site 2</scene>		There are also two active sites that can be seen here: <scene name='Sandbox28/Ac1/1'>active site 1</scene> <scene name='Sandbox28/Ac2/1'>active site 2</scene>
		+
		+	{{STRUCTURE_1h8f \| PDB=1h8f \| SCENE= }}
		+

	Publication Abstract from PubMed		Publication Abstract from PubMed
Line 12:		Line 15:

	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
-
-
-	{{STRUCTURE_1h8f \| PDB=1h8f \| SCENE= }}

Student at 06:51, 4 March 2009

Student — Wed, 04 Mar 2009 06:51:08 GMT

←Older revision		Revision as of 06:51, 4 March 2009
Line 5:		Line 5:
	There are also two active sites that can be seen here: <scene name='Sandbox28/Ac1/1'>active site 1</scene> <scene name='Sandbox28/Ac2/1'>active site 2</scene>		There are also two active sites that can be seen here: <scene name='Sandbox28/Ac1/1'>active site 1</scene> <scene name='Sandbox28/Ac2/1'>active site 2</scene>

-	~~{{STRUCTURE_1h8f \| PDB=1h8f \| SCENE= }}~~	+	Publication Abstract from PubMed

		+	Glycogen synthase kinase 3 beta (GSK3 beta) plays a key role in insulin and Wnt signaling, phosphorylating downstream targets by default, and becoming inhibited following the extracellular signaling event. The crystal structure of human GSK3 beta shows a catalytically active conformation in the absence of activation-segment phosphorylation, with the sulphonate of a buffer molecule bridging the activation-segment and N-terminal domain in the same way as the phosphate group of the activation-segment phospho-Ser/Thr in other kinases. The location of this oxyanion binding site in the substrate binding cleft indicates direct coupling of P+4 phosphate-primed substrate binding and catalytic activation, explains the ability of GSK3 beta to processively hyperphosphorylate substrates with Ser/Thr pentad-repeats, and suggests a mechanism for autoinhibition in which the phosphorylated N terminus binds as a competitive pseudosubstrate with phospho-Ser 9 occupying the P+4 site.

		+	Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition., Dajani R, Fraser E, Roe SM, Young N, Good V, Dale TC, Pearl LH, Cell. 2001 Jun 15;105(6):721-32. PMID:11440715

-	~~<scene name='Sandbox28~~/~~Beta_sheets/1'>beta sheet</scene>~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
		+

-		+	{{STRUCTURE_1h8f \| PDB=1h8f \| SCENE= }}
-	~~<scene name~~=~~'Sandbox28/Alpha_helix/1'>alpha helices</scene>~~	+
-		+
-	~~<scene name~~=~~'Sandbox28/Ac1/1'>active site 1</scene>~~	+
-		+
-	~~<scene name='Sandbox28/Ac2/1'>active site 2</scene>~~	+

Student at 06:49, 4 March 2009

Student — Wed, 04 Mar 2009 06:49:12 GMT

←Older revision		Revision as of 06:49, 4 March 2009
Line 2:		Line 2:

	Glycogen Synthase Kinase 3 Beta has <scene name='Sandbox28/Beta_sheets/1'>beta sheet</scene>		Glycogen Synthase Kinase 3 Beta has <scene name='Sandbox28/Beta_sheets/1'>beta sheet</scene>
-	in the two opposite quadrants and alpha helices in the other two opposite quadrants.	+	in the two opposite quadrants and <scene name='Sandbox28/Alpha_helix/1'>alpha helices</scene> in the other two opposite quadrants.
	There are also two active sites that can be seen here: <scene name='Sandbox28/Ac1/1'>active site 1</scene> <scene name='Sandbox28/Ac2/1'>active site 2</scene>		There are also two active sites that can be seen here: <scene name='Sandbox28/Ac1/1'>active site 1</scene> <scene name='Sandbox28/Ac2/1'>active site 2</scene>

Line 12:		Line 12:


-	<scene name='Sandbox28/Alpha_helix/1'>alpha ~~helix~~</scene>	+	<scene name='Sandbox28/Alpha_helix/1'>alpha helices</scene>

	<scene name='Sandbox28/Ac1/1'>active site 1</scene>		<scene name='Sandbox28/Ac1/1'>active site 1</scene>

	<scene name='Sandbox28/Ac2/1'>active site 2</scene>		<scene name='Sandbox28/Ac2/1'>active site 2</scene>

Student at 06:47, 4 March 2009

Student — Wed, 04 Mar 2009 06:47:40 GMT

←Older revision		Revision as of 06:47, 4 March 2009
Line 1:		Line 1:
	==GLYCOGEN SYNTHASE KINASE 3 BETA==		==GLYCOGEN SYNTHASE KINASE 3 BETA==

-	Glycogen Synthase Kinase 3 Beta has <scene name='Sandbox28/Beta_sheets/1'>beta sheet</scene>	+	Glycogen Synthase Kinase 3 Beta has <scene name='Sandbox28/Beta_sheets/1'>beta sheet</scene>
-	in the two opposite quadrants and alpha helices in the other two opposite quadrants. There are also two active sites that can be seen here: <scene name='Sandbox28/Ac1/1'>active site 1</scene>	+	in the two opposite quadrants and alpha helices in the other two opposite quadrants.
-	<scene name='Sandbox28/Ac2/1'>active site 2</scene>	+	There are also two active sites that can be seen here: <scene name='Sandbox28/Ac1/1'>active site 1</scene> <scene name='Sandbox28/Ac2/1'>active site 2</scene>

	{{STRUCTURE_1h8f \| PDB=1h8f \| SCENE= }}		{{STRUCTURE_1h8f \| PDB=1h8f \| SCENE= }}

Student: /* GLYCOGEN SYNTHASE KINASE 3 BETA. */

Student — Wed, 04 Mar 2009 06:46:00 GMT

GLYCOGEN SYNTHASE KINASE 3 BETA.

←Older revision		Revision as of 06:46, 4 March 2009
Line 1:		Line 1:
-	==GLYCOGEN SYNTHASE KINASE 3 BETA.==	+	==GLYCOGEN SYNTHASE KINASE 3 BETA==
-	~~This is a placeholder text to help you get started in~~	+
-	~~placing a Jmol applet on your page. At any time, click~~	+
-	~~"Show Preview" at the bottom of this page to see how it goes.~~	+

-	~~Replace the PDB id (use lowercase!) after the STRUCTURE_ and after PDB~~= ~~to load~~	+	Glycogen Synthase Kinase 3 Beta has <scene name='Sandbox28/Beta_sheets/1'>beta sheet</scene>
-	and ~~display another structure~~.	+	in the two opposite quadrants and alpha helices in the other two opposite quadrants. There are also two active sites that can be seen here: <scene name='Sandbox28/Ac1/1'>active site 1</scene>
		+	<scene name='Sandbox28/Ac2/1'>active site 2</scene>

	{{STRUCTURE_1h8f \| PDB=1h8f \| SCENE= }}		{{STRUCTURE_1h8f \| PDB=1h8f \| SCENE= }}