Sandbox Wabash07 - Revision history

Student at 18:45, 28 February 2016

Student — Sun, 28 Feb 2016 18:45:37 GMT

←Older revision		Revision as of 18:45, 28 February 2016
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	<StructureSection load='1yfe' size='340' side='right' caption='Fumarase' scene=''>		<StructureSection load='1yfe' size='340' side='right' caption='Fumarase' scene=''>

-	~~Trypsin is a Serine protease~~. It catalyzes ~~peptide bond hydrolysis in two sequential steps. In~~ the ~~first (acylation)~~ reaction, the ~~nucleophilic serine attacks the substrate scissile bond, forming first a tetrahedral intermediate~~ and ~~then a covalent acyl-enzyme with release of the C-terminal fragment~~. ~~In the second (deacylation) reaction, a water molecule attacks the acyl-enzyme, leading~~ to a ~~second tetrahedral intermediate followed by release~~ of ~~the N-terminal fragment. '''Sandbox Wabash07'''. Click above on '''edit this page''' to modify. Be careful~~ with ~~the < and > signs~~.	+	Fumarase C from E. coli catalyzes the hydration/dehydration reaction between the L-malate and fumarate. It belongs to a family of enzymes which are tetrameric with each monomer containing about 460 amino acids.
	You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.		You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

-	== ~~Function~~ ==	+	== Debate about Two Possible Active Site ==

-	== ~~Disease~~ ==	+	== Determination of True Active Site ==

-	== ~~Relevance ==~~	+	== Active Site Structure ==
-		+
-	~~== Structural highlights~~ ==	+

	This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.		This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

Student: /* Fumarase Active Site */

Student — Sun, 28 Feb 2016 18:34:28 GMT

Fumarase Active Site

←Older revision		Revision as of 18:34, 28 February 2016
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	==Fumarase Active Site==		==Fumarase Active Site==
-	<StructureSection load='1yfe' size='340' side='right' caption='~~Caption for this structure~~' scene=''>	+	<StructureSection load='1yfe' size='340' side='right' caption='Fumarase' scene=''>

	Trypsin is a Serine protease. It catalyzes peptide bond hydrolysis in two sequential steps. In the first (acylation) reaction, the nucleophilic serine attacks the substrate scissile bond, forming first a tetrahedral intermediate and then a covalent acyl-enzyme with release of the C-terminal fragment. In the second (deacylation) reaction, a water molecule attacks the acyl-enzyme, leading to a second tetrahedral intermediate followed by release of the N-terminal fragment. '''Sandbox Wabash07'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.		Trypsin is a Serine protease. It catalyzes peptide bond hydrolysis in two sequential steps. In the first (acylation) reaction, the nucleophilic serine attacks the substrate scissile bond, forming first a tetrahedral intermediate and then a covalent acyl-enzyme with release of the C-terminal fragment. In the second (deacylation) reaction, a water molecule attacks the acyl-enzyme, leading to a second tetrahedral intermediate followed by release of the N-terminal fragment. '''Sandbox Wabash07'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.

Student at 18:31, 28 February 2016

Student — Sun, 28 Feb 2016 18:31:29 GMT

←Older revision		Revision as of 18:31, 28 February 2016
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-	==~~The Mechanism of Trypsin~~==	+	==Fumarase Active Site==
-	<StructureSection load='~~2agg~~' size='340' side='right' caption='Caption for this structure' scene=''>	+	<StructureSection load='1yfe' size='340' side='right' caption='Caption for this structure' scene=''>

	Trypsin is a Serine protease. It catalyzes peptide bond hydrolysis in two sequential steps. In the first (acylation) reaction, the nucleophilic serine attacks the substrate scissile bond, forming first a tetrahedral intermediate and then a covalent acyl-enzyme with release of the C-terminal fragment. In the second (deacylation) reaction, a water molecule attacks the acyl-enzyme, leading to a second tetrahedral intermediate followed by release of the N-terminal fragment. '''Sandbox Wabash07'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.		Trypsin is a Serine protease. It catalyzes peptide bond hydrolysis in two sequential steps. In the first (acylation) reaction, the nucleophilic serine attacks the substrate scissile bond, forming first a tetrahedral intermediate and then a covalent acyl-enzyme with release of the C-terminal fragment. In the second (deacylation) reaction, a water molecule attacks the acyl-enzyme, leading to a second tetrahedral intermediate followed by release of the N-terminal fragment. '''Sandbox Wabash07'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.

Student: New page: ==The Mechanism of Trypsin== Trypsin is a Serine protease. It catalyzes peptide bond h...

Student — Fri, 12 Feb 2016 16:48:55 GMT

New page: ==The Mechanism of Trypsin== <StructureSection load='2agg' size='340' side='right' caption='Caption for this structure' scene=''> Trypsin is a Serine protease. It catalyzes peptide bond h...

New page

==The Mechanism of Trypsin==
<StructureSection load='2agg' size='340' side='right' caption='Caption for this structure' scene=''>

Trypsin is a Serine protease. It catalyzes peptide bond hydrolysis in two sequential steps. In the first (acylation) reaction, the nucleophilic serine attacks the substrate scissile bond, forming first a tetrahedral intermediate and then a covalent acyl-enzyme with release of the C-terminal fragment. In the second (deacylation) reaction, a water molecule attacks the acyl-enzyme, leading to a second tetrahedral intermediate followed by release of the N-terminal fragment. '''Sandbox Wabash07'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>