Tumor necrosis factor - Revision history

Michal Harel at 11:08, 5 February 2024

Michal Harel — Mon, 05 Feb 2024 11:08:45 GMT

←Older revision		Revision as of 11:08, 5 February 2024
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	== Structural highlights ==		== Structural highlights ==
	The biological assembly of human tumor necrosis factor is <scene name='55/551212/Cv/4'>homotetramer</scene> (PDB entry [[2az5]]). <scene name='55/551212/Cv/5'>Inhibitor binding site</scene>.		The biological assembly of human tumor necrosis factor is <scene name='55/551212/Cv/4'>homotetramer</scene> (PDB entry [[2az5]]). <scene name='55/551212/Cv/5'>Inhibitor binding site</scene>.
		+

	== 3D Structures of tumor necrosis factor ==		== 3D Structures of tumor necrosis factor ==
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	[[Tumor necrosis factor 3D structures]]		[[Tumor necrosis factor 3D structures]]

-	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-	{{#tree:id=OrganizedByTopic\|openlevels=0\|
-
-	*TNF α
-
-	**[[1tnf]] – hTNF – human <BR />
-	**[[2tun]], [[1a8m]], [[4tsv]], [[5tsw]], [[2e7e]], [[2zjc]], [[2zpx]], [[5tsw]], [[5uui]], [[6rmj]] – hTNF (mutant) <BR />
-	**[[2az5]], [[5mu8]], [[6ooy]], [[6ooz]], [[6op0]] – hTNF + inhibitor <BR />
-	**[[3it8]] – hTNF + poxvirus 2L protein <BR />
-	**[[3l9j]] – hTNF + antagonist <BR />
-	**[[3alq]] – hTNF (mutant) + TNF receptor <BR />
-	**[[4g3y]], [[3wd5]] – hTNF + antibody <BR />
-	**[[4twt]] – hTNF + peptide <BR />
-	**[[2tnf]] – mTNF – mouse <BR />
-	**[[7kp7]], [[7kp8]] – mTNF + hTNFR1A <BR />
-	**[[7kpb]] – mTNF + hTNFR1A + antibody<BR />
-
-	*TNF β
-
-	**[[1tnr]] – hTNF + TNF receptor p55 <BR />
-
-	*TNF
-
-	**[[2vfj]] – hTNF ovarian tumor domain <BR />
-	**[[5m2i]], [[5m2j]], [[5m2m]], [[5wux]], [[5yoy]] – hTNF + antibody <BR />
-	}}
	== References ==		== References ==
	<references/>		<references/>
	</StructureSection>		</StructureSection>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 11:05, 5 February 2024

Michal Harel — Mon, 05 Feb 2024 11:05:18 GMT

←Older revision		Revision as of 11:05, 5 February 2024
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	== Structural highlights ==		== Structural highlights ==
	The biological assembly of human tumor necrosis factor is <scene name='55/551212/Cv/4'>homotetramer</scene> (PDB entry [[2az5]]). <scene name='55/551212/Cv/5'>Inhibitor binding site</scene>.		The biological assembly of human tumor necrosis factor is <scene name='55/551212/Cv/4'>homotetramer</scene> (PDB entry [[2az5]]). <scene name='55/551212/Cv/5'>Inhibitor binding site</scene>.
-	</StructureSection>

	== 3D Structures of tumor necrosis factor ==		== 3D Structures of tumor necrosis factor ==
		+
		+	[[Tumor necrosis factor 3D structures]]

	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}		Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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	== References ==		== References ==
	<references/>		<references/>
		+	</StructureSection>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 06:56, 12 June 2022

Michal Harel — Sun, 12 Jun 2022 06:56:26 GMT

←Older revision		Revision as of 06:56, 12 June 2022
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	**[[4g3y]], [[3wd5]] – hTNF + antibody <BR />		**[[4g3y]], [[3wd5]] – hTNF + antibody <BR />
	**[[4twt]] – hTNF + peptide <BR />		**[[4twt]] – hTNF + peptide <BR />
-	**[[2tnf]] – ~~TNF~~ – mouse <BR />	+	**[[2tnf]] – mTNF – mouse <BR />
		+	**[[7kp7]], [[7kp8]] – mTNF + hTNFR1A <BR />
		+	**[[7kpb]] – mTNF + hTNFR1A + antibody<BR />

	*TNF β		*TNF β

Michal Harel at 07:33, 16 March 2020

Michal Harel — Mon, 16 Mar 2020 07:33:28 GMT

←Older revision		Revision as of 07:33, 16 March 2020
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	**[[1tnf]] – hTNF – human <BR />		**[[1tnf]] – hTNF – human <BR />
-	**[[2tun]], [[1a8m]], [[4tsv]], [[5tsw]], [[2e7e]], [[2zjc]], [[2zpx]], [[5tsw]], [[5uui]] – hTNF (mutant) <BR />	+	**[[2tun]], [[1a8m]], [[4tsv]], [[5tsw]], [[2e7e]], [[2zjc]], [[2zpx]], [[5tsw]], [[5uui]], [[6rmj]] – hTNF (mutant) <BR />
-	**[[~~2tnf~~]] ~~– TNF – mouse <BR />~~	+	**[[2az5]], [[5mu8]], [[6ooy]], [[6ooz]], [[6op0]] – hTNF + inhibitor <BR />
-	**[[~~2az5~~]], [[~~5mu8~~]] – hTNF + inhibitor <BR />	+
	**[[3it8]] – hTNF + poxvirus 2L protein <BR />		**[[3it8]] – hTNF + poxvirus 2L protein <BR />
	**[[3l9j]] – hTNF + antagonist <BR />		**[[3l9j]] – hTNF + antagonist <BR />
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	**[[4g3y]], [[3wd5]] – hTNF + antibody <BR />		**[[4g3y]], [[3wd5]] – hTNF + antibody <BR />
	**[[4twt]] – hTNF + peptide <BR />		**[[4twt]] – hTNF + peptide <BR />
		+	**[[2tnf]] – TNF – mouse <BR />

	*TNF β		*TNF β

Alexander Berchansky at 10:35, 29 December 2019

Alexander Berchansky — Sun, 29 Dec 2019 10:35:37 GMT

←Older revision		Revision as of 10:35, 29 December 2019
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	<StructureSection load='' size='350' side='right' caption='Structure of human tumor necrosis factor tetramer complex with inhibitor (PDB entry [[2az5]])' scene='55/551212/Cv/1'>		<StructureSection load='' size='350' side='right' caption='Structure of human tumor necrosis factor tetramer complex with inhibitor (PDB entry [[2az5]])' scene='55/551212/Cv/1'>
	== Function ==		== Function ==
-	'''Tumor necrosis factor''' (TNF) is a cytokine which can cause apoptosis. '''TNFα''' is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome). It is involved in the regulation of the immune cells<ref>PMID:11514191</ref>. '''TNFβ''' is inhibited by interleukin 10. TNF is a transmembrane homotrimer. The soluble TNF is produced by cleavage by the metalloprotease TNFα-converting enzyme (TACE or ADAM17 see [[A Disintegrin And Metalloproteinase]]).	+	'''Tumor necrosis factor''' (TNF) is a cytokine which can cause apoptosis. '''TNFα''' is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome). It is involved in the regulation of the immune cells<ref>PMID:11514191</ref>. '''TNFβ''' is inhibited by interleukin 10. TNF is a transmembrane homotrimer. The soluble TNF is produced by cleavage by the metalloprotease TNFα-converting enzyme (TACE or ADAM17 see [[A Disintegrin And Metalloproteinase]]). See also [[TRAIL]] and [[Molecular Playground/TRAIL]].

	== Relevance ==		== Relevance ==

Alexander Berchansky at 13:16, 6 October 2019

Alexander Berchansky — Sun, 06 Oct 2019 13:16:06 GMT

←Older revision		Revision as of 13:16, 6 October 2019
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	== Structural highlights ==		== Structural highlights ==
-	The biological assembly of human tumor necrosis factor is <scene name='55/551212/Cv/2'>homotetramer</scene> (PDB entry [[2az5]]). <scene name='55/551212/Cv/3'>Inhibitor binding site</scene>.	+	The biological assembly of human tumor necrosis factor is <scene name='55/551212/Cv/4'>homotetramer</scene> (PDB entry [[2az5]]). <scene name='55/551212/Cv/5'>Inhibitor binding site</scene>.
	</StructureSection>		</StructureSection>

Michal Harel at 20:23, 28 September 2018

Michal Harel — Fri, 28 Sep 2018 20:23:20 GMT

←Older revision		Revision as of 20:23, 28 September 2018
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-	<StructureSection load='' size='~~400~~' side='right' caption='Structure of human tumor necrosis factor tetramer complex with inhibitor (PDB entry [[2az5]])' scene='55/551212/Cv/1'>	+	<StructureSection load='' size='350' side='right' caption='Structure of human tumor necrosis factor tetramer complex with inhibitor (PDB entry [[2az5]])' scene='55/551212/Cv/1'>
	== Function ==		== Function ==
	'''Tumor necrosis factor''' (TNF) is a cytokine which can cause apoptosis. '''TNFα''' is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome). It is involved in the regulation of the immune cells<ref>PMID:11514191</ref>. '''TNFβ''' is inhibited by interleukin 10. TNF is a transmembrane homotrimer. The soluble TNF is produced by cleavage by the metalloprotease TNFα-converting enzyme (TACE or ADAM17 see [[A Disintegrin And Metalloproteinase]]).		'''Tumor necrosis factor''' (TNF) is a cytokine which can cause apoptosis. '''TNFα''' is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome). It is involved in the regulation of the immune cells<ref>PMID:11514191</ref>. '''TNFβ''' is inhibited by interleukin 10. TNF is a transmembrane homotrimer. The soluble TNF is produced by cleavage by the metalloprotease TNFα-converting enzyme (TACE or ADAM17 see [[A Disintegrin And Metalloproteinase]]).
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	**[[2vfj]] – hTNF ovarian tumor domain <BR />		**[[2vfj]] – hTNF ovarian tumor domain <BR />
-	**[[5m2i]], [[5m2j]], [[5m2m]], [[5wux]] – hTNF + antibody <BR />	+	**[[5m2i]], [[5m2j]], [[5m2m]], [[5wux]], [[5yoy]] – hTNF + antibody <BR />
	}}		}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Joel L. Sussman at 04:01, 16 October 2017

Joel L. Sussman — Mon, 16 Oct 2017 04:01:49 GMT

←Older revision		Revision as of 04:01, 16 October 2017
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-	<StructureSection load='~~2az5~~' size='400' side='right' caption='Structure of human tumor necrosis factor tetramer complex with inhibitor (PDB entry [[2az5]])' scene='55/551212/Cv/1'>	+	<StructureSection load='' size='400' side='right' caption='Structure of human tumor necrosis factor tetramer complex with inhibitor (PDB entry [[2az5]])' scene='55/551212/Cv/1'>
	== Function ==		== Function ==
	'''Tumor necrosis factor''' (TNF) is a cytokine which can cause apoptosis. '''TNFα''' is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome). It is involved in the regulation of the immune cells<ref>PMID:11514191</ref>. '''TNFβ''' is inhibited by interleukin 10. TNF is a transmembrane homotrimer. The soluble TNF is produced by cleavage by the metalloprotease TNFα-converting enzyme (TACE or ADAM17 see [[A Disintegrin And Metalloproteinase]]).		'''Tumor necrosis factor''' (TNF) is a cytokine which can cause apoptosis. '''TNFα''' is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome). It is involved in the regulation of the immune cells<ref>PMID:11514191</ref>. '''TNFβ''' is inhibited by interleukin 10. TNF is a transmembrane homotrimer. The soluble TNF is produced by cleavage by the metalloprotease TNFα-converting enzyme (TACE or ADAM17 see [[A Disintegrin And Metalloproteinase]]).

Michal Harel at 19:11, 12 October 2017

Michal Harel — Thu, 12 Oct 2017 19:11:42 GMT

←Older revision		Revision as of 19:11, 12 October 2017
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	**[[1tnf]] – hTNF – human <BR />		**[[1tnf]] – hTNF – human <BR />
-	**[[2tun]], [[1a8m]], [[4tsv]], [[5tsw]], [[2e7e]], [[2zjc]], [[2zpx]] – hTNF (mutant) <BR />	+	**[[2tun]], [[1a8m]], [[4tsv]], [[5tsw]], [[2e7e]], [[2zjc]], [[2zpx]], [[5tsw]], [[5uui]] – hTNF (mutant) <BR />
	**[[2tnf]] – TNF – mouse <BR />		**[[2tnf]] – TNF – mouse <BR />
-	**[[2az5]] – hTNF + inhibitor <BR />	+	**[[2az5]], [[5mu8]] – hTNF + inhibitor <BR />
	**[[3it8]] – hTNF + poxvirus 2L protein <BR />		**[[3it8]] – hTNF + poxvirus 2L protein <BR />
	**[[3l9j]] – hTNF + antagonist <BR />		**[[3l9j]] – hTNF + antagonist <BR />
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	**[[2vfj]] – hTNF ovarian tumor domain <BR />		**[[2vfj]] – hTNF ovarian tumor domain <BR />
		+	**[[5m2i]], [[5m2j]], [[5m2m]], [[5wux]] – hTNF + antibody <BR />
	}}		}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Alexander Berchansky at 08:51, 13 July 2017

Alexander Berchansky — Thu, 13 Jul 2017 08:51:56 GMT

←Older revision		Revision as of 08:51, 13 July 2017
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	== Structural highlights ==		== Structural highlights ==
-	The biological assembly of human tumor necrosis factor is <scene name='55/551212/Cv/2'>homotetramer</scene> (PDB entry [[2az5]]).	+	The biological assembly of human tumor necrosis factor is <scene name='55/551212/Cv/2'>homotetramer</scene> (PDB entry [[2az5]]). <scene name='55/551212/Cv/3'>Inhibitor binding site</scene>.
	</StructureSection>		</StructureSection>