Signalosome - Revision history

Michal Harel at 11:05, 20 November 2023

Michal Harel — Mon, 20 Nov 2023 11:05:55 GMT

←Older revision		Revision as of 11:05, 20 November 2023
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	[[6r7n]], [[6r7i]], [[6r7h]] – hCOP9 subunits 1,2,3,4,8 + elongin + RBX1 + CSN7B + cullin-2 – Cryo EM <br />		[[6r7n]], [[6r7i]], [[6r7h]] – hCOP9 subunits 1,2,3,4,8 + elongin + RBX1 + CSN7B + cullin-2 – Cryo EM <br />
	[[6r7f]] – hCOP9 subunits 1,2,3,4,5,6,7B,8 + elongin + RBX1 + PVHL + cullin-2 + Nedd8 – Cryo EM <br />		[[6r7f]] – hCOP9 subunits 1,2,3,4,5,6,7B,8 + elongin + RBX1 + PVHL + cullin-2 + Nedd8 – Cryo EM <br />
		+	[[8h3f]] – hCOP9 subunits 1,2,3,4,5,6,7B,8 + RBX1 + Kbtbd2 + cullin-3 – Cryo EM <br />
		+	[[8h38]], [[8h3a]] – hCOP9 subunits 1,2,3,4,5,6,7B,8 + RBX1 + Kbtbd2 + cullin-3 + Nedd8 – Cryo EM <br />
	[[6r6h]] – hCOP9 subunits 1,2,3,4,5,6,7B,8 + elongin + RBX1 + PVHL + cullin-2 – Cryo EM <br />		[[6r6h]] – hCOP9 subunits 1,2,3,4,5,6,7B,8 + elongin + RBX1 + PVHL + cullin-2 – Cryo EM <br />
	[[3chm]] – hCOP9 subunit 7 – ''Arabidopsis thaliana'' <br />		[[3chm]] – hCOP9 subunit 7 – ''Arabidopsis thaliana'' <br />
		+	[[7enf]], [[7ewm]] – COP9 subunit 12 + Thp3 + 26S proteasome subunit Sem1 – yeast <br />

	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 11:22, 9 November 2020

Michal Harel — Mon, 09 Nov 2020 11:22:56 GMT

←Older revision		Revision as of 11:22, 9 November 2020
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	[[4d10]], [[4d18]], [[4wsn]] – hCOP9 subunits 1,2,3,4,5,6,7A,8 <br />		[[4d10]], [[4d18]], [[4wsn]] – hCOP9 subunits 1,2,3,4,5,6,7A,8 <br />
	[[6r7n]], [[6r7i]], [[6r7h]] – hCOP9 subunits 1,2,3,4,8 + elongin + RBX1 + CSN7B + cullin-2 – Cryo EM <br />		[[6r7n]], [[6r7i]], [[6r7h]] – hCOP9 subunits 1,2,3,4,8 + elongin + RBX1 + CSN7B + cullin-2 – Cryo EM <br />
-	[[~~6r7h~~]] – hCOP9 subunits 1,2,3,4,5,6,7B,8 + elongin + RBX1 + PVHL + cullin-2 + Nedd8 – Cryo EM <br />	+	[[6r7f]] – hCOP9 subunits 1,2,3,4,5,6,7B,8 + elongin + RBX1 + PVHL + cullin-2 + Nedd8 – Cryo EM <br />
	[[6r6h]] – hCOP9 subunits 1,2,3,4,5,6,7B,8 + elongin + RBX1 + PVHL + cullin-2 – Cryo EM <br />		[[6r6h]] – hCOP9 subunits 1,2,3,4,5,6,7B,8 + elongin + RBX1 + PVHL + cullin-2 – Cryo EM <br />
	[[3chm]] – hCOP9 subunit 7 – ''Arabidopsis thaliana'' <br />		[[3chm]] – hCOP9 subunit 7 – ''Arabidopsis thaliana'' <br />

Michal Harel at 10:44, 5 November 2020

Michal Harel — Thu, 05 Nov 2020 10:44:36 GMT

←Older revision		Revision as of 10:44, 5 November 2020
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	[[4lct]] – hCOP9 subunit 1 – human <br />		[[4lct]] – hCOP9 subunit 1 – human <br />
		+	[[6a73]] – hCOP9 subunit 2 + IP6<br />
	[[4d0p]] – hCOP9 subunit 4 <br />		[[4d0p]] – hCOP9 subunit 4 <br />
	[[1ufm]] – hCOP9 subunit 4 PCI domain - NMR<br />		[[1ufm]] – hCOP9 subunit 4 PCI domain - NMR<br />

Michal Harel at 08:53, 6 February 2020

Michal Harel — Thu, 06 Feb 2020 08:53:00 GMT

←Older revision		Revision as of 08:53, 6 February 2020
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	[[4e0q]], [[4r14]] – hCOP9 subunit 6 MPN domain <br />		[[4e0q]], [[4r14]] – hCOP9 subunit 6 MPN domain <br />
	[[4d10]], [[4d18]], [[4wsn]] – hCOP9 subunits 1,2,3,4,5,6,7A,8 <br />		[[4d10]], [[4d18]], [[4wsn]] – hCOP9 subunits 1,2,3,4,5,6,7A,8 <br />
		+	[[6r7n]], [[6r7i]], [[6r7h]] – hCOP9 subunits 1,2,3,4,8 + elongin + RBX1 + CSN7B + cullin-2 – Cryo EM <br />
		+	[[6r7h]] – hCOP9 subunits 1,2,3,4,5,6,7B,8 + elongin + RBX1 + PVHL + cullin-2 + Nedd8 – Cryo EM <br />
		+	[[6r6h]] – hCOP9 subunits 1,2,3,4,5,6,7B,8 + elongin + RBX1 + PVHL + cullin-2 – Cryo EM <br />
		+	[[3chm]] – hCOP9 subunit 7 – ''Arabidopsis thaliana'' <br />

	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 21:05, 4 October 2017

Michal Harel — Wed, 04 Oct 2017 21:05:07 GMT

←Older revision		Revision as of 21:05, 4 October 2017
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	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}		Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

-	[[~~4d0p~~]] – hCOP9 subunit 4 – human <br />	+	[[4lct]] – hCOP9 subunit 1 – human <br />
		+	[[4d0p]] – hCOP9 subunit 4 <br />
	[[1ufm]] – hCOP9 subunit 4 PCI domain - NMR<br />		[[1ufm]] – hCOP9 subunit 4 PCI domain - NMR<br />
	[[4f7o]] – hCOP9 subunit 5 <br />		[[4f7o]] – hCOP9 subunit 5 <br />
		+	[[5jog]], [[5joh]], [[5m5q]] – hCOP9 subunit 5 + inhibitor <br />
	[[4qft]] – hCOP9 subunit 6 <br />		[[4qft]] – hCOP9 subunit 6 <br />
	[[4e0q]], [[4r14]] – hCOP9 subunit 6 MPN domain <br />		[[4e0q]], [[4r14]] – hCOP9 subunit 6 MPN domain <br />
-	[[4d10]], [[4d18]] – hCOP9 subunits 1,2,3,4,5,6,7A,8 <br />	+	[[4d10]], [[4d18]], [[4wsn]] – hCOP9 subunits 1,2,3,4,5,6,7A,8 <br />

	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 20:57, 4 October 2017

Michal Harel — Wed, 04 Oct 2017 20:57:08 GMT

←Older revision		Revision as of 20:57, 4 October 2017
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	== References ==		== References ==
	<references/>		<references/>
		+	[[Category:Topic Page]]

Michal Harel at 09:38, 30 August 2016

Michal Harel — Tue, 30 Aug 2016 09:38:48 GMT

←Older revision		Revision as of 09:38, 30 August 2016
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	<StructureSection load='4d10' size='340' side='right' caption='Human COP9 signalosome subunits 1 (grey and wheat), 2 (green and blue), 3 (pink and rust), 4 (yellow and aqua), 5 (magenta and olive), 6 (cyan and orchid), 7A (gold and turquoise), 8 (red and neon green) (PDB code [[4d10]])' scene=''>		<StructureSection load='4d10' size='340' side='right' caption='Human COP9 signalosome subunits 1 (grey and wheat), 2 (green and blue), 3 (pink and rust), 4 (yellow and aqua), 5 (magenta and olive), 6 (cyan and orchid), 7A (gold and turquoise), 8 (red and neon green) (PDB code [[4d10]])' scene=''>
-	'''COP9 (COnstitutive Photomorphogenesis 9) signalosome''' catalyzes the hydrolysis of NEDD8 protein from the cullin subunit of cullin-ring ubiquitin ligase. COP9 functions in the ubiquitin-proteasome pathway. COP9 contains 8 subunits and is homologous to the lid of the 26S proteasome.	+	'''COP9 (COnstitutive Photomorphogenesis 9) signalosome''' catalyzes the hydrolysis of NEDD8 protein from the cullin subunit of cullin-ring ubiquitin ligase. COP9 functions in the ubiquitin-proteasome pathway. COP9 contains 8 subunits and is homologous to the lid of the 26S proteasome<ref>PMID:16045761</ref>.
-		+
-	~~== Function ==~~	+
-		+
-	~~== Disease ==~~	+
-		+
-	~~== Relevance ==~~	+
-		+
-	~~== Structural highlights ==~~	+
-		+

	</StructureSection>		</StructureSection>

Michal Harel at 09:19, 13 July 2015

Michal Harel — Mon, 13 Jul 2015 09:19:02 GMT

←Older revision		Revision as of 09:19, 13 July 2015
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-	<StructureSection load='4d10' size='340' side='right' caption='Human COP9 signalosome subunits 1 (grey and wheat), 2 (green and blue), 3 (pink and rust), 4 (yellow and aqua), 5 (magenta and olive), 6 (cyan and ), 7A (gold and ), 8 (red and neon green) (PDB code [[4d10]])' scene=''>	+	<StructureSection load='4d10' size='340' side='right' caption='Human COP9 signalosome subunits 1 (grey and wheat), 2 (green and blue), 3 (pink and rust), 4 (yellow and aqua), 5 (magenta and olive), 6 (cyan and orchid), 7A (gold and turquoise), 8 (red and neon green) (PDB code [[4d10]])' scene=''>
	'''COP9 (COnstitutive Photomorphogenesis 9) signalosome''' catalyzes the hydrolysis of NEDD8 protein from the cullin subunit of cullin-ring ubiquitin ligase. COP9 functions in the ubiquitin-proteasome pathway. COP9 contains 8 subunits and is homologous to the lid of the 26S proteasome.		'''COP9 (COnstitutive Photomorphogenesis 9) signalosome''' catalyzes the hydrolysis of NEDD8 protein from the cullin subunit of cullin-ring ubiquitin ligase. COP9 functions in the ubiquitin-proteasome pathway. COP9 contains 8 subunits and is homologous to the lid of the 26S proteasome.

Michal Harel at 10:42, 8 July 2015

Michal Harel — Wed, 08 Jul 2015 10:42:21 GMT

←Older revision		Revision as of 10:42, 8 July 2015
Line 1:		Line 1:
-		+	<StructureSection load='4d10' size='340' side='right' caption='Human COP9 signalosome subunits 1 (grey and wheat), 2 (green and blue), 3 (pink and rust), 4 (yellow and aqua), 5 (magenta and olive), 6 (cyan and ), 7A (gold and ), 8 (red and neon green) (PDB code [[4d10]])' scene=''>
-	<StructureSection load='4d10' size='340' side='right' caption='~~Caption for this structure~~' scene=''>	+
	'''COP9 (COnstitutive Photomorphogenesis 9) signalosome''' catalyzes the hydrolysis of NEDD8 protein from the cullin subunit of cullin-ring ubiquitin ligase. COP9 functions in the ubiquitin-proteasome pathway. COP9 contains 8 subunits and is homologous to the lid of the 26S proteasome.		'''COP9 (COnstitutive Photomorphogenesis 9) signalosome''' catalyzes the hydrolysis of NEDD8 protein from the cullin subunit of cullin-ring ubiquitin ligase. COP9 functions in the ubiquitin-proteasome pathway. COP9 contains 8 subunits and is homologous to the lid of the 26S proteasome.

Michal Harel: New page: '''COP9 (COnstitutive Photomorphogenesis 9) signalosome''' catalyzes the hydrolysis of...

Michal Harel — Wed, 08 Jul 2015 10:32:41 GMT

New page: <StructureSection load='4d10' size='340' side='right' caption='Caption for this structure' scene=''> '''COP9 (COnstitutive Photomorphogenesis 9) signalosome''' catalyzes the hydrolysis of...

New page

<StructureSection load='4d10' size='340' side='right' caption='Caption for this structure' scene=''>
'''COP9 (COnstitutive Photomorphogenesis 9) signalosome''' catalyzes the hydrolysis of NEDD8 protein from the cullin subunit of cullin-ring ubiquitin ligase. COP9 functions in the ubiquitin-proteasome pathway. COP9 contains 8 subunits and is homologous to the lid of the 26S proteasome.

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

</StructureSection>

== 3D Structures of COP9 signalosome ==

Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

[[4d0p]] – hCOP9 subunit 4 – human 
[[1ufm]] – hCOP9 subunit 4 PCI domain - NMR 
[[4f7o]] – hCOP9 subunit 5 
[[4qft]] – hCOP9 subunit 6 
[[4e0q]], [[4r14]] – hCOP9 subunit 6 MPN domain 
[[4d10]], [[4d18]] – hCOP9 subunits 1,2,3,4,5,6,7A,8 

== References ==
<references/>