Sandbox Reserved 1391 - Revision history

Student at 20:38, 1 March 2018

Student — Thu, 01 Mar 2018 20:38:43 GMT

←Older revision		Revision as of 20:38, 1 March 2018
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	== Function ==		== Function ==

-	As mentioned DNA Polymerase 3 is responsible for replicating DNA in prokaryotes. It's activity starts after separation of strands at the origin of replication. The two most important subunits of this polymerase are the α subunit that links the nucleotides together via a phosphodiester bond and the ε subunit that ensures the bases are accurate via proofreading mechanisms. It can synthesize base pairs at a rate of about 1000 nucleotides per second and can only move in the 5' to 3' direction.	+	As mentioned DNA Polymerase 3 is responsible for replicating DNA in prokaryotes. It's activity starts after separation of strands at the origin of replication. The two most important subunits of this polymerase are the α subunit that links the nucleotides together via a phosphodiester bond and the ε subunit that ensures the bases are accurate via proofreading mechanisms. It can synthesize base pairs at a rate of about 1000 nucleotides per second and can only move in the 5' to 3' direction. One thing unique about this enzyme is the sliding clamp which is a donut shaped protein that allows the polymerase to bind to the DNA strands and move along it.
-		+
-	~~== Relevance ==~~	+

	== Structural highlights ==		== Structural highlights ==
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	== References ==		== References ==
		+	http://www.rcsb.org/structure/4GX8
		+	https://www.sciencedirect.com/topics/medicine-and-dentistry/dna-polymerase-iii-holoenzyme
	<references/>		<references/>

Student at 18:24, 1 March 2018

Student — Thu, 01 Mar 2018 18:24:02 GMT

←Older revision		Revision as of 18:24, 1 March 2018
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	<Structure load='4GX8' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /></StructureSection>{{Sandbox_Reserved_HLSC322}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE -->		<Structure load='4GX8' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /></StructureSection>{{Sandbox_Reserved_HLSC322}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE -->
-	DNA polymerase 3 is the primary enzyme responsible for prokaryotic DNA replication. It was first discovered by Thomas Kornberg and Malcolm Gefter in 1970.	+	DNA polymerase 3 is the primary enzyme responsible for prokaryotic DNA replication. It was first discovered by Thomas Kornberg and Malcolm Gefter in 1970. This polymerase works in conjunction with four other polymerases. These include polymerase 1,2,4, and 5.
-		+
	== Function ==		== Function ==

-	As mentioned DNA Polymerase 3 is responsible for replicating DNA in prokaryotes. The two most important subunits of this polymerase are the α subunit that links the nucleotides together via a phosphodiester bond and the ε subunit that ensures the bases are accurate via proofreading mechanisms. It can synthesize base pairs at a rate of about 1000 nucleotides per second and can only move in the 5' to 3' direction.	+	As mentioned DNA Polymerase 3 is responsible for replicating DNA in prokaryotes. It's activity starts after separation of strands at the origin of replication. The two most important subunits of this polymerase are the α subunit that links the nucleotides together via a phosphodiester bond and the ε subunit that ensures the bases are accurate via proofreading mechanisms. It can synthesize base pairs at a rate of about 1000 nucleotides per second and can only move in the 5' to 3' direction.

	== Relevance ==		== Relevance ==

Student: /* Structural highlights */

Student — Thu, 01 Mar 2018 18:13:51 GMT

Structural highlights

←Older revision		Revision as of 18:13, 1 March 2018
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	== Structural highlights ==		== Structural highlights ==
-	This enzyme contains many different regions that all have different properties. These are the <scene name='77/777711/Hydrophobic_and_polar_regions/1'>hydrophobic and polar regions</scene> of the polymerase. The purple regions are towards the outside because they are polar and therefore hydrophilic. The gray regions are hydrophobic regions. This next scene shows the <scene name='77/777711/Secondary_structure/2'>secondary structure </scene> of the polymerase. This consists of alpha helices which are pink and beta pleated sheets which are yellow. These secondary structures form via hydrogen bonding between the amino acid backbones.	+	This enzyme contains many different regions that all have different properties. These are the <scene name='77/777711/Hydrophobic_and_polar_regions/1'>hydrophobic and polar regions</scene> of the polymerase. The purple regions are towards the outside because they are polar and therefore hydrophilic. The gray regions are hydrophobic regions. This next scene shows the <scene name='77/777711/Secondary_structure/2'>secondary structure </scene> of the polymerase. This consists of alpha helices which are pink and beta pleated sheets which are yellow. These secondary structures form via hydrogen bonding between the amino acid backbones. Finally, another region we will talk about are the <scene name='77/777711/Basic_and_positive/1'>Basic and Positive </scene> regions of the polymerase. These regions are another example of the hydrophilic aspects of the proteins. All 3 of these and so many others that we did not talk about go to show the extreme complexity of this beautiful and indispensable enzyme. It's a shame we aren't prokaryotes! :(
-	</~~StructureSection~~>	+

	== References ==		== References ==
	<references/>		<references/>

Student at 17:45, 1 March 2018

Student — Thu, 01 Mar 2018 17:45:47 GMT

←Older revision		Revision as of 17:45, 1 March 2018
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	== Overview ==		== Overview ==
-		+
	<Structure load='4GX8' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /></StructureSection>{{Sandbox_Reserved_HLSC322}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE -->		<Structure load='4GX8' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /></StructureSection>{{Sandbox_Reserved_HLSC322}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE -->
	DNA polymerase 3 is the primary enzyme responsible for prokaryotic DNA replication. It was first discovered by Thomas Kornberg and Malcolm Gefter in 1970.		DNA polymerase 3 is the primary enzyme responsible for prokaryotic DNA replication. It was first discovered by Thomas Kornberg and Malcolm Gefter in 1970.
Line 11:		Line 11:

	== Structural highlights ==		== Structural highlights ==
-	This enzyme contains many different regions that all have different properties. These are the <scene name='77/777711/Hydrophobic_and_polar_regions/1'>hydrophobic and polar regions</scene> of the polymerase. The purple regions are towards the outside because they are polar and therefore hydrophilic. The gray regions are hydrophobic regions.	+	This enzyme contains many different regions that all have different properties. These are the <scene name='77/777711/Hydrophobic_and_polar_regions/1'>hydrophobic and polar regions</scene> of the polymerase. The purple regions are towards the outside because they are polar and therefore hydrophilic. The gray regions are hydrophobic regions. This next scene shows the <scene name='77/777711/Secondary_structure/2'>secondary structure </scene> of the polymerase. This consists of alpha helices which are pink and beta pleated sheets which are yellow. These secondary structures form via hydrogen bonding between the amino acid backbones.
	</StructureSection>		</StructureSection>

	== References ==		== References ==
	<references/>		<references/>

Student: /* Function */

Student — Thu, 01 Mar 2018 17:39:54 GMT

Function

←Older revision		Revision as of 17:39, 1 March 2018
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	== Function ==		== Function ==

-	As mentioned DNA Polymerase 3 is responsible for replicating DNA in prokaryotes.	+	As mentioned DNA Polymerase 3 is responsible for replicating DNA in prokaryotes. The two most important subunits of this polymerase are the α subunit that links the nucleotides together via a phosphodiester bond and the ε subunit that ensures the bases are accurate via proofreading mechanisms. It can synthesize base pairs at a rate of about 1000 nucleotides per second and can only move in the 5' to 3' direction.

	== Relevance ==		== Relevance ==

Student: /* Structural highlights */

Student — Thu, 01 Mar 2018 17:27:02 GMT

Structural highlights

←Older revision		Revision as of 17:27, 1 March 2018
Line 11:		Line 11:

	== Structural highlights ==		== Structural highlights ==
-	This enzyme contains many different regions that all have different properties. These are the <scene name='77/777711/Hydrophobic_and_polar_regions/1'>hydrophobic and polar regions</scene> of the polymerase. The purple regions are towards the outside because they are polar and therefore hydrophilic. The gray regions are hydrophobic regions ~~ands therefore are mostly packed in~~.	+	This enzyme contains many different regions that all have different properties. These are the <scene name='77/777711/Hydrophobic_and_polar_regions/1'>hydrophobic and polar regions</scene> of the polymerase. The purple regions are towards the outside because they are polar and therefore hydrophilic. The gray regions are hydrophobic regions.
	</StructureSection>		</StructureSection>
		+
	== References ==		== References ==
	<references/>		<references/>

Student at 17:26, 1 March 2018

Student — Thu, 01 Mar 2018 17:26:22 GMT

←Older revision		Revision as of 17:26, 1 March 2018
Line 11:		Line 11:

	== Structural highlights ==		== Structural highlights ==
-		+	This enzyme contains many different regions that all have different properties. These are the <scene name='77/777711/Hydrophobic_and_polar_regions/1'>hydrophobic and polar regions</scene> of the polymerase. The purple regions are towards the outside because they are polar and therefore hydrophilic. The gray regions are hydrophobic regions ands therefore are mostly packed in.
-	This is the	+
	</StructureSection>		</StructureSection>
	== References ==		== References ==
	<references/>		<references/>

Student at 17:21, 1 March 2018

Student — Thu, 01 Mar 2018 17:21:22 GMT

←Older revision		Revision as of 17:21, 1 March 2018
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	This is the		This is the
-
-	This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
-
	</StructureSection>		</StructureSection>
	== References ==		== References ==
	<references/>		<references/>

Student at 17:21, 1 March 2018

Student — Thu, 01 Mar 2018 17:21:02 GMT

←Older revision		Revision as of 17:21, 1 March 2018
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-
	== Overview ==		== Overview ==

	<Structure load='4GX8' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /></StructureSection>{{Sandbox_Reserved_HLSC322}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE -->		<Structure load='4GX8' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /></StructureSection>{{Sandbox_Reserved_HLSC322}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE -->
	DNA polymerase 3 is the primary enzyme responsible for prokaryotic DNA replication. It was first discovered by Thomas Kornberg and Malcolm Gefter in 1970.		DNA polymerase 3 is the primary enzyme responsible for prokaryotic DNA replication. It was first discovered by Thomas Kornberg and Malcolm Gefter in 1970.
-
-

	== Function ==		== Function ==

		+	As mentioned DNA Polymerase 3 is responsible for replicating DNA in prokaryotes.

	== Relevance ==		== Relevance ==

	== Structural highlights ==		== Structural highlights ==
		+
		+	This is the

	This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.		This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

Student at 17:09, 1 March 2018

Student — Thu, 01 Mar 2018 17:09:42 GMT

←Older revision		Revision as of 17:09, 1 March 2018
Line 1:		Line 1:
-	<Structure load='4GX8' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /></StructureSection>{{Sandbox_Reserved_HLSC322}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE -->	+
	== Overview ==		== Overview ==
-	DNA polymerase 3 is the primary enzyme responsible for prokaryotic DNA replication. It was first discovered by Thomas Kornberg and Malcolm Gefter in 1970.	+
		+	<Structure load='4GX8' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /></StructureSection>{{Sandbox_Reserved_HLSC322}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE -->
		+	DNA polymerase 3 is the primary enzyme responsible for prokaryotic DNA replication. It was first discovered by Thomas Kornberg and Malcolm Gefter in 1970.
		+