Sialidase - Revision history

Jaime Prilusky: Redirecting to Neuraminidase

Jaime Prilusky — Wed, 05 Feb 2020 09:43:17 GMT

←Older revision		Revision as of 09:43, 5 February 2020
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-	~~<StructureSection load='3h72' size='350' side='right' caption='Sialidase complex with sialic acid (PDB code [[3h72]])' scene='79/794406/Cv/1'>~~	+	#REDIRECT [[Neuraminidase]]
-		+
-	~~== Function ==~~	+
-		+
-	'''Sialidase''' is a neuraminidase which cleaves terminal sialic acid from a variety of natural substances <ref>PMID:12374200</ref>. The sialic acid-binding domain of sialidase is called CBD. For '''Anhydrosialidase''' catalyzes the elimination of sialyl group in N-acetylneuraminic acid glycosides to yield 2,7-anhydro-α-N-acetylneuraminate. For '''Trans-sialidase''' see [[Neuraminidase~~]].~~	+
-		+
-	~~== Structural highlights ==~~	+
-		+
-	~~<scene name='79/794406/Cv/4'>Sialidase active site interactions of sialidase with sialic acid</scene> include salt bridges, hydrogen bonds and polar interactions<ref>PMID:19284989</ref>.~~	+
-	~~</StructureSection>~~	+
-		+
-	~~==3D structures of salidase==~~	+
-		+
-	~~Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}~~	+
-	~~{{#tree:id=OrganizedByTopic\|openlevels=0\|~~	+
-		+
-	*Salidase	+
-		+
-	**[[1eur]] - MvNANA residues 43-407 – ''Micromonospora viridifaciens''<br />	+
-	**[[1euu]] - MvNANA residues 47-647<br />	+
-	**[[1wcq]], [[1w8n]], [[1w8o]], [[2hu0]], [[2hu4]] – MvNANA residues 47-647 (mutant) <br />	+
-	**[[5mqr]], [[5mqs]], [[4bbw]], [[5muk]], [[5mul]] - BtSal - ''Bacterioides thetaiotaomicron'' <br />	+
-	** [[1mz5]], [[1n1s]] - TrSal - ''Trypanosoma rangeli''<br />	+
-	** [[1wcs]] - TrSal (mutant) <br />	+
-	**[[3sil]] – StSal (mutant) – ''Salmonella typhimurium''<br />	+
-	**[[1snt]], [[1so7]] – hSal2 - human<br />	+
-	**[[2f24]], [[2f26]], [[2f28]] – hSal2 (mutant) <br />	+
-	**[[2w20]] – SpSal A catalytic domain - ''Streptococcus pneumoniae''<br />	+
-	**[[4zxk]] – SpSal A CBD <br />	+
-	**[[2vw0]], [[2vw2]], [[4xik]], [[2ya4]], [[2w20]], [[2vvz]], [[3h71]] - SpSal B<br />	+
-	** [[4xmi]], [[4xio]], [[4xj8]], [[4xma]], [[4xjz]], [[4xik]] - SpSal B (mutant) <br />	+
-	**[[4yw4]] – SpSal C <br />	+
-	**[[2xzi]], [[2xzj]], [[2xzk]], [[2xcy]] – AfSal – ''Aspergillus fumigatus''<br />	+
-	** [[4m4n]], [[4m4u]] - AfSal (mutant) <br />	+
-	**[[1sll]] – Sal L - leech<br />	+
-	**[[2vk5]], [[5tsp]] - CpSal I – ''Clostridium perfringens''<br />	+
-		+
-	*Salidase complexes	+
-		+
-	**[[2w68]] – VcSal CBD + sialic acid – ''Vibrio cholerae''<br />	+
-	**[[1kit]]– VcSal + sialic acid <br />	+
-	**[[1w0p]] – VcSal + sialic acid derivative<br />	+
-	**[[6eks]], [[6eku]] – VcSal + drug<br />	+
-	**[[3h72]], [[2ya5]] – SpSal A + sialic acid <br />	+
-	**[[4c1w]], [[4c1x]] – SpSal A CBD + sialic acid derivative<br />	+
-	**[[2ya7]], [[2ya8]], [[5kky]], [[5f9t]], [[2ya6]], [[2jkb]] - SpSal A catalytic domain + drug<br />	+
-	**[[2vvz]], [[3h73]] – SpSal A + neuraminic acid derivative <br />	+
-	**[[2vw1]] – SpSal B + neuraminic acid derivative <br />	+
-	**[[4xyx]] – SpSal B + drug<br />	+
-	**[[4xog]], [[4xjw]], [[4xj9]], [[4xil]], [[4xe9]] – SpSal B (mutant) + drug<br />	+
-	**[[4foq]], [[4fov]], [[4fow]], [[4foy]], [[4fp2]], [[4fp3]], [[4fpc]], [[4fpe]], [[4fpf]], [[4fpg]], [[4fph]], [[4fpj]], [[4fpk]], [[4fpl]], [[4fpo]], [[4fpy]], [[4fq4]] – SpSal B + inhibitor<br />	+
-	**[[4xju]], [[4xja]], [[4xhx]], [[4xhb]] – SpSal B (mutant) + inhibitor<br />	+
-	**[[2jkb]] – SpSal B + sialic acid derivative<br />	+
-	**[[4yz3]], [[4yw5]] – SpSal C + drug<br />	+
-	**[[4yw2]] – SpSal C + sialic acid <br />	+
-	**[[4yz4]], [[4yz2]] – SpSal C + neuraminic acid derivative <br />	+
-	**[[4yw1]], [[4yw3]] – SpSal C + sialic acid + neuraminic acid derivative<br />	+
-	**[[1w0o]] – VcSal + sialic acid + neuraminic acid derivative<br />	+
-	**[[2vk6]], [[2vk7]] – CpSal I + neuraminic acid derivative <br />	+
-	**[[2bf6]] – CpSal I residues 243-691 + sialic acid <br />	+
-	**[[5fra]], [[5fre]] – CpSal I CBD + sialic acid <br />	+
-	**[[2v73]]– CpSal J CBD + sialic acid <br />	+
-	**[[2v72]]– CpSal J CBD + galactose <br />	+
-	**[[1n1v]] – TrSal + neuraminic acid derivative <br />	+
-	**[[1mz6]], [[1n1t]], [[2ags]] – TrSal + inhibitor <br />	+
-	**[[1n1y]] – TrSal + sialic acid <br />	+
-	**[[2a75]], [[2fhr]] – TrSal + sialic acid derivative<br />	+
-	**[[1dim]], [[1dil]], [[2sil]], [[2sim]] – StSal + inhibitor <br />	+
-	**[[1eus]] - MvSal residues 43-407 + neuraminic acid derivative<br />	+
-	**[[1eut]] - MvSal residues 47-647 + galactose<br />	+
-	**[[2bzd]] - MvSal residues 47-647 (mutant) + galactose<br />	+
-	**[[1w80]] - MvSal residues 47-647 (mutant) + lactose<br />	+
-	**[[1wcq]], [[1w8n]] – MvSal (mutant) + neuraminic acid derivative<br />	+
-	**[[2ber]] – MvSal (mutant) + sialic acid derivative<br />	+
-	**[[4m4v]] – AfSal (mutant) + neuraminic acid derivative<br />	+
-	**[[1vcu]], [[2f0z]], [[2f10]], [[2f11]], [[2f12]], [[2f13]] - hSal2 + inhibitor<br />	+
-	**[[2f25]], [[2f27]], [[2f29]], [[4nc5]], [[4ncs]] - hSal2 (mutant) + inhibitor<br />	+
-	**[[5mul]] – BtSal + glucuronic acid<br />	+
-		+
-	*Anhydrosialidase	+
-		+
-	**[[4x47]], [[4x4a]] - RgSal + neuraminic acid derivative - ''Ruminococcus gnavus''<br />	+
-	**[[4x49]] - RgSal + tamiflu<br />	+
-	**[[4x6k]] - RgSal + siastatin<br />	+
-	}}	+
-		+
-	~~== References ==~~	+
-	~~<references/>~~	+
-		+
-	~~[[Category:Topic Page~~]]	+

Alexander Berchansky at 11:41, 15 November 2018

Alexander Berchansky — Thu, 15 Nov 2018 11:41:05 GMT

←Older revision		Revision as of 11:41, 15 November 2018
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	== Structural highlights ==		== Structural highlights ==

-	~~Sialidase active site interactions of sialidase with sialic acid include salt bridges,~~ <scene name='79/794406/Cv/4'>~~hydrogen bonds~~</scene> and polar interactions<ref>PMID:19284989</ref>.	+	<scene name='79/794406/Cv/4'>Sialidase active site interactions of sialidase with sialic acid</scene> include salt bridges, hydrogen bonds and polar interactions<ref>PMID:19284989</ref>.
	</StructureSection>		</StructureSection>

Alexander Berchansky at 11:40, 15 November 2018

Alexander Berchansky — Thu, 15 Nov 2018 11:40:07 GMT

←Older revision		Revision as of 11:40, 15 November 2018
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	== Structural highlights ==		== Structural highlights ==

-	Sialidase active site interactions of sialidase with sialic acid include salt bridges, hydrogen bonds and polar interactions<ref>PMID:19284989</ref>.	+	Sialidase active site interactions of sialidase with sialic acid include salt bridges, <scene name='79/794406/Cv/4'>hydrogen bonds</scene> and polar interactions<ref>PMID:19284989</ref>.
	</StructureSection>		</StructureSection>

Alexander Berchansky at 10:51, 15 November 2018

Alexander Berchansky — Thu, 15 Nov 2018 10:51:53 GMT

←Older revision		Revision as of 10:51, 15 November 2018
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-	<StructureSection load='3h72' size='~~340~~' side='right' caption='Sialidase complex with sialic acid (PDB code [[3h72]])' scene=''>	+	<StructureSection load='3h72' size='350' side='right' caption='Sialidase complex with sialic acid (PDB code [[3h72]])' scene='79/794406/Cv/1'>

	== Function ==		== Function ==

Michal Harel at 09:29, 11 November 2018

Michal Harel — Sun, 11 Nov 2018 09:29:52 GMT

←Older revision		Revision as of 09:29, 11 November 2018
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	'''Sialidase''' is a neuraminidase which cleaves terminal sialic acid from a variety of natural substances <ref>PMID:12374200</ref>. The sialic acid-binding domain of sialidase is called CBD. For '''Anhydrosialidase''' catalyzes the elimination of sialyl group in N-acetylneuraminic acid glycosides to yield 2,7-anhydro-α-N-acetylneuraminate. For '''Trans-sialidase''' see [[Neuraminidase]].		'''Sialidase''' is a neuraminidase which cleaves terminal sialic acid from a variety of natural substances <ref>PMID:12374200</ref>. The sialic acid-binding domain of sialidase is called CBD. For '''Anhydrosialidase''' catalyzes the elimination of sialyl group in N-acetylneuraminic acid glycosides to yield 2,7-anhydro-α-N-acetylneuraminate. For '''Trans-sialidase''' see [[Neuraminidase]].
-
-	== Disease ==
-
-	== Relevance ==

	== Structural highlights ==		== Structural highlights ==

Michal Harel at 08:58, 7 November 2018

Michal Harel — Wed, 07 Nov 2018 08:58:27 GMT

←Older revision		Revision as of 08:58, 7 November 2018
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-	<StructureSection load='3h72' size='340' side='right' caption='~~Caption for this structure~~' scene=''>	+	<StructureSection load='3h72' size='340' side='right' caption='Sialidase complex with sialic acid (PDB code [[3h72]])' scene=''>

	== Function ==		== Function ==
Line 11:		Line 11:
	== Structural highlights ==		== Structural highlights ==

-		+	Sialidase active site interactions of sialidase with sialic acid include salt bridges, hydrogen bonds and polar interactions<ref>PMID:19284989</ref>.
	</StructureSection>		</StructureSection>

Michal Harel at 08:49, 7 November 2018

Michal Harel — Wed, 07 Nov 2018 08:49:37 GMT

←Older revision		Revision as of 08:49, 7 November 2018
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-	<StructureSection load='~~2w68~~' size='340' side='right' caption='Caption for this structure' scene=''>	+	<StructureSection load='3h72' size='340' side='right' caption='Caption for this structure' scene=''>

	== Function ==		== Function ==

Michal Harel at 08:41, 7 November 2018

Michal Harel — Wed, 07 Nov 2018 08:41:46 GMT

←Older revision		Revision as of 08:41, 7 November 2018
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-	<StructureSection load='~~1stp~~' size='340' side='right' caption='Caption for this structure' scene=''>	+	<StructureSection load='2w68' size='340' side='right' caption='Caption for this structure' scene=''>

	== Function ==		== Function ==

-	'''Sialidase''' is a neuraminidase which cleaves terminal sialic acid from a variety of natural substances <ref>PMID:12374200</ref>. ~~For '''Trans~~-sialidase~~''' see [[Neuraminidase]]~~. '''Anhydrosialidase''' catalyzes the elimination of sialyl group in N-acetylneuraminic acid glycosides to yield 2,7-anhydro-α-N-acetylneuraminate.	+	'''Sialidase''' is a neuraminidase which cleaves terminal sialic acid from a variety of natural substances <ref>PMID:12374200</ref>. The sialic acid-binding domain of sialidase is called CBD. For '''Anhydrosialidase''' catalyzes the elimination of sialyl group in N-acetylneuraminic acid glycosides to yield 2,7-anhydro-α-N-acetylneuraminate. For '''Trans-sialidase''' see [[Neuraminidase]].

	== Disease ==		== Disease ==

	== Relevance ==		== Relevance ==
-
-	''Trypanosoma cruzi'' trans-sialidase is a drug target agains Chagas Disease<ref>PMID:24144418</ref>.

	== Structural highlights ==		== Structural highlights ==
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	**[[1n1v]] – TrSal + neuraminic acid derivative <br />		**[[1n1v]] – TrSal + neuraminic acid derivative <br />
	**[[1mz6]], [[1n1t]], [[2ags]] – TrSal + inhibitor <br />		**[[1mz6]], [[1n1t]], [[2ags]] – TrSal + inhibitor <br />
-	**[[1n1y]]– TrSal + sialic acid <br />	+	**[[1n1y]] – TrSal + sialic acid <br />
	**[[2a75]], [[2fhr]] – TrSal + sialic acid derivative<br />		**[[2a75]], [[2fhr]] – TrSal + sialic acid derivative<br />
	**[[1dim]], [[1dil]], [[2sil]], [[2sim]] – StSal + inhibitor <br />		**[[1dim]], [[1dil]], [[2sil]], [[2sim]] – StSal + inhibitor <br />

Michal Harel at 08:29, 7 November 2018

Michal Harel — Wed, 07 Nov 2018 08:29:14 GMT

←Older revision		Revision as of 08:29, 7 November 2018
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	**[[5mul]] – BtSal + glucuronic acid<br />		**[[5mul]] – BtSal + glucuronic acid<br />

-	*~~Trans-sialidase~~	+	*Anhydrosialidase

-	**[[1mr5]], [[1ms3]], [[1ms4]] - TcSal (mutant) - ''Trypanosoma cruzi''<br />
-	**[[1ms9]], [[1s0i]], [[3pjq]] - TcSal (mutant) + lactose derivative<br />
-	**[[1s0j]], [[2ah2]] - TcSal (mutant) + sialic acid derivative<br />
-	**[[3b69]], [[1ms0]], [[1ms1]], [[1ms5]], [[1ms8]] - TcSal (mutant) + neuraminic acid derivative<br />
-	**[[3opz]] - TcSal (mutant) + antibody<br />
-	**[[1sll]] – lSal L - leech<br />
-	**[[1sli]], [[2sli]], [[3sli]], [[4sli]] - lSal + neuraminic acid derivative <br />
	**[[4x47]], [[4x4a]] - RgSal + neuraminic acid derivative - ''Ruminococcus gnavus''<br />		**[[4x47]], [[4x4a]] - RgSal + neuraminic acid derivative - ''Ruminococcus gnavus''<br />
	**[[4x49]] - RgSal + tamiflu<br />		**[[4x49]] - RgSal + tamiflu<br />

Michal Harel at 08:27, 7 November 2018

Michal Harel — Wed, 07 Nov 2018 08:27:47 GMT

←Older revision		Revision as of 08:27, 7 November 2018
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	== Function ==		== Function ==

-	'''Sialidase''' is a neuraminidase which cleaves terminal sialic acid from a variety of natural substances <ref>PMID:12374200</ref>. For '''Trans-sialidase''' see [[Neuraminidase]].	+	'''Sialidase''' is a neuraminidase which cleaves terminal sialic acid from a variety of natural substances <ref>PMID:12374200</ref>. For '''Trans-sialidase''' see [[Neuraminidase]]. '''Anhydrosialidase''' catalyzes the elimination of sialyl group in N-acetylneuraminic acid glycosides to yield 2,7-anhydro-α-N-acetylneuraminate.

	== Disease ==		== Disease ==