Sandbox Reserved 1577 - Revision history

Keiri D. Johnson at 06:57, 4 December 2019

Keiri D. Johnson — Wed, 04 Dec 2019 06:57:24 GMT

←Older revision		Revision as of 06:57, 4 December 2019
Line 4:		Line 4:

	== Function ==		== Function ==
-	The human folate receptor(HFR) acts as a binder to folate in the body to reduce folic acid. HFR's are important for the absorbance of folic acid so that the body does not have an imbalance and can function properly. An improper imbalance in HFR can mainly effect the brain in the motor skills of a person. Human folate receptors also mediate the delivery of 5-methyltetrahydrofolate. As long as the HFR is in a neutral pH then it will have a high affinity for folic acid and folate. Expressed in the epithelial tissue of the brain, this is where the HFR is most effective; along with pregnant women who need HFR for the development of the baby in the uterus. If the mother does not have the proper HFR in the body while pregnant then it will effect the babies ability to function properly.	+	The human folate receptor(HFR) acts as a binder to folate in the body to reduce folic acid. HFR's are important for the absorbance of folic acid so that the body does not have an imbalance and can function properly. An improper imbalance in HFR can mainly effect the brain in the motor skills of a person. Human folate receptors also mediate the delivery of 5-methyltetrahydrofolate. As long as the HFR is in a neutral pH then it will have a high affinity for folic acid and folate. Expressed in the epithelial tissue of the brain, this is where the HFR is most effective; along with pregnant women who need HFR for the development of the baby in the uterus. If the mother does not have the proper HFR in the body while pregnant then it will effect the babies ability to function properly.<1>
	== Disease ==		== Disease ==
	Many of the diseases that carry out with an imbalance of HFR involve the brain. Not having the proper amount of HFR can cause a folate deficiency and cause brain damage, or known as neurodegeneration. The motor skills of the person will be effected and may cause movement disturbances such as epilepsy. The effects of low HFR can begin as soon as being in the uterus. If the carrier has an imbalance it can be passed down to the fetus while still in the uterus. Once born this imbalance and have developmental regression and the baby can have a reverse in the development. These changes can occur as loosing the ability to walk or talk at a young age. The folate deficiency can also cause leukodystrophy. This is a disruption of the white matter of the brain and the peripheral nerves.		Many of the diseases that carry out with an imbalance of HFR involve the brain. Not having the proper amount of HFR can cause a folate deficiency and cause brain damage, or known as neurodegeneration. The motor skills of the person will be effected and may cause movement disturbances such as epilepsy. The effects of low HFR can begin as soon as being in the uterus. If the carrier has an imbalance it can be passed down to the fetus while still in the uterus. Once born this imbalance and have developmental regression and the baby can have a reverse in the development. These changes can occur as loosing the ability to walk or talk at a young age. The folate deficiency can also cause leukodystrophy. This is a disruption of the white matter of the brain and the peripheral nerves.
	== Relevance ==		== Relevance ==
-	There are many studies done about HFR in the prevention of cancer and brain development. The cancer studies have been done mainly in women of child bearing age in the breast tissue, cervical tissue and gastrointestinal tissue; all that come in connection with the baby. The HFR that are transferred from the mother to the baby can effect the balance of HFR that is in the mother and increase the change of cancer in these organs now due to a deficiency from passing the HFR onto the baby. This can then lead to the research of the brain development of children that may have problems growing to the full potential. The research in brain development can then be linked to the folate transfer to research in the blood-brain and blood-cerebrospinal fluid. This is the largest cause of the leukodystrophy in the brain and not being fully developed. Human folate receptors are relevant to the development of the body as a whole due to the impact that they can positively or negatively have on the brain and the neurological system of humans.	+	There are many studies done about HFR in the prevention of cancer and brain development.<2> The cancer studies have been done mainly in women of child bearing age in the breast tissue, cervical tissue and gastrointestinal tissue; all that come in connection with the baby. The HFR that are transferred from the mother to the baby can effect the balance of HFR that is in the mother and increase the change of cancer in these organs now due to a deficiency from passing the HFR onto the baby. This can then lead to the research of the brain development of children that may have problems growing to the full potential. The research in brain development can then be linked to the folate transfer to research in the blood-brain and blood-cerebrospinal fluid. This is the largest cause of the leukodystrophy in the brain and not being fully developed. Human folate receptors are relevant to the development of the body as a whole due to the impact that they can positively or negatively have on the brain and the neurological system of humans.
	== Structural highlights ==		== Structural highlights ==
-	In the folate receptors that are forms of alpha, beta, delta and gamma. The main difference between them all is on what binding properties that they possess between folic acid, 5-methyltetrahydrofolate and anti-folates. They are all expressed as a single chain or a single unit. Human folate receptors are classified as folate binging proteins because they only carry folate like structures through the blood. Folates have three major structural features; a bicyclic pterin head group, aminobenzoate, and glutamate. Most of the bindings are bound to the glutamate part of the receptors because of the charges between the receptor and the cargo. The folate receptor has a binding pocket that is negative and surrounding it is a positively charges entrance. This allows the cargo to be more easily bonded due to the difference in charges. These can be shown by the smaller bonds located on the outside of the molecule.	+	In the folate receptors that are forms of alpha, beta, delta and gamma. The main difference between them all is on what binding properties that they possess between folic acid, 5-methyltetrahydrofolate and anti-folates. They are all expressed as a single chain or a single unit. Human folate receptors are classified as folate binging proteins because they only carry folate like structures through the blood. Folates have three major structural features; a bicyclic pterin head group, aminobenzoate, and glutamate. Most of the bindings are bound to the glutamate part of the receptors because of the charges between the receptor and the cargo. The folate receptor has a binding pocket that is negative and surrounding it is a positively charges entrance. This allows the cargo to be more easily bonded due to the difference in charges. These can be shown by the smaller bonds located on the outside of the molecule.<3>


	</StructureSection>		</StructureSection>
	== References ==		== References ==
-	<https://www.sciencedirect.com/topics/neuroscience/folate-receptor>	+	<<1><https://www.sciencedirect.com/topics/neuroscience/folate-receptor>>
-	<https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239573/>	+	<<2><https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239573/>>
-	<https://www.rcsb.org/structure/4LRH>	+	<<3><https://www.rcsb.org/structure/4LRH>>
	<references/>		<references/>

Keiri D. Johnson at 06:54, 4 December 2019

Keiri D. Johnson — Wed, 04 Dec 2019 06:54:54 GMT

←Older revision		Revision as of 06:54, 4 December 2019
Line 15:		Line 15:
	</StructureSection>		</StructureSection>
	== References ==		== References ==
-	<>	+	<https://www.sciencedirect.com/topics/neuroscience/folate-receptor>
		+	<https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239573/>
		+	<https://www.rcsb.org/structure/4LRH>
	<references/>		<references/>

Keiri D. Johnson at 06:47, 4 December 2019

Keiri D. Johnson — Wed, 04 Dec 2019 06:47:45 GMT

←Older revision		Revision as of 06:47, 4 December 2019
Line 10:		Line 10:
	There are many studies done about HFR in the prevention of cancer and brain development. The cancer studies have been done mainly in women of child bearing age in the breast tissue, cervical tissue and gastrointestinal tissue; all that come in connection with the baby. The HFR that are transferred from the mother to the baby can effect the balance of HFR that is in the mother and increase the change of cancer in these organs now due to a deficiency from passing the HFR onto the baby. This can then lead to the research of the brain development of children that may have problems growing to the full potential. The research in brain development can then be linked to the folate transfer to research in the blood-brain and blood-cerebrospinal fluid. This is the largest cause of the leukodystrophy in the brain and not being fully developed. Human folate receptors are relevant to the development of the body as a whole due to the impact that they can positively or negatively have on the brain and the neurological system of humans.		There are many studies done about HFR in the prevention of cancer and brain development. The cancer studies have been done mainly in women of child bearing age in the breast tissue, cervical tissue and gastrointestinal tissue; all that come in connection with the baby. The HFR that are transferred from the mother to the baby can effect the balance of HFR that is in the mother and increase the change of cancer in these organs now due to a deficiency from passing the HFR onto the baby. This can then lead to the research of the brain development of children that may have problems growing to the full potential. The research in brain development can then be linked to the folate transfer to research in the blood-brain and blood-cerebrospinal fluid. This is the largest cause of the leukodystrophy in the brain and not being fully developed. Human folate receptors are relevant to the development of the body as a whole due to the impact that they can positively or negatively have on the brain and the neurological system of humans.
	== Structural highlights ==		== Structural highlights ==
-	In the folate receptors that are forms of alpha, beta, delta and gamma. The main difference between them all is on what binding properties that they possess between folic acid, 5-methyltetrahydrofolate and anti-folates. They are all expressed as a single chain or a single unit. Human folate receptors are classified as folate binging proteins because they only carry folate like structures through the blood. Folates have three major structural features; a bicyclic pterin head group, aminobenzoate, and glutamate. Most of the bindings are bound to the glutamate part of the receptors because of the charges between the receptor and the cargo. The folate receptor has a binding pocket that is negative and surrounding it is a positively charges entrance. This allows the cargo to be more easily bonded due to the difference in charges.	+	In the folate receptors that are forms of alpha, beta, delta and gamma. The main difference between them all is on what binding properties that they possess between folic acid, 5-methyltetrahydrofolate and anti-folates. They are all expressed as a single chain or a single unit. Human folate receptors are classified as folate binging proteins because they only carry folate like structures through the blood. Folates have three major structural features; a bicyclic pterin head group, aminobenzoate, and glutamate. Most of the bindings are bound to the glutamate part of the receptors because of the charges between the receptor and the cargo. The folate receptor has a binding pocket that is negative and surrounding it is a positively charges entrance. This allows the cargo to be more easily bonded due to the difference in charges. These can be shown by the smaller bonds located on the outside of the molecule.
-	~~This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene>~~ by ~~Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of~~ the ~~protein. You can make your own scenes~~ on ~~SAT starting from scratch or loading and editing one~~ of ~~these sample scenes~~.	+

	</StructureSection>		</StructureSection>

Keiri D. Johnson at 06:45, 4 December 2019

Keiri D. Johnson — Wed, 04 Dec 2019 06:45:38 GMT

←Older revision		Revision as of 06:45, 4 December 2019
Line 15:		Line 15:
	</StructureSection>		</StructureSection>
	== References ==		== References ==
		+	<>
	<references/>		<references/>

Keiri D. Johnson at 06:21, 4 December 2019

Keiri D. Johnson — Wed, 04 Dec 2019 06:21:37 GMT

←Older revision		Revision as of 06:21, 4 December 2019
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	==Human Folate Receptor==		==Human Folate Receptor==
	<StructureSection load='4lrh' size='340' side='right' caption='Human Folate Receptor' scene=''>		<StructureSection load='4lrh' size='340' side='right' caption='Human Folate Receptor' scene=''>
-	This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
-	You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

	== Function ==		== Function ==

Keiri D. Johnson: The folate receptor can have an effect on the body from the time of being a feturs onto the later years in life. Something with such a simple job can take a toll on the development of a person.

Keiri D. Johnson — Wed, 04 Dec 2019 06:17:47 GMT

The folate receptor can have an effect on the body from the time of being a feturs onto the later years in life. Something with such a simple job can take a toll on the development of a person.

←Older revision		Revision as of 06:17, 4 December 2019
Line 1:		Line 1:
	{{Sandbox_Reserved_JMeans}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE -->		{{Sandbox_Reserved_JMeans}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE -->
-	==~~Your Heading Here (maybe something like 'Structure')~~==	+	==Human Folate Receptor==
	<StructureSection load='4lrh' size='340' side='right' caption='Human Folate Receptor' scene=''>		<StructureSection load='4lrh' size='340' side='right' caption='Human Folate Receptor' scene=''>
	This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.		This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.

Keiri D. Johnson at 06:11, 4 December 2019

Keiri D. Johnson — Wed, 04 Dec 2019 06:11:04 GMT

←Older revision		Revision as of 06:11, 4 December 2019
Line 12:		Line 12:
	There are many studies done about HFR in the prevention of cancer and brain development. The cancer studies have been done mainly in women of child bearing age in the breast tissue, cervical tissue and gastrointestinal tissue; all that come in connection with the baby. The HFR that are transferred from the mother to the baby can effect the balance of HFR that is in the mother and increase the change of cancer in these organs now due to a deficiency from passing the HFR onto the baby. This can then lead to the research of the brain development of children that may have problems growing to the full potential. The research in brain development can then be linked to the folate transfer to research in the blood-brain and blood-cerebrospinal fluid. This is the largest cause of the leukodystrophy in the brain and not being fully developed. Human folate receptors are relevant to the development of the body as a whole due to the impact that they can positively or negatively have on the brain and the neurological system of humans.		There are many studies done about HFR in the prevention of cancer and brain development. The cancer studies have been done mainly in women of child bearing age in the breast tissue, cervical tissue and gastrointestinal tissue; all that come in connection with the baby. The HFR that are transferred from the mother to the baby can effect the balance of HFR that is in the mother and increase the change of cancer in these organs now due to a deficiency from passing the HFR onto the baby. This can then lead to the research of the brain development of children that may have problems growing to the full potential. The research in brain development can then be linked to the folate transfer to research in the blood-brain and blood-cerebrospinal fluid. This is the largest cause of the leukodystrophy in the brain and not being fully developed. Human folate receptors are relevant to the development of the body as a whole due to the impact that they can positively or negatively have on the brain and the neurological system of humans.
	== Structural highlights ==		== Structural highlights ==
-		+	In the folate receptors that are forms of alpha, beta, delta and gamma. The main difference between them all is on what binding properties that they possess between folic acid, 5-methyltetrahydrofolate and anti-folates. They are all expressed as a single chain or a single unit. Human folate receptors are classified as folate binging proteins because they only carry folate like structures through the blood. Folates have three major structural features; a bicyclic pterin head group, aminobenzoate, and glutamate. Most of the bindings are bound to the glutamate part of the receptors because of the charges between the receptor and the cargo. The folate receptor has a binding pocket that is negative and surrounding it is a positively charges entrance. This allows the cargo to be more easily bonded due to the difference in charges.
	This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.		This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

Keiri D. Johnson at 05:37, 4 December 2019

Keiri D. Johnson — Wed, 04 Dec 2019 05:37:00 GMT

←Older revision		Revision as of 05:37, 4 December 2019
Line 6:		Line 6:

	== Function ==		== Function ==
-		+	The human folate receptor(HFR) acts as a binder to folate in the body to reduce folic acid. HFR's are important for the absorbance of folic acid so that the body does not have an imbalance and can function properly. An improper imbalance in HFR can mainly effect the brain in the motor skills of a person. Human folate receptors also mediate the delivery of 5-methyltetrahydrofolate. As long as the HFR is in a neutral pH then it will have a high affinity for folic acid and folate. Expressed in the epithelial tissue of the brain, this is where the HFR is most effective; along with pregnant women who need HFR for the development of the baby in the uterus. If the mother does not have the proper HFR in the body while pregnant then it will effect the babies ability to function properly.
	== Disease ==		== Disease ==
-		+	Many of the diseases that carry out with an imbalance of HFR involve the brain. Not having the proper amount of HFR can cause a folate deficiency and cause brain damage, or known as neurodegeneration. The motor skills of the person will be effected and may cause movement disturbances such as epilepsy. The effects of low HFR can begin as soon as being in the uterus. If the carrier has an imbalance it can be passed down to the fetus while still in the uterus. Once born this imbalance and have developmental regression and the baby can have a reverse in the development. These changes can occur as loosing the ability to walk or talk at a young age. The folate deficiency can also cause leukodystrophy. This is a disruption of the white matter of the brain and the peripheral nerves.
	== Relevance ==		== Relevance ==
-		+	There are many studies done about HFR in the prevention of cancer and brain development. The cancer studies have been done mainly in women of child bearing age in the breast tissue, cervical tissue and gastrointestinal tissue; all that come in connection with the baby. The HFR that are transferred from the mother to the baby can effect the balance of HFR that is in the mother and increase the change of cancer in these organs now due to a deficiency from passing the HFR onto the baby. This can then lead to the research of the brain development of children that may have problems growing to the full potential. The research in brain development can then be linked to the folate transfer to research in the blood-brain and blood-cerebrospinal fluid. This is the largest cause of the leukodystrophy in the brain and not being fully developed. Human folate receptors are relevant to the development of the body as a whole due to the impact that they can positively or negatively have on the brain and the neurological system of humans.
	== Structural highlights ==		== Structural highlights ==

Keiri D. Johnson at 15:55, 30 October 2019

Keiri D. Johnson — Wed, 30 Oct 2019 15:55:21 GMT

←Older revision		Revision as of 15:55, 30 October 2019
Line 1:		Line 1:
	{{Sandbox_Reserved_JMeans}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE -->		{{Sandbox_Reserved_JMeans}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE -->
	==Your Heading Here (maybe something like 'Structure')==		==Your Heading Here (maybe something like 'Structure')==
-	<StructureSection load='~~1stp~~' size='340' side='right' caption='~~Caption for this structure~~' scene=''>	+	<StructureSection load='4lrh' size='340' side='right' caption='Human Folate Receptor' scene=''>
	This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.		This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
	You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.		You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

OCA: New page: {{Sandbox_Reserved_JMeans}} ==Your Heading Here (maybe something like 'Structure')==
OCA — Sun, 29 Sep 2019 06:57:18 GMT

New page: {{Sandbox_Reserved_JMeans}} ==Your Heading Here (maybe something like 'Structure')== <StructureSection load='1stp' size='340' side='right' captio...

New page
{{Sandbox_Reserved_JMeans}}
==Your Heading Here (maybe something like 'Structure')==
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>