Transcription initiation factor - Revision history

Michal Harel at 08:52, 4 March 2020

Michal Harel — Wed, 04 Mar 2020 08:52:08 GMT

←Older revision		Revision as of 08:52, 4 March 2020
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	</StructureSection>		</StructureSection>

-	==3D structures of transcription initiation factors==
-
-	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-	{{#tree:id=OrganizedByTopic\|openlevels=0\|
-
-	*TFIIA
-
-	**[[5m4s]] – hTFIIA – human<br />
-	**[[6mzm]] – hTFIIA+TFIID + TBP + DNA – Cryo EM<br />
-	**[[1nvp]] – hTFIIA + TBP + DNA <br />
-	**[[5fur]] – hTFIIA + hTFIIF + TBP + DNA - CryoEM<br />
-	**[[1ytf]], [[1nh2]], [[1rm1]] – yTFIIA + TBP + DNA – yeast<br />
-
-	*TFIIB
-
-	**[[1tfb]] – hTFIIB - NMR<BR />
-	**[[1dl6]] - hTFIIB N terminal – NMR<br />
-	**[[5wh1]] - hTFIIB C terminal <br />
-	**[[1rly]] - hTFIIB Zn ribbon domain + Zn – NMR<br />
-	**[[1ro4]] - hTFIIB Zn ribbon domain – NMR<br />
-	**[[1ais]], [[1d3u]] - TFIIB C terminal + TBP + DNA – ''Pyrococcus woesei''<br />
-	**[[1pft]] – TFIIB N terminal – ''Pyrococcus furiosus'' – NMR<BR />
-	**[[5o9j]], [[5o9i]] - TFIIB – ''Methanocaldococcus jannaschii'' <br />
-
-	*TFIIA+TFIIB
-
-	**[[6o9l]] – hTFIIA+TFIIB in RNA polymerase II – Cryo EM<br />
-
-	*TFIIIB
-
-	**[[5n9g]] – hTFIIIB + TBP + DNA<br />
-	**[[6f44]], [[6f42]], [[6f41]], [[6f40]], [[6eu0]], [[6cnf]], [[6cnd]], [[6cnc]], [[6cnb]] – yTFIIIB + RNA polymerase III – Cryo EM<br />
-
-	*TFIID
-
-	**[[1bh8]] – hTFIID<BR />
-	**[[1eqf]] – hTFIID subunit 1<br />
-	**[[6fic]] – hTFIID subunit 1 + inhibitor<br />
-	**[[3uv5]] – hTFIID subunit 1 bromodomain 1-2<br />
-	**[[3uv4]] – hTFIID subunit 1 bromodomain 2<br />
-	**[[6bqd]] – hTFIID subunit 1 bromodomain 2 + inhibitor <br />
-	**[[3aad]] – hTFIID subunit 1 bromodomain 1-2 + histone chaperone ASF1A<br />
-	**[[5mg2]] – hTFIID subunit 1 bromodomain 2 + inhibitor<br />
-	**[[4yym]], [[4yyn]] – hTFIID subunit 1 bromodomain 2 + histone peptide<br />
-	**[[5c13]], [[5wxg]], [[5mxy]] – hTFIID subunit 3 PHD finger + histone peptide<br />
-	**[[5wxh]] – hTFIID subunit 3 PHD finger + histone peptide<br />
-	**[[5i1q]], [[5i29]] – hTFIID subunit 1 bromodomain 2 + pyrrolopyridone<br />
-	**[[5eg2]] - hTFIID subunit 10 + SETD7 + SAH<br />
-	**[[4wv4]] - hTFIID subunits 8+10 <br />
-	**[[4grw]] - hTFIID subunits 1+7 <br />
-	**[[6f39]] - hTFIID subunits 5+6+9 <br />
-	**[[6mzl]] - hTFIID subunits 1-13 + TBP – Cryo EM<br />
-	**[[6mzd]] - hTFIID subunits 1,3-6,9-13 + TBP – Cryo EM<br />
-	**[[6mzc]] - hTFIID subunits 2,4-6,8-12 – Cryo EM<br />
-	**[[1bh9]] – hTFIID + PCMBS<BR />
-	**[[6df7]], [[6df4]] – TFIID subunit 1 bromodomain 2 + inhibitor - rabbit<br />
-	**[[1tba]] – TFIID – ''Drosophila melanogaster'' - NMR<BR />
-	**[[1qn3]], [[1qn4]], [[1qn5]], [[1qn6]], [[1qn7]], [[1qn8]], [[1qn9]], [[1qna]], [[1qnb]], [[1qnc]], [[1qne]] – TFIID + DNA – ''Arabidopsis thaliana''<br />
-	**[[4oy2]] - yTFIID subunits 1+7 <br />
-	**[[6mip]] - yTFIID subunits 14 <br />
-	**[[5iok]], [[5o7e]], [[6miq]], [[6mio]], [[6min]] – yTFIID subunit 14 + histone peptide<br />
-	**[[6t9j]] - yTFIID subunit 12 + Spt20 + transcription-associated protein – Cryo EM <br />
-	**[[6t9k]], [[6t9i]] - yTFIID in SAGA complex – Cryo EM <br />
-	**[[6tbm]], [[6tb4]] - TFIID in SAGA complex – ''Komagataella phaffii'' – Cryo EM <br />
-
-	*TFIIE
-
-	**[[5gpy]] - hTFIIE subunits α+β<br />
-	**[[1vd4]] - hTFIIE Zn finger domain – NMR<br />
-	**[[2rnq]] – hTFIIE C terminal - NMR<br />
-	**[[2rnr]] – hTFIIE C terminal + TFIIH PH domain- NMR<br />
-
-	*TFIIF
-
-	**[[1f3u]] – hTFIIF<br />
-	**[[1nha]] – hTFIIF C terminal - NMR<br />
-	**[[1i27]] – hTFIIF C terminal (mutant)<br />
-	**[[1j2x]] – hTFIIF C terminal + RNA polymerase CTD phosphatase peptide<br />
-	**[[1onv]] – hTFIIF C terminal + serine phosphatase peptide - NMR<br />
-	**[[2k7l]] – hTFIIF C terminal + FCP1 peptide - NMR<br />
-
-	*TF in RNA polymerase II
-
-	**[[5iy6]], [[5iy7]], [[5iy8]], [[5iy9]], [[5iya]], [[5iyb]], [[5iyc]], [[5iyd]] – hTFIIA + hTFIIB + hTFIIE + hTFIIF + hTFIIH + DNA – Cryo EM<br />
-	**[[5fyw]] – yTFIIA + yTFIIE + yTFIIF + DNA <br />
-	**[[5fz5]], [[6gym]], [[6gyl]] – yTFIIA + yTFIIE + yTFIIF + DNA – Cryo EM<br />
-	**[[6gyk]] – yTFIIA + yTFIIB + yTFIIF + DNA – Cryo EM<br />
-	**[[4v1o]], [[4v1n]] – yTFIIB + yTFIIF – Cryo EM<br />
-	**[[3k1f]], [[3k7a]], [[4bbr]], [[4bbs]] – yTFIIB <br />
-	**[[5fmf]], [[5sva]], [[5oqj]], [[5oqm]] – yTFIIA + yTFIIB + yTFIIE + yTFIIF + yTFIIH + DNA – Cryo EM<br />
-
-	*TF RRN in RNA polymerase I
-
-	**[[5o7x]] – yTF RRN6+RRN7+RRN11 <br />
-	**[[5g5l]] – yTF RRN3 in RNA polymerase I<br />
-	**[[6rrd]], [[6rqt]] – yTF RRN3 in RNA polymerase I – Cryo EM<br />
-	**[[6ruo]] – yTF RRN3+RRN6+RRN11 in RNA polymerase I – Cryo EM<br />
-	**[[5w66]], [[5w65]], [[5w64]], [[5w5y]], [[5oa1]] – yTF RRN6+RRN7+RRN11 in RNA polymerase I – Cryo EM<br />
-	**[[6rwe]], [[6rui]], [[6rql]], [[6rqh]], [[5n61]], [[5n60]], [[5n5z]], [[5n5y]] – yTF RRN3+RRN6+RRN7+RRN11 in RNA polymerase I – Cryo EM<br />
-
-
-	}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 08:50, 4 March 2020

Michal Harel — Wed, 04 Mar 2020 08:50:58 GMT

←Older revision		Revision as of 08:50, 4 March 2020
Line 4:		Line 4:
	* '''TFIIA''' is one of several TFs which are required for transcription. TFIIA aids in binding the TATA-binding protein (TBP) to the TATA box containing sequence of the DNA.<br />		* '''TFIIA''' is one of several TFs which are required for transcription. TFIIA aids in binding the TATA-binding protein (TBP) to the TATA box containing sequence of the DNA.<br />
	* '''TFIIB''' bridges between TFIID and RNA polymerase II<ref>PMID:1876184</ref>.<br />		* '''TFIIB''' bridges between TFIID and RNA polymerase II<ref>PMID:1876184</ref>.<br />
		+	* '''TFIIIB''' is the core RNA polymerase III initiation factor. It recruits pol III to the transcriptional start site<ref>PMID:17073756</ref>.<br />
	* '''TFIID''' recognizes the promoter sequence on the DNA.<br />		* '''TFIID''' recognizes the promoter sequence on the DNA.<br />
	* '''TFIIE''' both subunits are are essential to form a preinitiation complex.<ref>PMID:1956398</ref><br />		* '''TFIIE''' both subunits are are essential to form a preinitiation complex.<ref>PMID:1956398</ref><br />
	* '''TFIIF''' binds RNA polymerase III prohibiting it to bind to DNA outside the promoter.<br />		* '''TFIIF''' binds RNA polymerase III prohibiting it to bind to DNA outside the promoter.<br />
-	* '''TF ~~RRN3~~''' ~~initiates~~ transcription by RNA polymerase I in yeast.<ref>PMID:8670901</ref><br />	+	* '''TF RRN''' initiate transcription by RNA polymerase I in yeast.<ref>PMID:8670901</ref><br />

	<scene name='51/517377/Cv/3'>Human TFIIB complex with TATA-binding protein and DNA</scene> (PDB entry [[1vol]]).		<scene name='51/517377/Cv/3'>Human TFIIB complex with TATA-binding protein and DNA</scene> (PDB entry [[1vol]]).
		+	==3D structures of transcription initiation factors==
		+	[[Transcription initiation factors 3D structures]]
		+
	</StructureSection>		</StructureSection>

Line 19:		Line 23:
	*TFIIA		*TFIIA

		+	**[[5m4s]] – hTFIIA – human<br />
		+	**[[6mzm]] – hTFIIA+TFIID + TBP + DNA – Cryo EM<br />
		+	**[[1nvp]] – hTFIIA + TBP + DNA <br />
		+	**[[5fur]] – hTFIIA + hTFIIF + TBP + DNA - CryoEM<br />
	**[[1ytf]], [[1nh2]], [[1rm1]] – yTFIIA + TBP + DNA – yeast<br />		**[[1ytf]], [[1nh2]], [[1rm1]] – yTFIIA + TBP + DNA – yeast<br />
-	**[[5m4s]] – hTFIIA – human<br />
-	**[[1nvp]] – hTFIIA + TATA-binding protein + DNA <br />
-	**[[5fur]] – hTFIIA + hTFIIF + TATA-binding protein + DNA - CryoEM<br />

	*TFIIB		*TFIIB

-	**[[1pft]] – TFIIB N terminal – ''Pyrococcus furiosus'' – NMR<BR />
	**[[1tfb]] – hTFIIB - NMR<BR />		**[[1tfb]] – hTFIIB - NMR<BR />
	**[[1dl6]] - hTFIIB N terminal – NMR<br />		**[[1dl6]] - hTFIIB N terminal – NMR<br />
		+	**[[5wh1]] - hTFIIB C terminal <br />
	**[[1rly]] - hTFIIB Zn ribbon domain + Zn – NMR<br />		**[[1rly]] - hTFIIB Zn ribbon domain + Zn – NMR<br />
	**[[1ro4]] - hTFIIB Zn ribbon domain – NMR<br />		**[[1ro4]] - hTFIIB Zn ribbon domain – NMR<br />
-	**[[1ais]], [[1d3u]] - TFIIB C terminal + TBP + DNA – ''Pyrococcus woesei''	+	**[[1ais]], [[1d3u]] - TFIIB C terminal + TBP + DNA – ''Pyrococcus woesei''<br />
		+	**[[1pft]] – TFIIB N terminal – ''Pyrococcus furiosus'' – NMR<BR />
		+	**[[5o9j]], [[5o9i]] - TFIIB – ''Methanocaldococcus jannaschii'' <br />
		+
		+	*TFIIA+TFIIB
		+
		+	**[[6o9l]] – hTFIIA+TFIIB in RNA polymerase II – Cryo EM<br />
		+
		+	*TFIIIB
		+
		+	**[[5n9g]] – hTFIIIB + TBP + DNA<br />
		+	**[[6f44]], [[6f42]], [[6f41]], [[6f40]], [[6eu0]], [[6cnf]], [[6cnd]], [[6cnc]], [[6cnb]] – yTFIIIB + RNA polymerase III – Cryo EM<br />

	*TFIID		*TFIID
Line 37:		Line 53:
	**[[1bh8]] – hTFIID<BR />		**[[1bh8]] – hTFIID<BR />
	**[[1eqf]] – hTFIID subunit 1<br />		**[[1eqf]] – hTFIID subunit 1<br />
		+	**[[6fic]] – hTFIID subunit 1 + inhibitor<br />
	**[[3uv5]] – hTFIID subunit 1 bromodomain 1-2<br />		**[[3uv5]] – hTFIID subunit 1 bromodomain 1-2<br />
	**[[3uv4]] – hTFIID subunit 1 bromodomain 2<br />		**[[3uv4]] – hTFIID subunit 1 bromodomain 2<br />
		+	**[[6bqd]] – hTFIID subunit 1 bromodomain 2 + inhibitor <br />
	**[[3aad]] – hTFIID subunit 1 bromodomain 1-2 + histone chaperone ASF1A<br />		**[[3aad]] – hTFIID subunit 1 bromodomain 1-2 + histone chaperone ASF1A<br />
	**[[5mg2]] – hTFIID subunit 1 bromodomain 2 + inhibitor<br />		**[[5mg2]] – hTFIID subunit 1 bromodomain 2 + inhibitor<br />
	**[[4yym]], [[4yyn]] – hTFIID subunit 1 bromodomain 2 + histone peptide<br />		**[[4yym]], [[4yyn]] – hTFIID subunit 1 bromodomain 2 + histone peptide<br />
-	**[[5c13]], [[5wxg]] – hTFIID subunit 3 + histone peptide<br />	+	**[[5c13]], [[5wxg]], [[5mxy]] – hTFIID subunit 3 PHD finger + histone peptide<br />
	**[[5wxh]] – hTFIID subunit 3 PHD finger + histone peptide<br />		**[[5wxh]] – hTFIID subunit 3 PHD finger + histone peptide<br />
	**[[5i1q]], [[5i29]] – hTFIID subunit 1 bromodomain 2 + pyrrolopyridone<br />		**[[5i1q]], [[5i29]] – hTFIID subunit 1 bromodomain 2 + pyrrolopyridone<br />
Line 48:		Line 66:
	**[[4wv4]] - hTFIID subunits 8+10 <br />		**[[4wv4]] - hTFIID subunits 8+10 <br />
	**[[4grw]] - hTFIID subunits 1+7 <br />		**[[4grw]] - hTFIID subunits 1+7 <br />
-	**[[~~4oy2~~]] - ~~yTFIID~~ subunits 1+7 <br />	+	**[[6f39]] - hTFIID subunits 5+6+9 <br />
-	**[[~~5iok~~]], [[~~5o7e~~]] ~~– yTFIID subunit 14~~ + ~~histone peptide~~<br />	+	**[[6mzl]] - hTFIID subunits 1-13 + TBP – Cryo EM<br />
-	**[[~~1tba~~]] ~~– TFIID – ''Drosophila melanogaster''~~ - ~~NMR~~<BR />	+	**[[6mzd]] - hTFIID subunits 1,3-6,9-13 + TBP – Cryo EM<br />
		+	**[[6mzc]] - hTFIID subunits 2,4-6,8-12 – Cryo EM<br />
	**[[1bh9]] – hTFIID + PCMBS<BR />		**[[1bh9]] – hTFIID + PCMBS<BR />
-	**[[1qn3]], [[1qn4]], [[1qn5]], [[1qn6]], [[1qn7]], [[1qn8]], [[1qn9]], [[1qna]], [[1qnb]], [[1qnc]], [[1qne]] – TFIID + DNA – ''Arabidopsis thaliana''	+	**[[6df7]], [[6df4]] – TFIID subunit 1 bromodomain 2 + inhibitor - rabbit<br />
		+	**[[1tba]] – TFIID – ''Drosophila melanogaster'' - NMR<BR />
		+	**[[1qn3]], [[1qn4]], [[1qn5]], [[1qn6]], [[1qn7]], [[1qn8]], [[1qn9]], [[1qna]], [[1qnb]], [[1qnc]], [[1qne]] – TFIID + DNA – ''Arabidopsis thaliana''<br />
		+	**[[4oy2]] - yTFIID subunits 1+7 <br />
		+	**[[6mip]] - yTFIID subunits 14 <br />
		+	**[[5iok]], [[5o7e]], [[6miq]], [[6mio]], [[6min]] – yTFIID subunit 14 + histone peptide<br />
		+	**[[6t9j]] - yTFIID subunit 12 + Spt20 + transcription-associated protein – Cryo EM <br />
		+	**[[6t9k]], [[6t9i]] - yTFIID in SAGA complex – Cryo EM <br />
		+	**[[6tbm]], [[6tb4]] - TFIID in SAGA complex – ''Komagataella phaffii'' – Cryo EM <br />

	*TFIIE		*TFIIE
Line 72:		Line 99:
	*TF in RNA polymerase II		*TF in RNA polymerase II

		+	**[[5iy6]], [[5iy7]], [[5iy8]], [[5iy9]], [[5iya]], [[5iyb]], [[5iyc]], [[5iyd]] – hTFIIA + hTFIIB + hTFIIE + hTFIIF + hTFIIH + DNA – Cryo EM<br />
	**[[5fyw]] – yTFIIA + yTFIIE + yTFIIF + DNA <br />		**[[5fyw]] – yTFIIA + yTFIIE + yTFIIF + DNA <br />
-	**[[5fz5]] – yTFIIA + yTFIIE + yTFIIF + DNA – Cryo EM<br />	+	**[[5fz5]], [[6gym]], [[6gyl]] – yTFIIA + yTFIIE + yTFIIF + DNA – Cryo EM<br />
		+	**[[6gyk]] – yTFIIA + yTFIIB + yTFIIF + DNA – Cryo EM<br />
	**[[4v1o]], [[4v1n]] – yTFIIB + yTFIIF – Cryo EM<br />		**[[4v1o]], [[4v1n]] – yTFIIB + yTFIIF – Cryo EM<br />
	**[[3k1f]], [[3k7a]], [[4bbr]], [[4bbs]] – yTFIIB <br />		**[[3k1f]], [[3k7a]], [[4bbr]], [[4bbs]] – yTFIIB <br />
-	**[[5iy6]], [[5iy7]], [[5iy8]], [[5iy9]], [[5iya]], [[5iyb]], [[5iyc]], [[5iyd]] – hTFIIA + hTFIIB + hTFIIE + hTFIIF + hTFIIH + DNA – Cryo EM<br />
	**[[5fmf]], [[5sva]], [[5oqj]], [[5oqm]] – yTFIIA + yTFIIB + yTFIIE + yTFIIF + yTFIIH + DNA – Cryo EM<br />		**[[5fmf]], [[5sva]], [[5oqj]], [[5oqm]] – yTFIIA + yTFIIB + yTFIIE + yTFIIF + yTFIIH + DNA – Cryo EM<br />

-	*TF ~~RRN3~~	+	*TF RRN in RNA polymerase I

		+	**[[5o7x]] – yTF RRN6+RRN7+RRN11 <br />
	**[[5g5l]] – yTF RRN3 in RNA polymerase I<br />		**[[5g5l]] – yTF RRN3 in RNA polymerase I<br />
		+	**[[6rrd]], [[6rqt]] – yTF RRN3 in RNA polymerase I – Cryo EM<br />
		+	**[[6ruo]] – yTF RRN3+RRN6+RRN11 in RNA polymerase I – Cryo EM<br />
		+	**[[5w66]], [[5w65]], [[5w64]], [[5w5y]], [[5oa1]] – yTF RRN6+RRN7+RRN11 in RNA polymerase I – Cryo EM<br />
		+	**[[6rwe]], [[6rui]], [[6rql]], [[6rqh]], [[5n61]], [[5n60]], [[5n5z]], [[5n5y]] – yTF RRN3+RRN6+RRN7+RRN11 in RNA polymerase I – Cryo EM<br />

Alexander Berchansky at 12:29, 25 September 2019

Alexander Berchansky — Wed, 25 Sep 2019 12:29:13 GMT

←Older revision		Revision as of 12:29, 25 September 2019
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	* '''TF RRN3''' initiates transcription by RNA polymerase I in yeast.<ref>PMID:8670901</ref><br />		* '''TF RRN3''' initiates transcription by RNA polymerase I in yeast.<ref>PMID:8670901</ref><br />

-	<scene name='51/517377/Cv/2'>Human TFIIB complex with TATA-binding protein and DNA</scene> (PDB entry [[1vol]]).	+	<scene name='51/517377/Cv/3'>Human TFIIB complex with TATA-binding protein and DNA</scene> (PDB entry [[1vol]]).
	</StructureSection>		</StructureSection>

Michal Harel at 19:18, 26 September 2018

Michal Harel — Wed, 26 Sep 2018 19:18:04 GMT

←Older revision		Revision as of 19:18, 26 September 2018
Line 1:		Line 1:
-	<StructureSection load='' size='~~400~~' side='right' caption='Structure of human TFIIB (cyan) complex with TATA-binding protein (green) and DNA (PDB entry [[1vol]])' scene='51/517377/Cv/1' pspeed='8'>	+	<StructureSection load='' size='350' side='right' caption='Structure of human TFIIB (cyan) complex with TATA-binding protein (green) and DNA (PDB entry [[1vol]])' scene='51/517377/Cv/1' pspeed='8'>

	'''Transcription initiation factors''' (TFII) are proteins which enable RNA polymerase II to bind to the DNA template in order to start the transcription process<ref>PMID:8870495</ref><ref>PMID:10022900</ref>.<br />		'''Transcription initiation factors''' (TFII) are proteins which enable RNA polymerase II to bind to the DNA template in order to start the transcription process<ref>PMID:8870495</ref><ref>PMID:10022900</ref>.<br />
Line 20:		Line 20:

	**[[1ytf]], [[1nh2]], [[1rm1]] – yTFIIA + TBP + DNA – yeast<br />		**[[1ytf]], [[1nh2]], [[1rm1]] – yTFIIA + TBP + DNA – yeast<br />
-	**[[~~5fur~~]] – ~~yTFIIA + yTFIIF~~ + TATA-binding protein + DNA ~~- CryoEM~~<br />	+	**[[5m4s]] – hTFIIA – human<br />
-	**[[~~1nvp~~]] – hTFIIA + TATA-binding protein + DNA ~~– human~~<br />	+	**[[1nvp]] – hTFIIA + TATA-binding protein + DNA <br />
		+	**[[5fur]] – hTFIIA + hTFIIF + TATA-binding protein + DNA - CryoEM<br />

	*TFIIB		*TFIIB
Line 76:		Line 77:
	**[[3k1f]], [[3k7a]], [[4bbr]], [[4bbs]] – yTFIIB <br />		**[[3k1f]], [[3k7a]], [[4bbr]], [[4bbs]] – yTFIIB <br />
	**[[5iy6]], [[5iy7]], [[5iy8]], [[5iy9]], [[5iya]], [[5iyb]], [[5iyc]], [[5iyd]] – hTFIIA + hTFIIB + hTFIIE + hTFIIF + hTFIIH + DNA – Cryo EM<br />		**[[5iy6]], [[5iy7]], [[5iy8]], [[5iy9]], [[5iya]], [[5iyb]], [[5iyc]], [[5iyd]] – hTFIIA + hTFIIB + hTFIIE + hTFIIF + hTFIIH + DNA – Cryo EM<br />
-	**[[5fmf]] – yTFIIA + yTFIIB + yTFIIE + yTFIIF + yTFIIH + DNA – Cryo EM<br />	+	**[[5fmf]], [[5sva]], [[5oqj]], [[5oqm]] – yTFIIA + yTFIIB + yTFIIE + yTFIIF + yTFIIH + DNA – Cryo EM<br />

	*TF RRN3		*TF RRN3

Joel L. Sussman at 05:09, 16 October 2017

Joel L. Sussman — Mon, 16 Oct 2017 05:09:27 GMT

←Older revision		Revision as of 05:09, 16 October 2017
Line 1:		Line 1:
-	<StructureSection load='~~1vol~~' size='400' side='right' caption='Structure of human TFIIB (cyan) complex with TATA-binding protein (green) and DNA (PDB entry [[1vol]])' scene='51/517377/Cv/1' pspeed='8'>	+	<StructureSection load='' size='400' side='right' caption='Structure of human TFIIB (cyan) complex with TATA-binding protein (green) and DNA (PDB entry [[1vol]])' scene='51/517377/Cv/1' pspeed='8'>

	'''Transcription initiation factors''' (TFII) are proteins which enable RNA polymerase II to bind to the DNA template in order to start the transcription process<ref>PMID:8870495</ref><ref>PMID:10022900</ref>.<br />		'''Transcription initiation factors''' (TFII) are proteins which enable RNA polymerase II to bind to the DNA template in order to start the transcription process<ref>PMID:8870495</ref><ref>PMID:10022900</ref>.<br />

Michal Harel at 22:39, 10 October 2017

Michal Harel — Tue, 10 Oct 2017 22:39:09 GMT

←Older revision		Revision as of 22:39, 10 October 2017
Line 39:		Line 39:
	**[[3uv4]] – hTFIID subunit 1 bromodomain 2<br />		**[[3uv4]] – hTFIID subunit 1 bromodomain 2<br />
	**[[3aad]] – hTFIID subunit 1 bromodomain 1-2 + histone chaperone ASF1A<br />		**[[3aad]] – hTFIID subunit 1 bromodomain 1-2 + histone chaperone ASF1A<br />
		+	**[[5mg2]] – hTFIID subunit 1 bromodomain 2 + inhibitor<br />
	**[[4yym]], [[4yyn]] – hTFIID subunit 1 bromodomain 2 + histone peptide<br />		**[[4yym]], [[4yyn]] – hTFIID subunit 1 bromodomain 2 + histone peptide<br />
-	**[[5c13]] – hTFIID subunit 3 + histone peptide<br />	+	**[[5c13]], [[5wxg]] – hTFIID subunit 3 + histone peptide<br />
		+	**[[5wxh]] – hTFIID subunit 3 PHD finger + histone peptide<br />
	**[[5i1q]], [[5i29]] – hTFIID subunit 1 bromodomain 2 + pyrrolopyridone<br />		**[[5i1q]], [[5i29]] – hTFIID subunit 1 bromodomain 2 + pyrrolopyridone<br />
	**[[5eg2]] - hTFIID subunit 10 + SETD7 + SAH<br />		**[[5eg2]] - hTFIID subunit 10 + SETD7 + SAH<br />
Line 53:		Line 55:
	*TFIIE		*TFIIE

-	**[[1vd4]] - ~~hTFIIB~~ Zn finger domain – NMR<br />	+	**[[5gpy]] - hTFIIE subunits α+β<br />
		+	**[[1vd4]] - hTFIIE Zn finger domain – NMR<br />
	**[[2rnq]] – hTFIIE C terminal - NMR<br />		**[[2rnq]] – hTFIIE C terminal - NMR<br />
	**[[2rnr]] – hTFIIE C terminal + TFIIH PH domain- NMR<br />		**[[2rnr]] – hTFIIE C terminal + TFIIH PH domain- NMR<br />

Alexander Berchansky at 07:55, 2 July 2017

Alexander Berchansky — Sun, 02 Jul 2017 07:55:28 GMT

←Older revision		Revision as of 07:55, 2 July 2017
Line 8:		Line 8:
	* '''TFIIF''' binds RNA polymerase III prohibiting it to bind to DNA outside the promoter.<br />		* '''TFIIF''' binds RNA polymerase III prohibiting it to bind to DNA outside the promoter.<br />
	* '''TF RRN3''' initiates transcription by RNA polymerase I in yeast.<ref>PMID:8670901</ref><br />		* '''TF RRN3''' initiates transcription by RNA polymerase I in yeast.<ref>PMID:8670901</ref><br />
		+
		+	<scene name='51/517377/Cv/2'>Human TFIIB complex with TATA-binding protein and DNA</scene> (PDB entry [[1vol]]).
	</StructureSection>		</StructureSection>

Alexander Berchansky at 07:52, 2 July 2017

Alexander Berchansky — Sun, 02 Jul 2017 07:52:14 GMT

←Older revision		Revision as of 07:52, 2 July 2017
Line 1:		Line 1:
-	<StructureSection load='1vol' size='400' side='right' caption='Structure of human TFIIB (~~grey~~) complex with TATA-binding protein (green) and DNA (PDB entry [[1vol]])' scene=''>	+	<StructureSection load='1vol' size='400' side='right' caption='Structure of human TFIIB (cyan) complex with TATA-binding protein (green) and DNA (PDB entry [[1vol]])' scene='51/517377/Cv/1' pspeed='8'>

	'''Transcription initiation factors''' (TFII) are proteins which enable RNA polymerase II to bind to the DNA template in order to start the transcription process<ref>PMID:8870495</ref><ref>PMID:10022900</ref>.<br />		'''Transcription initiation factors''' (TFII) are proteins which enable RNA polymerase II to bind to the DNA template in order to start the transcription process<ref>PMID:8870495</ref><ref>PMID:10022900</ref>.<br />

Michal Harel at 16:26, 12 January 2017

Michal Harel — Thu, 12 Jan 2017 16:26:47 GMT

←Older revision		Revision as of 16:26, 12 January 2017
Line 6:		Line 6:
	* '''TFIID''' recognizes the promoter sequence on the DNA.<br />		* '''TFIID''' recognizes the promoter sequence on the DNA.<br />
	* '''TFIIE''' both subunits are are essential to form a preinitiation complex.<ref>PMID:1956398</ref><br />		* '''TFIIE''' both subunits are are essential to form a preinitiation complex.<ref>PMID:1956398</ref><br />
-	* '''TFIIF''' binds RNA polymerase III prohibiting it to bind to DNA outside the promoter.<b />	+	* '''TFIIF''' binds RNA polymerase III prohibiting it to bind to DNA outside the promoter.<br />
	* '''TF RRN3''' initiates transcription by RNA polymerase I in yeast.<ref>PMID:8670901</ref><br />		* '''TF RRN3''' initiates transcription by RNA polymerase I in yeast.<ref>PMID:8670901</ref><br />
	</StructureSection>		</StructureSection>

Michal Harel at 10:03, 20 September 2016

Michal Harel — Tue, 20 Sep 2016 10:03:51 GMT

←Older revision		Revision as of 10:03, 20 September 2016
Line 6:		Line 6:
	* '''TFIID''' recognizes the promoter sequence on the DNA.<br />		* '''TFIID''' recognizes the promoter sequence on the DNA.<br />
	* '''TFIIE''' both subunits are are essential to form a preinitiation complex.<ref>PMID:1956398</ref><br />		* '''TFIIE''' both subunits are are essential to form a preinitiation complex.<ref>PMID:1956398</ref><br />
-	* '''TFIIF''' binds RNA polymerase III prohibiting it to bind to DNA outside the promoter.	+	* '''TFIIF''' binds RNA polymerase III prohibiting it to bind to DNA outside the promoter.<b />
		+	* '''TF RRN3''' initiates transcription by RNA polymerase I in yeast.<ref>PMID:8670901</ref><br />
	</StructureSection>		</StructureSection>