Serpin - Revision history

Michal Harel at 11:45, 4 February 2020

Michal Harel — Tue, 04 Feb 2020 11:45:00 GMT

←Older revision		Revision as of 11:45, 4 February 2020
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	</StructureSection>		</StructureSection>

-	==3D structures of serpin==
-
-	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-	{{#tree:id=OrganizedByTopic\|openlevels=0\|
-
-	*Serpin
-
-	**[[5hgc]] – Ser – zebra finch<br />
-	**[[1mtp]], [[1sng]] – Ser – ''Thermobifida fusca''
-
-	*Serpin A1 see [[Alpha-1-antitrypsin]]
-
-	*Serpin A3 (α 1-antichymotrypsin)
-
-	**[[2ach]], [[1as4]], [[3caa]], [[6hgd]], [[6hge]], [[6hgh]], [[6hgm]], [[6hgn]] – hSer-A3<br />
-	**[[4caa]], [[1qmn]], [[3dlw]] – hSer-A3 (mutant)<br />
-	**[[6hgf]], [[6hgg]] – hSer-A3 + cortisol<br />
-	**[[6hgi]], [[6hgj]], [[6hgk]], [[6hgl]] – hSer-A3 + corticoid hormone<br />
-	**[[5om2]], [[5om3]], [[5om5]], [[5om6]], [[5om7]], [[5om8]], [[6ftp]] – hSer-A3 (mutant) + antibiotic<br />
-	**[[1yxa]] – mSer-A3N - mouse<br />
-
-	*Ser A4 (kallistatin)
-
-	**[[6f4u]], [[6f02]] – hSer-A4 <br />
-	**[[6f4v]] – hSer-A4 + heparin<br />
-
-	*Serpin A5
-
-	**[[2ol2]] – hSer-A5<br />
-	**[[3dy0]] – hSer-A5 + heparin
-
-	*Serpin A6 see [[Corticosteroid-binding globulin]]
-
-	*Serpin A7 or thyroxine-binding globulin
-
-	**[[2riv]] – hSer-A7<br />
-	**[[2riw]], [[4x30]] – hSer-A7 + thyroxine<br />
-	**[[2xn3]] – hSer-A7 + mefenamic acid<br />
-	**[[2xn5]] – hSer-A7 + furosemide<br />
-	**[[2xn6]], [[2xn7]] – hSer-A7 + thyroxine-fluoresein<br />
-	**[[4yia]] - hSer-A7 + indomethacin<br />
-
-	*Serpin A8 or angiotensin-II
-
-	**[[2jp8]] – hSer-A8 – NMR<br />
-	**[[2wxw]], [[5m3x]], [[5m3y]] – hSer-A8<br />
-	**[[6i3i]] – hSer-A8 (mutant) <br />
-	**[[2x0b]] – hSer-A8 + renin<br />
-	**[[6i3f]] – hSer-A8 (mutant) + renin<br />
-	**[[5e2q]] – hSer-A8 + DPP<br />
-	**[[4fys]] – hSer-A8 + CD13<br />
-	**[[2wxx]], [[2wxy]], [[2wy0]] – mSer-A8 – mouse<br />
-	**[[2wxz]], [[2wy1]] – rSer-A8
-
-	*Serpin A10 or protein Z-dependent protease inhibitor
-
-	**[[4afx]], [[4aju]] – hSer-A10 (mutant)<br />
-	**[[3h5c]], [[3f1s]] – hSer-A10 + vitamin K-dependent protein Z<br />
-	**[[4ajt]] – mSer-A10 <br />
-
-	*Serpin A12 (Vaspin)
-
-	**[[4if8]] – hSer-A12<br />
-	**[[4y3k]], [[4y40]] – hSer-A12 (mutant) <br />
-	**[[5ei0]] – Ser-A12 – ''Escherichia coli''<br />
-
-	*Serpin A18
-
-	**[[4r9i]] – Ser-A18 – bee<br />
-
-	*Serpin B1 (leukocyte elastase inhibitor)
-
-	**[[1hle]] – Ser-B1 – horse <br />
-	**[[4ga7]] – hSer-B1 (mutant) <br />
-
-	*Serpin B3
-
-	**[[2zv6]], [[4zk3]] – hSer-B3
-
-	*Serpin B4
-
-	**[[4zk0]] – hSer-B4<br />
-
-	*Serpin B5 (Maspin)
-
-	**[[1xqg]], [[1wz9]], [[1xu8]] - hSer-B5<br />
-	**[[1xqj]] – hSer-B5 (mutant) <br />
-
-	*Serpin C1 see [[Antithrombin]]
-
-	*Ser crmA (ice inhibitor)
-
-	**[[1c8o]], [[1f0c]], [[1m93]] – cvSer-crmA (mutant) – cowpox virus<br />
-
-	*Serpin E1 see [[Plasminogen activator inhibitor]]
-
-	*Serpin E2 or Gila-derived nexin
-
-	**[[4dy0]] – hSer-E2 + heparin<br />
-	**[[4dy7]] – hSer-E2 + thrombin<br />
-
-	*Serpin I1 (Neuroserpin)
-
-	**[[3fgq]], [[2f02]], [[3f5n]] – hSer-I1<br />
-	**[[1jjo]] – mSer-I1<br />
-
-	*Serpin K
-
-	**[[1sek]] – ThSer-K – Tobacco hornworm
-
-	*Serpin 1
-
-	**[[1k9o]] – ThSer-1 (mutant) + trypsin II<br />
-	**[[3le2]] – Ser-1 – ''Arabidopsis thaliana''<br />
-	**[[6bj5]] – Ser-1 – Myxoma virus<br />
-
-	*Serpin 2
-
-	**[[1m93]] – cvSer-2 <br />
-	**[[3nda]] – Ser-2 – Sheep tick<br />
-	**[[3pzf]] – mmSer-2 – malaria mosquito<br />
-	**[[4ro9]], [[4roa]], [[4rob]], [[4rsq]] – mmSer-2 (mutant)<br />
-
-	*Serpin 4 (Serine protease inhibitor 4)
-
-	**[[4p0f]], [[4p0o]] – Ser-4 – ''Drosophila melanogaster''<br />
-
-	*Serpin 12
-
-	**[[6cj7]] – Ser-412 – ''Manduca sexta''<br />
-
-	*Serpin 18
-
-	**[[4r9i]] – Ser-18 - silkworm<br />
-
-	}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 11:43, 4 February 2020

Michal Harel — Tue, 04 Feb 2020 11:43:43 GMT

←Older revision		Revision as of 11:43, 4 February 2020
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	==Structural highlights ==		==Structural highlights ==
	Ser A7 - a thyrosine-binding globulin - <scene name='51/517379/Cv/3'>binding site contains thyroxin derivative</scene><ref>PMID:21325280</ref>. Water molecules are shown as red spheres.		Ser A7 - a thyrosine-binding globulin - <scene name='51/517379/Cv/3'>binding site contains thyroxin derivative</scene><ref>PMID:21325280</ref>. Water molecules are shown as red spheres.
		+
		+	==3D structures of serpin==
		+	[[Serpin 3D structures]]
		+
	</StructureSection>		</StructureSection>

Line 38:		Line 42:
	*Serpin A3 (α 1-antichymotrypsin)		*Serpin A3 (α 1-antichymotrypsin)

-	**[[2ach]], [[1as4]], [[3caa]] – hSer-A3<br />	+	**[[2ach]], [[1as4]], [[3caa]], [[6hgd]], [[6hge]], [[6hgh]], [[6hgm]], [[6hgn]] – hSer-A3<br />
	**[[4caa]], [[1qmn]], [[3dlw]] – hSer-A3 (mutant)<br />		**[[4caa]], [[1qmn]], [[3dlw]] – hSer-A3 (mutant)<br />
		+	**[[6hgf]], [[6hgg]] – hSer-A3 + cortisol<br />
		+	**[[6hgi]], [[6hgj]], [[6hgk]], [[6hgl]] – hSer-A3 + corticoid hormone<br />
	**[[5om2]], [[5om3]], [[5om5]], [[5om6]], [[5om7]], [[5om8]], [[6ftp]] – hSer-A3 (mutant) + antibiotic<br />		**[[5om2]], [[5om3]], [[5om5]], [[5om6]], [[5om7]], [[5om8]], [[6ftp]] – hSer-A3 (mutant) + antibiotic<br />
	**[[1yxa]] – mSer-A3N - mouse<br />		**[[1yxa]] – mSer-A3N - mouse<br />
		+
		+	*Ser A4 (kallistatin)
		+
		+	**[[6f4u]], [[6f02]] – hSer-A4 <br />
		+	**[[6f4v]] – hSer-A4 + heparin<br />

	*Serpin A5		*Serpin A5
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	**[[2jp8]] – hSer-A8 – NMR<br />		**[[2jp8]] – hSer-A8 – NMR<br />
	**[[2wxw]], [[5m3x]], [[5m3y]] – hSer-A8<br />		**[[2wxw]], [[5m3x]], [[5m3y]] – hSer-A8<br />
		+	**[[6i3i]] – hSer-A8 (mutant) <br />
	**[[2x0b]] – hSer-A8 + renin<br />		**[[2x0b]] – hSer-A8 + renin<br />
		+	**[[6i3f]] – hSer-A8 (mutant) + renin<br />
	**[[5e2q]] – hSer-A8 + DPP<br />		**[[5e2q]] – hSer-A8 + DPP<br />
	**[[4fys]] – hSer-A8 + CD13<br />		**[[4fys]] – hSer-A8 + CD13<br />
Line 128:		Line 141:

	**[[1k9o]] – ThSer-1 (mutant) + trypsin II<br />		**[[1k9o]] – ThSer-1 (mutant) + trypsin II<br />
-	**[[3le2]] – Ser-1 – ''Arabidopsis thaliana''	+	**[[3le2]] – Ser-1 – ''Arabidopsis thaliana''<br />
		+	**[[6bj5]] – Ser-1 – Myxoma virus<br />

	*Serpin 2		*Serpin 2
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	**[[4p0f]], [[4p0o]] – Ser-4 – ''Drosophila melanogaster''<br />		**[[4p0f]], [[4p0o]] – Ser-4 – ''Drosophila melanogaster''<br />
		+
		+	*Serpin 12
		+
		+	**[[6cj7]] – Ser-412 – ''Manduca sexta''<br />

	*Serpin 18		*Serpin 18

Alexander Berchansky at 12:53, 10 September 2019

Alexander Berchansky — Tue, 10 Sep 2019 12:53:00 GMT

←Older revision		Revision as of 12:53, 10 September 2019
Line 21:		Line 21:

	==Structural highlights ==		==Structural highlights ==
-	Ser A7 - a thyrosine-binding globulin - <scene name='51/517379/Cv/3'>binding site contains thyroxin derivative</scene><ref>PMID:21325280</ref>. Water molecules are shown as red spheres. ~~<scene name='51/517379/Bp/1'>TextToBeDisplayed</scene>~~	+	Ser A7 - a thyrosine-binding globulin - <scene name='51/517379/Cv/3'>binding site contains thyroxin derivative</scene><ref>PMID:21325280</ref>. Water molecules are shown as red spheres.
	</StructureSection>		</StructureSection>

Alexander Berchansky at 12:52, 10 September 2019

Alexander Berchansky — Tue, 10 Sep 2019 12:52:22 GMT

←Older revision		Revision as of 12:52, 10 September 2019
Line 21:		Line 21:

	==Structural highlights ==		==Structural highlights ==
-	Ser A7 - a thyrosine-binding globulin - <scene name='51/517379/Cv/3'>binding site contains thyroxin derivative</scene><ref>PMID:21325280</ref>. Water molecules are shown as red spheres.	+	Ser A7 - a thyrosine-binding globulin - <scene name='51/517379/Cv/3'>binding site contains thyroxin derivative</scene><ref>PMID:21325280</ref>. Water molecules are shown as red spheres. <scene name='51/517379/Bp/1'>TextToBeDisplayed</scene>
	</StructureSection>		</StructureSection>

Alexander Berchansky at 12:24, 5 September 2019

Alexander Berchansky — Thu, 05 Sep 2019 12:24:55 GMT

←Older revision		Revision as of 12:24, 5 September 2019
Line 21:		Line 21:

	==Structural highlights ==		==Structural highlights ==
-	Ser A7 - a thyrosine-binding globulin - <scene name='51/517379/Cv/2'>binding site contains thyroxin derivative</scene><ref>PMID:21325280</ref>. Water molecules shown as red spheres.	+	Ser A7 - a thyrosine-binding globulin - <scene name='51/517379/Cv/3'>binding site contains thyroxin derivative</scene><ref>PMID:21325280</ref>. Water molecules are shown as red spheres.
	</StructureSection>		</StructureSection>

Michal Harel at 22:36, 18 September 2018

Michal Harel — Tue, 18 Sep 2018 22:36:43 GMT

←Older revision		Revision as of 22:36, 18 September 2018
Line 1:		Line 1:
-	<StructureSection load='2xn6' size='~~450~~' side='right' caption='Structure of cleaved human serpin A7. Residues 32-380 (cyan), residues 381-415 (salmon) complex with thyroxine-fluoresein, ethylene glycol and Ca+2 ion (green) (PDB entry [[2xn6]])' scene='51/517379/Cv/1'>	+	<StructureSection load='2xn6' size='350' side='right' caption='Structure of cleaved human serpin A7. Residues 32-380 (cyan), residues 381-415 (salmon) complex with thyroxine-fluoresein, ethylene glycol and Ca+2 ion (green) (PDB entry [[2xn6]])' scene='51/517379/Cv/1'>
	== Function ==		== Function ==
	'''Serpin or serine protease inhibitor''' (Ser) are protease inhibitors.<br />		'''Serpin or serine protease inhibitor''' (Ser) are protease inhibitors.<br />
Line 40:		Line 40:
	**[[2ach]], [[1as4]], [[3caa]] – hSer-A3<br />		**[[2ach]], [[1as4]], [[3caa]] – hSer-A3<br />
	**[[4caa]], [[1qmn]], [[3dlw]] – hSer-A3 (mutant)<br />		**[[4caa]], [[1qmn]], [[3dlw]] – hSer-A3 (mutant)<br />
		+	**[[5om2]], [[5om3]], [[5om5]], [[5om6]], [[5om7]], [[5om8]], [[6ftp]] – hSer-A3 (mutant) + antibiotic<br />
	**[[1yxa]] – mSer-A3N - mouse<br />		**[[1yxa]] – mSer-A3N - mouse<br />

Line 49:		Line 50:
	*Serpin A6 see [[Corticosteroid-binding globulin]]		*Serpin A6 see [[Corticosteroid-binding globulin]]

-	*Serpin A7	+	*Serpin A7 or thyroxine-binding globulin

	**[[2riv]] – hSer-A7<br />		**[[2riv]] – hSer-A7<br />
Line 58:		Line 59:
	**[[4yia]] - hSer-A7 + indomethacin<br />		**[[4yia]] - hSer-A7 + indomethacin<br />

-	*Serpin A8	+	*Serpin A8 or angiotensin-II

	**[[2jp8]] – hSer-A8 – NMR<br />		**[[2jp8]] – hSer-A8 – NMR<br />
-	**[[2wxw]], [[~~m3x~~]], [[5m3y]] – hSer-A8<br />	+	**[[2wxw]], [[5m3x]], [[5m3y]] – hSer-A8<br />
	**[[2x0b]] – hSer-A8 + renin<br />		**[[2x0b]] – hSer-A8 + renin<br />
-	**[[2wxx]], [[2wxy]], [[2wy0]] – ~~Ser~~-A8 – mouse<br />	+	**[[5e2q]] – hSer-A8 + DPP<br />
		+	**[[4fys]] – hSer-A8 + CD13<br />
		+	**[[2wxx]], [[2wxy]], [[2wy0]] – mSer-A8 – mouse<br />
	**[[2wxz]], [[2wy1]] – rSer-A8		**[[2wxz]], [[2wy1]] – rSer-A8

-	*Serpin A10	+	*Serpin A10 or protein Z-dependent protease inhibitor

-	**[[3h5c]], [[3f1s]] – hSer-A10 + vitamin K-dependent protein Z	+	**[[4afx]], [[4aju]] – hSer-A10 (mutant)<br />
		+	**[[3h5c]], [[3f1s]] – hSer-A10 + vitamin K-dependent protein Z<br />
		+	**[[4ajt]] – mSer-A10 <br />

	*Serpin A12 (Vaspin)		*Serpin A12 (Vaspin)
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	**[[4r9i]] – Ser-A18 – bee<br />		**[[4r9i]] – Ser-A18 – bee<br />
-

	*Serpin B1 (leukocyte elastase inhibitor)		*Serpin B1 (leukocyte elastase inhibitor)
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	*Serpin B4		*Serpin B4

-	**[[~~5zk0~~]] – hSer-B4<br />	+	**[[4zk0]] – hSer-B4<br />

	*Serpin B5 (Maspin)		*Serpin B5 (Maspin)
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	*Ser crmA (ice inhibitor)		*Ser crmA (ice inhibitor)

-	**[[1c8o]], [[1f0c]] – cvSer-crmA (mutant) – cowpox virus<br />	+	**[[1c8o]], [[1f0c]], [[1m93]] – cvSer-crmA (mutant) – cowpox virus<br />

	*Serpin E1 see [[Plasminogen activator inhibitor]]		*Serpin E1 see [[Plasminogen activator inhibitor]]

-	*Serpin E2	+	*Serpin E2 or Gila-derived nexin

-	**[[4dy0]] – hSer-E2 + heparin	+	**[[4dy0]] – hSer-E2 + heparin<br />
		+	**[[4dy7]] – hSer-E2 + thrombin<br />

	*Serpin I1 (Neuroserpin)		*Serpin I1 (Neuroserpin)

Michal Harel at 09:49, 15 February 2018

Michal Harel — Thu, 15 Feb 2018 09:49:07 GMT

←Older revision		Revision as of 09:49, 15 February 2018
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	**[[2jp8]] – hSer-A8 – NMR<br />		**[[2jp8]] – hSer-A8 – NMR<br />
-	**[[2wxw]] – hSer-A8<br />	+	**[[2wxw]], [[m3x]], [[5m3y]] – hSer-A8<br />
	**[[2x0b]] – hSer-A8 + renin<br />		**[[2x0b]] – hSer-A8 + renin<br />
	**[[2wxx]], [[2wxy]], [[2wy0]] – Ser-A8 – mouse<br />		**[[2wxx]], [[2wxy]], [[2wy0]] – Ser-A8 – mouse<br />

Michal Harel at 21:40, 3 October 2017

Michal Harel — Tue, 03 Oct 2017 21:40:29 GMT

←Older revision		Revision as of 21:40, 3 October 2017
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	**[[5ei0]] – Ser-A12 – ''Escherichia coli''<br />		**[[5ei0]] – Ser-A12 – ''Escherichia coli''<br />

-	*~~Ser~~ A18	+	*Serpin A18

	**[[4r9i]] – Ser-A18 – bee<br />		**[[4r9i]] – Ser-A18 – bee<br />
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	*Serpin B3		*Serpin B3

-	**[[2zv6]] – hSer-B3	+	**[[2zv6]], [[4zk3]] – hSer-B3
		+
		+	*Serpin B4
		+
		+	**[[5zk0]] – hSer-B4<br />

	*Serpin B5 (Maspin)		*Serpin B5 (Maspin)
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	**[[4ro9]], [[4roa]], [[4rob]], [[4rsq]] – mmSer-2 (mutant)<br />		**[[4ro9]], [[4roa]], [[4rob]], [[4rsq]] – mmSer-2 (mutant)<br />

-	*~~Ser~~ 4 (Serine protease inhibitor 4)	+	*Serpin 4 (Serine protease inhibitor 4)

	**[[4p0f]], [[4p0o]] – Ser-4 – ''Drosophila melanogaster''<br />		**[[4p0f]], [[4p0o]] – Ser-4 – ''Drosophila melanogaster''<br />
		+
		+	*Serpin 18
		+
		+	**[[4r9i]] – Ser-18 - silkworm<br />

	}}		}}

Alexander Berchansky at 09:54, 28 August 2016

Alexander Berchansky — Sun, 28 Aug 2016 09:54:34 GMT

←Older revision		Revision as of 09:54, 28 August 2016
Line 21:		Line 21:

	==Structural highlights ==		==Structural highlights ==
-	Ser A7 - a thyrosine-binding globulin - binding site contains thyroxin derivative<ref>PMID:21325280</ref>.	+	Ser A7 - a thyrosine-binding globulin - <scene name='51/517379/Cv/2'>binding site contains thyroxin derivative</scene><ref>PMID:21325280</ref>. Water molecules shown as red spheres.
	</StructureSection>		</StructureSection>

Alexander Berchansky at 09:35, 28 August 2016

Alexander Berchansky — Sun, 28 Aug 2016 09:35:31 GMT

←Older revision		Revision as of 09:35, 28 August 2016
Line 1:		Line 1:
-	<StructureSection load='2xn6' size='~~350~~' side='right' caption='Structure of cleaved human serpin A7. Residues 32-380 (~~grey~~), residues 381-415 (~~green~~) complex with thyroxine-fluoresein, ethylene glycol and Ca+2 ion (green) (PDB entry [[2xn6]])' scene=''>	+	<StructureSection load='2xn6' size='450' side='right' caption='Structure of cleaved human serpin A7. Residues 32-380 (cyan), residues 381-415 (salmon) complex with thyroxine-fluoresein, ethylene glycol and Ca+2 ion (green) (PDB entry [[2xn6]])' scene='51/517379/Cv/1'>
	== Function ==		== Function ==
	'''Serpin or serine protease inhibitor''' (Ser) are protease inhibitors.<br />		'''Serpin or serine protease inhibitor''' (Ser) are protease inhibitors.<br />