Tryptophan RNA-binding attenuation protein - Revision history

Michal Harel at 10:31, 21 December 2020

Michal Harel — Mon, 21 Dec 2020 10:31:50 GMT

←Older revision		Revision as of 10:31, 21 December 2020
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	== Function ==		== Function ==

-	'''Tryptophan RNA-binding attenuation protein''' (TRAP) is a tryptophan-activated RNA-binding protein which regulates the expression of the tryptophan biosynthesis genes. Down regulation of Trp biosynthesis is observed upon binding of 11 tryptophan molecules to TRAP<ref>PMID:14687568</ref>.	+	'''Tryptophan RNA-binding attenuation protein''' (TRAP) or '''transcription attenuation protein MtrB''' is a tryptophan-activated RNA-binding protein which regulates the expression of the tryptophan biosynthesis genes. Down regulation of Trp biosynthesis is observed upon binding of 11 tryptophan molecules to TRAP<ref>PMID:14687568</ref>.

	== Structural highlights ==		== Structural highlights ==

Alexander Berchansky at 13:35, 3 October 2019

Alexander Berchansky — Thu, 03 Oct 2019 13:35:00 GMT

←Older revision		Revision as of 13:35, 3 October 2019
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	== Structural highlights ==		== Structural highlights ==
-	TRAP is composed of 11 identical subunits arranged in a <scene name='59/595823/Cv/4'>symmetrical ring</scene>. The <scene name='59/595823/Cv/2'>active site of TRAP</scene><ref>PMID:16698553</ref>.	+	TRAP is composed of 11 identical subunits arranged in a <scene name='59/595823/Cv/4'>symmetrical ring</scene>. The <scene name='59/595823/Cv/3'>active site of TRAP</scene><ref>PMID:16698553</ref>. Water molecules are shown as red spheres.
	</StructureSection>		</StructureSection>

Alexander Berchansky at 13:34, 3 October 2019

Alexander Berchansky — Thu, 03 Oct 2019 13:34:07 GMT

←Older revision		Revision as of 13:34, 3 October 2019
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	== Structural highlights ==		== Structural highlights ==
-	TRAP is composed of 11 identical subunits arranged in a symmetrical ring. The <scene name='59/595823/Cv/2'>active site of TRAP</scene><ref>PMID:16698553</ref>.	+	TRAP is composed of 11 identical subunits arranged in a <scene name='59/595823/Cv/4'>symmetrical ring</scene>. The <scene name='59/595823/Cv/2'>active site of TRAP</scene><ref>PMID:16698553</ref>.
	</StructureSection>		</StructureSection>

Michal Harel at 16:33, 28 September 2018

Michal Harel — Fri, 28 Sep 2018 16:33:50 GMT

←Older revision		Revision as of 16:33, 28 September 2018
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-	<StructureSection load='2exs' size='~~400~~' side='right' caption='Structure of tryptophan RNA-binding attenuation protein complex with Trp (PDB code [[2exs]]).' scene=''>	+	<StructureSection load='2exs' size='350' side='right' caption='Structure of tryptophan RNA-binding attenuation protein complex with Trp (PDB code [[2exs]]).' scene=''>

	== Function ==		== Function ==

-	'''Tryptophan RNA-binding attenuation protein''' (TRAP) is a tryptophan-activated RNA-binding protein which regulates the expression of the tryptophan biosynthesis genes. Down regulation of Trp biosynthesis is observed upon binding of 11 ~~Trp~~ to TRAP<ref>PMID:14687568</ref>.	+	'''Tryptophan RNA-binding attenuation protein''' (TRAP) is a tryptophan-activated RNA-binding protein which regulates the expression of the tryptophan biosynthesis genes. Down regulation of Trp biosynthesis is observed upon binding of 11 tryptophan molecules to TRAP<ref>PMID:14687568</ref>.

	== Structural highlights ==		== Structural highlights ==

Alexander Berchansky at 10:32, 30 March 2017

Alexander Berchansky — Thu, 30 Mar 2017 10:32:30 GMT

←Older revision		Revision as of 10:32, 30 March 2017
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	== Structural highlights ==		== Structural highlights ==
-	TRAP is composed of 11 identical subunits arranged in a symmetrical ring. ~~Tryptophan is bound to~~ TRAP ~~by mostly non-polar residues~~<ref>PMID:16698553</ref>.	+	TRAP is composed of 11 identical subunits arranged in a symmetrical ring. The <scene name='59/595823/Cv/2'>active site of TRAP</scene><ref>PMID:16698553</ref>.
	</StructureSection>		</StructureSection>

Alexander Berchansky at 10:19, 30 March 2017

Alexander Berchansky — Thu, 30 Mar 2017 10:19:54 GMT

←Older revision		Revision as of 10:19, 30 March 2017
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-	<StructureSection load='2exs' size='~~340~~' side='right' caption='Structure of tryptophan RNA-binding attenuation protein complex with Trp (PDB code [[2exs]]).' scene=''>	+	<StructureSection load='2exs' size='400' side='right' caption='Structure of tryptophan RNA-binding attenuation protein complex with Trp (PDB code [[2exs]]).' scene=''>

	== Function ==		== Function ==

Michal Harel at 09:29, 27 November 2016

Michal Harel — Sun, 27 Nov 2016 09:29:29 GMT

←Older revision		Revision as of 09:29, 27 November 2016
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	*Tryptophan RNA-binding attenuation protein ternary complex with Trp		*Tryptophan RNA-binding attenuation protein ternary complex with Trp

-	**[[1c9s]], [[1gtf]], [[1gtn]], [[1utd~~]], [[1utf]], [[1utv~~]], [[4v4f]] – GsTRAP + RNA + Trp <br />	+	**[[1c9s]], [[1gtf]], [[1gtn]], [[1utd]], [[4v4f]] – GsTRAP + RNA + Trp <br />
	**[[2zp8]], [[2zp9]] – GsTRAP + TRAP inhibitory protein + Trp <br />		**[[2zp8]], [[2zp9]] – GsTRAP + TRAP inhibitory protein + Trp <br />

Michal Harel at 08:36, 27 September 2016

Michal Harel — Tue, 27 Sep 2016 08:36:29 GMT

←Older revision		Revision as of 08:36, 27 September 2016
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	**[[2zdo]], [[2exs]], [[2ext]], [[2zcz]], [[2zd0]], [[3zzs]], [[1qaw]] – GsTRAP + Trp<br />		**[[2zdo]], [[2exs]], [[2ext]], [[2zcz]], [[2zd0]], [[3zzs]], [[1qaw]] – GsTRAP + Trp<br />
		+	**[[5eew]], [[5eex]], [[5eey]], [[5eez]], [[5ef0]], [[5ef1]], [[5ef2]], [[5ef3]] – GsTRAP + Trp – radiation damage<br />
	**[[1wap]], [[3zzq]] – BsTRAP + Trp – ''Bacillus subtilis''<br />		**[[1wap]], [[3zzq]] – BsTRAP + Trp – ''Bacillus subtilis''<br />
	**[[4b27]] – BsTRAP (mutant) + Trp <br />		**[[4b27]] – BsTRAP (mutant) + Trp <br />
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	*Tryptophan RNA-binding attenuation protein ternary complex with Trp		*Tryptophan RNA-binding attenuation protein ternary complex with Trp

-	**[[1c9s]], [[1gtf]], [[1gtn]], [[1utd]], [[1utf]], [[1utv]] – GsTRAP + RNA + Trp <br />	+	**[[1c9s]], [[1gtf]], [[1gtn]], [[1utd]], [[1utf]], [[1utv]], [[4v4f]] – GsTRAP + RNA + Trp <br />
	**[[2zp8]], [[2zp9]] – GsTRAP + TRAP inhibitory protein + Trp <br />		**[[2zp8]], [[2zp9]] – GsTRAP + TRAP inhibitory protein + Trp <br />

Michal Harel at 08:23, 27 September 2016

Michal Harel — Tue, 27 Sep 2016 08:23:14 GMT

←Older revision		Revision as of 08:23, 27 September 2016
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	== Function ==		== Function ==

-	'''Tryptophan RNA-binding attenuation protein''' (TRAP) is a tryptophan-activated RNA-binding protein which regulates the expression of the tryptophan biosynthesis genes~~. TRAP is composed of 11 identical subunits arranged in a symmetrical ring~~. Down regulation of Trp biosynthesis is observed upon binding of 11 Trp to TRAP<ref>PMID:14687568</ref>.	+	'''Tryptophan RNA-binding attenuation protein''' (TRAP) is a tryptophan-activated RNA-binding protein which regulates the expression of the tryptophan biosynthesis genes. Down regulation of Trp biosynthesis is observed upon binding of 11 Trp to TRAP<ref>PMID:14687568</ref>.

	== Structural highlights ==		== Structural highlights ==
-	Tryptophan is bound to TRAP by mostly non-polar residues<ref>PMID:16698553</ref>.	+	TRAP is composed of 11 identical subunits arranged in a symmetrical ring. Tryptophan is bound to TRAP by mostly non-polar residues<ref>PMID:16698553</ref>.
	</StructureSection>		</StructureSection>

Michal Harel at 08:21, 27 September 2016

Michal Harel — Tue, 27 Sep 2016 08:21:38 GMT

←Older revision		Revision as of 08:21, 27 September 2016
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-	<StructureSection load='2exs' size='340' side='right' caption='Structure of tryptophan RNA-binding attenuation protein complex with ~~RNA and~~ Trp (PDB code [[~~1utf~~]]).' scene=''>	+	<StructureSection load='2exs' size='340' side='right' caption='Structure of tryptophan RNA-binding attenuation protein complex with Trp (PDB code [[2exs]]).' scene=''>

	== Function ==		== Function ==

-	'''Tryptophan RNA-binding attenuation protein''' (TRAP) is a tryptophan-activated RNA-binding protein which regulates the expression of the tryptophan biosynthesis genes. TRAP is composed of 11 identical subunits arranged in a symmetrical ring. Down regulation of Trp biosynthesis is observed upon binding of 11 Trp to TRAP.	+	'''Tryptophan RNA-binding attenuation protein''' (TRAP) is a tryptophan-activated RNA-binding protein which regulates the expression of the tryptophan biosynthesis genes. TRAP is composed of 11 identical subunits arranged in a symmetrical ring. Down regulation of Trp biosynthesis is observed upon binding of 11 Trp to TRAP<ref>PMID:14687568</ref>.
-		+
-	~~== Disease ==~~	+
-		+
-	~~== Relevance ==~~	+

	== Structural highlights ==		== Structural highlights ==
		+	Tryptophan is bound to TRAP by mostly non-polar residues<ref>PMID:16698553</ref>.
	</StructureSection>		</StructureSection>