Tryptase inhibitor - Revision history

Alexander Berchansky at 13:29, 3 October 2019

Alexander Berchansky — Thu, 03 Oct 2019 13:29:26 GMT

←Older revision		Revision as of 13:29, 3 October 2019
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	== Relevance ==		== Relevance ==
	TI are used as anti-inflammatory agents in treating asthma and other airway inflammation diseases. Tryptase was found in elevated levels in various kinds of allergic inflammations.		TI are used as anti-inflammatory agents in treating asthma and other airway inflammation diseases. Tryptase was found in elevated levels in various kinds of allergic inflammations.
-	*<scene name='51/517374/Cv/2'>Tryptase inhibitor/trypsin interactions</scene> (PDB entry [[1ldt]]).	+	*<scene name='51/517374/Cv/3'>Tryptase inhibitor/trypsin interactions</scene> (PDB entry [[1ldt]]).
	</StructureSection>		</StructureSection>

Michal Harel at 23:00, 27 September 2018

Michal Harel — Thu, 27 Sep 2018 23:00:53 GMT

←Older revision		Revision as of 23:00, 27 September 2018
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-	<StructureSection load='1ldt' size='~~400~~' side='right' caption='Structure of leech tryptase inhibitor (magenta) complex with trypsin (cyan) and Ca+2 ion (green) (PDB entry [[1ldt]])' scene='51/517374/Cv/1'>	+	<StructureSection load='1ldt' size='350' side='right' caption='Structure of leech tryptase inhibitor (magenta) complex with trypsin (cyan) and Ca+2 ion (green) (PDB entry [[1ldt]])' scene='51/517374/Cv/1'>

	'''Tryptase inhibitors''' (TI) are protein inhibitors of tryptase belonging to the group of Kazal-type inhibitors and exhibiting a distinctive disulfide pattern<ref>PMID:9242660</ref>.		'''Tryptase inhibitors''' (TI) are protein inhibitors of tryptase belonging to the group of Kazal-type inhibitors and exhibiting a distinctive disulfide pattern<ref>PMID:9242660</ref>.

Alexander Berchansky at 09:16, 11 July 2017

Alexander Berchansky — Tue, 11 Jul 2017 09:16:48 GMT

←Older revision		Revision as of 09:16, 11 July 2017
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	== Relevance ==		== Relevance ==
	TI are used as anti-inflammatory agents in treating asthma and other airway inflammation diseases. Tryptase was found in elevated levels in various kinds of allergic inflammations.		TI are used as anti-inflammatory agents in treating asthma and other airway inflammation diseases. Tryptase was found in elevated levels in various kinds of allergic inflammations.
		+	*<scene name='51/517374/Cv/2'>Tryptase inhibitor/trypsin interactions</scene> (PDB entry [[1ldt]]).
	</StructureSection>		</StructureSection>

Alexander Berchansky at 09:04, 11 July 2017

Alexander Berchansky — Tue, 11 Jul 2017 09:04:42 GMT

←Older revision		Revision as of 09:04, 11 July 2017
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-	<StructureSection load='1ldt' size='400' side='right' caption='Structure of leech tryptase inhibitor (~~aqua~~) complex with trypsin (~~dark green~~) and Ca+2 ion (green) (PDB entry [[1ldt]])' scene=''>	+	<StructureSection load='1ldt' size='400' side='right' caption='Structure of leech tryptase inhibitor (magenta) complex with trypsin (cyan) and Ca+2 ion (green) (PDB entry [[1ldt]])' scene='51/517374/Cv/1'>

	'''Tryptase inhibitors''' (TI) are protein inhibitors of tryptase belonging to the group of Kazal-type inhibitors and exhibiting a distinctive disulfide pattern<ref>PMID:9242660</ref>.		'''Tryptase inhibitors''' (TI) are protein inhibitors of tryptase belonging to the group of Kazal-type inhibitors and exhibiting a distinctive disulfide pattern<ref>PMID:9242660</ref>.

Michal Harel at 08:06, 27 September 2016

Michal Harel — Tue, 27 Sep 2016 08:06:57 GMT

←Older revision		Revision as of 08:06, 27 September 2016
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	<StructureSection load='1ldt' size='400' side='right' caption='Structure of leech tryptase inhibitor (aqua) complex with trypsin (dark green) and Ca+2 ion (green) (PDB entry [[1ldt]])' scene=''>		<StructureSection load='1ldt' size='400' side='right' caption='Structure of leech tryptase inhibitor (aqua) complex with trypsin (dark green) and Ca+2 ion (green) (PDB entry [[1ldt]])' scene=''>

-	'''Tryptase inhibitors''' (TI) are used as anti-inflammatory agents in treating asthma and other airway inflammation diseases. Tryptase was found in elevated levels in various kinds of allergic inflammations.	+	'''Tryptase inhibitors''' (TI) are protein inhibitors of tryptase belonging to the group of Kazal-type inhibitors and exhibiting a distinctive disulfide pattern<ref>PMID:9242660</ref>.
		+
		+	== Relevance ==
		+	TI are used as anti-inflammatory agents in treating asthma and other airway inflammation diseases. Tryptase was found in elevated levels in various kinds of allergic inflammations.
	</StructureSection>		</StructureSection>

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	**[[2lfk]], [[2lfl]] – tTI - NMR		**[[2lfk]], [[2lfl]] – tTI - NMR
	}}		}}
		+	== References ==
		+	<references/>
	[[Category: Topic Page]]		[[Category: Topic Page]]

Michal Harel at 12:43, 15 December 2014

Michal Harel — Mon, 15 Dec 2014 12:43:38 GMT

←Older revision		Revision as of 12:43, 15 December 2014
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	'''Tryptase inhibitors''' (TI) are used as anti-inflammatory agents in treating asthma and other airway inflammation diseases. Tryptase was found in elevated levels in various kinds of allergic inflammations.		'''Tryptase inhibitors''' (TI) are used as anti-inflammatory agents in treating asthma and other airway inflammation diseases. Tryptase was found in elevated levels in various kinds of allergic inflammations.
		+	</StructureSection>

	==3D structures of tryptase inhibitor==		==3D structures of tryptase inhibitor==
		+	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
		+	{{#tree:id=OrganizedByTopic\|openlevels=0\|

-	~~===~~Leech-derived tryptase inhibitor~~===~~	+	*Leech-derived tryptase inhibitor

-	[[1ldt]] – MlTI + trypsin – Medicinal leech<br />	+	**[[1ldt]] – MlTI + trypsin – Medicinal leech<br />
-	[[1an1]] - MlTI (mutant) + trypsin<br />	+	**[[1an1]] - MlTI (mutant) + trypsin<br />
-	[[2kmo]], [[2kmp]], [[2kmq]], [[2kmr]] – MlTI - NMR	+	**[[2kmo]], [[2kmp]], [[2kmq]], [[2kmr]] – MlTI - NMR

-	~~===~~Tick-derived tryptase inhibitor~~===~~	+	*Tick-derived tryptase inhibitor

-	[[2uux]] – tTI residues 44-96 – tick<br />	+	**[[2uux]] – tTI residues 44-96 – tick<br />
-	[[2uuy]] - tTI + trypsin<br />	+	**[[2uuy]] - tTI + trypsin<br />
-	[[2lfk]], [[2lfl]] – tTI - NMR	+	**[[2lfk]], [[2lfl]] – tTI - NMR
-		+	}}
-	~~</StructureSection>~~	+	[[Category: Topic Page]]

Michal Harel at 13:01, 18 November 2012

Michal Harel — Sun, 18 Nov 2012 13:01:13 GMT

←Older revision		Revision as of 13:01, 18 November 2012
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-	<StructureSection load='1ldt' size='400' side='right' caption='Structure of leech tryptase inhibitor complex with trypsin and Ca+2 (PDB entry [[1ldt]])' scene=''>	+	<StructureSection load='1ldt' size='400' side='right' caption='Structure of leech tryptase inhibitor (aqua) complex with trypsin (dark green) and Ca+2 ion (green) (PDB entry [[1ldt]])' scene=''>

	'''Tryptase inhibitors''' (TI) are used as anti-inflammatory agents in treating asthma and other airway inflammation diseases. Tryptase was found in elevated levels in various kinds of allergic inflammations.		'''Tryptase inhibitors''' (TI) are used as anti-inflammatory agents in treating asthma and other airway inflammation diseases. Tryptase was found in elevated levels in various kinds of allergic inflammations.

Michal Harel at 10:18, 17 October 2012

Michal Harel — Wed, 17 Oct 2012 10:18:48 GMT

←Older revision		Revision as of 10:18, 17 October 2012
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-		+	<StructureSection load='1ldt' size='400' side='right' caption='Structure of leech tryptase inhibitor complex with trypsin and Ca+2 (PDB entry [[1ldt]])' scene=''>
-	<StructureSection load='1ldt' size='400' side='right' caption='Structure of leech tryptase inhibitor complex with trypsin (PDB entry [[1ldt]])' scene=''>	+

	'''Tryptase inhibitors''' (TI) are used as anti-inflammatory agents in treating asthma and other airway inflammation diseases. Tryptase was found in elevated levels in various kinds of allergic inflammations.		'''Tryptase inhibitors''' (TI) are used as anti-inflammatory agents in treating asthma and other airway inflammation diseases. Tryptase was found in elevated levels in various kinds of allergic inflammations.

Michal Harel: New page: '''Tryptase inhibitors''' (TI) a...

Michal Harel — Wed, 17 Oct 2012 10:18:04 GMT

New page: <StructureSection load='1ldt' size='400' side='right' caption='Structure of leech tryptase inhibitor complex with trypsin (PDB entry 1ldt)' scene=''> '''Tryptase inhibitors''' (TI) a...

New page

<StructureSection load='1ldt' size='400' side='right' caption='Structure of leech tryptase inhibitor complex with trypsin (PDB entry [[1ldt]])' scene=''>

'''Tryptase inhibitors''' (TI) are used as anti-inflammatory agents in treating asthma and other airway inflammation diseases. Tryptase was found in elevated levels in various kinds of allergic inflammations.

==3D structures of tryptase inhibitor==

===Leech-derived tryptase inhibitor===

[[1ldt]] – MlTI + trypsin – Medicinal leech<br />
[[1an1]] - MlTI (mutant) + trypsin<br />
[[2kmo]], [[2kmp]], [[2kmq]], [[2kmr]] – MlTI - NMR

===Tick-derived tryptase inhibitor===

[[2uux]] – tTI residues 44-96 – tick<br />
[[2uuy]] - tTI + trypsin<br />
[[2lfk]], [[2lfl]] – tTI - NMR

</StructureSection>