Squalene synthase - Revision history

Michal Harel at 10:36, 4 December 2023

Michal Harel — Mon, 04 Dec 2023 10:36:17 GMT

←Older revision		Revision as of 10:36, 4 December 2023
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	**[[3wei]], [[3wej]], [[3wek]] – hSQS (mutant) + presqualene pyrophosphate <br />		**[[3wei]], [[3wej]], [[3wek]] – hSQS (mutant) + presqualene pyrophosphate <br />
	**[[3wca]], [[3wcb]], [[3wcc]], [[3wce]], [[3wcg]] – SQS (mutant) + FPP analog – ''Trypanosoma cruzi''<br />		**[[3wca]], [[3wcb]], [[3wcc]], [[3wce]], [[3wcg]] – SQS (mutant) + FPP analog – ''Trypanosoma cruzi''<br />
		+	**[[7wgi]] – AfSQS + PO4 + indole – ''Aspergillus flavus''<br />
		+	**[[7wgh]] – AfSQS (mutant) + POP + PO4 +farnesyl thiopyrophosphate<br />

	*Dehydrosqualene synthase (DSQS)		*Dehydrosqualene synthase (DSQS)

Alexander Berchansky — Mon, 23 Nov 2020 13:57:32 GMT

←Older revision		Revision as of 13:57, 23 November 2020
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	== Structural highlights ==		== Structural highlights ==
-	The <scene name='59/591996/Cv/6'>active site of SQS contains a substrate analog</scene><ref>PMID:24789335</ref>. Water molecules are shown as red spheres.	+	The <scene name='59/591996/Cv/6'>active site of SQS contains a substrate analog</scene><ref>PMID:24789335</ref>. Water molecules are shown as red spheres. <scene name='59/591996/Cv/7'>Mg coordination site</scene>.
	</StructureSection>		</StructureSection>

Alexander Berchansky — Mon, 23 Nov 2020 13:49:13 GMT

←Older revision		Revision as of 13:49, 23 November 2020
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	== Function ==		== Function ==

-	'''Squalene synthase''' (SQS) catalyzes the conversion of 2 molecules of farnesyl pyrophosphate (FPP) to the isoprenoid squalene. SQS is part of the isoprenoid biosynthesis pathway. SQS catalysis is the first step in the sterols synthesis including cholesterol<ref>PMID:11008488</ref>. '''Dehydrosqualene synthase''' of '''phytene synthase''' catalyzes the condensation of farnesyl diphosphate producing presqualene diphosphate<ref>PMID:21098670</ref>.	+	'''Squalene synthase''' (SQS) catalyzes the conversion of 2 molecules of farnesyl pyrophosphate (FPP) to the isoprenoid squalene. SQS is part of the isoprenoid biosynthesis pathway. SQS catalysis is the first step in the sterols synthesis including cholesterol<ref>PMID:11008488</ref>. '''Dehydrosqualene synthase''' of '''phytene synthase''' catalyzes the condensation of farnesyl diphosphate producing presqualene diphosphate<ref>PMID:21098670</ref>.

	== Relevance ==		== Relevance ==
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	== Structural highlights ==		== Structural highlights ==
-	The <scene name='59/591996/Cv/5'>active site of SQS contains a substrate analog</scene><ref>PMID:24789335</ref>. Water molecules are shown as red spheres.	+	The <scene name='59/591996/Cv/6'>active site of SQS contains a substrate analog</scene><ref>PMID:24789335</ref>. Water molecules are shown as red spheres.
	</StructureSection>		</StructureSection>

Michal Harel — Wed, 11 Nov 2020 10:45:32 GMT

←Older revision		Revision as of 10:45, 11 November 2020
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	== Function ==		== Function ==

-	'''Squalene synthase''' (SQS) catalyzes the conversion of 2 molecules of farnesyl pyrophosphate (FPP) to the isoprenoid squalene. SQS is part of the isoprenoid biosynthesis pathway. SQS catalysis is the first step in the sterols synthesis including cholesterol<ref>PMID:11008488</ref>.	+	'''Squalene synthase''' (SQS) catalyzes the conversion of 2 molecules of farnesyl pyrophosphate (FPP) to the isoprenoid squalene. SQS is part of the isoprenoid biosynthesis pathway. SQS catalysis is the first step in the sterols synthesis including cholesterol<ref>PMID:11008488</ref>. '''Dehydrosqualene synthase''' of '''phytene synthase''' catalyzes the condensation of farnesyl diphosphate producing presqualene diphosphate<ref>PMID:21098670</ref>.

	== Relevance ==		== Relevance ==

Michal Harel — Wed, 11 Nov 2020 10:32:17 GMT

←Older revision		Revision as of 10:32, 11 November 2020
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	**[[3wei]], [[3wej]], [[3wek]] – hSQS (mutant) + presqualene pyrophosphate <br />		**[[3wei]], [[3wej]], [[3wek]] – hSQS (mutant) + presqualene pyrophosphate <br />
	**[[3wca]], [[3wcb]], [[3wcc]], [[3wce]], [[3wcg]] – SQS (mutant) + FPP analog – ''Trypanosoma cruzi''<br />		**[[3wca]], [[3wcb]], [[3wcc]], [[3wce]], [[3wcg]] – SQS (mutant) + FPP analog – ''Trypanosoma cruzi''<br />
		+
		+	*Dehydrosqualene synthase (DSQS)
		+
		+	**[[3vjd]], [[2zco]] – SaDSQS – ''Staphylococcus aureus'' <br />
		+	**[[3nri]] – SaDSQS + dehydrosqualene <br />
		+	**[[3npr]], [[3adz]] – SaSQS + presqualene pyrophosphate <br />
		+	**[[3lgz]] – SaSQS (mutant) + presqualene pyrophosphate <br />
		+	**[[3vje]] – SaDSQS (mutant) + zaragozic acid <br />
		+	**[[3ae0]] – SaDSQS + geranylgeranyl + thiopyrophosphate <br />
		+	**[[3w7f]], [[5yis]] – SaDSQS + farnesyl + thiopyrophosphate <br />
		+	**[[3acw]], [[3acx]], [[3acy]], [[3tfv]], [[3tfn]], [[3tfp]], [[4f6v]], [[4f6x]], [[2zcs]], [[2zcq]], [[2zy1]], [[2zcr]], [[4e9z]], [[4e9u]], [[4ea0]], [[4ea1]], [[4ea2]] – SaDSQS + inhibitor<br />

	}}		}}

Alexander Berchansky — Thu, 12 Sep 2019 13:22:28 GMT

←Older revision		Revision as of 13:22, 12 September 2019
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	== Structural highlights ==		== Structural highlights ==
-	The <scene name='59/591996/Cv/4'>active site of SQS contains a substrate analog</scene><ref>PMID:24789335</ref>. Water molecules shown as red spheres.	+	The <scene name='59/591996/Cv/5'>active site of SQS contains a substrate analog</scene><ref>PMID:24789335</ref>. Water molecules are shown as red spheres.
	</StructureSection>		</StructureSection>

Michal Harel — Thu, 20 Sep 2018 20:00:35 GMT

←Older revision		Revision as of 20:00, 20 September 2018
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-	<StructureSection load='3wca' size='~~450~~' side='right' caption='Structure of SQS complex with FPP analog and Mg+2 ions (green) (PDB code [[3wca]]).' scene='59/591996/Cv/1'>	+	<StructureSection load='3wca' size='350' side='right' caption='Structure of SQS complex with FPP analog and Mg+2 ions (green) (PDB code [[3wca]]).' scene='59/591996/Cv/1'>

	== Function ==		== Function ==

Alexander Berchansky — Wed, 31 Aug 2016 12:20:36 GMT

←Older revision		Revision as of 12:20, 31 August 2016
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	== Structural highlights ==		== Structural highlights ==
-	The active site of SQS contains a substrate analog<ref>PMID:24789335</ref>.	+	The <scene name='59/591996/Cv/4'>active site of SQS contains a substrate analog</scene><ref>PMID:24789335</ref>. Water molecules shown as red spheres.
	</StructureSection>		</StructureSection>

Alexander Berchansky — Wed, 31 Aug 2016 12:04:39 GMT

←Older revision		Revision as of 12:04, 31 August 2016
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-	<StructureSection load='3wca' size='~~340~~' side='right' caption='Structure of SQS complex with FPP analog and Mg+2 ions (green) (PDB code [[3wca]]).' scene=''>	+	<StructureSection load='3wca' size='450' side='right' caption='Structure of SQS complex with FPP analog and Mg+2 ions (green) (PDB code [[3wca]]).' scene='59/591996/Cv/1'>

	== Function ==		== Function ==

Michal Harel — Wed, 31 Aug 2016 09:59:17 GMT

←Older revision		Revision as of 09:59, 31 August 2016
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-	<StructureSection load='3wca' size='340' side='right' caption='Structure of SQS complex with FPP analog (PDB code [[3wca]]).' scene=''>	+	<StructureSection load='3wca' size='340' side='right' caption='Structure of SQS complex with FPP analog and Mg+2 ions (green) (PDB code [[3wca]]).' scene=''>

	== Function ==		== Function ==