T-cell receptor - Revision history

Michal Harel at 09:37, 16 February 2020

Michal Harel — Sun, 16 Feb 2020 09:37:03 GMT

←Older revision		Revision as of 09:37, 16 February 2020
Line 13:		Line 13:

	</StructureSection>		</StructureSection>
-	== 3D structures of T-cell receptor==

-	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-	{{#tree:id=OrganizedByTopic\|openlevels=0\|
-
-	*TCR α chain
-
-	**[[4udt]] – hTCR α chain variable domain + TRBV7-9 - human<br />
-	**[[4udu]] – hTCR α chain variable domain + TRBV7-9 + enterotoxin type E<br />
-	**[[1ac6]], [[1b88]], [[1h5b]], [[1i9e]] – mTCR α chain variable domain - mouse<br />
-	**[[6mf8]] – mTCR α chain transmembrane domain - NMR<br />
-
-	*TCR β chain
-
-	**[[2axh]] – hTCR β chain (mutant) <br />
-	**[[2axj]] – hTCR β chain <br />
-	**[[2apb]], [[2apf]], [[2apt]], [[2apv]], [[2apw]], [[2apx]] – TCR β chain (mutant) - rat<br />
-	**[[1bec]] – mTCR β chain <br />
-
-	*TCR β chain + antigen
-
-	**[[1ktk]], [[3byt]], [[3byy]], [[3bzd]] – hTCR β chain (mutant) + exotoxin type C <br />
-	**[[2ij0]] – hTCR β chain + toxic shock syndrome toxin-1 <br />
-	**[[1jck]], [[1sbb]], [[1l0x]], [[1l0y]], [[2aq1]], [[2aq2]], [[2aq3]], [[3mc0]] – mTCR β chain (mutant) + antigen<br />
-
-	*TCR δ chain
-
-	**[[1tvd]] – hTCR δ chain variable domain <br />
-
-	*TCR α+β chains
-
-	**[[1kgc]], [[2nw2]], [[2vlm]], [[3dx9]], [[3mff]], [[3qeu]], [[3skn]], [[4dzb]], [[4e42]], [[4jfh]], [[4g8f]], [[4g8e]], [[4ww1]], [[4x6b]], [[4zdh]], [[6eh4]], [[6eh5]], [[6eh6]], [[6eh7]], [[6eh8]], [[6eh9]], [[6fr6]], [[6fr7]], [[6fr8]], [[6fr9]], [[6fra]], [[6frb]], [[6frc]], [[6fum]], [[6fun]], [[6fuo]], [[6fup]], [[6fuq]], [[6fur]], [[6at6]], [[6fr3]], [[6fr4]], [[6fr5]], [[6ovo]], [[6cuh]], [[6cph]], [[5nmd]] – hTCR α+β chains<br />
-	**[[4ei6]] – h/mTCR α+β chains <br />
-	**[[2ial]], [[4gg8]], [[4onh]] – hTCR α+β chains (mutant)<br />
-	**[[3of6]] – hTCR pre-α+β (mutant) chains<br />
-	**[[1tcr]], [[2z35]], [[2p1y]] – mTCR α+β chains<br />
-	**[[1tcr]], [[2q86]], [[5iw1]]– mTCR α+β chains (mutant)<br />
-	**[[1bwm]] – mTCR α+β chains variable domains (mutant) - NMR<br />
-
-	*TCR α+β+γ chains
-
-	**[[4mnh]] – hTCR α+β+γ chains<br />
-
-	*TCR γ+δ chains
-
-	**[[1hxm]], [[3omz]] – hTCR γ+δ chains<br />
-	**[[4ndm]] – hTCR γ+δ chains (mutant)<br />
-
-	*TCR complex with antigen
-
-	**[[2xna]], [[5fk9]], [[5fka]] – hTCR α+β chains + enterotoxin <br />
-	**[[5tl5]], [[5tlj]], [[5tlk]] – h/mTCR α+β chains + CD27 antigen <br />
-	**[[1nfd]], [[1kb5]] – mTCR α+β chains + FAB fragment<br />
-
-	*TCR complex with MHC and antigen
-
-	**[[1ao7]], [[1bd2]], [[1qrn]], [[1qse]], [[1qsf]], [[1mi5]], [[1oga]], [[1lp9]], [[2bnq]], [[2bnr]], [[2bnu]], [[2ak4]], [[2esv]], [[2f53]], [[2f54]], [[2gj6]], [[2nx5]], [[2p5e]], [[2p5w]], [[2pye]], [[2pyf]], [[3dxa]], [[3hg1]], [[3gsn]], [[3kpr]], [[3kps]], [[3kxf]], [[3o4l]], [[3qdg]], [[3qdj]], [[3qdm]], [[3qeq]], [[3sjv]], [[2ypl]], [[4jff]], [[4jfe]], [[4jfd]], [[4jry]], [[4jrx]], [[2jcc]], [[3d39]], [[3d3v]], [[4mji]], [[4prh]], [[4pri]], [[4prp]], [[5brz]], [[5bs0]], [[5c07]], [[5c08]], [[5c09]], [[5c0a]], [[5c0b]], [[5c0c]], [[5e6i]], [[5eu6]], [[5hhm]], [[5hho]], [[5hyj]], [[5ivx]], [[5ks9]], [[5ksa]], [[5ksb]], [[5m01]], [[5w1v]], [[5w1w]], [[5wkf]], [[5wkh]], [[6at5]], [[6avf]], [[6avg]], [[6bj2]], [[6bj3]], [[6bj8]], [[4nqc]], [[4nqd]], [[4nqe]], [[6rpb]], [[6rpa]], [[6rp9]], [[6q3s]], [[6dkp]], [[5yxu]], [[5yxn]], [[5nqk]], [[5nmg]], [[5nmf]], [[5nme]], [[5nht]] – hTCR α+β chains + MHC + β-2 microglobulin + polypeptide <br />
-	**[[1fyt]], [[1ymm]], [[1zgl]], [[4e41]], [[4z7u]], [[4z7v]], [[4z7w]], [[6u3o]], [[6u3n]], [[6py2]], [[6px6]], [[6cqr]], [[6cqq]], [[6cqn]], [[6cql]] – hTCR α+β chains + MHC + polypeptide <br />
-	**[[4ozf]], [[4ozg]], [[4ozh]], [[4ozi]], [2iam]], [[2ian]], [[1j8h]], [[4gg6]] – hTCR α+β chains (mutant) + MHC + polypeptide <br />
-	**[[3o6f]], [[5u16]], [[5u17]] – hTCR α+β chains + MHC <br />
-	**[[3pl6]] – hTCR α chain + MHC + polypeptide <br />
-	**[[2xn9]], [[4c56]] – hTCR α+β chains + MHC + polypeptide + enterotoxin<br />
-	**[[5xot]] – hTCR δ+β chains + MHC + β-2 microglobulin + polypeptide <br />
-	**[[1ypz]], [[6mwr]] – hTCR γ+δ chains + MHC + β-2 microglobulin <br />
-	**[[4l4t]], [[4l4v]], [[4l8s]], [[4l9l]], [[4lcc]], [[4lcw]], [[5u1r]], [[5u2v]], [[5u6q]], [[5u72]] – hTCR MAIT α+β chains + MHC + β-2 microglobulin <br />
-	**[[2ckb]], [[1fo0]], [[1g6r]], [[1kj2]], [[1mwa]], [[1nam]], [[2ol3]], [[2j8u]], [[5til]], [[5tje]] – mTCR α+β chains + MHC + β-2 microglobulin + polypeptide <br />
-	**[[2pxy]] – mTCR α+β chains (mutant) + MHC + β-2 microglobulin + polypeptide <br />
-	**[[4p2o]], [[4p2q]], [[4p2r]], [[4p46]] – mTCR α+β chains + MHC + polypeptide <br />
-	**[[1u3h]] – mTCR α+β chains (mutant) + MHC + polypeptide <br />
-	**[[2icw]] – mTCR α+β chains + MHC + mycoplasma arthritidis mitogen + polypeptide <br />
-	**[[1d9k]], [[2e7l]], [[2oi9]], [[2z31]], [[3e2h]], [[3e3q]], [[3qib]], [[3mbe]], [[6bga]] – mTCR α+β chains + MHC + polypeptide <br />
-
-	*TCR complex with CD
-
-	**[[4x6c]], [[4x6d]] – hTCR α+β chains + β-2 microglobulin + CD1A <br />
-	**[[5wki]], [[6cug]] – hTCR α+β chains + β-2 microglobulin + CD1B <br />
-	**[[6c09]] – hTCR α+β chains + β-2 microglobulin + CD1C <br />
-	**[[3huj]], [[3vwj]], [[3vwk]], [[4en3]], [[4ww2]], [[4wwk]] – hTCR NKT α+β chains + β-2 microglobulin + CD1D <br />
-	**[[3tzv]] – hTCR NKT α+β chains (mutant) + β-2 microglobulin + CD1D <br />
-	**[[3o8x]], [[3o9w]], [[4ei5]], [[4y16]], [[4y2d]], [[4y4h]], [[4y4k]], [[4y4f]], [[4zak]] – h/mTCR NKT α+β chains + β-2 microglobulin + CD1D <br />
-	**[[3scm]], [[3sda]], [[3sdc]], [[3sdd]], [[3sdx]] – h/mTCR NKT α+β chains + β-2 microglobulin + CD1D + ceramide derivative<br />
-	**[[3t0e]] – hTCR α+β chains + MHC + CD4 <br />
-	**[[6cxa]], [[6cx9]], [[6cx7]], [[6cx5]], [[6cwe]], [[6cwb]], [[6cw9]], [[6cw6]], [[5wlg]], [[5m02]] – mTCR α+β chains + β-2 microglobulin + CD1D1 <br />
-
-	}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 09:36, 16 February 2020

Michal Harel — Sun, 16 Feb 2020 09:36:08 GMT

←Older revision		Revision as of 09:36, 16 February 2020
Line 9:		Line 9:
	== Relevance ==		== Relevance ==
	Genes encoding antigen-specific receptors into T cells can redirect their functional activity against targets including virally infected or cancer cells<ref>PMID:22610778</ref>. This technique is currently developed by several biotechnology companies and implemented in therapy.		Genes encoding antigen-specific receptors into T cells can redirect their functional activity against targets including virally infected or cancer cells<ref>PMID:22610778</ref>. This technique is currently developed by several biotechnology companies and implemented in therapy.
		+	== 3D structures of T-cell receptor==
		+	[[T-cell receptor 3D structures]]
		+
	</StructureSection>		</StructureSection>
	== 3D structures of T-cell receptor==		== 3D structures of T-cell receptor==
Line 17:		Line 20:
	*TCR α chain		*TCR α chain

-	**[[1ac6]], [[1b88]], [[1h5b]], [[1i9e]] – mTCR α chain variable domain - mouse<br />
	**[[4udt]] – hTCR α chain variable domain + TRBV7-9 - human<br />		**[[4udt]] – hTCR α chain variable domain + TRBV7-9 - human<br />
	**[[4udu]] – hTCR α chain variable domain + TRBV7-9 + enterotoxin type E<br />		**[[4udu]] – hTCR α chain variable domain + TRBV7-9 + enterotoxin type E<br />
		+	**[[1ac6]], [[1b88]], [[1h5b]], [[1i9e]] – mTCR α chain variable domain - mouse<br />
		+	**[[6mf8]] – mTCR α chain transmembrane domain - NMR<br />

	*TCR β chain		*TCR β chain

-	**[[1bec]] – mTCR β chain <br />
	**[[2axh]] – hTCR β chain (mutant) <br />		**[[2axh]] – hTCR β chain (mutant) <br />
	**[[2axj]] – hTCR β chain <br />		**[[2axj]] – hTCR β chain <br />
	**[[2apb]], [[2apf]], [[2apt]], [[2apv]], [[2apw]], [[2apx]] – TCR β chain (mutant) - rat<br />		**[[2apb]], [[2apf]], [[2apt]], [[2apv]], [[2apw]], [[2apx]] – TCR β chain (mutant) - rat<br />
		+	**[[1bec]] – mTCR β chain <br />

	*TCR β chain + antigen		*TCR β chain + antigen

-	**[[1jck]], [[1sbb]], [[1l0x]], [[1l0y]], [[2aq1]], [[2aq2]], [[2aq3]], [[3mc0]] – mTCR β chain (mutant) + antigen<br />
	**[[1ktk]], [[3byt]], [[3byy]], [[3bzd]] – hTCR β chain (mutant) + exotoxin type C <br />		**[[1ktk]], [[3byt]], [[3byy]], [[3bzd]] – hTCR β chain (mutant) + exotoxin type C <br />
	**[[2ij0]] – hTCR β chain + toxic shock syndrome toxin-1 <br />		**[[2ij0]] – hTCR β chain + toxic shock syndrome toxin-1 <br />
		+	**[[1jck]], [[1sbb]], [[1l0x]], [[1l0y]], [[2aq1]], [[2aq2]], [[2aq3]], [[3mc0]] – mTCR β chain (mutant) + antigen<br />

	*TCR δ chain		*TCR δ chain
Line 40:		Line 44:
	*TCR α+β chains		*TCR α+β chains

-	**[[1tcr]], [[2z35]], [[2p1y]] – mTCR α+β chains<br />	+	**[[1kgc]], [[2nw2]], [[2vlm]], [[3dx9]], [[3mff]], [[3qeu]], [[3skn]], [[4dzb]], [[4e42]], [[4jfh]], [[4g8f]], [[4g8e]], [[4ww1]], [[4x6b]], [[4zdh]], [[6eh4]], [[6eh5]], [[6eh6]], [[6eh7]], [[6eh8]], [[6eh9]], [[6fr6]], [[6fr7]], [[6fr8]], [[6fr9]], [[6fra]], [[6frb]], [[6frc]], [[6fum]], [[6fun]], [[6fuo]], [[6fup]], [[6fuq]], [[6fur]], [[6at6]], [[6fr3]], [[6fr4]], [[6fr5]], [[6ovo]], [[6cuh]], [[6cph]], [[5nmd]] – hTCR α+β chains<br />
-	**[[1tcr]], [[2q86]], [[5iw1]]– mTCR α+β chains (mutant)<br />	+
-	**[[1bwm]] – mTCR α+β chains variable domains (mutant) - NMR<br />	+
-	**[[1kgc]], [[2nw2]], [[2vlm]], [[3dx9]], [[3mff]], [[3qeu]], [[3skn]], [[4dzb]], [[4e42]], [[4jfh]], [[4g8f]], [[4g8e]], [[4ww1]], [[4x6b]], [[4zdh]], [[6eh4]], [[6eh5]], [[6eh6]], [[6eh7]], [[6eh8]], [[6eh9]], [[6fr6]], [[6fr7]], [[6fr8]], [[6fr9]], [[6fra]], [[6frb]], [[6frc]], [[6fum]], [[6fun]], [[6fuo]], [[6fup]], [[6fuq]], [[6fur]], [[6at6]], [[6fr3]], [[6fr4]], [[6fr5]] – hTCR α+β chains<br />	+
	**[[4ei6]] – h/mTCR α+β chains <br />		**[[4ei6]] – h/mTCR α+β chains <br />
	**[[2ial]], [[4gg8]], [[4onh]] – hTCR α+β chains (mutant)<br />		**[[2ial]], [[4gg8]], [[4onh]] – hTCR α+β chains (mutant)<br />
	**[[3of6]] – hTCR pre-α+β (mutant) chains<br />		**[[3of6]] – hTCR pre-α+β (mutant) chains<br />
		+	**[[1tcr]], [[2z35]], [[2p1y]] – mTCR α+β chains<br />
		+	**[[1tcr]], [[2q86]], [[5iw1]]– mTCR α+β chains (mutant)<br />
		+	**[[1bwm]] – mTCR α+β chains variable domains (mutant) - NMR<br />

	*TCR α+β+γ chains		*TCR α+β+γ chains
Line 59:		Line 63:
	*TCR complex with antigen		*TCR complex with antigen

-	**[[1nfd]], [[1kb5]] – mTCR α+β chains + FAB fragment<br />
	**[[2xna]], [[5fk9]], [[5fka]] – hTCR α+β chains + enterotoxin <br />		**[[2xna]], [[5fk9]], [[5fka]] – hTCR α+β chains + enterotoxin <br />
	**[[5tl5]], [[5tlj]], [[5tlk]] – h/mTCR α+β chains + CD27 antigen <br />		**[[5tl5]], [[5tlj]], [[5tlk]] – h/mTCR α+β chains + CD27 antigen <br />
		+	**[[1nfd]], [[1kb5]] – mTCR α+β chains + FAB fragment<br />

	*TCR complex with MHC and antigen		*TCR complex with MHC and antigen

-	**[[1ao7]], [[1bd2]], [[1qrn]], [[1qse]], [[1qsf]], [[1mi5]], [[1oga]], [[1lp9]], [[2bnq]], [[2bnr]], [[2bnu]], [[2ak4]], [[2esv]], [[2f53]], [[2f54]], [[2gj6]], [[2nx5]], [[2p5e]], [[2p5w]], [[2pye]], [[2pyf]], [[3dxa]], [[3hg1]], [[3gsn]], [[3kpr]], [[3kps]], [[3kxf]], [[3o4l]], [[3qdg]], [[3qdj]], [[3qdm]], [[3qeq]], [[3sjv]], [[2ypl]], [[4jff]], [[4jfe]], [[4jfd]], [[4jry]], [[4jrx]], [[2jcc]], [[3d39]], [[3d3v]], [[4mji]], [[4prh]], [[4pri]], [[4prp]], [[5brz]], [[5bs0]], [[5c07]], [[5c08]], [[5c09]], [[5c0a]], [[5c0b]], [[5c0c]], [[5e6i]], [[5eu6]], [[5hhm]], [[5hho]], [[5hyj]], [[5ivx]], [[5ks9]], [[5ksa]], [[5ksb]], [[5m01]], [[5w1v]], [[5w1w]], [[5wkf]], [[5wkh]], [[6at5]], [[6avf]], [[6avg]], [[6bj2]], [[6bj3]], [[6bj8]] ~~– hTCR α+β chains + MHC + β-2 microglobulin + polypeptide <br />~~	+	**[[1ao7]], [[1bd2]], [[1qrn]], [[1qse]], [[1qsf]], [[1mi5]], [[1oga]], [[1lp9]], [[2bnq]], [[2bnr]], [[2bnu]], [[2ak4]], [[2esv]], [[2f53]], [[2f54]], [[2gj6]], [[2nx5]], [[2p5e]], [[2p5w]], [[2pye]], [[2pyf]], [[3dxa]], [[3hg1]], [[3gsn]], [[3kpr]], [[3kps]], [[3kxf]], [[3o4l]], [[3qdg]], [[3qdj]], [[3qdm]], [[3qeq]], [[3sjv]], [[2ypl]], [[4jff]], [[4jfe]], [[4jfd]], [[4jry]], [[4jrx]], [[2jcc]], [[3d39]], [[3d3v]], [[4mji]], [[4prh]], [[4pri]], [[4prp]], [[5brz]], [[5bs0]], [[5c07]], [[5c08]], [[5c09]], [[5c0a]], [[5c0b]], [[5c0c]], [[5e6i]], [[5eu6]], [[5hhm]], [[5hho]], [[5hyj]], [[5ivx]], [[5ks9]], [[5ksa]], [[5ksb]], [[5m01]], [[5w1v]], [[5w1w]], [[5wkf]], [[5wkh]], [[6at5]], [[6avf]], [[6avg]], [[6bj2]], [[6bj3]], [[6bj8]], [[4nqc]], [[4nqd]], [[4nqe]], [[6rpb]], [[6rpa]], [[6rp9]], [[6q3s]], [[6dkp]], [[5yxu]], [[5yxn]], [[5nqk]], [[5nmg]], [[5nmf]], [[5nme]], [[5nht]] – hTCR α+β chains + MHC + β-2 microglobulin + polypeptide <br />
-	**[[4nqc]], [[4nqd]], [[4nqe]] – hTCR α+β chains + MHC + β-2 microglobulin + ~~antigen~~ <br />	+	**[[1fyt]], [[1ymm]], [[1zgl]], [[4e41]], [[4z7u]], [[4z7v]], [[4z7w]], [[6u3o]], [[6u3n]], [[6py2]], [[6px6]], [[6cqr]], [[6cqq]], [[6cqn]], [[6cql]] – hTCR α+β chains + MHC + polypeptide <br />
-	**[[1fyt]], [[1ymm]], [[1zgl]], [[4e41]], [[4z7u]], [[4z7v]], [[4z7w]] – hTCR α+β chains + MHC + polypeptide <br />	+	**[[4ozf]], [[4ozg]], [[4ozh]], [[4ozi]], [2iam]], [[2ian]], [[1j8h]], [[4gg6]] – hTCR α+β chains (mutant) + MHC + polypeptide <br />
-	**[[4ozf]], [[4ozg]], [[4ozh]], [[4ozi]] – hTCR α+β chains (mutant) + MHC + polypeptide <br />	+
	**[[3o6f]], [[5u16]], [[5u17]] – hTCR α+β chains + MHC <br />		**[[3o6f]], [[5u16]], [[5u17]] – hTCR α+β chains + MHC <br />
	**[[3pl6]] – hTCR α chain + MHC + polypeptide <br />		**[[3pl6]] – hTCR α chain + MHC + polypeptide <br />
	**[[2xn9]], [[4c56]] – hTCR α+β chains + MHC + polypeptide + enterotoxin<br />		**[[2xn9]], [[4c56]] – hTCR α+β chains + MHC + polypeptide + enterotoxin<br />
-	**[[~~3t0e~~]] – hTCR α+β chains + MHC ~~+ CD4 <br />~~	+	**[[5xot]] – hTCR δ+β chains + MHC + β-2 microglobulin + polypeptide <br />
-	**[[2iam]], [[2ian]] – hTCR α+β ~~chains (mutant)~~ + ~~MHC +~~ polypeptide <br />	+	**[[1ypz]], [[6mwr]] – hTCR γ+δ chains + MHC + β-2 microglobulin <br />
-	**[[~~1j8h~~]], [[~~4gg6~~]] – hTCR α+~~β chains (mutant) + MHC + polypeptide <br />~~	+
-	**[[5xov]], [[5xot]] – hTCR δ+β chains + MHC + β-2 microglobulin ~~+ polypeptide~~ <br />	+
	**[[4l4t]], [[4l4v]], [[4l8s]], [[4l9l]], [[4lcc]], [[4lcw]], [[5u1r]], [[5u2v]], [[5u6q]], [[5u72]] – hTCR MAIT α+β chains + MHC + β-2 microglobulin <br />		**[[4l4t]], [[4l4v]], [[4l8s]], [[4l9l]], [[4lcc]], [[4lcw]], [[5u1r]], [[5u2v]], [[5u6q]], [[5u72]] – hTCR MAIT α+β chains + MHC + β-2 microglobulin <br />
	**[[2ckb]], [[1fo0]], [[1g6r]], [[1kj2]], [[1mwa]], [[1nam]], [[2ol3]], [[2j8u]], [[5til]], [[5tje]] – mTCR α+β chains + MHC + β-2 microglobulin + polypeptide <br />		**[[2ckb]], [[1fo0]], [[1g6r]], [[1kj2]], [[1mwa]], [[1nam]], [[2ol3]], [[2j8u]], [[5til]], [[5tje]] – mTCR α+β chains + MHC + β-2 microglobulin + polypeptide <br />
-	**[[4p2o]], [[4p2q]], [[4p2r]], [[4p46]] – mTCR α+β chains + MHC + polypeptide <br />
	**[[2pxy]] – mTCR α+β chains (mutant) + MHC + β-2 microglobulin + polypeptide <br />		**[[2pxy]] – mTCR α+β chains (mutant) + MHC + β-2 microglobulin + polypeptide <br />
		+	**[[4p2o]], [[4p2q]], [[4p2r]], [[4p46]] – mTCR α+β chains + MHC + polypeptide <br />
		+	**[[1u3h]] – mTCR α+β chains (mutant) + MHC + polypeptide <br />
	**[[2icw]] – mTCR α+β chains + MHC + mycoplasma arthritidis mitogen + polypeptide <br />		**[[2icw]] – mTCR α+β chains + MHC + mycoplasma arthritidis mitogen + polypeptide <br />
	**[[1d9k]], [[2e7l]], [[2oi9]], [[2z31]], [[3e2h]], [[3e3q]], [[3qib]], [[3mbe]], [[6bga]] – mTCR α+β chains + MHC + polypeptide <br />		**[[1d9k]], [[2e7l]], [[2oi9]], [[2z31]], [[3e2h]], [[3e3q]], [[3qib]], [[3mbe]], [[6bga]] – mTCR α+β chains + MHC + polypeptide <br />
-	**[[1u3h]] – mTCR α+β chains (mutant) + MHC + polypeptide <br />
-	**[[1ypz]] – hTCR γ+δ chains + MHC + β-2 microglobulin <br />

-	*TCR complex with ~~CD1~~	+	*TCR complex with CD

	**[[4x6c]], [[4x6d]] – hTCR α+β chains + β-2 microglobulin + CD1A <br />		**[[4x6c]], [[4x6d]] – hTCR α+β chains + β-2 microglobulin + CD1A <br />
-	**[[5wki]] – hTCR α+β chains + β-2 microglobulin + CD1B <br />	+	**[[5wki]], [[6cug]] – hTCR α+β chains + β-2 microglobulin + CD1B <br />
	**[[6c09]] – hTCR α+β chains + β-2 microglobulin + CD1C <br />		**[[6c09]] – hTCR α+β chains + β-2 microglobulin + CD1C <br />
	**[[3huj]], [[3vwj]], [[3vwk]], [[4en3]], [[4ww2]], [[4wwk]] – hTCR NKT α+β chains + β-2 microglobulin + CD1D <br />		**[[3huj]], [[3vwj]], [[3vwk]], [[4en3]], [[4ww2]], [[4wwk]] – hTCR NKT α+β chains + β-2 microglobulin + CD1D <br />
Line 94:		Line 94:
	**[[3o8x]], [[3o9w]], [[4ei5]], [[4y16]], [[4y2d]], [[4y4h]], [[4y4k]], [[4y4f]], [[4zak]] – h/mTCR NKT α+β chains + β-2 microglobulin + CD1D <br />		**[[3o8x]], [[3o9w]], [[4ei5]], [[4y16]], [[4y2d]], [[4y4h]], [[4y4k]], [[4y4f]], [[4zak]] – h/mTCR NKT α+β chains + β-2 microglobulin + CD1D <br />
	**[[3scm]], [[3sda]], [[3sdc]], [[3sdd]], [[3sdx]] – h/mTCR NKT α+β chains + β-2 microglobulin + CD1D + ceramide derivative<br />		**[[3scm]], [[3sda]], [[3sdc]], [[3sdd]], [[3sdx]] – h/mTCR NKT α+β chains + β-2 microglobulin + CD1D + ceramide derivative<br />
		+	**[[3t0e]] – hTCR α+β chains + MHC + CD4 <br />
		+	**[[6cxa]], [[6cx9]], [[6cx7]], [[6cx5]], [[6cwe]], [[6cwb]], [[6cw9]], [[6cw6]], [[5wlg]], [[5m02]] – mTCR α+β chains + β-2 microglobulin + CD1D1 <br />

	}}		}}

Alexander Berchansky at 12:48, 19 September 2019

Alexander Berchansky — Thu, 19 Sep 2019 12:48:41 GMT

←Older revision		Revision as of 12:48, 19 September 2019
Line 3:		Line 3:
	== Function ==		== Function ==
	'''T-cell receptors''' (TCR) reside on the surface of T lymphocytes. TCR recognizes antigens bound to major histocompatibility complex (MHC) molecules. The binding of TCR to the antigen-MHC activates the T lymphocytes<ref>PMID:17624994</ref>. TCR is a heterodimer of α+β subunits and ca. 5% the T cells have a γ+δ subumits. TCR NKT reside in Natural Killer T-cells.		'''T-cell receptors''' (TCR) reside on the surface of T lymphocytes. TCR recognizes antigens bound to major histocompatibility complex (MHC) molecules. The binding of TCR to the antigen-MHC activates the T lymphocytes<ref>PMID:17624994</ref>. TCR is a heterodimer of α+β subunits and ca. 5% the T cells have a γ+δ subumits. TCR NKT reside in Natural Killer T-cells.
-	*<scene name='53/536684/Cv/2'>T-cell receptor α chain, β chain complex with enterotoxin and Na+ ion</scene> ([[2xna]]).	+	*<scene name='53/536684/Cv/3'>T-cell receptor α chain, β chain complex with enterotoxin and Na+ ion</scene> ([[2xna]]).

	For more details see [[SP3.4-TCR-HLA-DQ8-∝-1-gliadin_complex]].		For more details see [[SP3.4-TCR-HLA-DQ8-∝-1-gliadin_complex]].

	== Relevance ==		== Relevance ==
-	Genes encoding antigen-specific receptors into T cells can redirect their functional activity against targets including virally infected or cancer cells<ref>PMID:22610778</ref>. This technique is currently developed by several biotechnology companies and implemented in therapy.	+	Genes encoding antigen-specific receptors into T cells can redirect their functional activity against targets including virally infected or cancer cells<ref>PMID:22610778</ref>. This technique is currently developed by several biotechnology companies and implemented in therapy.
	</StructureSection>		</StructureSection>
	== 3D structures of T-cell receptor==		== 3D structures of T-cell receptor==

Michal Harel at 19:39, 24 September 2018

Michal Harel — Mon, 24 Sep 2018 19:39:24 GMT

Joel L. Sussman at 15:00, 6 November 2017

Joel L. Sussman — Mon, 06 Nov 2017 15:00:55 GMT

←Older revision		Revision as of 15:00, 6 November 2017
Line 1:		Line 1:
-	<StructureSection load='~~2xna~~' size='400' side='right' scene='53/536684/Cv/1' caption='T-cell receptor α chain (deepskyblue), β chain (green) complex with enterotoxin (pink), glycerol and Na+ ion (purple) [[2xna]].'>	+	<StructureSection load='' size='400' side='right' scene='53/536684/Cv/1' caption='T-cell receptor α chain (deepskyblue), β chain (green) complex with enterotoxin (pink), glycerol and Na+ ion (purple) [[2xna]].'>

	== Function ==		== Function ==

Michal Harel at 11:33, 6 November 2017

Michal Harel — Mon, 06 Nov 2017 11:33:49 GMT

←Older revision		Revision as of 11:33, 6 November 2017
Line 18:		Line 18:

	**[[1ac6]], [[1b88]], [[1h5b]], [[1i9e]] – mTCR α chain variable domain - mouse<br />		**[[1ac6]], [[1b88]], [[1h5b]], [[1i9e]] – mTCR α chain variable domain - mouse<br />
		+	**[[4udt]] – hTCR α chain variable domain + TRBV7-9 - human<br />
		+	**[[4udu]] – hTCR α chain variable domain + TRBV7-9 + enterotoxin type E<br />

	*TCR β chain		*TCR β chain

	**[[1bec]] – mTCR β chain <br />		**[[1bec]] – mTCR β chain <br />
-	**[[2axh]] – hTCR β chain (mutant) ~~- human~~<br />	+	**[[2axh]] – hTCR β chain (mutant) <br />
	**[[2axj]] – hTCR β chain <br />		**[[2axj]] – hTCR β chain <br />
	**[[2apb]], [[2apf]], [[2apt]], [[2apv]], [[2apw]], [[2apx]] – TCR β chain (mutant) - rat<br />		**[[2apb]], [[2apf]], [[2apt]], [[2apv]], [[2apw]], [[2apx]] – TCR β chain (mutant) - rat<br />
Line 39:		Line 41:

	**[[1tcr]], [[2z35]], [[2p1y]] – mTCR α+β chains<br />		**[[1tcr]], [[2z35]], [[2p1y]] – mTCR α+β chains<br />
-	**[[1tcr]], [[2q86]] – mTCR α+β chains (mutant)<br />	+	**[[1tcr]], [[2q86]], [[5iw1]]– mTCR α+β chains (mutant)<br />
	**[[1bwm]] – mTCR α+β chains variable domains (mutant) - NMR<br />		**[[1bwm]] – mTCR α+β chains variable domains (mutant) - NMR<br />
-	**[[1kgc]], [[2nw2]], [[2vlm]], [[3dx9]], [[3mff]], [[3qeu]], [[3skn]], [[4dzb]], [[4e42]], [[4jfh]], [[4g8f]], [[4g8e]] – hTCR α+β chains<br />	+	**[[1kgc]], [[2nw2]], [[2vlm]], [[3dx9]], [[3mff]], [[3qeu]], [[3skn]], [[4dzb]], [[4e42]], [[4jfh]], [[4g8f]], [[4g8e]], [[4ww1]], [[4x6b]], [[4zdh]] – hTCR α+β chains<br />
	**[[4ei6]] – h/mTCR α+β chains <br />		**[[4ei6]] – h/mTCR α+β chains <br />
	**[[2ial]], [[4gg8]], [[4onh]] – hTCR α+β chains (mutant)<br />		**[[2ial]], [[4gg8]], [[4onh]] – hTCR α+β chains (mutant)<br />
Line 58:		Line 60:

	**[[1nfd]], [[1kb5]] – mTCR α+β chains + FAB fragment<br />		**[[1nfd]], [[1kb5]] – mTCR α+β chains + FAB fragment<br />
-	**[[2xna]] – hTCR α+β chains + enterotoxin <br />	+	**[[2xna]], [[5fk9]], [[5fka]] – hTCR α+β chains + enterotoxin <br />
		+	**[[5tl5]], [[5tlj]], [[5tlk]] – h/mTCR α+β chains + CD27 antigen <br />

	*TCR complex with MHC and antigen		*TCR complex with MHC and antigen

-	**[[1ao7]], [[1bd2]], [[1qrn]], [[1qse]], [[1qsf]], [[1mi5]], [[1oga]], [[1lp9]], [[2bnq]], [[2bnr]], [[2bnu]], [[2ak4]], [[2esv]], [[2f53]], [[2f54]], [[2gj6]], [[2nx5]], [[2p5e]], [[2p5w]], [[2pye]], [[2pyf]], [[3dxa]], [[3hg1]], [[3gsn]], [[3kpr]], [[3kps]], [[3kxf]], [[3o4l]], [[3qdg]], [[3qdj]], [[3qdm]], [[3qeq]], [[3sjv]], [[2ypl]], [[4jff]], [[4jfe]], [[4jfd]], [[4jry]], [[4jrx]], [[2jcc]], [[3d39]], [[3d3v]], [[4mji]], [[4prh]], [[4pri]], [[4prp]] – hTCR α+β chains + MHC + β-2 microglobulin + polypeptide <br />	+	**[[1ao7]], [[1bd2]], [[1qrn]], [[1qse]], [[1qsf]], [[1mi5]], [[1oga]], [[1lp9]], [[2bnq]], [[2bnr]], [[2bnu]], [[2ak4]], [[2esv]], [[2f53]], [[2f54]], [[2gj6]], [[2nx5]], [[2p5e]], [[2p5w]], [[2pye]], [[2pyf]], [[3dxa]], [[3hg1]], [[3gsn]], [[3kpr]], [[3kps]], [[3kxf]], [[3o4l]], [[3qdg]], [[3qdj]], [[3qdm]], [[3qeq]], [[3sjv]], [[2ypl]], [[4jff]], [[4jfe]], [[4jfd]], [[4jry]], [[4jrx]], [[2jcc]], [[3d39]], [[3d3v]], [[4mji]], [[4prh]], [[4pri]], [[4prp]], [[5brz]], [[5bs0]], [[5c07]], [[5c08]], [[5c09]], [[5c0a]], [[5c0b]], [[5c0c]], [[5e6i]], [[5eu6]], [[5hhm]], [[5hho]], [[5hyj]], [[5ivx]], [[5ks9]], [[5ksa]], [[5ksb]], [[5m01]], [[5w1v]], [[5w1w]], [[5wkf]], [[5wkh]] – hTCR α+β chains + MHC + β-2 microglobulin + polypeptide <br />
	**[[4nqc]], [[4nqd]], [[4nqe]] – hTCR α+β chains + MHC + β-2 microglobulin + antigen <br />		**[[4nqc]], [[4nqd]], [[4nqe]] – hTCR α+β chains + MHC + β-2 microglobulin + antigen <br />
	**[[1fyt]], [[1ymm]], [[1zgl]], [[4e41]], [[4z7u]], [[4z7v]], [[4z7w]] – hTCR α+β chains + MHC + polypeptide <br />		**[[1fyt]], [[1ymm]], [[1zgl]], [[4e41]], [[4z7u]], [[4z7v]], [[4z7w]] – hTCR α+β chains + MHC + polypeptide <br />
	**[[4ozf]], [[4ozg]], [[4ozh]], [[4ozi]] – hTCR α+β chains (mutant) + MHC + polypeptide <br />		**[[4ozf]], [[4ozg]], [[4ozh]], [[4ozi]] – hTCR α+β chains (mutant) + MHC + polypeptide <br />
-	**[[3o6f]] – hTCR α+β chains + MHC <br />	+	**[[3o6f]], [[5u16]], [[5u17]] – hTCR α+β chains + MHC <br />
	**[[3pl6]] – hTCR α chain + MHC + polypeptide <br />		**[[3pl6]] – hTCR α chain + MHC + polypeptide <br />
	**[[2xn9]], [[4c56]] – hTCR α+β chains + MHC + polypeptide + enterotoxin<br />		**[[2xn9]], [[4c56]] – hTCR α+β chains + MHC + polypeptide + enterotoxin<br />
Line 72:		Line 75:
	**[[2iam]], [[2ian]] – hTCR α+β chains (mutant) + MHC + polypeptide <br />		**[[2iam]], [[2ian]] – hTCR α+β chains (mutant) + MHC + polypeptide <br />
	**[[1j8h]], [[4gg6]] – hTCR α+β chains (mutant) + MHC + polypeptide <br />		**[[1j8h]], [[4gg6]] – hTCR α+β chains (mutant) + MHC + polypeptide <br />
-	**[[4l4t]], [[4l4v]], [[4l8s]], [[4l9l]], [[4lcc]], [[4lcw]] – hTCR MAIT α+β chains + MHC + β-2 microglobulin <br />	+	**[[5xov]] – hTCR δ+β chains + MHC + β-2 microglobulin + polypeptide <br />
-	**[[2ckb]], [[1fo0]], [[1g6r]], [[1kj2]], [[1mwa]], [[1nam]], [[2ol3]], [[2j8u]] – mTCR α+β chains + MHC + β-2 microglobulin + polypeptide <br />	+	**[[4l4t]], [[4l4v]], [[4l8s]], [[4l9l]], [[4lcc]], [[4lcw]], [[5u1r]], [[5u2v]], [[5u6q]], [[5u72]] – hTCR MAIT α+β chains + MHC + β-2 microglobulin <br />
		+	**[[2ckb]], [[1fo0]], [[1g6r]], [[1kj2]], [[1mwa]], [[1nam]], [[2ol3]], [[2j8u]], [[5til]], [[5tje]] – mTCR α+β chains + MHC + β-2 microglobulin + polypeptide <br />
	**[[4p2o]], [[4p2q]], [[4p2r]], [[4p46]] – mTCR α+β chains + MHC + polypeptide <br />		**[[4p2o]], [[4p2q]], [[4p2r]], [[4p46]] – mTCR α+β chains + MHC + polypeptide <br />
	**[[2pxy]] – mTCR α+β chains (mutant) + MHC + β-2 microglobulin + polypeptide <br />		**[[2pxy]] – mTCR α+β chains (mutant) + MHC + β-2 microglobulin + polypeptide <br />
Line 81:		Line 85:
	**[[1ypz]] – hTCR γ+δ chains + MHC + β-2 microglobulin <br />		**[[1ypz]] – hTCR γ+δ chains + MHC + β-2 microglobulin <br />

-	*TCR complex with ~~CD1D~~	+	*TCR complex with CD1

-	**[[3huj]], [[3vwj]], [[3vwk]], [[4en3]] – hTCR NKT α+β chains + β-2 microglobulin + CD1D <br />	+	**[[4x6c]], [[4x6d]] – hTCR α+β chains + β-2 microglobulin + CD1A <br />
		+	**[[5wki]] – hTCR α+β chains + β-2 microglobulin + CD1B <br />
		+	**[[3huj]], [[3vwj]], [[3vwk]], [[4en3]], [[4ww2]], [[4wwk]] – hTCR NKT α+β chains + β-2 microglobulin + CD1D <br />
	**[[3tzv]] – hTCR NKT α+β chains (mutant) + β-2 microglobulin + CD1D <br />		**[[3tzv]] – hTCR NKT α+β chains (mutant) + β-2 microglobulin + CD1D <br />
-	**[[3o8x]], [[3o9w]], [[4ei5]], [[4y16]], [[4y2d]], [[4y4h]], [[4y4k]] – h/mTCR NKT α+β chains + β-2 microglobulin + CD1D <br />	+	**[[3o8x]], [[3o9w]], [[4ei5]], [[4y16]], [[4y2d]], [[4y4h]], [[4y4k]], [[4y4f]], [[4zak]] – h/mTCR NKT α+β chains + β-2 microglobulin + CD1D <br />
	**[[3scm]], [[3sda]], [[3sdc]], [[3sdd]], [[3sdx]] – h/mTCR NKT α+β chains + β-2 microglobulin + CD1D + ceramide derivative<br />		**[[3scm]], [[3sda]], [[3sdc]], [[3sdd]], [[3sdx]] – h/mTCR NKT α+β chains + β-2 microglobulin + CD1D + ceramide derivative<br />

Alexander Berchansky at 13:56, 21 June 2017

Alexander Berchansky — Wed, 21 Jun 2017 13:56:20 GMT

←Older revision		Revision as of 13:56, 21 June 2017
Line 1:		Line 1:
-	<StructureSection load='2xna' size='400' side='right' scene='53/536684/Cv/1' caption='T-cell receptor α chain (~~grey~~), β chain (green) complex with enterotoxin (pink), glycerol and Na+ ion (purple) [[2xna]].'>	+	<StructureSection load='2xna' size='400' side='right' scene='53/536684/Cv/1' caption='T-cell receptor α chain (deepskyblue), β chain (green) complex with enterotoxin (pink), glycerol and Na+ ion (purple) [[2xna]].'>

	== Function ==		== Function ==
-	'''T-cell receptors''' (TCR) reside on the surface of T lymphocytes. TCR recognizes antigens bound to major histocompatibility complex (MHC) molecules. The binding of TCR to the antigen-MHC activates the T lymphocytes<ref>PMID:17624994</ref>. TCR is a heterodimer of α+β subunits and ca. 5% the T cells have a γ+δ subumits. TCR NKT reside in Natural Killer T-cells. For more details see [[SP3.4-TCR-HLA-DQ8-∝-1-gliadin_complex]].	+	'''T-cell receptors''' (TCR) reside on the surface of T lymphocytes. TCR recognizes antigens bound to major histocompatibility complex (MHC) molecules. The binding of TCR to the antigen-MHC activates the T lymphocytes<ref>PMID:17624994</ref>. TCR is a heterodimer of α+β subunits and ca. 5% the T cells have a γ+δ subumits. TCR NKT reside in Natural Killer T-cells.
		+	*<scene name='53/536684/Cv/2'>T-cell receptor α chain, β chain complex with enterotoxin and Na+ ion</scene> ([[2xna]]).
		+
		+	For more details see [[SP3.4-TCR-HLA-DQ8-∝-1-gliadin_complex]].

	== Relevance ==		== Relevance ==

Alexander Berchansky at 13:52, 21 June 2017

Alexander Berchansky — Wed, 21 Jun 2017 13:52:05 GMT

←Older revision		Revision as of 13:52, 21 June 2017
Line 1:		Line 1:
-	<StructureSection load='2xna' size='400' side='right' scene='' caption='T-cell receptor α chain (grey), β chain (green) complex with enterotoxin (pink), glycerol and Na+ ion (purple) [[2xna]].'>	+	<StructureSection load='2xna' size='400' side='right' scene='53/536684/Cv/1' caption='T-cell receptor α chain (grey), β chain (green) complex with enterotoxin (pink), glycerol and Na+ ion (purple) [[2xna]].'>

	== Function ==		== Function ==

Alexander Berchansky at 13:47, 21 June 2017

Alexander Berchansky — Wed, 21 Jun 2017 13:47:23 GMT

←Older revision		Revision as of 13:47, 21 June 2017
Line 1:		Line 1:
-	~~{{STRUCTURE_2xna\| PDB~~=2xna ~~\| SIZE~~=400~~\| SCENE~~= \|right~~\|CAPTION~~= T-cell receptor α chain (grey), β chain (green) complex with enterotoxin (pink), glycerol and Na+ ion (purple) [[2xna]].}}	+	<StructureSection load='2xna' size='400' side='right' scene='' caption='T-cell receptor α chain (grey), β chain (green) complex with enterotoxin (pink), glycerol and Na+ ion (purple) [[2xna]].'>
		+
	== Function ==		== Function ==
	'''T-cell receptors''' (TCR) reside on the surface of T lymphocytes. TCR recognizes antigens bound to major histocompatibility complex (MHC) molecules. The binding of TCR to the antigen-MHC activates the T lymphocytes<ref>PMID:17624994</ref>. TCR is a heterodimer of α+β subunits and ca. 5% the T cells have a γ+δ subumits. TCR NKT reside in Natural Killer T-cells. For more details see [[SP3.4-TCR-HLA-DQ8-∝-1-gliadin_complex]].		'''T-cell receptors''' (TCR) reside on the surface of T lymphocytes. TCR recognizes antigens bound to major histocompatibility complex (MHC) molecules. The binding of TCR to the antigen-MHC activates the T lymphocytes<ref>PMID:17624994</ref>. TCR is a heterodimer of α+β subunits and ca. 5% the T cells have a γ+δ subumits. TCR NKT reside in Natural Killer T-cells. For more details see [[SP3.4-TCR-HLA-DQ8-∝-1-gliadin_complex]].
Line 5:		Line 6:
	== Relevance ==		== Relevance ==
	Genes encoding antigen-specific receptors into T cells can redirect their functional activity against targets including virally infected or cancer cells<ref>PMID:22610778</ref>. This technique is currently developed by several biotechnology companies and implemented in therapy.		Genes encoding antigen-specific receptors into T cells can redirect their functional activity against targets including virally infected or cancer cells<ref>PMID:22610778</ref>. This technique is currently developed by several biotechnology companies and implemented in therapy.
-		+	</StructureSection>
	== 3D structures of T-cell receptor==		== 3D structures of T-cell receptor==

Michal Harel at 09:38, 7 September 2016

Michal Harel — Wed, 07 Sep 2016 09:38:18 GMT

←Older revision		Revision as of 09:38, 7 September 2016
Line 1:		Line 1:
	{{STRUCTURE_2xna\| PDB=2xna \| SIZE=400\| SCENE= \|right\|CAPTION= T-cell receptor α chain (grey), β chain (green) complex with enterotoxin (pink), glycerol and Na+ ion (purple) [[2xna]].}}		{{STRUCTURE_2xna\| PDB=2xna \| SIZE=400\| SCENE= \|right\|CAPTION= T-cell receptor α chain (grey), β chain (green) complex with enterotoxin (pink), glycerol and Na+ ion (purple) [[2xna]].}}
		+	== Function ==
		+	'''T-cell receptors''' (TCR) reside on the surface of T lymphocytes. TCR recognizes antigens bound to major histocompatibility complex (MHC) molecules. The binding of TCR to the antigen-MHC activates the T lymphocytes<ref>PMID:17624994</ref>. TCR is a heterodimer of α+β subunits and ca. 5% the T cells have a γ+δ subumits. TCR NKT reside in Natural Killer T-cells. For more details see [[SP3.4-TCR-HLA-DQ8-∝-1-gliadin_complex]].

-	~~'''T~~-~~cell~~ receptors~~''' (TCR) reside on the surface of~~ T ~~lymphocytes~~. ~~TCR recognizes antigens bound to major histocompatibility complex (MHC) molecules. The binding of TCR to the antigen-MHC activates the T lymphocytes. TCR~~ is ~~a heterodimer of α+β subunits~~ and ~~ca. 5% the T cells have a γ+δ subumits TCR heterodimer. TCR NKT reside~~ in ~~Ntural Killer T-cells. For more details see [[SP3.4-TCR-HLA-DQ8-∝-1-gliadin_complex]]~~.	+	== Relevance ==
		+	Genes encoding antigen-specific receptors into T cells can redirect their functional activity against targets including virally infected or cancer cells<ref>PMID:22610778</ref>. This technique is currently developed by several biotechnology companies and implemented in therapy.

	== 3D structures of T-cell receptor==		== 3D structures of T-cell receptor==
Line 82:		Line 85:

	}}		}}
		+	== References ==
		+	<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

←Older revision		Revision as of 19:39, 24 September 2018
Line 1:		Line 1:
-	<StructureSection load='' size='~~400~~' side='right' scene='53/536684/Cv/1' caption='T-cell receptor α chain (deepskyblue), β chain (green) complex with enterotoxin (pink), glycerol and Na+ ion (purple) [[2xna]].'>	+	<StructureSection load='' size='350' side='right' scene='53/536684/Cv/1' caption='T-cell receptor α chain (deepskyblue), β chain (green) complex with enterotoxin (pink), glycerol and Na+ ion (purple) [[2xna]].'>

	== Function ==		== Function ==
Line 43:		Line 43:
	**[[1tcr]], [[2q86]], [[5iw1]]– mTCR α+β chains (mutant)<br />		**[[1tcr]], [[2q86]], [[5iw1]]– mTCR α+β chains (mutant)<br />
	**[[1bwm]] – mTCR α+β chains variable domains (mutant) - NMR<br />		**[[1bwm]] – mTCR α+β chains variable domains (mutant) - NMR<br />
-	**[[1kgc]], [[2nw2]], [[2vlm]], [[3dx9]], [[3mff]], [[3qeu]], [[3skn]], [[4dzb]], [[4e42]], [[4jfh]], [[4g8f]], [[4g8e]], [[4ww1]], [[4x6b]], [[4zdh]] – hTCR α+β chains<br />	+	**[[1kgc]], [[2nw2]], [[2vlm]], [[3dx9]], [[3mff]], [[3qeu]], [[3skn]], [[4dzb]], [[4e42]], [[4jfh]], [[4g8f]], [[4g8e]], [[4ww1]], [[4x6b]], [[4zdh]], [[6eh4]], [[6eh5]], [[6eh6]], [[6eh7]], [[6eh8]], [[6eh9]], [[6fr6]], [[6fr7]], [[6fr8]], [[6fr9]], [[6fra]], [[6frb]], [[6frc]], [[6fum]], [[6fun]], [[6fuo]], [[6fup]], [[6fuq]], [[6fur]], [[6at6]], [[6fr3]], [[6fr4]], [[6fr5]] – hTCR α+β chains<br />
	**[[4ei6]] – h/mTCR α+β chains <br />		**[[4ei6]] – h/mTCR α+β chains <br />
	**[[2ial]], [[4gg8]], [[4onh]] – hTCR α+β chains (mutant)<br />		**[[2ial]], [[4gg8]], [[4onh]] – hTCR α+β chains (mutant)<br />
Line 65:		Line 65:
	*TCR complex with MHC and antigen		*TCR complex with MHC and antigen

-	**[[1ao7]], [[1bd2]], [[1qrn]], [[1qse]], [[1qsf]], [[1mi5]], [[1oga]], [[1lp9]], [[2bnq]], [[2bnr]], [[2bnu]], [[2ak4]], [[2esv]], [[2f53]], [[2f54]], [[2gj6]], [[2nx5]], [[2p5e]], [[2p5w]], [[2pye]], [[2pyf]], [[3dxa]], [[3hg1]], [[3gsn]], [[3kpr]], [[3kps]], [[3kxf]], [[3o4l]], [[3qdg]], [[3qdj]], [[3qdm]], [[3qeq]], [[3sjv]], [[2ypl]], [[4jff]], [[4jfe]], [[4jfd]], [[4jry]], [[4jrx]], [[2jcc]], [[3d39]], [[3d3v]], [[4mji]], [[4prh]], [[4pri]], [[4prp]], [[5brz]], [[5bs0]], [[5c07]], [[5c08]], [[5c09]], [[5c0a]], [[5c0b]], [[5c0c]], [[5e6i]], [[5eu6]], [[5hhm]], [[5hho]], [[5hyj]], [[5ivx]], [[5ks9]], [[5ksa]], [[5ksb]], [[5m01]], [[5w1v]], [[5w1w]], [[5wkf]], [[5wkh]] – hTCR α+β chains + MHC + β-2 microglobulin + polypeptide <br />	+	**[[1ao7]], [[1bd2]], [[1qrn]], [[1qse]], [[1qsf]], [[1mi5]], [[1oga]], [[1lp9]], [[2bnq]], [[2bnr]], [[2bnu]], [[2ak4]], [[2esv]], [[2f53]], [[2f54]], [[2gj6]], [[2nx5]], [[2p5e]], [[2p5w]], [[2pye]], [[2pyf]], [[3dxa]], [[3hg1]], [[3gsn]], [[3kpr]], [[3kps]], [[3kxf]], [[3o4l]], [[3qdg]], [[3qdj]], [[3qdm]], [[3qeq]], [[3sjv]], [[2ypl]], [[4jff]], [[4jfe]], [[4jfd]], [[4jry]], [[4jrx]], [[2jcc]], [[3d39]], [[3d3v]], [[4mji]], [[4prh]], [[4pri]], [[4prp]], [[5brz]], [[5bs0]], [[5c07]], [[5c08]], [[5c09]], [[5c0a]], [[5c0b]], [[5c0c]], [[5e6i]], [[5eu6]], [[5hhm]], [[5hho]], [[5hyj]], [[5ivx]], [[5ks9]], [[5ksa]], [[5ksb]], [[5m01]], [[5w1v]], [[5w1w]], [[5wkf]], [[5wkh]], [[6at5]], [[6avf]], [[6avg]], [[6bj2]], [[6bj3]], [[6bj8]] – hTCR α+β chains + MHC + β-2 microglobulin + polypeptide <br />
	**[[4nqc]], [[4nqd]], [[4nqe]] – hTCR α+β chains + MHC + β-2 microglobulin + antigen <br />		**[[4nqc]], [[4nqd]], [[4nqe]] – hTCR α+β chains + MHC + β-2 microglobulin + antigen <br />
	**[[1fyt]], [[1ymm]], [[1zgl]], [[4e41]], [[4z7u]], [[4z7v]], [[4z7w]] – hTCR α+β chains + MHC + polypeptide <br />		**[[1fyt]], [[1ymm]], [[1zgl]], [[4e41]], [[4z7u]], [[4z7v]], [[4z7w]] – hTCR α+β chains + MHC + polypeptide <br />
Line 75:		Line 75:
	**[[2iam]], [[2ian]] – hTCR α+β chains (mutant) + MHC + polypeptide <br />		**[[2iam]], [[2ian]] – hTCR α+β chains (mutant) + MHC + polypeptide <br />
	**[[1j8h]], [[4gg6]] – hTCR α+β chains (mutant) + MHC + polypeptide <br />		**[[1j8h]], [[4gg6]] – hTCR α+β chains (mutant) + MHC + polypeptide <br />
-	**[[5xov]] – hTCR δ+β chains + MHC + β-2 microglobulin + polypeptide <br />	+	**[[5xov]], [[5xot]] – hTCR δ+β chains + MHC + β-2 microglobulin + polypeptide <br />
	**[[4l4t]], [[4l4v]], [[4l8s]], [[4l9l]], [[4lcc]], [[4lcw]], [[5u1r]], [[5u2v]], [[5u6q]], [[5u72]] – hTCR MAIT α+β chains + MHC + β-2 microglobulin <br />		**[[4l4t]], [[4l4v]], [[4l8s]], [[4l9l]], [[4lcc]], [[4lcw]], [[5u1r]], [[5u2v]], [[5u6q]], [[5u72]] – hTCR MAIT α+β chains + MHC + β-2 microglobulin <br />
	**[[2ckb]], [[1fo0]], [[1g6r]], [[1kj2]], [[1mwa]], [[1nam]], [[2ol3]], [[2j8u]], [[5til]], [[5tje]] – mTCR α+β chains + MHC + β-2 microglobulin + polypeptide <br />		**[[2ckb]], [[1fo0]], [[1g6r]], [[1kj2]], [[1mwa]], [[1nam]], [[2ol3]], [[2j8u]], [[5til]], [[5tje]] – mTCR α+β chains + MHC + β-2 microglobulin + polypeptide <br />
Line 81:		Line 81:
	**[[2pxy]] – mTCR α+β chains (mutant) + MHC + β-2 microglobulin + polypeptide <br />		**[[2pxy]] – mTCR α+β chains (mutant) + MHC + β-2 microglobulin + polypeptide <br />
	**[[2icw]] – mTCR α+β chains + MHC + mycoplasma arthritidis mitogen + polypeptide <br />		**[[2icw]] – mTCR α+β chains + MHC + mycoplasma arthritidis mitogen + polypeptide <br />
-	**[[1d9k]], [[2e7l]], [[2oi9]], [[2z31]], [[3e2h]], [[3e3q]], [[3qib]], [[3mbe]] – mTCR α+β chains + MHC + polypeptide <br />	+	**[[1d9k]], [[2e7l]], [[2oi9]], [[2z31]], [[3e2h]], [[3e3q]], [[3qib]], [[3mbe]], [[6bga]] – mTCR α+β chains + MHC + polypeptide <br />
	**[[1u3h]] – mTCR α+β chains (mutant) + MHC + polypeptide <br />		**[[1u3h]] – mTCR α+β chains (mutant) + MHC + polypeptide <br />
	**[[1ypz]] – hTCR γ+δ chains + MHC + β-2 microglobulin <br />		**[[1ypz]] – hTCR γ+δ chains + MHC + β-2 microglobulin <br />
Line 89:		Line 89:
	**[[4x6c]], [[4x6d]] – hTCR α+β chains + β-2 microglobulin + CD1A <br />		**[[4x6c]], [[4x6d]] – hTCR α+β chains + β-2 microglobulin + CD1A <br />
	**[[5wki]] – hTCR α+β chains + β-2 microglobulin + CD1B <br />		**[[5wki]] – hTCR α+β chains + β-2 microglobulin + CD1B <br />
		+	**[[6c09]] – hTCR α+β chains + β-2 microglobulin + CD1C <br />
	**[[3huj]], [[3vwj]], [[3vwk]], [[4en3]], [[4ww2]], [[4wwk]] – hTCR NKT α+β chains + β-2 microglobulin + CD1D <br />		**[[3huj]], [[3vwj]], [[3vwk]], [[4en3]], [[4ww2]], [[4wwk]] – hTCR NKT α+β chains + β-2 microglobulin + CD1D <br />
	**[[3tzv]] – hTCR NKT α+β chains (mutant) + β-2 microglobulin + CD1D <br />		**[[3tzv]] – hTCR NKT α+β chains (mutant) + β-2 microglobulin + CD1D <br />