Tacrine - Revision history

Joel L. Sussman at 09:28, 20 January 2022

Joel L. Sussman — Thu, 20 Jan 2022 09:28:26 GMT

←Older revision		Revision as of 09:28, 20 January 2022
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	* See: [[Pharmaceutical Drugs]] for more information about other drugs and disorders		* See: [[Pharmaceutical Drugs]] for more information about other drugs and disorders

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-	<scene name='42/428172/Ache/1'>TextToBeDisplayed</scene>

	===Mechanism of Action===		===Mechanism of Action===

Joel L. Sussman at 09:23, 20 January 2022

Joel L. Sussman — Thu, 20 Jan 2022 09:23:34 GMT

←Older revision		Revision as of 09:23, 20 January 2022
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	* Importance: One of the the first treatments for the symptoms of [[Alzheimer's Disease]], although no definitive proof exists as to whether it alters the progression of the disease.		* Importance: One of the the first treatments for the symptoms of [[Alzheimer's Disease]], although no definitive proof exists as to whether it alters the progression of the disease.
	* See: [[Pharmaceutical Drugs]] for more information about other drugs and disorders		* See: [[Pharmaceutical Drugs]] for more information about other drugs and disorders
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		+	<scene name='42/428172/Ache/1'>TextToBeDisplayed</scene>

	===Mechanism of Action===		===Mechanism of Action===

David Canner at 20:36, 9 December 2010

David Canner — Thu, 09 Dec 2010 20:36:52 GMT

←Older revision		Revision as of 20:36, 9 December 2010
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	===Pharmacokinetics===		===Pharmacokinetics===
-	<table style="background: cellspacing="0px" align="" cellpadding="0px" width="47%">	+	<table style="background: cellspacing="0px" align="" cellpadding="0px" width="42%">
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	<td style="width:100%; vertical-align:top;border-width:0px; border-style:inset">		<td style="width:100%; vertical-align:top;border-width:0px; border-style:inset">

David Canner at 20:30, 9 December 2010

David Canner — Thu, 09 Dec 2010 20:30:47 GMT

←Older revision		Revision as of 20:30, 9 December 2010
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	Tacrine is an [[Acetylcholinesterase]] (AChE) inhibitor. It binds to the active site of <scene name='Tacrine/Ache/1'>AChE</scene>, utilizing many of the same residues which <scene name='Tacrine/Ac/1'>bind and break down acetylcholine</scene>. By inhibiting AChE, the important neurotransmitter, [[acetylcholine]], is degraded at a slower rate, helping reverse the marked decrease in neuronal function evident in [[Alzheimer's Disease]] patients. Tacrine <scene name='Tacrine/Bound/2'>primarily interacts with residues</scene> Phe 330, His 440, Trp 84, & Ser 200 in tightly binding to the AChE binding site via pi stacking interactions. It is clearly visible how <scene name='Tacrine/Inter/3'>Tacrine interferes</scene> with the binding of acetylcholine, outcompeting acetylcholine for nearly the same space in the active site. <ref>PMID:8415649</ref>		Tacrine is an [[Acetylcholinesterase]] (AChE) inhibitor. It binds to the active site of <scene name='Tacrine/Ache/1'>AChE</scene>, utilizing many of the same residues which <scene name='Tacrine/Ac/1'>bind and break down acetylcholine</scene>. By inhibiting AChE, the important neurotransmitter, [[acetylcholine]], is degraded at a slower rate, helping reverse the marked decrease in neuronal function evident in [[Alzheimer's Disease]] patients. Tacrine <scene name='Tacrine/Bound/2'>primarily interacts with residues</scene> Phe 330, His 440, Trp 84, & Ser 200 in tightly binding to the AChE binding site via pi stacking interactions. It is clearly visible how <scene name='Tacrine/Inter/3'>Tacrine interferes</scene> with the binding of acetylcholine, outcompeting acetylcholine for nearly the same space in the active site. <ref>PMID:8415649</ref>

-	<table style="background: cellspacing="0px" align="" cellpadding="0px" width="40%">	+	===Pharmacokinetics===
		+	<table style="background: cellspacing="0px" align="" cellpadding="0px" width="47%">
	<tr>		<tr>
	<td style="width:100%; vertical-align:top;border-width:0px; border-style:inset">		<td style="width:100%; vertical-align:top;border-width:0px; border-style:inset">

David Canner at 20:26, 9 December 2010

David Canner — Thu, 09 Dec 2010 20:26:51 GMT

←Older revision		Revision as of 20:26, 9 December 2010
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	Tacrine is an [[Acetylcholinesterase]] (AChE) inhibitor. It binds to the active site of <scene name='Tacrine/Ache/1'>AChE</scene>, utilizing many of the same residues which <scene name='Tacrine/Ac/1'>bind and break down acetylcholine</scene>. By inhibiting AChE, the important neurotransmitter, [[acetylcholine]], is degraded at a slower rate, helping reverse the marked decrease in neuronal function evident in [[Alzheimer's Disease]] patients. Tacrine <scene name='Tacrine/Bound/2'>primarily interacts with residues</scene> Phe 330, His 440, Trp 84, & Ser 200 in tightly binding to the AChE binding site via pi stacking interactions. It is clearly visible how <scene name='Tacrine/Inter/3'>Tacrine interferes</scene> with the binding of acetylcholine, outcompeting acetylcholine for nearly the same space in the active site. <ref>PMID:8415649</ref>		Tacrine is an [[Acetylcholinesterase]] (AChE) inhibitor. It binds to the active site of <scene name='Tacrine/Ache/1'>AChE</scene>, utilizing many of the same residues which <scene name='Tacrine/Ac/1'>bind and break down acetylcholine</scene>. By inhibiting AChE, the important neurotransmitter, [[acetylcholine]], is degraded at a slower rate, helping reverse the marked decrease in neuronal function evident in [[Alzheimer's Disease]] patients. Tacrine <scene name='Tacrine/Bound/2'>primarily interacts with residues</scene> Phe 330, His 440, Trp 84, & Ser 200 in tightly binding to the AChE binding site via pi stacking interactions. It is clearly visible how <scene name='Tacrine/Inter/3'>Tacrine interferes</scene> with the binding of acetylcholine, outcompeting acetylcholine for nearly the same space in the active site. <ref>PMID:8415649</ref>

-	~~===Pharmacokinetics===~~	+	<table style="background: cellspacing="0px" align="" cellpadding="0px" width="40%">
-	<table style="background: cellspacing="0px" align="" cellpadding="0px" width="47%">	+
	<tr>		<tr>
	<td style="width:100%; vertical-align:top;border-width:0px; border-style:inset">		<td style="width:100%; vertical-align:top;border-width:0px; border-style:inset">

David Canner at 20:22, 9 December 2010

David Canner — Thu, 09 Dec 2010 20:22:53 GMT

←Older revision		Revision as of 20:22, 9 December 2010
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	===Pharmacokinetics===		===Pharmacokinetics===
-	<table style="background: cellspacing="0px" align="" cellpadding="0px" width="50%">	+	<table style="background: cellspacing="0px" align="" cellpadding="0px" width="47%">
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David Canner at 20:22, 9 December 2010

David Canner — Thu, 09 Dec 2010 20:22:43 GMT

←Older revision		Revision as of 20:22, 9 December 2010
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	===Pharmacokinetics===		===Pharmacokinetics===
-	<table style="background: cellspacing="0px" align="" cellpadding="0px" width="30%">	+	<table style="background: cellspacing="0px" align="" cellpadding="0px" width="50%">
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David Canner at 20:18, 9 December 2010

David Canner — Thu, 09 Dec 2010 20:18:04 GMT

←Older revision		Revision as of 20:18, 9 December 2010
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	===Pharmacokinetics===		===Pharmacokinetics===
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David Canner at 20:17, 9 December 2010

David Canner — Thu, 09 Dec 2010 20:17:48 GMT

←Older revision		Revision as of 20:17, 9 December 2010
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	===Pharmacokinetics===		===Pharmacokinetics===
-	<table style="background: cellspacing="0px" align="" cellpadding="0px" width="43%">	+	<table style="background: cellspacing="0px" align="left" cellpadding="0px" width="43%">
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David Canner at 20:15, 9 December 2010

David Canner — Thu, 09 Dec 2010 20:15:43 GMT

←Older revision		Revision as of 20:15, 9 December 2010
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	===Pharmacokinetics===		===Pharmacokinetics===
-	<table style="background: cellspacing="0px" align="" cellpadding="0px" width="45%">	+	<table style="background: cellspacing="0px" align="" cellpadding="0px" width="43%">
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