Sandbox Reserved 1181 - Revision history

Allie Paton at 22:08, 20 April 2016

Allie Paton — Wed, 20 Apr 2016 22:08:31 GMT

←Older revision		Revision as of 22:08, 20 April 2016
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	<Structure load='4L6R' size='350' frame='true' align='right' caption='7TM structure of human class B GPCR 4L6R' scene='72/727091/Full_structure_with_labels/1'/>		<Structure load='4L6R' size='350' frame='true' align='right' caption='7TM structure of human class B GPCR 4L6R' scene='72/727091/Full_structure_with_labels/1'/>
		+
		+	<scene name='72/727091/Full_Structure_with_Labels/1'>Labels</scene>

	<scene name='72/721552/Ligand_binding_interactions/1'>Ligand Binding Interactions and Crucial Disulfide Bond</scene>		<scene name='72/721552/Ligand_binding_interactions/1'>Ligand Binding Interactions and Crucial Disulfide Bond</scene>
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-	<scene name='72/721552/Glucagon_binding/1'>Glucagon Binding Zoomed Out</scene>
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-	<scene name='72/721552/Glucagon_binding/2'>Glucagon Binding Zoomed Out</scene>

	<scene name='72/721552/Glucagon_binding/3'>Glucagon Binding Full Rendering</scene>		<scene name='72/721552/Glucagon_binding/3'>Glucagon Binding Full Rendering</scene>
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	[[Image:Movie_Frame_2.png\|100 px\|left\|thumb\|Fig. 7: Active site buried deep in 7TMD of glucagon receptor.]]		[[Image:Movie_Frame_2.png\|100 px\|left\|thumb\|Fig. 7: Active site buried deep in 7TMD of glucagon receptor.]]
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-	[[Image:Movie Frame 3.png \|200 px\|right\|thumb\|Fig. 9: Location of anchoring pocket within central cavity.<ref name= "Siu 2013"/>]]
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-	[[Image:Movie Frame 6.png \|100 px\|left\|thumb\|Fig. 10: Ballooned pocket functioning as anchoring site for glucagon residues 1-4.]]

	[[Image:Movie_Frame_7.png\|175 px\|left\|thumb\|Fig. 14: Distance measurement of GCGR 7TMD Y138-D362 of 19-20 angstroms and labeled with complimentary glucagon interaction residues.]]		[[Image:Movie_Frame_7.png\|175 px\|left\|thumb\|Fig. 14: Distance measurement of GCGR 7TMD Y138-D362 of 19-20 angstroms and labeled with complimentary glucagon interaction residues.]]

Allie Paton at 20:45, 20 April 2016

Allie Paton — Wed, 20 Apr 2016 20:45:32 GMT

←Older revision		Revision as of 20:45, 20 April 2016
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	[[Image:Movie Frame 6.png \|100 px\|left\|thumb\|Fig. 10: Ballooned pocket functioning as anchoring site for glucagon residues 1-4.]]		[[Image:Movie Frame 6.png \|100 px\|left\|thumb\|Fig. 10: Ballooned pocket functioning as anchoring site for glucagon residues 1-4.]]
		+
		+	[[Image:Movie_Frame_7.png\|175 px\|left\|thumb\|Fig. 14: Distance measurement of GCGR 7TMD Y138-D362 of 19-20 angstroms and labeled with complimentary glucagon interaction residues.]]
		+	[[Image:H1___Y10_with_measurement.png\|175 px\|right\|thumb\|Fig. 15: Distance measurement of H1-Y10 of 22-24 angstroms and labeled with complimentary GCGR 7TMD residue interactions.]]
		+
		+	===Future research direction===
		+	Research for Class A GPCRs is much more extensive than for its secretin, class B counterparts, although class B is proving to be a worthwhile to invest researching. The challenge of class B stabilization, expression, and molecular size , has made class B GPCRs particularly hard to assay. Biochemical research has increased in the class B specifications, because it has been realized that receptors can be modulated by more than the agonist and antagonists present in vivo. Leading research consists of a complex interwoven scheme of equilibria manipulation in multi-receptor conformations. <ref name="Salon 2011"/>

Allie Paton at 17:54, 20 April 2016

Allie Paton — Wed, 20 Apr 2016 17:54:50 GMT

←Older revision		Revision as of 17:54, 20 April 2016
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	<scene name='72/721552/Glucagon_binding_zoomed_in/1'>Glucagon Binding Zoomed in</scene>		<scene name='72/721552/Glucagon_binding_zoomed_in/1'>Glucagon Binding Zoomed in</scene>
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		+	Old Stuff:
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		+	[[Image:ALA135PRO stalk unwinding.png\|150 px\|left\|thumb\|Fig. 1: A135P Mutation and effect on stalk stability <ref name= "Siu 2013"/>. ]] [[Image:Gln142 Tyr138 Glucagon interaction.png\|150 px\|right\|thumb\|Fig. 2: Stalk stabilized by salt bridge between Glu133-Lys136. Residues in yellow are demonstrated to have an effect on ligand binding affinity.<ref name= "Siu 2013"/>]]
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		+	[[Image:Asn_298__Trp_295.png\|150 px\|left\|thumb\|Fig. 3: Active sites linked to glucagon binding affinity located on ECL1 are labeled<ref name= "Siu 2013"/>.]]
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		+	[[Image:Corticotropin class B and Glucagon class B receptors aligned.png \|150 px\|left\|thumb\|Fig. 4: Corticotropin-releasing factor 1 and glucagon receptors; Class B GPCRs with notable central splay]] [[Image:Beta2 class A and Glucagon class B receptors aligned.png \|150 px\|right\|thumb\|Fig. 5: Beta 2-adrenergic (class A) and glucagon receptors; showing an absence of central splay in Class A GPCRs.]]
		+
		+	[[Image:Movie_Frame_2.png\|100 px\|left\|thumb\|Fig. 7: Active site buried deep in 7TMD of glucagon receptor.]]
		+
		+	[[Image:Movie Frame 3.png \|200 px\|right\|thumb\|Fig. 9: Location of anchoring pocket within central cavity.<ref name= "Siu 2013"/>]]
		+
		+	[[Image:Movie Frame 6.png \|100 px\|left\|thumb\|Fig. 10: Ballooned pocket functioning as anchoring site for glucagon residues 1-4.]]

Allie Paton at 18:52, 15 April 2016

Allie Paton — Fri, 15 Apr 2016 18:52:18 GMT

←Older revision		Revision as of 18:52, 15 April 2016
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	<scene name='72/721552/Glucagon_binding/3'>Glucagon Binding Full Rendering</scene>		<scene name='72/721552/Glucagon_binding/3'>Glucagon Binding Full Rendering</scene>
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		+	<scene name='72/721552/Glucagon_binding_zoomed_in/1'>Glucagon Binding Zoomed in</scene>

Allie Paton at 18:32, 15 April 2016

Allie Paton — Fri, 15 Apr 2016 18:32:30 GMT

←Older revision		Revision as of 18:32, 15 April 2016
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	<scene name='72/721552/Glucagon_binding/2'>Glucagon Binding Zoomed Out</scene>		<scene name='72/721552/Glucagon_binding/2'>Glucagon Binding Zoomed Out</scene>
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		+	<scene name='72/721552/Glucagon_binding/3'>Glucagon Binding Full Rendering</scene>

Allie Paton at 18:29, 15 April 2016

Allie Paton — Fri, 15 Apr 2016 18:29:21 GMT

←Older revision		Revision as of 18:29, 15 April 2016
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	<scene name='72/721552/Glucagon_binding/1'>Glucagon Binding Zoomed Out</scene>		<scene name='72/721552/Glucagon_binding/1'>Glucagon Binding Zoomed Out</scene>
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		+	<scene name='72/721552/Glucagon_binding/2'>Glucagon Binding Zoomed Out</scene>

Allie Paton at 18:26, 15 April 2016

Allie Paton — Fri, 15 Apr 2016 18:26:42 GMT

←Older revision		Revision as of 18:26, 15 April 2016
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	<scene name='72/721552/Ligand_binding_interactions/1'>Ligand Binding Interactions and Crucial Disulfide Bond</scene>		<scene name='72/721552/Ligand_binding_interactions/1'>Ligand Binding Interactions and Crucial Disulfide Bond</scene>
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		+	<scene name='72/721552/Glucagon_binding/1'>Glucagon Binding Zoomed Out</scene>

Allie Paton at 18:02, 15 April 2016

Allie Paton — Fri, 15 Apr 2016 18:02:36 GMT

←Older revision		Revision as of 18:02, 15 April 2016
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	<Structure load='4L6R' size='350' frame='true' align='right' caption='7TM structure of human class B GPCR 4L6R' scene='72/727091/Full_structure_with_labels/1'/>		<Structure load='4L6R' size='350' frame='true' align='right' caption='7TM structure of human class B GPCR 4L6R' scene='72/727091/Full_structure_with_labels/1'/>
		+
		+	<scene name='72/721552/Ligand_binding_interactions/1'>Ligand Binding Interactions and Crucial Disulfide Bond</scene>

Allie Paton at 17:22, 15 April 2016

Allie Paton — Fri, 15 Apr 2016 17:22:31 GMT

←Older revision		Revision as of 17:22, 15 April 2016
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-	<Structure load='4L6R' size='350' frame='true' align='right' caption='~~Insert caption here~~' scene='~~Insert optional scene name here~~' />	+	<Structure load='4L6R' size='350' frame='true' align='right' caption='7TM structure of human class B GPCR 4L6R' scene='72/727091/Full_structure_with_labels/1'/>

Allie Paton at 17:16, 15 April 2016

Allie Paton — Fri, 15 Apr 2016 17:16:27 GMT

←Older revision		Revision as of 17:16, 15 April 2016
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-	~~{{Sandbox_Reserved_CH462_Central_Metabolism}}~~<~~!-- PLEASE ADD YOUR CONTENT BELOW HERE -->~~	+	<Structure load='4L6R' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />
-	~~==Your Heading Here (maybe something like '~~Structure~~')==~~	+
-	~~<StructureSection~~ load='~~1stp~~' size='~~340~~' ~~side~~='right' caption='~~Caption for this structure~~' scene=''>	+
-	~~This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.~~	+
-	~~You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.~~	+
-		+
-	~~== Function ==~~	+
-		+
-	~~== Disease ==~~	+
-		+
-	~~== Relevance ==~~	+
-		+
-	~~== Structural highlights ==~~	+
-		+
-	~~This is a sample scene created with SAT to <~~scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.	+
-		+
-	~~</StructureSection>~~	+
-	~~== References ==~~	+
-	~~<references~~/>	+