Sandbox GGC11 - Revision history

Student at 19:31, 28 April 2021

Student — Wed, 28 Apr 2021 19:31:09 GMT

←Older revision		Revision as of 19:31, 28 April 2021
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	==5CEQ DLK in complex with inhibitor 50F (2-((1-cyclopentyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-3-yl)amino)isonicotinonitrile)==		==5CEQ DLK in complex with inhibitor 50F (2-((1-cyclopentyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-3-yl)amino)isonicotinonitrile)==
	<StructureSection load='5ceq' size='340' side='right'caption='[[5ceq]], [[Resolution\|resolution]] 1.91Å' scene=''>		<StructureSection load='5ceq' size='340' side='right'caption='[[5ceq]], [[Resolution\|resolution]] 1.91Å' scene=''>
-	5CEQ is a MAP3K12 protein ~~This is a default text for your page~~. ~~Click above on '''edit this page''' to modify. Be careful~~ with the ~~<~~ and ~~> signs.~~	+	5CEQ is a MAP3K12 protein from homo sapiens. It plays a role in the MAPK Cascade pathway mostly by interacting with the JNKs, SAPKs, and ERKs which are part of part of the MAP kinases. Since some of the MAP kinases are involved with the central nervous system signaling, it has been shown that DLK also plays a role in protection of neurons when inhibited by 50F.
-	~~You may include any references to papers as in: the use~~ of ~~JSmol in Proteopedia <ref>DOI 10~~.~~1002/ijch.201300024</ref> or to~~ the ~~article describing Jmol <ref>PMID:21638687</ref> to~~ the ~~rescue~~.	+

	== Function ==		== Function ==
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	Neuron degenerative diseases such as Parkinson’s, and Alzheimer.		Neuron degenerative diseases such as Parkinson’s, and Alzheimer.
	== Relevance ==		== Relevance ==
-		+	This protein will help us understand more about the physiology of degenerative diseases, which will lead to making more medicine that could possibly slow the deterioration process, or even cure the diseases.
	== Structural highlights ==		== Structural highlights ==
-	This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
-
-	</StructureSection>
	<scene name='78/781195/00ligand/1'>50F</scene>		<scene name='78/781195/00ligand/1'>50F</scene>

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	<scene name='78/781195/03asp161/1'>ASP161</scene>		<scene name='78/781195/03asp161/1'>ASP161</scene>
		+
		+	</StructureSection>
		+	Gene: MAP3K12
		+
		+	Related proteins: 5CEO, 5CEN, Q12852
		+
		+	Ligand: 50F
		+
	== References ==		== References ==
	1. Patel S, Harris SF, Gibbons P, Deshmukh G, Gustafson A, Kellar T, Lin H, Liu X, Liu Y, Liu Y, Ma C, Scearce-Levie K, Ghosh AS, Shin YG, Solanoy H, Wang J, Wang B, Yin J, Siu M, Lewcock JW. Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12). J Med Chem. 2015 Oct 2. PMID:26431428 doi:http://dx.doi.org/10.1021/acs.jmedchem.5b01072		1. Patel S, Harris SF, Gibbons P, Deshmukh G, Gustafson A, Kellar T, Lin H, Liu X, Liu Y, Liu Y, Ma C, Scearce-Levie K, Ghosh AS, Shin YG, Solanoy H, Wang J, Wang B, Yin J, Siu M, Lewcock JW. Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12). J Med Chem. 2015 Oct 2. PMID:26431428 doi:http://dx.doi.org/10.1021/acs.jmedchem.5b01072

Student at 18:48, 28 April 2021

Student — Wed, 28 Apr 2021 18:48:52 GMT

←Older revision		Revision as of 18:48, 28 April 2021
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	</StructureSection>		</StructureSection>
	<scene name='78/781195/00ligand/1'>50F</scene>		<scene name='78/781195/00ligand/1'>50F</scene>
		+
	<scene name='78/781195/01dfg_active_site/1'>active site</scene>		<scene name='78/781195/01dfg_active_site/1'>active site</scene>
		+
		+	<scene name='78/781195/03asp161/1'>ASP161</scene>
	== References ==		== References ==
	1. Patel S, Harris SF, Gibbons P, Deshmukh G, Gustafson A, Kellar T, Lin H, Liu X, Liu Y, Liu Y, Ma C, Scearce-Levie K, Ghosh AS, Shin YG, Solanoy H, Wang J, Wang B, Yin J, Siu M, Lewcock JW. Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12). J Med Chem. 2015 Oct 2. PMID:26431428 doi:http://dx.doi.org/10.1021/acs.jmedchem.5b01072		1. Patel S, Harris SF, Gibbons P, Deshmukh G, Gustafson A, Kellar T, Lin H, Liu X, Liu Y, Liu Y, Ma C, Scearce-Levie K, Ghosh AS, Shin YG, Solanoy H, Wang J, Wang B, Yin J, Siu M, Lewcock JW. Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12). J Med Chem. 2015 Oct 2. PMID:26431428 doi:http://dx.doi.org/10.1021/acs.jmedchem.5b01072

Student at 17:58, 28 April 2021

Student — Wed, 28 Apr 2021 17:58:51 GMT

←Older revision		Revision as of 17:58, 28 April 2021
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	</StructureSection>		</StructureSection>
	<scene name='78/781195/00ligand/1'>50F</scene>		<scene name='78/781195/00ligand/1'>50F</scene>
-		+	<scene name='78/781195/01dfg_active_site/1'>active site</scene>
	== References ==		== References ==
	1. Patel S, Harris SF, Gibbons P, Deshmukh G, Gustafson A, Kellar T, Lin H, Liu X, Liu Y, Liu Y, Ma C, Scearce-Levie K, Ghosh AS, Shin YG, Solanoy H, Wang J, Wang B, Yin J, Siu M, Lewcock JW. Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12). J Med Chem. 2015 Oct 2. PMID:26431428 doi:http://dx.doi.org/10.1021/acs.jmedchem.5b01072		1. Patel S, Harris SF, Gibbons P, Deshmukh G, Gustafson A, Kellar T, Lin H, Liu X, Liu Y, Liu Y, Ma C, Scearce-Levie K, Ghosh AS, Shin YG, Solanoy H, Wang J, Wang B, Yin J, Siu M, Lewcock JW. Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12). J Med Chem. 2015 Oct 2. PMID:26431428 doi:http://dx.doi.org/10.1021/acs.jmedchem.5b01072

Student at 13:57, 28 April 2021

Student — Wed, 28 Apr 2021 13:57:33 GMT

←Older revision		Revision as of 13:57, 28 April 2021
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	==5CEQ DLK in complex with inhibitor 50F (2-((1-cyclopentyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-3-yl)amino)isonicotinonitrile)==		==5CEQ DLK in complex with inhibitor 50F (2-((1-cyclopentyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-3-yl)amino)isonicotinonitrile)==
	<StructureSection load='5ceq' size='340' side='right'caption='[[5ceq]], [[Resolution\|resolution]] 1.91Å' scene=''>		<StructureSection load='5ceq' size='340' side='right'caption='[[5ceq]], [[Resolution\|resolution]] 1.91Å' scene=''>
-	5CEQ is a This is a default text for your page. Click above on '''edit this page''' to modify. Be careful with the < and > signs.	+	5CEQ is a MAP3K12 protein This is a default text for your page. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
	You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.		You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

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	</StructureSection>		</StructureSection>
		+	<scene name='78/781195/00ligand/1'>50F</scene>
		+
	== References ==		== References ==
	1. Patel S, Harris SF, Gibbons P, Deshmukh G, Gustafson A, Kellar T, Lin H, Liu X, Liu Y, Liu Y, Ma C, Scearce-Levie K, Ghosh AS, Shin YG, Solanoy H, Wang J, Wang B, Yin J, Siu M, Lewcock JW. Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12). J Med Chem. 2015 Oct 2. PMID:26431428 doi:http://dx.doi.org/10.1021/acs.jmedchem.5b01072		1. Patel S, Harris SF, Gibbons P, Deshmukh G, Gustafson A, Kellar T, Lin H, Liu X, Liu Y, Liu Y, Ma C, Scearce-Levie K, Ghosh AS, Shin YG, Solanoy H, Wang J, Wang B, Yin J, Siu M, Lewcock JW. Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12). J Med Chem. 2015 Oct 2. PMID:26431428 doi:http://dx.doi.org/10.1021/acs.jmedchem.5b01072

Student at 05:24, 26 April 2021

Student — Mon, 26 Apr 2021 05:24:28 GMT

←Older revision		Revision as of 05:24, 26 April 2021
Line 5:		Line 5:

	== Function ==		== Function ==
-	~~Phosphholyrates~~	+	Regulates JNK/SAPK cascade, transferase phosphorylation
	== Disease ==		== Disease ==
-		+	Neuron degenerative diseases such as Parkinson’s, and Alzheimer.
	== Relevance ==		== Relevance ==

Student at 05:02, 26 April 2021

Student — Mon, 26 Apr 2021 05:02:45 GMT

←Older revision		Revision as of 05:02, 26 April 2021
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	== Function ==		== Function ==
-		+	Phosphholyrates
	== Disease ==		== Disease ==

Student at 04:05, 26 April 2021

Student — Mon, 26 Apr 2021 04:05:10 GMT

←Older revision		Revision as of 04:05, 26 April 2021
Line 1:		Line 1:
	==5CEQ DLK in complex with inhibitor 50F (2-((1-cyclopentyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-3-yl)amino)isonicotinonitrile)==		==5CEQ DLK in complex with inhibitor 50F (2-((1-cyclopentyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-3-yl)amino)isonicotinonitrile)==
		+	<StructureSection load='5ceq' size='340' side='right'caption='[[5ceq]], [[Resolution\|resolution]] 1.91Å' scene=''>
	5CEQ is a This is a default text for your page. Click above on '''edit this page''' to modify. Be careful with the < and > signs.		5CEQ is a This is a default text for your page. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
	You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.		You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
Line 12:		Line 13:
	This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.		This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

		+	</StructureSection>
	== References ==		== References ==
	1. Patel S, Harris SF, Gibbons P, Deshmukh G, Gustafson A, Kellar T, Lin H, Liu X, Liu Y, Liu Y, Ma C, Scearce-Levie K, Ghosh AS, Shin YG, Solanoy H, Wang J, Wang B, Yin J, Siu M, Lewcock JW. Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12). J Med Chem. 2015 Oct 2. PMID:26431428 doi:http://dx.doi.org/10.1021/acs.jmedchem.5b01072		1. Patel S, Harris SF, Gibbons P, Deshmukh G, Gustafson A, Kellar T, Lin H, Liu X, Liu Y, Liu Y, Ma C, Scearce-Levie K, Ghosh AS, Shin YG, Solanoy H, Wang J, Wang B, Yin J, Siu M, Lewcock JW. Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12). J Med Chem. 2015 Oct 2. PMID:26431428 doi:http://dx.doi.org/10.1021/acs.jmedchem.5b01072

Student at 04:01, 26 April 2021

Student — Mon, 26 Apr 2021 04:01:52 GMT

←Older revision		Revision as of 04:01, 26 April 2021
Line 13:		Line 13:

	== References ==		== References ==
		+	1. Patel S, Harris SF, Gibbons P, Deshmukh G, Gustafson A, Kellar T, Lin H, Liu X, Liu Y, Liu Y, Ma C, Scearce-Levie K, Ghosh AS, Shin YG, Solanoy H, Wang J, Wang B, Yin J, Siu M, Lewcock JW. Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12). J Med Chem. 2015 Oct 2. PMID:26431428 doi:http://dx.doi.org/10.1021/acs.jmedchem.5b01072
		+
		+	2. Cargnello, M., & Roux, P. P. (2011). Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. Microbiology and molecular biology reviews : MMBR, 75(1), 50–83. https://doi.org/10.1128/MMBR.00031-10
		+
		+	3. Siu M, Sengupta Ghosh A, Lewcock JW. Dual Leucine Zipper Kinase Inhibitors for the Treatment of Neurodegeneration. J Med Chem. 2018 Sep 27;61(18):8078-8087. doi: 10.1021/acs.jmedchem.8b00370. Epub 2018 Jun 4. PMID: 29863360.
		+
		+	4. Patel S, Cohen F, Dean BJ, De La Torre K, Deshmukh G, Estrada AA, Ghosh AS, Gibbons P, Gustafson A, Huestis MP, Le Pichon CE, Lin H, Liu W, Liu X, Liu Y, Ly CQ, Lyssikatos JP, Ma C, Scearce-Levie K, Shin YG, Solanoy H, Stark KL, Wang J, Wang B, Zhao X, Lewcock JW, Siu M. Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models. J Med Chem. 2015 Jan 8;58(1):401-18. doi: 10.1021/jm5013984. Epub 2014 Oct 23. PMID: 25341110./>

Student at 04:00, 26 April 2021

Student — Mon, 26 Apr 2021 04:00:30 GMT

←Older revision		Revision as of 04:00, 26 April 2021
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-	~~<scene name='78/781195/Edited_protein/2'><scene name='78/781195/Ligand/1'>Text To Be Displayed</scene></scene>~~==5CEQ DLK in complex with inhibitor 50F (2-((1-cyclopentyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-3-yl)amino)isonicotinonitrile)==	+	==5CEQ DLK in complex with inhibitor 50F (2-((1-cyclopentyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-3-yl)amino)isonicotinonitrile)==
-	~~<StructureSection load='5CEQ' size='340' side='right' caption='5ceq=''>~~	+
	5CEQ is a This is a default text for your page. Click above on '''edit this page''' to modify. Be careful with the < and > signs.		5CEQ is a This is a default text for your page. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
	You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.		You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

Student at 03:59, 26 April 2021

Student — Mon, 26 Apr 2021 03:59:51 GMT

←Older revision		Revision as of 03:59, 26 April 2021
Line 11:		Line 11:

	== Structural highlights ==		== Structural highlights ==
-
	This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.		This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

-	</StructureSection>
	== References ==		== References ==